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Protein

Polycomb group RING finger protein 2

Gene

PCGF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri18 – 57RING-typePROSITE-ProRule annotationAdd BLAST40

GO - Molecular functioni

  • chromatin binding Source: Ensembl
  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: ProtInc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-8953750 Transcriptional Regulation by E2F6
SIGNORiP35227

Names & Taxonomyi

Protein namesi
Recommended name:
Polycomb group RING finger protein 2
Alternative name(s):
DNA-binding protein Mel-18
RING finger protein 110
Zinc finger protein 144
Gene namesi
Name:PCGF2
Synonyms:MEL18, RNF110, ZNF144
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000277258.4
HGNCiHGNC:12929 PCGF2
MIMi600346 gene
neXtProtiNX_P35227

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7703
OpenTargetsiENSG00000277258
PharmGKBiPA37516

Polymorphism and mutation databases

BioMutaiPCGF2
DMDMi462585

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000559841 – 344Polycomb group RING finger protein 2Add BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki51Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei344PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylated. Homodimer formation is regulated by phosphorylation with only unphosphorylated proteins forming homodimers.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP35227
MaxQBiP35227
PaxDbiP35227
PeptideAtlasiP35227
PRIDEiP35227

PTM databases

iPTMnetiP35227
PhosphoSitePlusiP35227

Expressioni

Tissue specificityi

Detected in all tissues examined with high expression found in placenta lung and kidney and low expression, in liver, pancreas and skeletal muscle.

Gene expression databases

BgeeiENSG00000277258
CleanExiHS_PCGF2
ExpressionAtlasiP35227 baseline and differential
GenevisibleiP35227 HS

Organism-specific databases

HPAiHPA047732
HPA063531

Interactioni

Subunit structurei

Exists as both a monomer and homodimer (By similarity). Component of a PRC1-like complex (PubMed:19636380, PubMed:21282530, PubMed:26151332). Interacts with CBX8, RING1 AND RNF2 (PubMed:19636380). Interacts with CBX7 (By similarity). Interacts with PHC2 (By similarity).By similarity2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113497, 58 interactors
DIPiDIP-41880N
IntActiP35227, 33 interactors
MINTiP35227
STRINGi9606.ENSP00000354033

Structurei

3D structure databases

ProteinModelPortaliP35227
SMRiP35227
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi81 – 95Nuclear localization signalSequence analysisAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi242 – 344Pro/Ser-richAdd BLAST103

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri18 – 57RING-typePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2660 Eukaryota
ENOG410XPCN LUCA
GeneTreeiENSGT00550000074463
HOGENOMiHOG000231945
HOVERGENiHBG052826
InParanoidiP35227
KOiK11460
OMAiFYEWRRT
OrthoDBiEOG091G09IB
PhylomeDBiP35227
TreeFamiTF324206

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR032443 RAWUL
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF16207 RAWUL, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

P35227-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRTTRIKIT ELNPHLMCAL CGGYFIDATT IVECLHSFCK TCIVRYLETN
60 70 80 90 100
KYCPMCDVQV HKTRPLLSIR SDKTLQDIVY KLVPGLFKDE MKRRRDFYAA
110 120 130 140 150
YPLTEVPNGS NEDRGEVLEQ EKGALSDDEI VSLSIEFYEG ARDRDEKKGP
160 170 180 190 200
LENGDGDKEK TGVRFLRCPA AMTVMHLAKF LRNKMDVPSK YKVEVLYEDE
210 220 230 240 250
PLKEYYTLMD IAYIYPWRRN GPLPLKYRVQ PACKRLTLAT VPTPSEGTNT
260 270 280 290 300
SGASECESVS DKAPSPATLP ATSSSLPSPA TPSHGSPSSH GPPATHPTSP
310 320 330 340
TPPSTASGAT TAANGGSLNC LQTPSSTSRG RKMTVNGAPV PPLT
Length:344
Mass (Da):37,788
Last modified:February 1, 1994 - v1
Checksum:iA910BCD4C0CE9927
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13969 mRNA Translation: BAA03074.1
BX647429 mRNA No translation available.
AC006449 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60528.1
BC004858 mRNA Translation: AAH04858.1
BC024255 mRNA Translation: AAH24255.1
CCDSiCCDS32638.1
PIRiJN0717
RefSeqiNP_009075.1, NM_007144.2
XP_005257697.1, XM_005257640.2
XP_005257698.1, XM_005257641.4
XP_005257699.1, XM_005257642.3
XP_016880505.1, XM_017025016.1
UniGeneiHs.371617
Hs.713595

Genome annotation databases

EnsembliENST00000610440; ENSP00000478517; ENSG00000278644
ENST00000611883; ENSP00000478970; ENSG00000277258
ENST00000616199; ENSP00000482063; ENSG00000277258
ENST00000620225; ENSP00000482815; ENSG00000277258
ENST00000631566; ENSP00000488872; ENSG00000278644
ENST00000631610; ENSP00000488868; ENSG00000278644
GeneIDi7703
KEGGihsa:7703
UCSCiuc002hqp.2 human

Similar proteinsi

Entry informationi

Entry nameiPCGF2_HUMAN
AccessioniPrimary (citable) accession number: P35227
Secondary accession number(s): A6NGD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health