P35220 (CTNA_DROME) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 111.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Catenin alpha | ||||
| Gene names |
| ||||
| Organism | Drosophila melanogaster (Fruit fly) | ||||
| Taxonomic identifier | 7227 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 917 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with the armadillo protein. |
| Subcellular location | Cytoplasm › cytoskeleton By similarity. Cell junction › adherens junction By similarity. Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cell junction. Note: Found only at cell-cell boundaries. |
| Developmental stage | Present at all stages, but reached the highest levels during early to mid-embryogenesis. |
| Sequence similarities | Belongs to the vinculin/alpha-catenin family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell adhesion |
| Cellular component | Cell junction Cell membrane Cytoplasm Cytoskeleton Membrane |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW establishment or maintenance of cell polarityNon-traceable author statement. Source: FlyBase oocyte localization involved in germarium-derived egg chamber formationTraceable author statement. Source: FlyBase |
| Cellular component | actin cytoskeleton Inferred from electronic annotation. Source: InterPro cytoplasmInferred from electronic annotation. Source: UniProtKB-KW spot adherens junctionNon-traceable author statement. Source: FlyBase zonula adherensNon-traceable author statement. Source: FlyBase |
| Molecular function | cadherin binding Inferred from electronic annotation. Source: InterPro structural molecule activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 917 | 917 | Catenin alpha | PRO_0000064260 | |||||
Amino acid modifications | |||||||||
| Modified residue | 643 | 1 | Phosphothreonine Ref.6 | ||||||
| Modified residue | 645 | 1 | Phosphothreonine Ref.6 | ||||||
| Modified residue | 659 | 1 | Phosphoserine Ref.6 | ||||||
| Modified residue | 662 | 1 | Phosphoserine Ref.6 | ||||||
Experimental info | |||||||||
| Sequence conflict | 711 | 1 | F → S in AAK93204. Ref.5 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of a Drosophila homologue of alpha-catenin and its association with the armadillo protein." Oda H., Uemura T., Shiomi K., Nagafuchi A., Tsukita S., Takeichi M. J. Cell Biol. 121:1133-1140(1993) [PubMed: 8501118] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | Takeichi M. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO N-TERMINUS. |
| [3] | "The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. Venter J.C.Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley. |
| [4] | "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. Lewis S.E.Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley. |
| [5] | "A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo. |
| [6] | "Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-643; THR-645; SER-659 AND SER-662, MASS SPECTROMETRY. Tissue: Embryo. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | D13964 mRNA. Translation: BAA03067.2. AE014296 Genomic DNA. Translation: AAF45466.1. AY051780 mRNA. Translation: AAK93204.1. |
| PIR | A40694. |
| RefSeq | NP_524219.1. NM_079495.2. |
| UniGene | Dm.7158. |
3D structure databases | |
| ProteinModelPortal | P35220. |
| SMR | P35220. Positions 62-266, 380-634. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-21662N. |
| IntAct | P35220. 1 interaction. |
| MINT | MINT-769048. |
| STRING | P35220. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblMetazoa | FBtr0070038; FBpp0070037; FBgn0010215. |
| GeneID | 40517. |
| KEGG | dme:Dmel_CG17947. |
| NMPDR | fig|7227.3.peg.11131. |
Organism-specific databases | |
| CTD | 40517. |
| FlyBase | FBgn0010215. alpha-Cat. |
Phylogenomic databases | |
| eggNOG | inNOG04138. |
| GeneTree | EMGT00050000016484. |
| InParanoid | P35220. |
| OMA | DIIFLAK. |
| OrthoDB | EOG4MKKX6. |
| PhylomeDB | P35220. |
Gene expression databases | |
| Bgee | P35220. |
| GermOnline | CG17947. Drosophila melanogaster. |
Family and domain databases | |
| InterPro | IPR001033. Alpha_catenin. IPR006077. Vinculin/catenin. IPR000633. Vinculin_CS. [Graphical view] |
| KO | K05691. |
| Pfam | PF01044. Vinculin. 2 hits. [Graphical view] |
| PRINTS | PR00805. ALPHACATENIN. |
| SUPFAM | SSF47220. Vinculin/catenin. 4 hits. |
| PROSITE | PS00663. VINCULIN_1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 819161. |
Entry information
| Entry name | CTNA_DROME | ||||||||
| Accession | Primary (citable) accession number: P35220 Secondary accession number(s): Q960Y2, Q9W5V9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| SIMILARITY comments Index of protein domains and families |

Clusters with