P35217 (CAH1_MACNE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Carbonic anhydrase 1
EC=4.2.1.1

Alternative name(s):
Carbonate dehydratase I
Carbonic anhydrase I
Short name=CA-I

Gene names

Name:

CA1

Organism

Macaca nemestrina (Pig-tailed macaque)

Taxonomic identifier

9545 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Reversible hydration of carbon dioxide.
Catalytic activity	H2CO3 = CO2 + H2O.
Cofactor	Zinc.
Enzyme regulation	Inhibited by acetazolamide By similarity.
Subcellular location	Cytoplasm.
Polymorphism	Four electrophoretic alleles are know to exist, they are designated A (shown here), B, C and D.
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Ligand	Metal-binding Zinc
Molecular function	Lyase
PTM	Acetylation
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 261	260	Carbonic anhydrase 1		PRO_0000077411
Regions
	Region	200 – 201	2	Substrate binding By similarity
Sites
	Active site	65	1	Proton acceptor By similarity
	Active site	129	1	By similarity
	Metal binding	95	1	Zinc; catalytic
	Metal binding	97	1	Zinc; catalytic
	Metal binding	120	1	Zinc; catalytic
	Binding site	200	1	Substrate By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
Natural variations
	Natural variant	242 – 243	2	SQ → IE in allele B.

Sequences

	Sequence		Length	Mass (Da)
	P35217 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 25754FEA874DB5E0	FASTA	261	28,938
	10 20 30 40 50 60 MASPDWGYDD KNGPEQWSKL YPIANGNNQS PVDIKTSEAK HDTSLKPISV SYNPATAKEI 70 80 90 100 110 120 INVGHSFHVN FEDNDNRSVL KGGPFSDSYR LFQFHFHWGS SNEYGSEHTV DGVKYSSELH 130 140 150 160 170 180 IVHWNSAKYS SLAEAVSKAD GLAVIGVLMK VGEANPKLQK VLDALHAIKT KGKRAPFTNF 190 200 210 220 230 240 DPSTLLPSSL DFWTYSGSLT HPPLYESVTW IICKESISVS SEQLAQFRSL LSNVEGDNPV 250 260 PSQRNNRPTQ PLKGRTVRAS F

References

[1]	"Characterization of the gene encoding carbonic anhydrase I from the pigtail macaque." Hopkins P.J., Bergenhem N.C.H., Venta P.J., Hewett-Emmett D., Tashian R.E. Gene 152:265-269(1995) [PubMed: 7835713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L25082 mRNA. Translation: AAA65198.1.
3D structure databases
ProteinModelPortal	P35217.
SMR	P35217. Positions 2-261.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG002837.
Family and domain databases
InterPro	IPR001148. a_carbonic_anhydrase. IPR023561. Carbonic_anhydrase_a-class. IPR018338. Carbonic_anhydrase_a-class_CS. IPR018442. Carbonic_anhydrase_CA1. [Graphical view]
Gene3D	G3DSA:3.10.200.10. Euk_COanhd. 1 hit.
PANTHER	PTHR18952:SF30. Carbonic_anhydrase_CA1. 1 hit. PTHR18952. Euk_COanhd. 1 hit.
Pfam	PF00194. Carb_anhydrase. 1 hit. [Graphical view]
SMART	SM01057. Carb_anhydrase. 1 hit. [Graphical view]
SUPFAM	SSF51069. Euk_COanhd. 1 hit.
PROSITE	PS00162. ALPHA_CA_1. 1 hit. PS51144. ALPHA_CA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAH1_MACNE

Accession

Primary (citable) accession number: P35217

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program