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Protein

Protein SPT23

Gene

SPT23

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Dosage-dependent suppressor of Ty-induced promoter mutations. May exert its suppression effect through protein-protein interactions since does not present any of the motifs generally found in transcriptional activators or DNA binding proteins.

GO - Biological processi

  • cellular response to cold Source: SGD
  • chromatin silencing at silent mating-type cassette Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31828-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SPT23
Gene namesi
Name:SPT23
Ordered Locus Names:YKL020C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL020C.
SGDiS000001503. SPT23.

Subcellular locationi

GO - Cellular componenti

  • integral component of endoplasmic reticulum membrane Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000670761 – 1082Protein SPT23Add BLAST1082

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei468PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP35210.
PRIDEiP35210.

PTM databases

iPTMnetiP35210.

Interactioni

Protein-protein interaction databases

BioGridi34111. 93 interactors.
DIPiDIP-1307N.
IntActiP35210. 5 interactors.
MINTiMINT-400551.

Structurei

3D structure databases

ProteinModelPortaliP35210.
SMRiP35210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini508 – 585IPT/TIGAdd BLAST78
Repeati709 – 738ANK 1Add BLAST30
Repeati742 – 771ANK 2Add BLAST30

Sequence similaritiesi

Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 1 IPT/TIG domain.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

GeneTreeiENSGT00530000067551.
HOGENOMiHOG000113576.
InParanoidiP35210.
KOiK06867.
OMAiIMIMDKK.
OrthoDBiEOG092C06NJ.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF81296. SSF81296. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35210-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSGTGNVSS MLHSYSANIQ HNDGSPDLDL LESELLDIAL LNSGSSLQDP
60 70 80 90 100
GLLSLNQEKM ITAGTTTPGK EDEGELRDDI ASLQGLLDRH VQFGRKLPLR
110 120 130 140 150
TPYANPLDFI NINPQSLPLS LEIIGLPKVS RVETQMKLSF RIRNAHARKN
160 170 180 190 200
FFIHLPSDCI AKDKFFTSSD DPTNLTIPNR DINERTLFLD AFLLCASNNN
210 220 230 240 250
SNNFKQTYVC NRCINREKRR ASRRKSGLND NSIWQNNENK RAIIFNSKQL
260 270 280 290 300
FIISNNGLSG NSNCINFDLP TRIVCYCRHH KATNGFVVLF LLRDHNGDIL
310 320 330 340 350
AKTITDPIMI MDKKNASNTT TPTSTSNAQV SPMTNDTRSF SSPQSDLNFP
360 370 380 390 400
SEFPLPSNSK NFVISTNCML DSNCNNNNND NDNKNNIKTN TAMMNNNRHF
410 420 430 440 450
PSPNSSSEDS NHSFSDIHFS NNNDNNLHRS LDSWSSTGFN SSSNPALTTL
460 470 480 490 500
TSDFSAASAR HTGKRQRSVN EPFMSTPNTF SRLPQKFIDS SKDISNHNSV
510 520 530 540 550
PVALNNKPSI QRVIPAQGSI NGGIEVTLLG SKFKQGLIIK FGENIALSSQ
560 570 580 590 600
CWNESTMVTY LPPSSKPGPV LVTIVDPSET SMRNNSNSSV STSNSTNDIL
610 620 630 640 650
HLNKYTGEKA IFTYVDDTDR QLIELALQIV GLKMNGKLED ARNIAKRIVG
660 670 680 690 700
SDSSPSNNNA GLHSQNSSLN SYTNMMRNIN DEQLITEVIK SFKRNNNLST
710 720 730 740 750
VNLSMCDVRG RTLLHLAAFN NWYSLVSLLI KYGSHLNDQD LFGFTPLHMA
760 770 780 790 800
CINGDLRIIR LLLECNVNIM KKTRNGFIAK QFFLMNYTVN KTRYSNYETS
810 820 830 840 850
LFDDILTRLT KNTTGSSDTQ PFERNVSQSS FNSSLFDDDD ADHDYVQERK
860 870 880 890 900
YLLADSAALA PEQSNCNDNT SFSILDSDSG YDISDCESSS DEIALEFFNT
910 920 930 940 950
HKIKDFSSKP NEIPKTTKTS IEPDGSLWNR MLTRLNDELP KYEDLFPKKP
960 970 980 990 1000
KNWELGSKSV EIGPDNSAQM TVDDSQTSSE DDELEALQVG FNTIFSKKQN
1010 1020 1030 1040 1050
FQNDKMLLFF WIPLTLVLLL CFTLSNLGKD DDMFHNLSKI VQEYLRIGLA
1060 1070 1080
KVLLGNERMK TSFKMQLSKF QNNNILNDMR VN
Length:1,082
Mass (Da):121,338
Last modified:June 1, 1994 - v2
Checksum:i620C688ECC0ECBD7
GO

Sequence cautioni

The sequence AAA20575 differs from that shown. Reason: Frameshift at position 738.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti715H → P in AAA20575 (PubMed:8203154).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28020 Genomic DNA. Translation: CAA81855.1.
L24760 Genomic DNA. Translation: AAA20575.1. Frameshift.
BK006944 Genomic DNA. Translation: DAA09135.1.
PIRiS37837.
RefSeqiNP_012905.1. NM_001179586.1.

Genome annotation databases

EnsemblFungiiYKL020C; YKL020C; YKL020C.
GeneIDi853848.
KEGGisce:YKL020C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28020 Genomic DNA. Translation: CAA81855.1.
L24760 Genomic DNA. Translation: AAA20575.1. Frameshift.
BK006944 Genomic DNA. Translation: DAA09135.1.
PIRiS37837.
RefSeqiNP_012905.1. NM_001179586.1.

3D structure databases

ProteinModelPortaliP35210.
SMRiP35210.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34111. 93 interactors.
DIPiDIP-1307N.
IntActiP35210. 5 interactors.
MINTiMINT-400551.

PTM databases

iPTMnetiP35210.

Proteomic databases

MaxQBiP35210.
PRIDEiP35210.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL020C; YKL020C; YKL020C.
GeneIDi853848.
KEGGisce:YKL020C.

Organism-specific databases

EuPathDBiFungiDB:YKL020C.
SGDiS000001503. SPT23.

Phylogenomic databases

GeneTreeiENSGT00530000067551.
HOGENOMiHOG000113576.
InParanoidiP35210.
KOiK06867.
OMAiIMIMDKK.
OrthoDBiEOG092C06NJ.

Enzyme and pathway databases

BioCyciYEAST:G3O-31828-MONOMER.

Miscellaneous databases

PROiP35210.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF81296. SSF81296. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPT23_YEAST
AccessioniPrimary (citable) accession number: P35210
Secondary accession number(s): D6VXR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 432 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.