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P35223 (CTNB_TRIGR) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Catenin beta
Alternative name(s):
Beta-catenin
OrganismTripneustes gratilla (Hawaian sea urchin) (Echinus gratilla)
Taxonomic identifier7673 [NCBI]
Taxonomic lineageEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaTemnopleuroidaToxopneustidaeTripneustes

Protein attributes

Sequence length820 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds to the cytoplasmic domain of the cell-cell adhesion molecule E-cadherin, and perhaps to other (membrane) proteins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties.

Subcellular location

Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity.

Sequence similarities

Belongs to the beta-catenin family.

Contains 10 ARM repeats.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCytoplasm
Cytoskeleton
   DomainRepeat
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 820820Catenin beta
PRO_0000064274

Regions

Repeat157 – 19640ARM 1
Repeat199 – 23941ARM 2
Repeat241 – 28040ARM 3
Repeat283 – 32240ARM 4
Repeat367 – 40539ARM 5
Repeat406 – 44540ARM 6
Repeat448 – 48942ARM 7
Repeat495 – 53541ARM 8
Repeat603 – 64240ARM 9
Repeat644 – 68340ARM 10

Sequences

Sequence LengthMass (Da)Tools
P35223 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 57255E0F57795FD3

FASTA82089,361
        10         20         30         40         50         60 
MEQARYSNQQ SVNPQQKGFG GPGLQDLPKQ DPMQNTMEWQ HHGYGMDSGF QSSATSHPPS 

        70         80         90        100        110        120 
VSSKSRHEDG GEEAQAQGMF EWDAGYGQAY TQEQVDEMNQ QLTQTRSQRV RAAMFPETLE 

       130        140        150        160        170        180 
EGVQIPSTQF DPAHPTAVQR LSEPSQMLKH AVVNLINYQD DADLATRAIP ELTKLLNDDD 

       190        200        210        220        230        240 
LVVVNQAAMM VHQLSKKEAS RHAIMNSPQM VAALVRAMSN SNDAETTRCA AGTLHNLSHH 

       250        260        270        280        290        300 
RAGLLQIFKS GGIPALIKLL SSPVESVLFY AITTLHNLLL HQEGSKMAVR LAGGLQKMVA 

       310        320        330        340        350        360 
LLSRNNPKFL AITTDCLQIL AYGNQESKLI ILASGGPAAL VHIMRTYDYE KLLWTTSRVL 

       370        380        390        400        410        420 
KVLSVCHNNK PAIVEAGGMS ALGLHLGHHS NRLVQNCLWT LRNLSDCHRG TDDIEPLLQM 

       430        440        450        460        470        480 
LVQLLASNDI NVVTCACGIL SNLTCNNSRN KMIVSQMAGV EALVQTLMKA GDREEITEPA 

       490        500        510        520        530        540 
VCALRHVTSR HPGAEMGQNT VRLNYGIPVI VKLLHPPSRW PLIKATVGLI RNLALCSANH 

       550        560        570        580        590        600 
APLREQGALH RLVQLLMRAH QDTQRRSSMG STGSQGGNYA DGVRMEDIVE GTTGALHILA 

       610        620        630        640        650        660 
RDSHNRALIQ GLNCIPLFVQ LLYNNIENIQ RVAAGVLSEL SLEKQGAEMI EQEGATAPLT 

       670        680        690        700        710        720 
ELLHSRNEGV ATYAAAVLYR MSDDKPQDYK KRISVELGNS LFRGDSVPWG DPLDMPSDNQ 

       730        740        750        760        770        780 
ILPPSSMGGH PPDPGYPQPG SVHSLHSNHG EYRQPPPPMQ GYHDGTGPIE PMMQDLDLGG 

       790        800        810        820 
GGDFGMDPGL PDMGPPASDL NLDSIPPADN TGLAFFDTDL 

« Hide

References

[1]"Identification of homologues to beta-catenin/plakoglobin/armadillo in two invertebrates, Urechis caupo and Tripneustes gratilla."
Rosenthal E.T.
Biochim. Biophys. Acta 1173:337-341(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L10354 mRNA. Translation: AAA30089.1.
PIRS33794.

3D structure databases

ProteinModelPortalP35223.
SMRP35223. Positions 143-701.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP35223.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.25.10.10. 1 hit.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PfamPF00514. Arm. 4 hits.
[Graphical view]
PRINTSPR01869. BCATNINFAMLY.
SMARTSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
PROSITEPS50176. ARM_REPEAT. 9 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCTNB_TRIGR
AccessionPrimary (citable) accession number: P35223
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 16, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families