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P35225

- IL13_HUMAN

UniProt

P35225 - IL13_HUMAN

Protein

Interleukin-13

Gene

IL13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.

    GO - Molecular functioni

    1. cytokine activity Source: ProtInc
    2. protein binding Source: IntAct

    GO - Biological processi

    1. cell-cell signaling Source: UniProtKB
    2. cellular component movement Source: ProtInc
    3. cellular response to cytokine stimulus Source: Ensembl
    4. cellular response to mechanical stimulus Source: Ensembl
    5. immune response Source: InterPro
    6. inflammatory response Source: ProtInc
    7. negative regulation of lung ciliated cell differentiation Source: BHF-UCL
    8. negative regulation of transforming growth factor beta production Source: Ensembl
    9. positive regulation of B cell proliferation Source: Ensembl
    10. positive regulation of connective tissue growth factor production Source: Ensembl
    11. positive regulation of immunoglobulin production Source: Ensembl
    12. positive regulation of lung goblet cell differentiation Source: BHF-UCL
    13. positive regulation of macrophage activation Source: Ensembl
    14. positive regulation of pancreatic stellate cell proliferation Source: Ensembl
    15. positive regulation of protein secretion Source: Ensembl
    16. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
    17. positive regulation of smooth muscle cell proliferation Source: Ensembl
    18. positive regulation of tyrosine phosphorylation of Stat6 protein Source: Ensembl
    19. regulation of proton transport Source: Ensembl
    20. response to ethanol Source: Ensembl
    21. response to lipopolysaccharide Source: Ensembl
    22. response to nicotine Source: Ensembl
    23. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Cytokine

    Enzyme and pathway databases

    SignaLinkiP35225.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-13
    Short name:
    IL-13
    Gene namesi
    Name:IL13
    Synonyms:NC30
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:5973. IL13.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. external side of plasma membrane Source: Ensembl
    3. extracellular region Source: BHF-UCL
    4. extracellular space Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Allergic rhinitis (ALRH) [MIM:607154]: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure.
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi607154. phenotype.
    PharmGKBiPA199.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 146122Interleukin-13PRO_0000015547Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi62 ↔ 90
    Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi78 ↔ 104
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP35225.

    Expressioni

    Gene expression databases

    ArrayExpressiP35225.
    BgeeiP35225.
    CleanExiHS_IL13.
    GenevestigatoriP35225.

    Organism-specific databases

    HPAiHPA042421.

    Interactioni

    Subunit structurei

    Interacts with IL13RA2.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    IL13RA1P785524EBI-1647828,EBI-1391535

    Protein-protein interaction databases

    BioGridi109810. 1 interaction.
    DIPiDIP-3224N.
    IntActiP35225. 1 interaction.
    STRINGi9606.ENSP00000304915.

    Structurei

    Secondary structure

    1
    146
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi41 – 5414
    Turni61 – 644
    Beta strandi66 – 683
    Turni74 – 763
    Helixi77 – 848
    Helixi91 – 933
    Helixi94 – 10310
    Beta strandi104 – 1063
    Beta strandi122 – 1243
    Helixi125 – 14218

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1GA3NMR-A35-146[»]
    1IJZNMR-A35-146[»]
    1IK0NMR-A35-146[»]
    1J9Umodel-A38-146[»]
    3BPOX-ray3.00A34-146[»]
    3G6DX-ray3.20A35-146[»]
    3ITRmodel-A38-146[»]
    3ITSmodel-A38-146[»]
    3L5WX-ray2.00I/J35-146[»]
    3L5XX-ray1.90A35-146[»]
    3LB6X-ray3.05A/B15-146[»]
    4I77X-ray1.90Z35-146[»]
    4PS4X-ray2.80A35-146[»]
    ProteinModelPortaliP35225.
    SMRiP35225. Positions 38-146.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP35225.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-4/IL-13 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42350.
    HOGENOMiHOG000113028.
    HOVERGENiHBG006140.
    InParanoidiP35225.
    KOiK05435.
    OrthoDBiEOG78SQMB.
    PhylomeDBiP35225.
    TreeFamiTF336383.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR020470. IL-13.
    IPR001325. IL-4/IL-13.
    IPR018096. IL-4/IL-13_CS.
    [Graphical view]
    PANTHERiPTHR11322. PTHR11322. 1 hit.
    PfamiPF03487. IL13. 1 hit.
    [Graphical view]
    PRINTSiPR01929. INTRLEUKIN13.
    SMARTiSM00190. IL4_13. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P35225-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHPLLNPLLL ALGLMALLLT TVIALTCLGG FASPGPVPPS TALRELIEEL    50
    VNITQNQKAP LCNGSMVWSI NLTAGMYCAA LESLINVSGC SAIEKTQRML 100
    SGFCPHKVSA GQFSSLHVRD TKIEVAQFVK DLLLHLKKLF REGRFN 146
    Length:146
    Mass (Da):15,816
    Last modified:June 16, 2009 - v2
    Checksum:iBE2D46CCF913D129
    GO

    Sequence cautioni

    The sequence AAA36107.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAA83738.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAB01681.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAC03535.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAK53823.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAA48824.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 11M → R in CAA48824. (PubMed:8097324)Curated
    Sequence conflicti26 – 261T → A no nucleotide entry (PubMed:1408833)Curated
    Sequence conflicti32 – 321A → D no nucleotide entry (PubMed:1408833)Curated
    Sequence conflicti51 – 511V → S no nucleotide entry (PubMed:1408833)Curated
    Sequence conflicti56 – 561N → T no nucleotide entry (PubMed:1408833)Curated
    Sequence conflicti59 – 591A → R in AAA83738. (PubMed:7721105)Curated
    Sequence conflicti101 – 1011S → G in AAC03535. 1 PublicationCurated
    Sequence conflicti112 – 1121Missing in AAA83738. (PubMed:7721105)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti144 – 1441R → Q Associated with increased risk for asthma development; at homozygosity associated with higher levels of serum total IgE in some allergic rhinitis patients. 6 Publications
    Corresponds to variant rs20541 [ dbSNP | Ensembl ].
    VAR_010037

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69079 mRNA. Translation: CAA48823.1.
    X69079 mRNA. Translation: CAA48824.1. Different initiation.
    L06801 mRNA. Translation: AAA36107.1. Different initiation.
    U10307 Genomic DNA. Translation: AAA83738.1. Different initiation.
    U31120 Genomic DNA. Translation: AAB01681.1. Different initiation.
    AF377331 Genomic DNA. Translation: AAK53823.1. Different initiation.
    AC004039 Genomic DNA. No translation available.
    BC096139 mRNA. Translation: AAH96139.1.
    AF043334 mRNA. Translation: AAC03535.1. Different initiation.
    CCDSiCCDS4157.1.
    PIRiI38060. A47481.
    RefSeqiNP_002179.2. NM_002188.2.
    UniGeneiHs.845.

    Genome annotation databases

    EnsembliENST00000304506; ENSP00000304915; ENSG00000169194.
    GeneIDi3596.
    KEGGihsa:3596.

    Polymorphism databases

    DMDMi239938644.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Interleukin-13 entry

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69079 mRNA. Translation: CAA48823.1 .
    X69079 mRNA. Translation: CAA48824.1 . Different initiation.
    L06801 mRNA. Translation: AAA36107.1 . Different initiation.
    U10307 Genomic DNA. Translation: AAA83738.1 . Different initiation.
    U31120 Genomic DNA. Translation: AAB01681.1 . Different initiation.
    AF377331 Genomic DNA. Translation: AAK53823.1 . Different initiation.
    AC004039 Genomic DNA. No translation available.
    BC096139 mRNA. Translation: AAH96139.1 .
    AF043334 mRNA. Translation: AAC03535.1 . Different initiation.
    CCDSi CCDS4157.1.
    PIRi I38060. A47481.
    RefSeqi NP_002179.2. NM_002188.2.
    UniGenei Hs.845.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1GA3 NMR - A 35-146 [» ]
    1IJZ NMR - A 35-146 [» ]
    1IK0 NMR - A 35-146 [» ]
    1J9U model - A 38-146 [» ]
    3BPO X-ray 3.00 A 34-146 [» ]
    3G6D X-ray 3.20 A 35-146 [» ]
    3ITR model - A 38-146 [» ]
    3ITS model - A 38-146 [» ]
    3L5W X-ray 2.00 I/J 35-146 [» ]
    3L5X X-ray 1.90 A 35-146 [» ]
    3LB6 X-ray 3.05 A/B 15-146 [» ]
    4I77 X-ray 1.90 Z 35-146 [» ]
    4PS4 X-ray 2.80 A 35-146 [» ]
    ProteinModelPortali P35225.
    SMRi P35225. Positions 38-146.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109810. 1 interaction.
    DIPi DIP-3224N.
    IntActi P35225. 1 interaction.
    STRINGi 9606.ENSP00000304915.

    Polymorphism databases

    DMDMi 239938644.

    Proteomic databases

    PRIDEi P35225.

    Protocols and materials databases

    DNASUi 3596.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304506 ; ENSP00000304915 ; ENSG00000169194 .
    GeneIDi 3596.
    KEGGi hsa:3596.

    Organism-specific databases

    CTDi 3596.
    GeneCardsi GC05P131991.
    H-InvDB HIX0031957.
    HGNCi HGNC:5973. IL13.
    HPAi HPA042421.
    MIMi 147683. gene.
    607154. phenotype.
    neXtProti NX_P35225.
    PharmGKBi PA199.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42350.
    HOGENOMi HOG000113028.
    HOVERGENi HBG006140.
    InParanoidi P35225.
    KOi K05435.
    OrthoDBi EOG78SQMB.
    PhylomeDBi P35225.
    TreeFami TF336383.

    Enzyme and pathway databases

    SignaLinki P35225.

    Miscellaneous databases

    ChiTaRSi IL13. human.
    EvolutionaryTracei P35225.
    GeneWikii Interleukin_13.
    GenomeRNAii 3596.
    NextBioi 14053.
    PROi P35225.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P35225.
    Bgeei P35225.
    CleanExi HS_IL13.
    Genevestigatori P35225.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR020470. IL-13.
    IPR001325. IL-4/IL-13.
    IPR018096. IL-4/IL-13_CS.
    [Graphical view ]
    PANTHERi PTHR11322. PTHR11322. 1 hit.
    Pfami PF03487. IL13. 1 hit.
    [Graphical view ]
    PRINTSi PR01929. INTRLEUKIN13.
    SMARTi SM00190. IL4_13. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00838. INTERLEUKIN_4_13. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Tandem arrangement of human genes for interleukin-4 and interleukin-13: resemblance in their organization."
      Smirnov D.V., Smirnova M.G., Korobko V.G., Frolova E.I.
      Gene 155:277-281(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Blood.
    4. "Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31."
      Dolganov G., Bort S., Lovett M., Burr J., Schubert L., Short D., McGurn M., Gibson C., Lewis D.B.
      Blood 87:3316-3326(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. SeattleSNPs variation discovery resource
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-144.
    6. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLN-144.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-144.
    8. Jang J.S., Kim B.E.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-146.
    9. "The selective isolation of novel cDNAs encoded by the regions surrounding the human interleukin 4 and 5 genes."
      Morgan J.G., Dolganov G.M., Robbins S.E., Hinton L.M., Lovett M.
      Nucleic Acids Res. 20:5173-5179(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-63.
      Tissue: Peripheral blood lymphocyte.
    10. "Solution structure of human IL-13 and implication for receptor binding."
      Moy F.J., Diblasio E., Wilhelm J., Powers R.
      J. Mol. Biol. 310:219-230(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 35-146, DISULFIDE BONDS.
    11. "Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2."
      Lupardus P.J., Birnbaum M.E., Garcia K.C.
      Structure 18:332-342(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.05 ANGSTROMS) OF 15-146 IN COMPLEX WITH IL13RA2, DISULFIDE BONDS.
    12. Cited for: VARIANT GLN-144.
    13. "Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population."
      Howard T.D., Whittaker P.A., Zaiman A.L., Koppelman G.H., Xu J., Hanley M.T., Meyers D.A., Postma D.S., Bleecker E.R.
      Am. J. Respir. Cell Mol. Biol. 25:377-384(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT GLN-144.
    14. "A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis."
      Wang M., Xing Z.-M., Lu C., Ma Y.-X., Yu D.-L., Yan Z., Wang S.-W., Yu L.-S.
      Hum. Genet. 113:387-390(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT GLN-144.

    Entry informationi

    Entry nameiIL13_HUMAN
    AccessioniPrimary (citable) accession number: P35225
    Secondary accession number(s): O43644, Q4VB52, Q9UDC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 156 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-15 is the initiator.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3