Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-13

Gene

IL13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.

GO - Molecular functioni

  1. cytokine activity Source: ProtInc

GO - Biological processi

  1. cell-cell signaling Source: UniProtKB
  2. cellular response to cytokine stimulus Source: Ensembl
  3. cellular response to mechanical stimulus Source: Ensembl
  4. immune response Source: InterPro
  5. inflammatory response Source: ProtInc
  6. microglial cell activation Source: Ensembl
  7. movement of cell or subcellular component Source: ProtInc
  8. negative regulation of complement-dependent cytotoxicity Source: AgBase
  9. negative regulation of endothelial cell apoptotic process Source: AgBase
  10. negative regulation of lung ciliated cell differentiation Source: BHF-UCL
  11. negative regulation of NAD(P)H oxidase activity Source: Ensembl
  12. negative regulation of neuron death Source: Ensembl
  13. negative regulation of transforming growth factor beta production Source: Ensembl
  14. positive regulation of B cell proliferation Source: Ensembl
  15. positive regulation of connective tissue growth factor production Source: Ensembl
  16. positive regulation of immunoglobulin production Source: Ensembl
  17. positive regulation of lung goblet cell differentiation Source: BHF-UCL
  18. positive regulation of macrophage activation Source: Ensembl
  19. positive regulation of pancreatic stellate cell proliferation Source: Ensembl
  20. positive regulation of protein secretion Source: Ensembl
  21. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  22. positive regulation of smooth muscle cell proliferation Source: Ensembl
  23. positive regulation of tyrosine phosphorylation of Stat6 protein Source: Ensembl
  24. regulation of proton transport Source: Ensembl
  25. response to ethanol Source: Ensembl
  26. response to lipopolysaccharide Source: Ensembl
  27. response to nicotine Source: Ensembl
  28. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

SignaLinkiP35225.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13
Short name:
IL-13
Gene namesi
Name:IL13
Synonyms:NC30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:5973. IL13.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. external side of plasma membrane Source: Ensembl
  3. extracellular region Source: BHF-UCL
  4. extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Allergic rhinitis (ALRH)

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure.

See also OMIM:607154

Organism-specific databases

MIMi607154. phenotype.
PharmGKBiPA199.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 146122Interleukin-13PRO_0000015547Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi62 ↔ 90
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi78 ↔ 104
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP35225.

Expressioni

Gene expression databases

BgeeiP35225.
CleanExiHS_IL13.
ExpressionAtlasiP35225. baseline and differential.
GenevestigatoriP35225.

Organism-specific databases

HPAiHPA042421.

Interactioni

Subunit structurei

Interacts with IL13RA2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
IL13RA1P785524EBI-1647828,EBI-1391535

Protein-protein interaction databases

BioGridi109810. 1 interaction.
DIPiDIP-3224N.
IntActiP35225. 1 interaction.
STRINGi9606.ENSP00000304915.

Structurei

Secondary structure

1
146
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi41 – 5414Combined sources
Turni61 – 644Combined sources
Beta strandi66 – 683Combined sources
Turni74 – 763Combined sources
Helixi77 – 848Combined sources
Helixi91 – 933Combined sources
Helixi94 – 10310Combined sources
Beta strandi104 – 1063Combined sources
Beta strandi122 – 1243Combined sources
Helixi125 – 14218Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GA3NMR-A35-146[»]
1IJZNMR-A35-146[»]
1IK0NMR-A35-146[»]
1J9Umodel-A38-146[»]
3BPOX-ray3.00A34-146[»]
3G6DX-ray3.20A35-146[»]
3ITRmodel-A38-146[»]
3ITSmodel-A38-146[»]
3L5WX-ray2.00I/J35-146[»]
3L5XX-ray1.90A35-146[»]
3LB6X-ray3.05A/B15-146[»]
4I77X-ray1.90Z35-146[»]
4PS4X-ray2.80A35-146[»]
SMRiP35225. Positions 38-146.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35225.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42350.
HOGENOMiHOG000113028.
HOVERGENiHBG006140.
InParanoidiP35225.
KOiK05435.
OrthoDBiEOG78SQMB.
PhylomeDBiP35225.
TreeFamiTF336383.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020470. IL-13.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERiPTHR11322. PTHR11322. 1 hit.
PfamiPF03487. IL13. 1 hit.
[Graphical view]
PRINTSiPR01929. INTRLEUKIN13.
SMARTiSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35225-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPLLNPLLL ALGLMALLLT TVIALTCLGG FASPGPVPPS TALRELIEEL
60 70 80 90 100
VNITQNQKAP LCNGSMVWSI NLTAGMYCAA LESLINVSGC SAIEKTQRML
110 120 130 140
SGFCPHKVSA GQFSSLHVRD TKIEVAQFVK DLLLHLKKLF REGRFN
Length:146
Mass (Da):15,816
Last modified:June 15, 2009 - v2
Checksum:iBE2D46CCF913D129
GO

Sequence cautioni

The sequence AAA36107.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAA83738.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAB01681.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAC03535.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAK53823.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA48824.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 11M → R in CAA48824 (PubMed:8097324).Curated
Sequence conflicti26 – 261T → A no nucleotide entry (PubMed:1408833).Curated
Sequence conflicti32 – 321A → D no nucleotide entry (PubMed:1408833).Curated
Sequence conflicti51 – 511V → S no nucleotide entry (PubMed:1408833).Curated
Sequence conflicti56 – 561N → T no nucleotide entry (PubMed:1408833).Curated
Sequence conflicti59 – 591A → R in AAA83738 (PubMed:7721105).Curated
Sequence conflicti101 – 1011S → G in AAC03535 (Ref. 8) Curated
Sequence conflicti112 – 1121Missing in AAA83738 (PubMed:7721105).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti144 – 1441R → Q Associated with increased risk for asthma development; at homozygosity associated with higher levels of serum total IgE in some allergic rhinitis patients. 6 Publications
Corresponds to variant rs20541 [ dbSNP | Ensembl ].
VAR_010037

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69079 mRNA. Translation: CAA48823.1.
X69079 mRNA. Translation: CAA48824.1. Different initiation.
L06801 mRNA. Translation: AAA36107.1. Different initiation.
U10307 Genomic DNA. Translation: AAA83738.1. Different initiation.
U31120 Genomic DNA. Translation: AAB01681.1. Different initiation.
AF377331 Genomic DNA. Translation: AAK53823.1. Different initiation.
AC004039 Genomic DNA. No translation available.
BC096139 mRNA. Translation: AAH96139.1.
AF043334 mRNA. Translation: AAC03535.1. Different initiation.
CCDSiCCDS4157.1.
PIRiI38060. A47481.
RefSeqiNP_002179.2. NM_002188.2.
UniGeneiHs.845.

Genome annotation databases

EnsembliENST00000304506; ENSP00000304915; ENSG00000169194.
GeneIDi3596.
KEGGihsa:3596.

Polymorphism databases

DMDMi239938644.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-13 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69079 mRNA. Translation: CAA48823.1.
X69079 mRNA. Translation: CAA48824.1. Different initiation.
L06801 mRNA. Translation: AAA36107.1. Different initiation.
U10307 Genomic DNA. Translation: AAA83738.1. Different initiation.
U31120 Genomic DNA. Translation: AAB01681.1. Different initiation.
AF377331 Genomic DNA. Translation: AAK53823.1. Different initiation.
AC004039 Genomic DNA. No translation available.
BC096139 mRNA. Translation: AAH96139.1.
AF043334 mRNA. Translation: AAC03535.1. Different initiation.
CCDSiCCDS4157.1.
PIRiI38060. A47481.
RefSeqiNP_002179.2. NM_002188.2.
UniGeneiHs.845.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GA3NMR-A35-146[»]
1IJZNMR-A35-146[»]
1IK0NMR-A35-146[»]
1J9Umodel-A38-146[»]
3BPOX-ray3.00A34-146[»]
3G6DX-ray3.20A35-146[»]
3ITRmodel-A38-146[»]
3ITSmodel-A38-146[»]
3L5WX-ray2.00I/J35-146[»]
3L5XX-ray1.90A35-146[»]
3LB6X-ray3.05A/B15-146[»]
4I77X-ray1.90Z35-146[»]
4PS4X-ray2.80A35-146[»]
SMRiP35225. Positions 38-146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109810. 1 interaction.
DIPiDIP-3224N.
IntActiP35225. 1 interaction.
STRINGi9606.ENSP00000304915.

Polymorphism databases

DMDMi239938644.

Proteomic databases

PRIDEiP35225.

Protocols and materials databases

DNASUi3596.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304506; ENSP00000304915; ENSG00000169194.
GeneIDi3596.
KEGGihsa:3596.

Organism-specific databases

CTDi3596.
GeneCardsiGC05P131991.
H-InvDBHIX0031957.
HGNCiHGNC:5973. IL13.
HPAiHPA042421.
MIMi147683. gene.
607154. phenotype.
neXtProtiNX_P35225.
PharmGKBiPA199.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG42350.
HOGENOMiHOG000113028.
HOVERGENiHBG006140.
InParanoidiP35225.
KOiK05435.
OrthoDBiEOG78SQMB.
PhylomeDBiP35225.
TreeFamiTF336383.

Enzyme and pathway databases

SignaLinkiP35225.

Miscellaneous databases

ChiTaRSiIL13. human.
EvolutionaryTraceiP35225.
GeneWikiiInterleukin_13.
GenomeRNAii3596.
NextBioi14053.
PROiP35225.
SOURCEiSearch...

Gene expression databases

BgeeiP35225.
CleanExiHS_IL13.
ExpressionAtlasiP35225. baseline and differential.
GenevestigatoriP35225.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020470. IL-13.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERiPTHR11322. PTHR11322. 1 hit.
PfamiPF03487. IL13. 1 hit.
[Graphical view]
PRINTSiPR01929. INTRLEUKIN13.
SMARTiSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Tandem arrangement of human genes for interleukin-4 and interleukin-13: resemblance in their organization."
    Smirnov D.V., Smirnova M.G., Korobko V.G., Frolova E.I.
    Gene 155:277-281(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Blood.
  4. "Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31."
    Dolganov G., Bort S., Lovett M., Burr J., Schubert L., Short D., McGurn M., Gibson C., Lewis D.B.
    Blood 87:3316-3326(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. SeattleSNPs variation discovery resource
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-144.
  6. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLN-144.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-144.
  8. Jang J.S., Kim B.E.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-146.
  9. "The selective isolation of novel cDNAs encoded by the regions surrounding the human interleukin 4 and 5 genes."
    Morgan J.G., Dolganov G.M., Robbins S.E., Hinton L.M., Lovett M.
    Nucleic Acids Res. 20:5173-5179(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-63.
    Tissue: Peripheral blood lymphocyte.
  10. "Solution structure of human IL-13 and implication for receptor binding."
    Moy F.J., Diblasio E., Wilhelm J., Powers R.
    J. Mol. Biol. 310:219-230(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 35-146, DISULFIDE BONDS.
  11. "Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2."
    Lupardus P.J., Birnbaum M.E., Garcia K.C.
    Structure 18:332-342(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.05 ANGSTROMS) OF 15-146 IN COMPLEX WITH IL13RA2, DISULFIDE BONDS.
  12. Cited for: VARIANT GLN-144.
  13. "Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population."
    Howard T.D., Whittaker P.A., Zaiman A.L., Koppelman G.H., Xu J., Hanley M.T., Meyers D.A., Postma D.S., Bleecker E.R.
    Am. J. Respir. Cell Mol. Biol. 25:377-384(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLN-144.
  14. "A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis."
    Wang M., Xing Z.-M., Lu C., Ma Y.-X., Yu D.-L., Yan Z., Wang S.-W., Yu L.-S.
    Hum. Genet. 113:387-390(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLN-144.

Entry informationi

Entry nameiIL13_HUMAN
AccessioniPrimary (citable) accession number: P35225
Secondary accession number(s): O43644, Q4VB52, Q9UDC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 1994
Last sequence update: June 15, 2009
Last modified: March 31, 2015
This is version 161 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-15 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.