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P35208

- SPT10_YEAST

UniProt

P35208 - SPT10_YEAST

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Protein

Protein SPT10

Gene

SPT10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Required for normal transcription at a number of loci in yeast. Affects transcription at Ty1 elements, at PHO5, STE6 and ADH2.

GO - Molecular functioni

  1. histone acetyltransferase activity Source: SGD
  2. sequence-specific DNA binding Source: SGD

GO - Biological processi

  1. chromatin silencing at rDNA Source: SGD
  2. chromatin silencing at silent mating-type cassette Source: SGD
  3. chromatin silencing at telomere Source: SGD
  4. DNA repair Source: SGD
  5. histone acetylation Source: SGD
  6. negative regulation of transcription from RNA polymerase II promoter Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31577-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SPT10
Gene namesi
Name:SPT10
Synonyms:CRE1, SUD1
Ordered Locus Names:YJL127C
ORF Names:J0702
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJL127c.
SGDiS000003663. SPT10.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi388 – 3881C → S: Loss of complementation of the suppression phenotype. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 640640Protein SPT10PRO_0000072160Add
BLAST

Proteomic databases

MaxQBiP35208.
PaxDbiP35208.

Expressioni

Gene expression databases

GenevestigatoriP35208.

Interactioni

Protein-protein interaction databases

BioGridi33629. 102 interactions.
IntActiP35208. 32 interactions.
MINTiMINT-4491021.
STRINGi4932.YJL127C.

Structurei

3D structure databases

ProteinModelPortaliP35208.
SMRiP35208. Positions 168-250.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini121 – 259139N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0454.
HOGENOMiHOG000141837.
InParanoidiP35208.
OMAiTIMNDAM.
OrthoDBiEOG7NPG51.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR015416. Znf_H2C2_histone_UAS-bd.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
PF09337. zf-H2C2. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35208-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLNQHTSSVP DDEHLQMAHQ NSSSEVRNEA AVPDQLLTPL QPYTILLKDG
60 70 80 90 100
ETIATMYPIP AYPDLLPLGL LNFLLDEFNM EVEKGDSFPY YETLSLEEFK
110 120 130 140 150
NVWFHNDGHV CIMVLGEIPE LDYSMDTEAD TNDNFGTEIE TTKHTTQYKK
160 170 180 190 200
RKERRNLNLS MQWEKQCLGI FDLKPAYPGR SAHVVTGTFL VNAGIRGKGI
210 220 230 240 250
GKTLMETFIE WSKKLGFTSS FFPLIYGTNV GIRRILEGLN FRRIGKLPEA
260 270 280 290 300
GILKGFDVPV DSFMYGKEFT HITKSIDLLR DPQKSIEIGK YERLKHFLET
310 320 330 340 350
GKYPLHCDRN EKARLRVLSK THSVLNGKLM TKGKEIIYDT DQQIQIALEI
360 370 380 390 400
HLMEHLGINK VTSKIGEKYH WRGIKSTVSE VISRCQKCKM RYKDGTGVII
410 420 430 440 450
EQKRAVKQAH MLPTQHIETI NNPRKSKKHD NALLGQAINF PQNIISSTLN
460 470 480 490 500
DVEGEPTPPD TNIVQPTFQN ATNSPATTAE ANEANKRSEF LSSIQSTPLL
510 520 530 540 550
DDEQSMNSFN RFVEEENSRK RRKYLDVASN GIVPHLTNNE SQDHANPVNR
560 570 580 590 600
DERDMNHSVP DLDRNDHTIM NDAMLSLEDN VMAALEMVQK EQQQKINHRG
610 620 630 640
EDVTGQQIDL NNSEGNENSV TKIVNNESNT FTEHNSNIYY
Length:640
Mass (Da):72,922
Last modified:February 1, 1994 - v1
Checksum:i9E81C87E2A66D6C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L24435 Genomic DNA. Translation: AAA35077.1.
Z49402 Genomic DNA. Translation: CAA89422.1.
X65186 Genomic DNA. Translation: CAA46300.1.
BK006943 Genomic DNA. Translation: DAA08675.1.
PIRiS47865.
RefSeqiNP_012408.1. NM_001181560.1.

Genome annotation databases

EnsemblFungiiYJL127C; YJL127C; YJL127C.
GeneIDi853315.
KEGGisce:YJL127C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L24435 Genomic DNA. Translation: AAA35077.1 .
Z49402 Genomic DNA. Translation: CAA89422.1 .
X65186 Genomic DNA. Translation: CAA46300.1 .
BK006943 Genomic DNA. Translation: DAA08675.1 .
PIRi S47865.
RefSeqi NP_012408.1. NM_001181560.1.

3D structure databases

ProteinModelPortali P35208.
SMRi P35208. Positions 168-250.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33629. 102 interactions.
IntActi P35208. 32 interactions.
MINTi MINT-4491021.
STRINGi 4932.YJL127C.

Proteomic databases

MaxQBi P35208.
PaxDbi P35208.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJL127C ; YJL127C ; YJL127C .
GeneIDi 853315.
KEGGi sce:YJL127C.

Organism-specific databases

CYGDi YJL127c.
SGDi S000003663. SPT10.

Phylogenomic databases

eggNOGi COG0454.
HOGENOMi HOG000141837.
InParanoidi P35208.
OMAi TIMNDAM.
OrthoDBi EOG7NPG51.

Enzyme and pathway databases

BioCyci YEAST:G3O-31577-MONOMER.

Miscellaneous databases

NextBioi 973657.

Gene expression databases

Genevestigatori P35208.

Family and domain databases

Gene3Di 3.40.630.30. 2 hits.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR015416. Znf_H2C2_histone_UAS-bd.
[Graphical view ]
Pfami PF00583. Acetyltransf_1. 1 hit.
PF09337. zf-H2C2. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The SPT10 and SPT21 genes of Saccharomyces cerevisiae."
    Natsoulis G., Winston F., Boeke J.D.
    Genetics 136:93-105(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], MUTAGENESIS.
  2. "Sequencing analysis of a 40.2 kb fragment of yeast chromosome X reveals 19 open reading frames including URA2 (5' end), TRK1, PBS2, SPT10, GCD14, RPE1, PHO86, NCA3, ASF1, CCT7, GZF3, two tRNA genes, three remnant delta elements and a Ty4 transposon."
    Cziepluch C., Kordes E., Pujol A., Jauniaux J.-C.
    Yeast 12:1471-1474(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  3. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Isolation and characterization of the SUD1 gene, which encodes a global repressor of core promoter activity in Saccharomyces cerevisiae."
    Yamashita I.
    Mol. Gen. Genet. 241:616-626(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 80-640.
    Strain: S288c / GRF88.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSPT10_YEAST
AccessioniPrimary (citable) accession number: P35208
Secondary accession number(s): D6VW59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1500 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3