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Protein

Catenin beta

Gene
N/A
Organism
Tripneustes gratilla (Hawaian sea urchin) (Echinus gratilla)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the cytoplasmic domain of the cell-cell adhesion molecule E-cadherin, and perhaps to other (membrane) proteins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Catenin beta
Alternative name(s):
Beta-catenin
OrganismiTripneustes gratilla (Hawaian sea urchin) (Echinus gratilla)
Taxonomic identifieri7673 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaTemnopleuroidaToxopneustidaeTripneustes

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 820820Catenin betaPRO_0000064274Add
BLAST

Proteomic databases

PRIDEiP35223.

Structurei

3D structure databases

ProteinModelPortaliP35223.
SMRiP35223. Positions 143-701.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati157 – 19640ARM 1Add
BLAST
Repeati199 – 23941ARM 2Add
BLAST
Repeati241 – 28040ARM 3Add
BLAST
Repeati283 – 32240ARM 4Add
BLAST
Repeati367 – 40539ARM 5Add
BLAST
Repeati406 – 44540ARM 6Add
BLAST
Repeati448 – 48942ARM 7Add
BLAST
Repeati495 – 53541ARM 8Add
BLAST
Repeati603 – 64240ARM 9Add
BLAST
Repeati644 – 68340ARM 10Add
BLAST

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 10 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PfamiPF00514. Arm. 4 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35223-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQARYSNQQ SVNPQQKGFG GPGLQDLPKQ DPMQNTMEWQ HHGYGMDSGF
60 70 80 90 100
QSSATSHPPS VSSKSRHEDG GEEAQAQGMF EWDAGYGQAY TQEQVDEMNQ
110 120 130 140 150
QLTQTRSQRV RAAMFPETLE EGVQIPSTQF DPAHPTAVQR LSEPSQMLKH
160 170 180 190 200
AVVNLINYQD DADLATRAIP ELTKLLNDDD LVVVNQAAMM VHQLSKKEAS
210 220 230 240 250
RHAIMNSPQM VAALVRAMSN SNDAETTRCA AGTLHNLSHH RAGLLQIFKS
260 270 280 290 300
GGIPALIKLL SSPVESVLFY AITTLHNLLL HQEGSKMAVR LAGGLQKMVA
310 320 330 340 350
LLSRNNPKFL AITTDCLQIL AYGNQESKLI ILASGGPAAL VHIMRTYDYE
360 370 380 390 400
KLLWTTSRVL KVLSVCHNNK PAIVEAGGMS ALGLHLGHHS NRLVQNCLWT
410 420 430 440 450
LRNLSDCHRG TDDIEPLLQM LVQLLASNDI NVVTCACGIL SNLTCNNSRN
460 470 480 490 500
KMIVSQMAGV EALVQTLMKA GDREEITEPA VCALRHVTSR HPGAEMGQNT
510 520 530 540 550
VRLNYGIPVI VKLLHPPSRW PLIKATVGLI RNLALCSANH APLREQGALH
560 570 580 590 600
RLVQLLMRAH QDTQRRSSMG STGSQGGNYA DGVRMEDIVE GTTGALHILA
610 620 630 640 650
RDSHNRALIQ GLNCIPLFVQ LLYNNIENIQ RVAAGVLSEL SLEKQGAEMI
660 670 680 690 700
EQEGATAPLT ELLHSRNEGV ATYAAAVLYR MSDDKPQDYK KRISVELGNS
710 720 730 740 750
LFRGDSVPWG DPLDMPSDNQ ILPPSSMGGH PPDPGYPQPG SVHSLHSNHG
760 770 780 790 800
EYRQPPPPMQ GYHDGTGPIE PMMQDLDLGG GGDFGMDPGL PDMGPPASDL
810 820
NLDSIPPADN TGLAFFDTDL
Length:820
Mass (Da):89,361
Last modified:February 1, 1994 - v1
Checksum:i57255E0F57795FD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10354 mRNA. Translation: AAA30089.1.
PIRiS33794.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10354 mRNA. Translation: AAA30089.1.
PIRiS33794.

3D structure databases

ProteinModelPortaliP35223.
SMRiP35223. Positions 143-701.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP35223.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PfamiPF00514. Arm. 4 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of homologues to beta-catenin/plakoglobin/armadillo in two invertebrates, Urechis caupo and Tripneustes gratilla."
    Rosenthal E.T.
    Biochim. Biophys. Acta 1173:337-341(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCTNB_TRIGR
AccessioniPrimary (citable) accession number: P35223
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 27, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.