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P35224 (CTNB_URECA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Catenin beta
Alternative name(s):
Beta-catenin
OrganismUrechis caupo (Innkeeper worm) (Spoonworm)
Taxonomic identifier6431 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaAnnelidaPolychaetaEchiuraXenopneustaUrechidaeUrechis

Protein attributes

Sequence length818 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds to the cytoplasmic domain of the cell-cell adhesion molecule E-cadherin, and perhaps to other (membrane) proteins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties.

Subcellular location

Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity.

Sequence similarities

Belongs to the beta-catenin family.

Contains 7 ARM repeats.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCytoplasm
Cytoskeleton
   DomainRepeat
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 818818Catenin beta
PRO_0000064275

Regions

Repeat164 – 20340ARM 1
Repeat248 – 28740ARM 2
Repeat412 – 45140ARM 3
Repeat454 – 49542ARM 4
Repeat501 – 54141ARM 5
Repeat543 – 58240ARM 6
Repeat648 – 68740ARM 7

Sequences

Sequence LengthMass (Da)Tools
P35224 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 1DF174BEEF745C1D

FASTA81889,070
        10         20         30         40         50         60 
METYQQMNSG SGPRSVGTPQ GQYMDVGEMP PMDAKQQTML WQQNQYMGDS GIQSGATTQA 

        70         80         90        100        110        120 
PPSVSSKHGL DDMDTGEGMD TSRMMFDFDQ GFSTQAFTQE QVDEMNQQLN QTRSQRVRAA 

       130        140        150        160        170        180 
MFPETLEEGV QIPSTQLDPG QPTAVQRLSE PSQMLKHAVV NLINYQDDAD LATRAIPELT 

       190        200        210        220        230        240 
KLLNDEDQVV VSQAAMMVHQ LSKKEASRHA IMNSPQMVAA LVRAMTNTND LETTRCAAGT 

       250        260        270        280        290        300 
LHNLSHHRQG LLTIFKSGGI PALVKLLSSP VESVLFYAIT TLHNLLLHQE GSKMAVRLAG 

       310        320        330        340        350        360 
GLQKMVLLLQ RNNLKFLAIT TDCLQILAYG NQESKLIILA SGGPGELVRI MRSYTYEKLL 

       370        380        390        400        410        420 
WTTSRVLKVL SVCASNKPAI VEAGSAGPSM HLGHQSQRLV QNCLWTLRNL SDAATKSSDI 

       430        440        450        460        470        480 
EGLLQMLVQL LASNDINIVT CAAGILSNLT CNNQRNKVTV CQVGGIEALV RTILQAGDRE 

       490        500        510        520        530        540 
DITEPAVCAL RHLTSRHGEA EMAQNAVRLH YGLPVLVKLL HPPSRWPLIK AVVGLIRNLA 

       550        560        570        580        590        600 
LCPANHAPLR EHGAIPRIVQ LLIRAHQDTQ RRATAGSGNT SAYVDGVRME EIVEGTVGAL 

       610        620        630        640        650        660 
HIMAREAHNR AVIRGLNCIS LFAQLLYSPI DNIQRVAAGV LCELAADKEG AEMIEQEGTT 

       670        680        690        700        710        720 
APLTELLHSR NEGVATYAAA VLFRMSEDKP QDYKKRLSVE LTSSLFRGEQ VPWGEPPGLD 

       730        740        750        760        770        780 
DMDSSQLLPE EQGFRGYQGS GPGSVPSGPP HDMNRQDSMQ GLELGSQQGT AYGSHMPDLG 

       790        800        810 
PNTDLHFDPM DGGGSSMGGP HTPTDPQNQM AAWFDTDL 

« Hide

References

[1]"Identification of homologues to beta-catenin/plakoglobin/armadillo in two invertebrates, Urechis caupo and Tripneustes gratilla."
Rosenthal E.T.
Biochim. Biophys. Acta 1173:337-341(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L10355 mRNA. Translation: AAA30330.1.
PIRS33793.

3D structure databases

ProteinModelPortalP35224.
SMRP35224. Positions 150-705.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP35224.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.25.10.10. 1 hit.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PfamPF00514. Arm. 4 hits.
[Graphical view]
PRINTSPR01869. BCATNINFAMLY.
SMARTSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
PROSITEPS50176. ARM_REPEAT. 9 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCTNB_URECA
AccessionPrimary (citable) accession number: P35224
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 16, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families