Reviewed,
UniProtKB/Swiss-Prot P35218 (CAH5A_HUMAN)
Last modified
January 19, 2010.
Version 88.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Carbonic anhydrase 5A, mitochondrial EC=4.2.1.1 Alternative name(s): Carbonic anhydrase VA Short name=CA-VA Carbonate dehydratase VA | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 305 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Reversible hydration of carbon dioxide. |
| Catalytic activity | H2CO3 = CO2 + H2O. |
| Cofactor | Zinc By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the alpha-carbonic anhydrase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Ligand | Metal-binding Zinc |
| Molecular function | Lyase |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | one-carbon metabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | mitochondrial matrix Ref.2 Non-traceable author statement. Source: ProtInc |
| Molecular function | carbonate dehydratase activity Ref.1 Traceable author statement. Source: ProtInc zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 38 | 38 | Mitochondrion | ||||||
| Chain | 39 – 305 | 267 | Carbonic anhydrase 5A, mitochondrial | PRO_0000004234 | |||||
Sites | |||||||||
| Metal binding | 130 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 132 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 155 | 1 | Zinc; catalytic By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Human mitochondrial carbonic anhydrase: cDNA cloning, expression, subcellular localization, and mapping to chromosome 16." Nagao Y., Platero J.S., Waheed A., Sly W.S. Proc. Natl. Acad. Sci. U.S.A. 90:7623-7627(1993) [PubMed: 8356065] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Tissue: Liver. |
| [2] | "Genomic organization of the human gene (CA5) and pseudogene for mitochondrial carbonic anhydrase V and their localization to chromosomes 16q and 16p." Nagao Y., Batanian J.R., Clemente M.F., Sly W.S. Genomics 28:477-484(1995) [PubMed: 7490083] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Umbilical cord. |
| [3] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | L19297 mRNA. Translation: AAA02890.1. U25134 Genomic DNA. Translation: AAC99806.1. S80181 S80180 Genomic DNA. Translation: AAB47048.1. CH471114 Genomic DNA. Translation: EAW95372.1. BC137405 mRNA. Translation: AAI37406.1. BC137411 mRNA. Translation: AAI37412.1. |
| IPI | IPI00017262. |
| PIR | CRHU5. A47745. |
| RefSeq | NP_001730.1. |
| UniGene | Hs.177446 |
3D structure databases | |
| SMR | P35218. Positions 61-296. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P35218. |
Proteomic databases | |
| PRIDE | P35218. |
Genome annotation databases | |
| Ensembl | ENST00000309893; ENSP00000309649; ENSG00000174990; Homo sapiens. [Genome view] |
| GeneID | 763. |
| KEGG | hsa:763. |
| UCSC | uc002fkn.1. human. |
Organism-specific databases | |
| CTD | 763. |
| GeneCards | GC16M086479. |
| H-InvDB | HIX0038659. |
| HGNC | HGNC:1377. CA5A. |
| MIM | 114761. gene. |
| PharmGKB | PA25992. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG08743. |
| HOGENOM | HBG717384. |
| HOVERGEN | P35218. |
| InParanoid | P35218. |
| OMA | SYDAASC. |
| OrthoDB | EOG9GJ27G. |
| PhylomeDB | P35218. |
Enzyme and pathway databases | |
| BRENDA | 4.2.1.1. 247. |
Gene expression databases | |
| ArrayExpress | P35218. |
| Bgee | P35218. |
| CleanEx | HS_CA5A. |
| Genevestigator | P35218. |
| GermOnline | ENSG00000174990. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001148. Carbonic_anhydrase_a-class_cat. IPR018338. Carbonic_anhydrase_a-class_CS. IPR018437. Carbonic_anhydrase_CA5_mt. [Graphical view] |
| Gene3D | G3DSA:3.10.200.10. Euk_COanhd. 1 hit. |
| PANTHER | PTHR18952:SF25. Carbonic_anhydrase_CA5_mt. 1 hit. PTHR18952. Euk_COanhd. 1 hit. |
| Pfam | PF00194. Carb_anhydrase. 1 hit. [Graphical view] |
| PROSITE | PS00162. ALPHA_CA_1. 1 hit. PS51144. ALPHA_CA_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| BindingDB | P35218. |
| NextBio | 3086. |
| SOURCE | Search... |
Entry information
| Entry name | CAH5A_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P35218 Secondary accession number(s): B2RPF2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 16 Human chromosome 16: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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