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P35226

- BMI1_HUMAN

UniProt

P35226 - BMI1_HUMAN

Protein

Polycomb complex protein BMI-1

Gene

BMI1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 152 (01 Oct 2014)
      Sequence version 2 (13 Aug 2002)
      Previous versions | rss
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    Functioni

    Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri18 – 5740RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. RING-like zinc finger domain binding Source: UniProtKB
    3. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. chromatin modification Source: UniProtKB-KW
    2. hemopoiesis Source: UniProtKB
    3. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    4. positive regulation of fibroblast proliferation Source: BHF-UCL
    5. positive regulation of ubiquitin-protein transferase activity Source: UniProtKB
    6. regulation of gene expression Source: BHF-UCL
    7. segment specification Source: ProtInc
    8. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_169436. Oxidative Stress Induced Senescence.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polycomb complex protein BMI-1
    Alternative name(s):
    Polycomb group RING finger protein 4
    RING finger protein 51
    Gene namesi
    Name:BMI1
    Synonyms:PCGF4, RNF51
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:1066. BMI1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleoplasm Source: Reactome
    3. nucleus Source: UniProtKB
    4. PcG protein complex Source: UniProtKB
    5. PRC1 complex Source: UniProtKB
    6. ubiquitin ligase complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    PharmGKBiPA25376.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Polycomb complex protein BMI-1PRO_0000055987Add
    BLAST

    Post-translational modificationi

    Monoubiquitinated By similarity. May be polyubiquitinated; which does not lead to proteasomal degradation.By similarity1 Publication

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    MaxQBiP35226.
    PaxDbiP35226.
    PRIDEiP35226.

    PTM databases

    PhosphoSiteiP35226.

    Expressioni

    Gene expression databases

    ArrayExpressiP35226.
    BgeeiP35226.
    CleanExiHS_BMI1.
    GenevestigatoriP35226.

    Organism-specific databases

    HPAiCAB011120.
    HPA030472.

    Interactioni

    Subunit structurei

    Component of a PRC1-like complex. Interacts with RING1 and RING2 By similarity. Interacts vwith CBX7 and CBX8. Interacts with SPOP. Part of a complex consisting of BMI1, CUL3 and SPOP. Interacts with E4F1.By similarity9 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CBX4O002574EBI-2341576,EBI-722425
    CBX4O00257-32EBI-2341576,EBI-4392727
    CBX6O955033EBI-2341576,EBI-3951758
    CBX7O959317EBI-2341576,EBI-3923843
    CBX8Q9HC5213EBI-2341576,EBI-712912
    PTENP604843EBI-2341576,EBI-696162
    RING1Q0658711EBI-2341576,EBI-752313
    RNF2Q994969EBI-2341576,EBI-722416
    UBCP0CG482EBI-2341576,EBI-3390054
    USP11P517847EBI-2341576,EBI-306876
    USP7Q930097EBI-2341576,EBI-302474
    VPS11Q9H2702EBI-2341576,EBI-373380

    Protein-protein interaction databases

    BioGridi107116. 357 interactions.
    1529410. 1 interaction.
    DIPiDIP-41879N.
    IntActiP35226. 36 interactions.
    MINTiMINT-158260.
    STRINGi9606.ENSP00000365851.

    Structurei

    Secondary structure

    1
    326
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi6 – 83
    Helixi9 – 124
    Helixi13 – 153
    Turni19 – 213
    Beta strandi22 – 243
    Beta strandi29 – 313
    Turni32 – 343
    Helixi40 – 467
    Turni54 – 563
    Helixi65 – 684
    Beta strandi69 – 713
    Helixi73 – 8210
    Helixi86 – 10015

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2H0DX-ray2.50A5-101[»]
    3RPGX-ray2.65B1-109[»]
    ProteinModelPortaliP35226.
    SMRiP35226. Positions 6-103.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP35226.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni164 – 22865Interaction with E4F1Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi81 – 9515Nuclear localization signalSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi251 – 32676Pro/Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri18 – 5740RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG304672.
    HOGENOMiHOG000231945.
    HOVERGENiHBG052826.
    InParanoidiP35226.
    KOiK11459.
    PhylomeDBiP35226.
    TreeFamiTF324206.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR018957. Znf_C3HC4_RING-type.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF00097. zf-C3HC4. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    [Graphical view]
    PROSITEiPS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35226-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHRTTRIKIT ELNPHLMCVL CGGYFIDATT IIECLHSFCK TCIVRYLETS    50
    KYCPICDVQV HKTRPLLNIR SDKTLQDIVY KLVPGLFKNE MKRRRDFYAA 100
    HPSADAANGS NEDRGEVADE DKRIITDDEI ISLSIEFFDQ NRLDRKVNKD 150
    KEKSKEEVND KRYLRCPAAM TVMHLRKFLR SKMDIPNTFQ IDVMYEEEPL 200
    KDYYTLMDIA YIYTWRRNGP LPLKYRVRPT CKRMKISHQR DGLTNAGELE 250
    SDSGSDKANS PAGGIPSTSS CLPSPSTPVQ SPHPQFPHIS STMNGTSNSP 300
    SGNHQSSFAN RPRKSSVNGS SATSSG 326
    Length:326
    Mass (Da):36,949
    Last modified:August 13, 2002 - v2
    Checksum:i030A7D396BADA543
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti109 – 1091G → S in AAB27059. (PubMed:8390036)Curated
    Sequence conflicti265 – 2651I → V in AAA19873. (PubMed:8268912)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti18 – 181C → Y.
    Corresponds to variant rs1042059 [ dbSNP | Ensembl ].
    VAR_052087

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13689 mRNA. Translation: AAA19873.1.
    AK313235 mRNA. Translation: BAG36046.1.
    AL158211 Genomic DNA. Translation: CAI15958.1.
    CH471072 Genomic DNA. Translation: EAW86148.1.
    CH471072 Genomic DNA. Translation: EAW86150.1.
    CH471072 Genomic DNA. Translation: EAW86151.1.
    CH471072 Genomic DNA. Translation: EAW86154.1.
    BC011652 mRNA. Translation: AAH11652.1.
    AH004292 mRNA. Translation: AAB27059.1.
    CCDSiCCDS7138.1.
    PIRiI54339.
    RefSeqiNP_001190991.1. NM_001204062.1.
    NP_005171.4. NM_005180.8.
    UniGeneiHs.380403.
    Hs.731287.

    Genome annotation databases

    EnsembliENST00000376663; ENSP00000365851; ENSG00000168283.
    GeneIDi100532731.
    648.
    KEGGihsa:100532731.
    hsa:648.
    UCSCiuc001irh.3. human.

    Polymorphism databases

    DMDMi22258801.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13689 mRNA. Translation: AAA19873.1 .
    AK313235 mRNA. Translation: BAG36046.1 .
    AL158211 Genomic DNA. Translation: CAI15958.1 .
    CH471072 Genomic DNA. Translation: EAW86148.1 .
    CH471072 Genomic DNA. Translation: EAW86150.1 .
    CH471072 Genomic DNA. Translation: EAW86151.1 .
    CH471072 Genomic DNA. Translation: EAW86154.1 .
    BC011652 mRNA. Translation: AAH11652.1 .
    AH004292 mRNA. Translation: AAB27059.1 .
    CCDSi CCDS7138.1.
    PIRi I54339.
    RefSeqi NP_001190991.1. NM_001204062.1.
    NP_005171.4. NM_005180.8.
    UniGenei Hs.380403.
    Hs.731287.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2H0D X-ray 2.50 A 5-101 [» ]
    3RPG X-ray 2.65 B 1-109 [» ]
    ProteinModelPortali P35226.
    SMRi P35226. Positions 6-103.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107116. 357 interactions.
    1529410. 1 interaction.
    DIPi DIP-41879N.
    IntActi P35226. 36 interactions.
    MINTi MINT-158260.
    STRINGi 9606.ENSP00000365851.

    PTM databases

    PhosphoSitei P35226.

    Polymorphism databases

    DMDMi 22258801.

    Proteomic databases

    MaxQBi P35226.
    PaxDbi P35226.
    PRIDEi P35226.

    Protocols and materials databases

    DNASUi 648.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376663 ; ENSP00000365851 ; ENSG00000168283 .
    GeneIDi 100532731.
    648.
    KEGGi hsa:100532731.
    hsa:648.
    UCSCi uc001irh.3. human.

    Organism-specific databases

    CTDi 100532731.
    648.
    GeneCardsi GC10P022605.
    HGNCi HGNC:1066. BMI1.
    HPAi CAB011120.
    HPA030472.
    MIMi 164831. gene.
    neXtProti NX_P35226.
    PharmGKBi PA25376.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG304672.
    HOGENOMi HOG000231945.
    HOVERGENi HBG052826.
    InParanoidi P35226.
    KOi K11459.
    PhylomeDBi P35226.
    TreeFami TF324206.

    Enzyme and pathway databases

    Reactomei REACT_169436. Oxidative Stress Induced Senescence.

    Miscellaneous databases

    EvolutionaryTracei P35226.
    GeneWikii BMI1.
    NextBioi 2628.
    PROi P35226.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P35226.
    Bgeei P35226.
    CleanExi HS_BMI1.
    Genevestigatori P35226.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR018957. Znf_C3HC4_RING-type.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF00097. zf-C3HC4. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    [Graphical view ]
    PROSITEi PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and chromosomal localization of the human proto-oncogene BMI-1."
      Alkema M.J., Wiegand J., Raap A.K., Berns A., van Lohuizen M.
      Hum. Mol. Genet. 2:1597-1603(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Erythrocyte.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    6. "flvi-2, a target of retroviral insertional mutagenesis in feline thymic lymphosarcomas, encodes bmi-1."
      Levy L.S., Lobelle-Rich P.A., Overbaugh J.
      Oncogene 8:1833-1838(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-300.
      Tissue: Thymus.
    7. "Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic."
      Gunster M.J., Satijn D.P.E., Hamer K.M., den Blaauwen J.L., de Bruijn D., Alkema M.J., van Lohuizen M., van Driel R., Otte A.P.
      Mol. Cell. Biol. 17:2326-2335(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PHC2.
    8. "RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor."
      Satijn D.P.E., Gunster M.J., van der Vlag J., Hamer K.M., Schul W., Alkema M.J., Saurin A.J., Freemont P.S., van Driel R., Otte A.P.
      Mol. Cell. Biol. 17:4105-4113(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PHC2.
    9. "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans."
      Levine S.S., Weiss A., Erdjument-Bromage H., Shao Z., Tempst P., Kingston R.E.
      Mol. Cell. Biol. 22:6070-6078(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN A PRC1-LIKE HPRC-H COMPLEX WITH CBX2; CBX4; CBX8; PHC1; PHC2; PHC3; RING1 AND RNF2.
    10. "Role of histone H2A ubiquitination in Polycomb silencing."
      Wang H., Wang L., Erdjument-Bromage H., Vidal M., Tempst P., Jones R.S., Zhang Y.
      Nature 431:873-878(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A PRC1-LIKE COMPLEX.
    11. "Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing."
      Cao R., Tsukada Y., Zhang Y.
      Mol. Cell 20:845-854(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase."
      Hernandez-Munoz I., Lund A.H., van der Stoop P., Boutsma E., Muijrers I., Verhoeven E., Nusinow D.A., Panning B., Marahrens Y., van Lohuizen M.
      Proc. Natl. Acad. Sci. U.S.A. 102:7635-7640(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SPOP, IDENTIFICATION IN A COMPLEX WITH CUL3 AND SPOP, UBIQUITINATION.
    13. "E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells."
      Chagraoui J., Niessen S.L., Lessard J., Girard S., Coulombe P., Sauvageau M., Meloche S., Sauvageau G.
      Genes Dev. 20:2110-2120(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH E4F1, SUBCELLULAR LOCATION.
    14. "Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus."
      Maertens G.N., El Messaoudi-Aubert S., Racek T., Stock J.K., Nicholls J., Rodriguez-Niedenfuhr M., Gil J., Peters G.
      PLoS ONE 4:E6380-E6380(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A PRC1-LIKE COMPLEX, INTERACTION WITH CBX7 AND CBX8.
    15. "Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells."
      Vandamme J., Volkel P., Rosnoblet C., Le Faou P., Angrand P.O.
      Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A PRC1-LIKE COMPLEX, SUBCELLULAR LOCATION.
    16. "Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex."
      Li Z., Cao R., Wang M., Myers M.P., Zhang Y., Xu R.M.
      J. Biol. Chem. 281:20643-20649(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 5-101 IN COMPLEX WITH RNF2 AND ZINC IONS, FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, SUBUNIT.

    Entry informationi

    Entry nameiBMI1_HUMAN
    AccessioniPrimary (citable) accession number: P35226
    Secondary accession number(s): Q16030, Q5T8Z3, Q96F37
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: August 13, 2002
    Last modified: October 1, 2014
    This is version 152 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3