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Protein

Catenin beta

Gene
N/A
Organism
Urechis caupo (Innkeeper worm) (Spoonworm)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the cytoplasmic domain of the cell-cell adhesion molecule E-cadherin, and perhaps to other (membrane) proteins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties.

GO - Molecular functioni

  1. signal transducer activity Source: InterPro

GO - Biological processi

  1. adherens junction assembly Source: InterPro
  2. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Catenin beta
Alternative name(s):
Beta-catenin
OrganismiUrechis caupo (Innkeeper worm) (Spoonworm)
Taxonomic identifieri6431 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaPolychaetaEchiuraXenopneustaUrechidaeUrechis

Subcellular locationi

Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 818818Catenin betaPRO_0000064275Add
BLAST

Proteomic databases

PRIDEiP35224.

Structurei

3D structure databases

ProteinModelPortaliP35224.
SMRiP35224. Positions 150-705.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati164 – 20340ARM 1Add
BLAST
Repeati248 – 28740ARM 2Add
BLAST
Repeati412 – 45140ARM 3Add
BLAST
Repeati454 – 49542ARM 4Add
BLAST
Repeati501 – 54141ARM 5Add
BLAST
Repeati543 – 58240ARM 6Add
BLAST
Repeati648 – 68740ARM 7Add
BLAST

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 7 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PfamiPF00514. Arm. 4 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35224-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METYQQMNSG SGPRSVGTPQ GQYMDVGEMP PMDAKQQTML WQQNQYMGDS
60 70 80 90 100
GIQSGATTQA PPSVSSKHGL DDMDTGEGMD TSRMMFDFDQ GFSTQAFTQE
110 120 130 140 150
QVDEMNQQLN QTRSQRVRAA MFPETLEEGV QIPSTQLDPG QPTAVQRLSE
160 170 180 190 200
PSQMLKHAVV NLINYQDDAD LATRAIPELT KLLNDEDQVV VSQAAMMVHQ
210 220 230 240 250
LSKKEASRHA IMNSPQMVAA LVRAMTNTND LETTRCAAGT LHNLSHHRQG
260 270 280 290 300
LLTIFKSGGI PALVKLLSSP VESVLFYAIT TLHNLLLHQE GSKMAVRLAG
310 320 330 340 350
GLQKMVLLLQ RNNLKFLAIT TDCLQILAYG NQESKLIILA SGGPGELVRI
360 370 380 390 400
MRSYTYEKLL WTTSRVLKVL SVCASNKPAI VEAGSAGPSM HLGHQSQRLV
410 420 430 440 450
QNCLWTLRNL SDAATKSSDI EGLLQMLVQL LASNDINIVT CAAGILSNLT
460 470 480 490 500
CNNQRNKVTV CQVGGIEALV RTILQAGDRE DITEPAVCAL RHLTSRHGEA
510 520 530 540 550
EMAQNAVRLH YGLPVLVKLL HPPSRWPLIK AVVGLIRNLA LCPANHAPLR
560 570 580 590 600
EHGAIPRIVQ LLIRAHQDTQ RRATAGSGNT SAYVDGVRME EIVEGTVGAL
610 620 630 640 650
HIMAREAHNR AVIRGLNCIS LFAQLLYSPI DNIQRVAAGV LCELAADKEG
660 670 680 690 700
AEMIEQEGTT APLTELLHSR NEGVATYAAA VLFRMSEDKP QDYKKRLSVE
710 720 730 740 750
LTSSLFRGEQ VPWGEPPGLD DMDSSQLLPE EQGFRGYQGS GPGSVPSGPP
760 770 780 790 800
HDMNRQDSMQ GLELGSQQGT AYGSHMPDLG PNTDLHFDPM DGGGSSMGGP
810
HTPTDPQNQM AAWFDTDL
Length:818
Mass (Da):89,070
Last modified:January 31, 1994 - v1
Checksum:i1DF174BEEF745C1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10355 mRNA. Translation: AAA30330.1.
PIRiS33793.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10355 mRNA. Translation: AAA30330.1.
PIRiS33793.

3D structure databases

ProteinModelPortaliP35224.
SMRiP35224. Positions 150-705.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP35224.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PfamiPF00514. Arm. 4 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of homologues to beta-catenin/plakoglobin/armadillo in two invertebrates, Urechis caupo and Tripneustes gratilla."
    Rosenthal E.T.
    Biochim. Biophys. Acta 1173:337-341(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCTNB_URECA
AccessioniPrimary (citable) accession number: P35224
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 1994
Last sequence update: January 31, 1994
Last modified: March 3, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.