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Protein

Interleukin-13

Gene

IL13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity).By similarity2 Publications

GO - Molecular functioni

  • cytokine activity Source: ProtInc
  • interleukin-13 receptor binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169194-MONOMER.
ReactomeiR-HSA-449147. Signaling by Interleukins.
SignaLinkiP35225.
SIGNORiP35225.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13
Short name:
IL-13
Gene namesi
Name:IL13
Synonyms:NC30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:5973. IL13.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • external side of plasma membrane Source: Ensembl
  • extracellular region Source: BHF-UCL
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Allergic rhinitis (ALRH)
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure.
See also OMIM:607154

Organism-specific databases

DisGeNETi3596.
MalaCardsiIL13.
MIMi607154. phenotype.
PharmGKBiPA199.

Chemistry databases

ChEMBLiCHEMBL3580486.

Polymorphism and mutation databases

BioMutaiIL13.
DMDMi239938644.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001554725 – 146Interleukin-13Add BLAST122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi62 ↔ 90
Glycosylationi63N-linked (GlcNAc...)Sequence analysis1
Glycosylationi71N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi78 ↔ 104
Glycosylationi86N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35225.
PRIDEiP35225.

Expressioni

Gene expression databases

BgeeiENSG00000169194.
CleanExiHS_IL13.
ExpressionAtlasiP35225. baseline and differential.
GenevisibleiP35225. HS.

Organism-specific databases

HPAiHPA042421.

Interactioni

Subunit structurei

Interacts with IL13RA2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
IL13RA1P785524EBI-1647828,EBI-1391535

GO - Molecular functioni

  • cytokine activity Source: ProtInc
  • interleukin-13 receptor binding Source: GO_Central

Protein-protein interaction databases

DIPiDIP-3224N.
IntActiP35225. 1 interactor.
STRINGi9606.ENSP00000304915.

Structurei

Secondary structure

1146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi41 – 54Combined sources14
Turni61 – 64Combined sources4
Beta strandi66 – 68Combined sources3
Turni74 – 76Combined sources3
Helixi77 – 84Combined sources8
Helixi91 – 93Combined sources3
Helixi94 – 103Combined sources10
Beta strandi104 – 106Combined sources3
Helixi113 – 116Combined sources4
Beta strandi122 – 124Combined sources3
Helixi125 – 142Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GA3NMR-A35-146[»]
1IJZNMR-A35-146[»]
1IK0NMR-A35-146[»]
1J9Umodel-A38-146[»]
3BPOX-ray3.00A34-146[»]
3G6DX-ray3.20A35-146[»]
3ITRmodel-A38-146[»]
3ITSmodel-A38-146[»]
3L5WX-ray2.00I/J35-146[»]
3L5XX-ray1.90A35-146[»]
3LB6X-ray3.05A/B15-146[»]
4I77X-ray1.90Z35-146[»]
4PS4X-ray2.80A35-146[»]
5E4EX-ray3.00A34-146[»]
ProteinModelPortaliP35225.
SMRiP35225.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35225.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCI3. Eukaryota.
ENOG4111BX2. LUCA.
HOGENOMiHOG000113028.
HOVERGENiHBG006140.
InParanoidiP35225.
KOiK05435.
OrthoDBiEOG091G10SR.
PhylomeDBiP35225.
TreeFamiTF336383.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020470. IL-13.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERiPTHR11322. PTHR11322. 1 hit.
PfamiPF03487. IL13. 1 hit.
[Graphical view]
PRINTSiPR01929. INTRLEUKIN13.
SMARTiSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35225-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPLLNPLLL ALGLMALLLT TVIALTCLGG FASPGPVPPS TALRELIEEL
60 70 80 90 100
VNITQNQKAP LCNGSMVWSI NLTAGMYCAA LESLINVSGC SAIEKTQRML
110 120 130 140
SGFCPHKVSA GQFSSLHVRD TKIEVAQFVK DLLLHLKKLF REGRFN
Length:146
Mass (Da):15,816
Last modified:June 16, 2009 - v2
Checksum:iBE2D46CCF913D129
GO

Sequence cautioni

The sequence AAA36107 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAA83738 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAB01681 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAC03535 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAK53823 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA48824 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → R in CAA48824 (PubMed:8097324).Curated1
Sequence conflicti26T → A no nucleotide entry (PubMed:1408833).Curated1
Sequence conflicti32A → D no nucleotide entry (PubMed:1408833).Curated1
Sequence conflicti51V → S no nucleotide entry (PubMed:1408833).Curated1
Sequence conflicti56N → T no nucleotide entry (PubMed:1408833).Curated1
Sequence conflicti59A → R in AAA83738 (PubMed:7721105).Curated1
Sequence conflicti101S → G in AAC03535 (Ref. 8) Curated1
Sequence conflicti112Missing in AAA83738 (PubMed:7721105).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010037144R → Q Associated with increased risk for asthma development; at homozygosity associated with higher levels of serum total IgE in some allergic rhinitis patients. 6 PublicationsCorresponds to variant rs20541dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69079 mRNA. Translation: CAA48823.1.
X69079 mRNA. Translation: CAA48824.1. Different initiation.
L06801 mRNA. Translation: AAA36107.1. Different initiation.
U10307 Genomic DNA. Translation: AAA83738.1. Different initiation.
U31120 Genomic DNA. Translation: AAB01681.1. Different initiation.
AF377331 Genomic DNA. Translation: AAK53823.1. Different initiation.
AC004039 Genomic DNA. No translation available.
BC096139 mRNA. Translation: AAH96139.1.
AF043334 mRNA. Translation: AAC03535.1. Different initiation.
CCDSiCCDS4157.1.
PIRiI38060. A47481.
RefSeqiNP_002179.2. NM_002188.2.
UniGeneiHs.845.

Genome annotation databases

EnsembliENST00000304506; ENSP00000304915; ENSG00000169194.
GeneIDi3596.
KEGGihsa:3596.
UCSCiuc003kxj.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-13 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69079 mRNA. Translation: CAA48823.1.
X69079 mRNA. Translation: CAA48824.1. Different initiation.
L06801 mRNA. Translation: AAA36107.1. Different initiation.
U10307 Genomic DNA. Translation: AAA83738.1. Different initiation.
U31120 Genomic DNA. Translation: AAB01681.1. Different initiation.
AF377331 Genomic DNA. Translation: AAK53823.1. Different initiation.
AC004039 Genomic DNA. No translation available.
BC096139 mRNA. Translation: AAH96139.1.
AF043334 mRNA. Translation: AAC03535.1. Different initiation.
CCDSiCCDS4157.1.
PIRiI38060. A47481.
RefSeqiNP_002179.2. NM_002188.2.
UniGeneiHs.845.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GA3NMR-A35-146[»]
1IJZNMR-A35-146[»]
1IK0NMR-A35-146[»]
1J9Umodel-A38-146[»]
3BPOX-ray3.00A34-146[»]
3G6DX-ray3.20A35-146[»]
3ITRmodel-A38-146[»]
3ITSmodel-A38-146[»]
3L5WX-ray2.00I/J35-146[»]
3L5XX-ray1.90A35-146[»]
3LB6X-ray3.05A/B15-146[»]
4I77X-ray1.90Z35-146[»]
4PS4X-ray2.80A35-146[»]
5E4EX-ray3.00A34-146[»]
ProteinModelPortaliP35225.
SMRiP35225.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3224N.
IntActiP35225. 1 interactor.
STRINGi9606.ENSP00000304915.

Chemistry databases

ChEMBLiCHEMBL3580486.

Polymorphism and mutation databases

BioMutaiIL13.
DMDMi239938644.

Proteomic databases

PaxDbiP35225.
PRIDEiP35225.

Protocols and materials databases

DNASUi3596.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304506; ENSP00000304915; ENSG00000169194.
GeneIDi3596.
KEGGihsa:3596.
UCSCiuc003kxj.2. human.

Organism-specific databases

CTDi3596.
DisGeNETi3596.
GeneCardsiIL13.
H-InvDBHIX0031957.
HGNCiHGNC:5973. IL13.
HPAiHPA042421.
MalaCardsiIL13.
MIMi147683. gene.
607154. phenotype.
neXtProtiNX_P35225.
PharmGKBiPA199.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JCI3. Eukaryota.
ENOG4111BX2. LUCA.
HOGENOMiHOG000113028.
HOVERGENiHBG006140.
InParanoidiP35225.
KOiK05435.
OrthoDBiEOG091G10SR.
PhylomeDBiP35225.
TreeFamiTF336383.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169194-MONOMER.
ReactomeiR-HSA-449147. Signaling by Interleukins.
SignaLinkiP35225.
SIGNORiP35225.

Miscellaneous databases

ChiTaRSiIL13. human.
EvolutionaryTraceiP35225.
GeneWikiiInterleukin_13.
GenomeRNAii3596.
PROiP35225.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169194.
CleanExiHS_IL13.
ExpressionAtlasiP35225. baseline and differential.
GenevisibleiP35225. HS.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020470. IL-13.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERiPTHR11322. PTHR11322. 1 hit.
PfamiPF03487. IL13. 1 hit.
[Graphical view]
PRINTSiPR01929. INTRLEUKIN13.
SMARTiSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL13_HUMAN
AccessioniPrimary (citable) accession number: P35225
Secondary accession number(s): O43644, Q4VB52, Q9UDC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 16, 2009
Last modified: November 30, 2016
This is version 175 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-15 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.