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P35225 (IL13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 152. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-13

Short name=IL-13
Gene names
Name:IL13
Synonyms:NC30
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length146 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.

Subunit structure

Interacts with IL13RA2.

Subcellular location

Secreted.

Involvement in disease

Allergic rhinitis (ALRH) [MIM:607154]: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Sequence similarities

Belongs to the IL-4/IL-13 family.

Caution

It is uncertain whether Met-1 or Met-15 is the initiator.

Sequence caution

The sequence AAA36107.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAA83738.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAB01681.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAC03535.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAK53823.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAA48824.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell-cell signaling

Inferred by curator PubMed 10725748. Source: UniProtKB

cellular component movement

Traceable author statement PubMed 10725748. Source: ProtInc

cellular response to cytokine stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Traceable author statement Ref.1. Source: ProtInc

negative regulation of lung ciliated cell differentiation

Non-traceable author statement PubMed 20539013. Source: BHF-UCL

negative regulation of transforming growth factor beta production

Inferred from electronic annotation. Source: Ensembl

positive regulation of B cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of connective tissue growth factor production

Inferred from electronic annotation. Source: Ensembl

positive regulation of immunoglobulin production

Inferred from electronic annotation. Source: Ensembl

positive regulation of lung goblet cell differentiation

Non-traceable author statement PubMed 20539013. Source: BHF-UCL

positive regulation of macrophage activation

Inferred from electronic annotation. Source: Ensembl

positive regulation of pancreatic stellate cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of release of sequestered calcium ion into cytosol

Inferred from electronic annotation. Source: Ensembl

positive regulation of smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of tyrosine phosphorylation of Stat6 protein

Inferred from electronic annotation. Source: Ensembl

regulation of proton transport

Inferred from electronic annotation. Source: Ensembl

response to ethanol

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

response to nicotine

Inferred from electronic annotation. Source: Ensembl

signal transduction

Non-traceable author statement PubMed 10725748. Source: ProtInc

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

external side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

extracellular region

Inferred from direct assay PubMed 20041150. Source: BHF-UCL

extracellular space

Inferred from sequence or structural similarity PubMed 16275384. Source: UniProtKB

   Molecular_functioncytokine activity

Traceable author statement PubMed 10725748. Source: ProtInc

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

IL13RA1P785524EBI-1647828,EBI-1391535

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 146122Interleukin-13
PRO_0000015547

Amino acid modifications

Glycosylation521N-linked (GlcNAc...) Potential
Glycosylation631N-linked (GlcNAc...) Potential
Glycosylation711N-linked (GlcNAc...) Potential
Glycosylation861N-linked (GlcNAc...) Potential
Disulfide bond62 ↔ 90 Ref.10 Ref.11
Disulfide bond78 ↔ 104 Ref.10 Ref.11

Natural variations

Natural variant1441R → Q Associated with increased risk for asthma development; at homozygosity associated with higher levels of serum total IgE in some allergic rhinitis patients. Ref.5 Ref.6 Ref.7 Ref.12 Ref.13 Ref.14
Corresponds to variant rs20541 [ dbSNP | Ensembl ].
VAR_010037

Experimental info

Sequence conflict11M → R in CAA48824. Ref.2
Sequence conflict261T → A no nucleotide entry Ref.9
Sequence conflict321A → D no nucleotide entry Ref.9
Sequence conflict511V → S no nucleotide entry Ref.9
Sequence conflict561N → T no nucleotide entry Ref.9
Sequence conflict591A → R in AAA83738. Ref.3
Sequence conflict1011S → G in AAC03535. Ref.8
Sequence conflict1121Missing in AAA83738. Ref.3

Secondary structure

................. 146
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P35225 [UniParc].

Last modified June 16, 2009. Version 2.
Checksum: BE2D46CCF913D129

FASTA14615,816
        10         20         30         40         50         60 
MHPLLNPLLL ALGLMALLLT TVIALTCLGG FASPGPVPPS TALRELIEEL VNITQNQKAP 

        70         80         90        100        110        120 
LCNGSMVWSI NLTAGMYCAA LESLINVSGC SAIEKTQRML SGFCPHKVSA GQFSSLHVRD 

       130        140 
TKIEVAQFVK DLLLHLKKLF REGRFN 

« Hide

References

« Hide 'large scale' references
[1]"Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses."
Minty A.J., Chalon P., Derocq J.-M., Dumont X., Guillemot J.-C., Kaghad M., Labit C., Leplatois P., Liauzun P., Miloux B., Minty C., Casellas P., Loison G., Lupker J., Shire D., Ferrara P., Caput D.
Nature 362:248-250(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function."
McKenzie A.N., Culpepper J.A., Waal Malefyt R., Briere F., Punnonen J., Aversa G., Sato A., Dang W., Cocks B.G., Menon S., de Vries J.E., Banchereau J., Zurawski G.R.
Proc. Natl. Acad. Sci. U.S.A. 90:3735-3739(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Tandem arrangement of human genes for interleukin-4 and interleukin-13: resemblance in their organization."
Smirnov D.V., Smirnova M.G., Korobko V.G., Frolova E.I.
Gene 155:277-281(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Blood.
[4]"Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31."
Dolganov G., Bort S., Lovett M., Burr J., Schubert L., Short D., McGurn M., Gibson C., Lewis D.B.
Blood 87:3316-3326(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]SeattleSNPs variation discovery resource
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-144.
[6]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLN-144.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-144.
[8]Jang J.S., Kim B.E.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-146.
[9]"The selective isolation of novel cDNAs encoded by the regions surrounding the human interleukin 4 and 5 genes."
Morgan J.G., Dolganov G.M., Robbins S.E., Hinton L.M., Lovett M.
Nucleic Acids Res. 20:5173-5179(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-63.
Tissue: Peripheral blood lymphocyte.
[10]"Solution structure of human IL-13 and implication for receptor binding."
Moy F.J., Diblasio E., Wilhelm J., Powers R.
J. Mol. Biol. 310:219-230(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 35-146, DISULFIDE BONDS.
[11]"Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2."
Lupardus P.J., Birnbaum M.E., Garcia K.C.
Structure 18:332-342(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.05 ANGSTROMS) OF 15-146 IN COMPLEX WITH IL13RA2, DISULFIDE BONDS.
[12]"Genetic variants of IL-13 signalling and human asthma and atopy."
Heinzmann A., Mao X.-Q., Akaiwa M., Kreomer R.T., Gao P.-S., Ohshima K., Umeshita R., Abe Y., Braun S., Yamashita T., Roberts M.H., Sugimoto R., Arima K., Arinobu Y., Yu B., Kruse S., Enomoto T., Dake Y. expand/collapse author list , Kawai M., Shimazu S., Sasaki S., Adra C.N., Kitaichi M., Inoue H., Yamauchi K., Tomichi N., Kurimoto F., Hamasaki N., Hopkin J.M., Izuhara K., Shirakawa T., Deichmann K.A.
Hum. Mol. Genet. 9:549-559(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GLN-144.
[13]"Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population."
Howard T.D., Whittaker P.A., Zaiman A.L., Koppelman G.H., Xu J., Hanley M.T., Meyers D.A., Postma D.S., Bleecker E.R.
Am. J. Respir. Cell Mol. Biol. 25:377-384(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GLN-144.
[14]"A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis."
Wang M., Xing Z.-M., Lu C., Ma Y.-X., Yu D.-L., Yan Z., Wang S.-W., Yu L.-S.
Hum. Genet. 113:387-390(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GLN-144.
+Additional computationally mapped references.

Web resources

Wikipedia

Interleukin-13 entry

SeattleSNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X69079 mRNA. Translation: CAA48823.1.
X69079 mRNA. Translation: CAA48824.1. Different initiation.
L06801 mRNA. Translation: AAA36107.1. Different initiation.
U10307 Genomic DNA. Translation: AAA83738.1. Different initiation.
U31120 Genomic DNA. Translation: AAB01681.1. Different initiation.
AF377331 Genomic DNA. Translation: AAK53823.1. Different initiation.
AC004039 Genomic DNA. No translation available.
BC096139 mRNA. Translation: AAH96139.1.
AF043334 mRNA. Translation: AAC03535.1. Different initiation.
PIRA47481. I38060.
RefSeqNP_002179.2. NM_002188.2.
UniGeneHs.845.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1GA3NMR-A35-146[»]
1IJZNMR-A35-146[»]
1IK0NMR-A35-146[»]
1J9Umodel-A38-146[»]
3BPOX-ray3.00A34-146[»]
3G6DX-ray3.20A35-146[»]
3ITRmodel-A38-146[»]
3ITSmodel-A38-146[»]
3L5WX-ray2.00I/J35-146[»]
3L5XX-ray1.90A35-146[»]
3L5YX-ray2.80A35-146[»]
3LB6X-ray3.05A/B15-146[»]
4I77X-ray1.90Z35-146[»]
ProteinModelPortalP35225.
SMRP35225. Positions 38-146.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109810. 1 interaction.
DIPDIP-3224N.
IntActP35225. 1 interaction.
STRING9606.ENSP00000304915.

Polymorphism databases

DMDM239938644.

Proteomic databases

PRIDEP35225.

Protocols and materials databases

DNASU3596.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304506; ENSP00000304915; ENSG00000169194.
GeneID3596.
KEGGhsa:3596.

Organism-specific databases

CTD3596.
GeneCardsGC05P131991.
H-InvDBHIX0031957.
HGNCHGNC:5973. IL13.
HPAHPA042421.
MIM147683. gene.
607154. phenotype.
neXtProtNX_P35225.
PharmGKBPA199.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42350.
HOGENOMHOG000113028.
HOVERGENHBG006140.
InParanoidP35225.
KOK05435.
OrthoDBEOG78SQMB.
PhylomeDBP35225.
TreeFamTF336383.

Enzyme and pathway databases

SignaLinkP35225.

Gene expression databases

ArrayExpressP35225.
BgeeP35225.
CleanExHS_IL13.
GenevestigatorP35225.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020470. IL-13.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERPTHR11322. PTHR11322. 1 hit.
PfamPF03487. IL13. 1 hit.
[Graphical view]
PRINTSPR01929. INTRLEUKIN13.
SMARTSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIL13. human.
EvolutionaryTraceP35225.
GeneWikiInterleukin_13.
GenomeRNAi3596.
NextBio14053.
PROP35225.
SOURCESearch...

Entry information

Entry nameIL13_HUMAN
AccessionPrimary (citable) accession number: P35225
Secondary accession number(s): O43644, Q4VB52, Q9UDC7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 16, 2009
Last modified: April 16, 2014
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM