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P35225

- IL13_HUMAN

UniProt

P35225 - IL13_HUMAN

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Protein

Interleukin-13

Gene

IL13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.

GO - Molecular functioni

  1. cytokine activity Source: ProtInc

GO - Biological processi

  1. cell-cell signaling Source: UniProtKB
  2. cellular component movement Source: ProtInc
  3. cellular response to cytokine stimulus Source: Ensembl
  4. cellular response to mechanical stimulus Source: Ensembl
  5. immune response Source: InterPro
  6. inflammatory response Source: ProtInc
  7. negative regulation of lung ciliated cell differentiation Source: BHF-UCL
  8. negative regulation of transforming growth factor beta production Source: Ensembl
  9. positive regulation of B cell proliferation Source: Ensembl
  10. positive regulation of connective tissue growth factor production Source: Ensembl
  11. positive regulation of immunoglobulin production Source: Ensembl
  12. positive regulation of lung goblet cell differentiation Source: BHF-UCL
  13. positive regulation of macrophage activation Source: Ensembl
  14. positive regulation of pancreatic stellate cell proliferation Source: Ensembl
  15. positive regulation of protein secretion Source: Ensembl
  16. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  17. positive regulation of smooth muscle cell proliferation Source: Ensembl
  18. positive regulation of tyrosine phosphorylation of Stat6 protein Source: Ensembl
  19. regulation of proton transport Source: Ensembl
  20. response to ethanol Source: Ensembl
  21. response to lipopolysaccharide Source: Ensembl
  22. response to nicotine Source: Ensembl
  23. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

SignaLinkiP35225.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13
Short name:
IL-13
Gene namesi
Name:IL13
Synonyms:NC30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:5973. IL13.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. external side of plasma membrane Source: Ensembl
  3. extracellular region Source: BHF-UCL
  4. extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Allergic rhinitis (ALRH) [MIM:607154]: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Organism-specific databases

MIMi607154. phenotype.
PharmGKBiPA199.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 146122Interleukin-13PRO_0000015547Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi62 ↔ 90
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi78 ↔ 104
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP35225.

Expressioni

Gene expression databases

BgeeiP35225.
CleanExiHS_IL13.
ExpressionAtlasiP35225. baseline and differential.
GenevestigatoriP35225.

Organism-specific databases

HPAiHPA042421.

Interactioni

Subunit structurei

Interacts with IL13RA2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
IL13RA1P785524EBI-1647828,EBI-1391535

Protein-protein interaction databases

BioGridi109810. 1 interaction.
DIPiDIP-3224N.
IntActiP35225. 1 interaction.
STRINGi9606.ENSP00000304915.

Structurei

Secondary structure

1
146
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi41 – 5414
Turni61 – 644
Beta strandi66 – 683
Turni74 – 763
Helixi77 – 848
Helixi91 – 933
Helixi94 – 10310
Beta strandi104 – 1063
Beta strandi122 – 1243
Helixi125 – 14218

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GA3NMR-A35-146[»]
1IJZNMR-A35-146[»]
1IK0NMR-A35-146[»]
1J9Umodel-A38-146[»]
3BPOX-ray3.00A34-146[»]
3G6DX-ray3.20A35-146[»]
3ITRmodel-A38-146[»]
3ITSmodel-A38-146[»]
3L5WX-ray2.00I/J35-146[»]
3L5XX-ray1.90A35-146[»]
3LB6X-ray3.05A/B15-146[»]
4I77X-ray1.90Z35-146[»]
4PS4X-ray2.80A35-146[»]
ProteinModelPortaliP35225.
SMRiP35225. Positions 38-146.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35225.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42350.
GeneTreeiENSGT00390000003225.
HOGENOMiHOG000113028.
HOVERGENiHBG006140.
InParanoidiP35225.
KOiK05435.
OrthoDBiEOG78SQMB.
PhylomeDBiP35225.
TreeFamiTF336383.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020470. IL-13.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERiPTHR11322. PTHR11322. 1 hit.
PfamiPF03487. IL13. 1 hit.
[Graphical view]
PRINTSiPR01929. INTRLEUKIN13.
SMARTiSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35225-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHPLLNPLLL ALGLMALLLT TVIALTCLGG FASPGPVPPS TALRELIEEL
60 70 80 90 100
VNITQNQKAP LCNGSMVWSI NLTAGMYCAA LESLINVSGC SAIEKTQRML
110 120 130 140
SGFCPHKVSA GQFSSLHVRD TKIEVAQFVK DLLLHLKKLF REGRFN
Length:146
Mass (Da):15,816
Last modified:June 16, 2009 - v2
Checksum:iBE2D46CCF913D129
GO

Sequence cautioni

The sequence AAA36107.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAA83738.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAB01681.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAC03535.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAK53823.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAA48824.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 11M → R in CAA48824. (PubMed:8097324)Curated
Sequence conflicti26 – 261T → A no nucleotide entry (PubMed:1408833)Curated
Sequence conflicti32 – 321A → D no nucleotide entry (PubMed:1408833)Curated
Sequence conflicti51 – 511V → S no nucleotide entry (PubMed:1408833)Curated
Sequence conflicti56 – 561N → T no nucleotide entry (PubMed:1408833)Curated
Sequence conflicti59 – 591A → R in AAA83738. (PubMed:7721105)Curated
Sequence conflicti101 – 1011S → G in AAC03535. 1 PublicationCurated
Sequence conflicti112 – 1121Missing in AAA83738. (PubMed:7721105)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti144 – 1441R → Q Associated with increased risk for asthma development; at homozygosity associated with higher levels of serum total IgE in some allergic rhinitis patients. 6 Publications
Corresponds to variant rs20541 [ dbSNP | Ensembl ].
VAR_010037

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69079 mRNA. Translation: CAA48823.1.
X69079 mRNA. Translation: CAA48824.1. Different initiation.
L06801 mRNA. Translation: AAA36107.1. Different initiation.
U10307 Genomic DNA. Translation: AAA83738.1. Different initiation.
U31120 Genomic DNA. Translation: AAB01681.1. Different initiation.
AF377331 Genomic DNA. Translation: AAK53823.1. Different initiation.
AC004039 Genomic DNA. No translation available.
BC096139 mRNA. Translation: AAH96139.1.
AF043334 mRNA. Translation: AAC03535.1. Different initiation.
CCDSiCCDS4157.1.
PIRiI38060. A47481.
RefSeqiNP_002179.2. NM_002188.2.
UniGeneiHs.845.

Genome annotation databases

EnsembliENST00000304506; ENSP00000304915; ENSG00000169194.
GeneIDi3596.
KEGGihsa:3596.

Polymorphism databases

DMDMi239938644.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-13 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69079 mRNA. Translation: CAA48823.1 .
X69079 mRNA. Translation: CAA48824.1 . Different initiation.
L06801 mRNA. Translation: AAA36107.1 . Different initiation.
U10307 Genomic DNA. Translation: AAA83738.1 . Different initiation.
U31120 Genomic DNA. Translation: AAB01681.1 . Different initiation.
AF377331 Genomic DNA. Translation: AAK53823.1 . Different initiation.
AC004039 Genomic DNA. No translation available.
BC096139 mRNA. Translation: AAH96139.1 .
AF043334 mRNA. Translation: AAC03535.1 . Different initiation.
CCDSi CCDS4157.1.
PIRi I38060. A47481.
RefSeqi NP_002179.2. NM_002188.2.
UniGenei Hs.845.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1GA3 NMR - A 35-146 [» ]
1IJZ NMR - A 35-146 [» ]
1IK0 NMR - A 35-146 [» ]
1J9U model - A 38-146 [» ]
3BPO X-ray 3.00 A 34-146 [» ]
3G6D X-ray 3.20 A 35-146 [» ]
3ITR model - A 38-146 [» ]
3ITS model - A 38-146 [» ]
3L5W X-ray 2.00 I/J 35-146 [» ]
3L5X X-ray 1.90 A 35-146 [» ]
3LB6 X-ray 3.05 A/B 15-146 [» ]
4I77 X-ray 1.90 Z 35-146 [» ]
4PS4 X-ray 2.80 A 35-146 [» ]
ProteinModelPortali P35225.
SMRi P35225. Positions 38-146.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109810. 1 interaction.
DIPi DIP-3224N.
IntActi P35225. 1 interaction.
STRINGi 9606.ENSP00000304915.

Polymorphism databases

DMDMi 239938644.

Proteomic databases

PRIDEi P35225.

Protocols and materials databases

DNASUi 3596.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304506 ; ENSP00000304915 ; ENSG00000169194 .
GeneIDi 3596.
KEGGi hsa:3596.

Organism-specific databases

CTDi 3596.
GeneCardsi GC05P131991.
H-InvDB HIX0031957.
HGNCi HGNC:5973. IL13.
HPAi HPA042421.
MIMi 147683. gene.
607154. phenotype.
neXtProti NX_P35225.
PharmGKBi PA199.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42350.
GeneTreei ENSGT00390000003225.
HOGENOMi HOG000113028.
HOVERGENi HBG006140.
InParanoidi P35225.
KOi K05435.
OrthoDBi EOG78SQMB.
PhylomeDBi P35225.
TreeFami TF336383.

Enzyme and pathway databases

SignaLinki P35225.

Miscellaneous databases

ChiTaRSi IL13. human.
EvolutionaryTracei P35225.
GeneWikii Interleukin_13.
GenomeRNAii 3596.
NextBioi 14053.
PROi P35225.
SOURCEi Search...

Gene expression databases

Bgeei P35225.
CleanExi HS_IL13.
ExpressionAtlasi P35225. baseline and differential.
Genevestigatori P35225.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020470. IL-13.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view ]
PANTHERi PTHR11322. PTHR11322. 1 hit.
Pfami PF03487. IL13. 1 hit.
[Graphical view ]
PRINTSi PR01929. INTRLEUKIN13.
SMARTi SM00190. IL4_13. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Tandem arrangement of human genes for interleukin-4 and interleukin-13: resemblance in their organization."
    Smirnov D.V., Smirnova M.G., Korobko V.G., Frolova E.I.
    Gene 155:277-281(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Blood.
  4. "Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31."
    Dolganov G., Bort S., Lovett M., Burr J., Schubert L., Short D., McGurn M., Gibson C., Lewis D.B.
    Blood 87:3316-3326(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. SeattleSNPs variation discovery resource
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-144.
  6. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLN-144.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-144.
  8. Jang J.S., Kim B.E.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-146.
  9. "The selective isolation of novel cDNAs encoded by the regions surrounding the human interleukin 4 and 5 genes."
    Morgan J.G., Dolganov G.M., Robbins S.E., Hinton L.M., Lovett M.
    Nucleic Acids Res. 20:5173-5179(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-63.
    Tissue: Peripheral blood lymphocyte.
  10. "Solution structure of human IL-13 and implication for receptor binding."
    Moy F.J., Diblasio E., Wilhelm J., Powers R.
    J. Mol. Biol. 310:219-230(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 35-146, DISULFIDE BONDS.
  11. "Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2."
    Lupardus P.J., Birnbaum M.E., Garcia K.C.
    Structure 18:332-342(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.05 ANGSTROMS) OF 15-146 IN COMPLEX WITH IL13RA2, DISULFIDE BONDS.
  12. Cited for: VARIANT GLN-144.
  13. "Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population."
    Howard T.D., Whittaker P.A., Zaiman A.L., Koppelman G.H., Xu J., Hanley M.T., Meyers D.A., Postma D.S., Bleecker E.R.
    Am. J. Respir. Cell Mol. Biol. 25:377-384(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLN-144.
  14. "A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis."
    Wang M., Xing Z.-M., Lu C., Ma Y.-X., Yu D.-L., Yan Z., Wang S.-W., Yu L.-S.
    Hum. Genet. 113:387-390(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLN-144.

Entry informationi

Entry nameiIL13_HUMAN
AccessioniPrimary (citable) accession number: P35225
Secondary accession number(s): O43644, Q4VB52, Q9UDC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 16, 2009
Last modified: October 29, 2014
This is version 157 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-15 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3