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Reviewed, UniProtKB/Swiss-Prot P35218 (CAH5A_HUMAN)

Last modified July 7, 2009. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Carbonic anhydrase 5A, mitochondrial
    EC=4.2.1.1
Alternative name(s):
    Carbonic anhydrase VA
      Short name=CA-VA
    Carbonate dehydratase VA
Gene names
Name: CA5A
Synonyms: CA5
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Reversible hydration of carbon dioxide.

Catalytic activity

H2CO3 = CO2 + H2O.

Cofactor

Zinc By similarity.

Subcellular location

Mitochondrion.

Sequence similarities

Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandMetal-binding
Zinc
   Molecular functionLyase
   Technical termComplete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological processone-carbon compound metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentmitochondrial matrix Ref.2

Non-traceable author statement. Source: ProtInc

   Molecular functioncarbonate dehydratase activity Ref.1

Traceable author statement. Source: ProtInc

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3838Mitochondrion
Chain39 – 305267Carbonic anhydrase 5A, mitochondrial
PRO_0000004234

Sites

Metal binding1301Zinc; catalytic By similarity
Metal binding1321Zinc; catalytic By similarity
Metal binding1551Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
P35218-1 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: C4E998D269AB1FE5

FASTA30534,750
        10         20         30         40         50         60 
MLGRNTWKTS AFSFLVEQMW APLWSRSMRP GRWCSQRSCA WQTSNNTLHP LWTVPVSVPG 

        70         80         90        100        110        120 
GTRQSPINIQ WRDSVYDPQL KPLRVSYEAA SCLYIWNTGY LFQVEFDDAT EASGISGGPL 

       130        140        150        160        170        180 
ENHYRLKQFH FHWGAVNEGG SEHTVDGHAY PAELHLVHWN SVKYQNYKEA VVGENGLAVI 

       190        200        210        220        230        240 
GVFLKLGAHH QTLQRLVDIL PEIKHKDARA AMRPFDPSTL LPTCWDYWTY AGSLTTPPLT 

       250        260        270        280        290        300 
ESVTWIIQKE PVEVAPSQLS AFRTLLFSAL GEEEKMMVNN YRPLQPLMNR KVWASFQATN 


EGTRS 

« Hide

References

[1]"Human mitochondrial carbonic anhydrase: cDNA cloning, expression, subcellular localization, and mapping to chromosome 16."
Nagao Y., Platero J.S., Waheed A., Sly W.S.
Proc. Natl. Acad. Sci. U.S.A. 90:7623-7627(1993) [PubMed: 8356065] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Liver.
[2]"Genomic organization of the human gene (CA5) and pseudogene for mitochondrial carbonic anhydrase V and their localization to chromosomes 16q and 16p."
Nagao Y., Batanian J.R., Clemente M.F., Sly W.S.
Genomics 28:477-484(1995) [PubMed: 7490083] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Umbilical cord.
+Additional computationally mapped references.

Cross-references

Sequence databases

L19297 mRNA. Translation: AAA02890.1.
U25134 Genomic DNA. Translation: AAC99806.1.
S80181 expand/collapse EMBL AC list , S80175, S80176, S80177, S80178, S80240, S80180 Genomic DNA. Translation: AAB47048.1.
IPIIPI00017262.
PIRCRHU5. A47745.
RefSeqNP_001730.1.
UniGeneHs.177446

3D structure databases

HSSPHSSP built from PDB template 1DMY based on UniProtKB P23589.
SMRP35218. Positions 61-297.
ModBaseSearch...

Proteomic databases

PRIDEP35218.

Genome annotation databases

EnsemblENSG00000174990. Homo sapiens. [Contig view]
GeneID763.
KEGGhsa:763.
UCSCuc002fkn.1. human.

Organism-specific databases

GeneCardsGC16M086479.
H-InvDBHIX0038659.
HGNCHGNC:1377. CA5A.
MIM114761. gene.
PharmGKBPA25992.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP35218.
HOVERGENP35218.
OMAP35218. SYDAASC.

Enzyme and pathway databases

BRENDA4.2.1.1. 247.

Gene expression databases

ArrayExpressP35218.
BgeeP35218.
CleanExHS_CA5A.
GermOnlineENSG00000174990. Homo sapiens.

Family and domain databases

InterProIPR001148. Carbonic_anhydrase_a-class_cat.
IPR018338. Carbonic_anhydrase_a-class_CS.
IPR018437. Carbonic_anhydrase_CA5_mt.
[Graphical view]
Gene3DG3DSA:3.10.200.10. Euk_COanhd. 1 hit.
PANTHERPTHR18952:SF25. Carbonic_anhydrase_CA5_mt. 1 hit.
PTHR18952. Euk_COanhd. 1 hit.
PfamPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
ProDomPD000865. Euk_COanhd. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

BindingDBP35218.
NextBio3086.
SOURCESearch...

Entry information

Entry nameCAH5A_HUMAN
AccessionPrimary (citable) accession number: P35218
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 7, 2009
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents