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Protein

Polycomb group RING finger protein 2

Gene

PCGF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Is not functionally redundant with BMI1; unlike BMI1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri18 – 57RING-typePROSITE-ProRule annotationAdd BLAST40

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-3108214. SUMOylation of DNA damage response and repair proteins.
R-HSA-4551638. SUMOylation of chromatin organization proteins.
R-HSA-4570464. SUMOylation of RNA binding proteins.
R-HSA-5617472. Activation of anterior HOX genes in hindbrain development during early embryogenesis.
SIGNORiP35227.

Names & Taxonomyi

Protein namesi
Recommended name:
Polycomb group RING finger protein 2
Alternative name(s):
DNA-binding protein Mel-18
RING finger protein 110
Zinc finger protein 144
Gene namesi
Name:PCGF2
Synonyms:MEL18, RNF110, ZNF144
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000277258.4.
HGNCiHGNC:12929. PCGF2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7703.
OpenTargetsiENSG00000277258.
PharmGKBiPA37516.

Polymorphism and mutation databases

BioMutaiPCGF2.
DMDMi462585.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000559841 – 344Polycomb group RING finger protein 2Add BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki51Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei344PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylated. Homodimer formation is regulated by phosphorylation state with unphosphorylated protein forming homodimers (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP35227.
MaxQBiP35227.
PaxDbiP35227.
PeptideAtlasiP35227.
PRIDEiP35227.

PTM databases

iPTMnetiP35227.
PhosphoSitePlusiP35227.

Expressioni

Tissue specificityi

Detected in all tissues examined with high expression found in placenta lung and kidney and low expression, in liver, pancreas and skeletal muscle.

Gene expression databases

BgeeiENSG00000277258.
CleanExiHS_PCGF2.
ExpressionAtlasiP35227. baseline and differential.
GenevisibleiP35227. HS.

Organism-specific databases

HPAiHPA047732.
HPA063531.

Interactioni

Subunit structurei

Exists as both a monomer and homodimer (By similarity). Component of a PRC1-like complex. Interacts WITH CBX8, RING1 AND RNF2.By similarity2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113497. 58 interactors.
DIPiDIP-41880N.
IntActiP35227. 34 interactors.
MINTiMINT-158325.
STRINGi9606.ENSP00000354033.

Structurei

3D structure databases

ProteinModelPortaliP35227.
SMRiP35227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi81 – 95Nuclear localization signalSequence analysisAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi242 – 344Pro/Ser-richAdd BLAST103

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri18 – 57RING-typePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2660. Eukaryota.
ENOG410XPCN. LUCA.
GeneTreeiENSGT00550000074463.
HOGENOMiHOG000231945.
HOVERGENiHBG052826.
InParanoidiP35227.
KOiK11460.
OMAiFYEWRRT.
OrthoDBiEOG091G09IB.
PhylomeDBiP35227.
TreeFamiTF324206.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR032443. RAWUL.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
PfamiView protein in Pfam
PF16207. RAWUL. 1 hit.
SMARTiView protein in SMART
SM00184. RING. 1 hit.
PROSITEiView protein in PROSITE
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P35227-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRTTRIKIT ELNPHLMCAL CGGYFIDATT IVECLHSFCK TCIVRYLETN
60 70 80 90 100
KYCPMCDVQV HKTRPLLSIR SDKTLQDIVY KLVPGLFKDE MKRRRDFYAA
110 120 130 140 150
YPLTEVPNGS NEDRGEVLEQ EKGALSDDEI VSLSIEFYEG ARDRDEKKGP
160 170 180 190 200
LENGDGDKEK TGVRFLRCPA AMTVMHLAKF LRNKMDVPSK YKVEVLYEDE
210 220 230 240 250
PLKEYYTLMD IAYIYPWRRN GPLPLKYRVQ PACKRLTLAT VPTPSEGTNT
260 270 280 290 300
SGASECESVS DKAPSPATLP ATSSSLPSPA TPSHGSPSSH GPPATHPTSP
310 320 330 340
TPPSTASGAT TAANGGSLNC LQTPSSTSRG RKMTVNGAPV PPLT
Length:344
Mass (Da):37,788
Last modified:February 1, 1994 - v1
Checksum:iA910BCD4C0CE9927
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13969 mRNA. Translation: BAA03074.1.
BX647429 mRNA. No translation available.
AC006449 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60528.1.
BC004858 mRNA. Translation: AAH04858.1.
BC024255 mRNA. Translation: AAH24255.1.
CCDSiCCDS32638.1.
PIRiJN0717.
RefSeqiNP_009075.1. NM_007144.2.
XP_005257697.1. XM_005257640.2.
XP_005257698.1. XM_005257641.4.
XP_005257699.1. XM_005257642.3.
XP_016880505.1. XM_017025016.1.
UniGeneiHs.371617.
Hs.713595.

Genome annotation databases

EnsembliENST00000610440; ENSP00000478517; ENSG00000278644.
ENST00000611883; ENSP00000478970; ENSG00000277258.
ENST00000616199; ENSP00000482063; ENSG00000277258.
ENST00000620225; ENSP00000482815; ENSG00000277258.
ENST00000631566; ENSP00000488872; ENSG00000278644.
ENST00000631610; ENSP00000488868; ENSG00000278644.
GeneIDi7703.
KEGGihsa:7703.
UCSCiuc002hqp.2. human.

Similar proteinsi

Entry informationi

Entry nameiPCGF2_HUMAN
AccessioniPrimary (citable) accession number: P35227
Secondary accession number(s): A6NGD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 27, 2017
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot