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Protein

Catenin beta

Gene
N/A
Organism
Tripneustes gratilla (Hawaian sea urchin) (Echinus gratilla)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the cytoplasmic domain of the cell-cell adhesion molecule E-cadherin, and perhaps to other (membrane) proteins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Catenin beta
Alternative name(s):
Beta-catenin
OrganismiTripneustes gratilla (Hawaian sea urchin) (Echinus gratilla)
Taxonomic identifieri7673 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaTemnopleuroidaToxopneustidaeTripneustes

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642741 – 820Catenin betaAdd BLAST820

Proteomic databases

PRIDEiP35223.

Structurei

3D structure databases

ProteinModelPortaliP35223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati157 – 196ARM 1Add BLAST40
Repeati199 – 239ARM 2Add BLAST41
Repeati241 – 280ARM 3Add BLAST40
Repeati283 – 322ARM 4Add BLAST40
Repeati367 – 405ARM 5Add BLAST39
Repeati406 – 445ARM 6Add BLAST40
Repeati448 – 489ARM 7Add BLAST42
Repeati495 – 535ARM 8Add BLAST41
Repeati603 – 642ARM 9Add BLAST40
Repeati644 – 683ARM 10Add BLAST40

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 10 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PfamiPF00514. Arm. 3 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35223-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQARYSNQQ SVNPQQKGFG GPGLQDLPKQ DPMQNTMEWQ HHGYGMDSGF
60 70 80 90 100
QSSATSHPPS VSSKSRHEDG GEEAQAQGMF EWDAGYGQAY TQEQVDEMNQ
110 120 130 140 150
QLTQTRSQRV RAAMFPETLE EGVQIPSTQF DPAHPTAVQR LSEPSQMLKH
160 170 180 190 200
AVVNLINYQD DADLATRAIP ELTKLLNDDD LVVVNQAAMM VHQLSKKEAS
210 220 230 240 250
RHAIMNSPQM VAALVRAMSN SNDAETTRCA AGTLHNLSHH RAGLLQIFKS
260 270 280 290 300
GGIPALIKLL SSPVESVLFY AITTLHNLLL HQEGSKMAVR LAGGLQKMVA
310 320 330 340 350
LLSRNNPKFL AITTDCLQIL AYGNQESKLI ILASGGPAAL VHIMRTYDYE
360 370 380 390 400
KLLWTTSRVL KVLSVCHNNK PAIVEAGGMS ALGLHLGHHS NRLVQNCLWT
410 420 430 440 450
LRNLSDCHRG TDDIEPLLQM LVQLLASNDI NVVTCACGIL SNLTCNNSRN
460 470 480 490 500
KMIVSQMAGV EALVQTLMKA GDREEITEPA VCALRHVTSR HPGAEMGQNT
510 520 530 540 550
VRLNYGIPVI VKLLHPPSRW PLIKATVGLI RNLALCSANH APLREQGALH
560 570 580 590 600
RLVQLLMRAH QDTQRRSSMG STGSQGGNYA DGVRMEDIVE GTTGALHILA
610 620 630 640 650
RDSHNRALIQ GLNCIPLFVQ LLYNNIENIQ RVAAGVLSEL SLEKQGAEMI
660 670 680 690 700
EQEGATAPLT ELLHSRNEGV ATYAAAVLYR MSDDKPQDYK KRISVELGNS
710 720 730 740 750
LFRGDSVPWG DPLDMPSDNQ ILPPSSMGGH PPDPGYPQPG SVHSLHSNHG
760 770 780 790 800
EYRQPPPPMQ GYHDGTGPIE PMMQDLDLGG GGDFGMDPGL PDMGPPASDL
810 820
NLDSIPPADN TGLAFFDTDL
Length:820
Mass (Da):89,361
Last modified:February 1, 1994 - v1
Checksum:i57255E0F57795FD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10354 mRNA. Translation: AAA30089.1.
PIRiS33794.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10354 mRNA. Translation: AAA30089.1.
PIRiS33794.

3D structure databases

ProteinModelPortaliP35223.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP35223.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PfamiPF00514. Arm. 3 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTNB_TRIGR
AccessioniPrimary (citable) accession number: P35223
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 5, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.