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P35208 (SPT10_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein SPT10
Gene names
Name:SPT10
Synonyms:CRE1, SUD1
Ordered Locus Names:YJL127C
ORF Names:J0702
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length640 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for normal transcription at a number of loci in yeast. Affects transcription at Ty1 elements, at PHO5, STE6 and ADH2.

Miscellaneous

Present with 1500 molecules/cell in log phase SD medium.

Sequence similarities

Contains 1 N-acetyltransferase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 640640Protein SPT10
PRO_0000072160

Regions

Domain121 – 259139N-acetyltransferase

Experimental info

Mutagenesis3881C → S: Loss of complementation of the suppression phenotype.

Sequences

Sequence LengthMass (Da)Tools
P35208 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 9E81C87E2A66D6C5

FASTA64072,922
        10         20         30         40         50         60 
MLNQHTSSVP DDEHLQMAHQ NSSSEVRNEA AVPDQLLTPL QPYTILLKDG ETIATMYPIP 

        70         80         90        100        110        120 
AYPDLLPLGL LNFLLDEFNM EVEKGDSFPY YETLSLEEFK NVWFHNDGHV CIMVLGEIPE 

       130        140        150        160        170        180 
LDYSMDTEAD TNDNFGTEIE TTKHTTQYKK RKERRNLNLS MQWEKQCLGI FDLKPAYPGR 

       190        200        210        220        230        240 
SAHVVTGTFL VNAGIRGKGI GKTLMETFIE WSKKLGFTSS FFPLIYGTNV GIRRILEGLN 

       250        260        270        280        290        300 
FRRIGKLPEA GILKGFDVPV DSFMYGKEFT HITKSIDLLR DPQKSIEIGK YERLKHFLET 

       310        320        330        340        350        360 
GKYPLHCDRN EKARLRVLSK THSVLNGKLM TKGKEIIYDT DQQIQIALEI HLMEHLGINK 

       370        380        390        400        410        420 
VTSKIGEKYH WRGIKSTVSE VISRCQKCKM RYKDGTGVII EQKRAVKQAH MLPTQHIETI 

       430        440        450        460        470        480 
NNPRKSKKHD NALLGQAINF PQNIISSTLN DVEGEPTPPD TNIVQPTFQN ATNSPATTAE 

       490        500        510        520        530        540 
ANEANKRSEF LSSIQSTPLL DDEQSMNSFN RFVEEENSRK RRKYLDVASN GIVPHLTNNE 

       550        560        570        580        590        600 
SQDHANPVNR DERDMNHSVP DLDRNDHTIM NDAMLSLEDN VMAALEMVQK EQQQKINHRG 

       610        620        630        640 
EDVTGQQIDL NNSEGNENSV TKIVNNESNT FTEHNSNIYY 

« Hide

References

« Hide 'large scale' references
[1]"The SPT10 and SPT21 genes of Saccharomyces cerevisiae."
Natsoulis G., Winston F., Boeke J.D.
Genetics 136:93-105(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], MUTAGENESIS.
[2]"Sequencing analysis of a 40.2 kb fragment of yeast chromosome X reveals 19 open reading frames including URA2 (5' end), TRK1, PBS2, SPT10, GCD14, RPE1, PHO86, NCA3, ASF1, CCT7, GZF3, two tRNA genes, three remnant delta elements and a Ty4 transposon."
Cziepluch C., Kordes E., Pujol A., Jauniaux J.-C.
Yeast 12:1471-1474(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[3]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. expand/collapse author list , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Isolation and characterization of the SUD1 gene, which encodes a global repressor of core promoter activity in Saccharomyces cerevisiae."
Yamashita I.
Mol. Gen. Genet. 241:616-626(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 80-640.
Strain: S288c / GRF88.
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L24435 Genomic DNA. Translation: AAA35077.1.
Z49402 Genomic DNA. Translation: CAA89422.1.
X65186 Genomic DNA. Translation: CAA46300.1.
BK006943 Genomic DNA. Translation: DAA08675.1.
PIRS47865.
RefSeqNP_012408.1. NM_001181560.1.

3D structure databases

ProteinModelPortalP35208.
SMRP35208. Positions 168-250, 321-392.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33629. 102 interactions.
IntActP35208. 32 interactions.
MINTMINT-4491021.
STRING4932.YJL127C.

Proteomic databases

PaxDbP35208.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYJL127C; YJL127C; YJL127C.
GeneID853315.
KEGGsce:YJL127C.

Organism-specific databases

CYGDYJL127c.
SGDS000003663. SPT10.

Phylogenomic databases

eggNOGCOG0454.
HOGENOMHOG000141837.
OrthoDBEOG7NPG51.

Enzyme and pathway databases

BioCycYEAST:G3O-31577-MONOMER.

Gene expression databases

GenevestigatorP35208.

Family and domain databases

Gene3D3.40.630.30. 2 hits.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR015416. Znf_H2C2_histone_UAS-bd.
[Graphical view]
PfamPF00583. Acetyltransf_1. 1 hit.
PF09337. zf-H2C2. 1 hit.
[Graphical view]
SUPFAMSSF55729. SSF55729. 1 hit.
PROSITEPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio973657.

Entry information

Entry nameSPT10_YEAST
AccessionPrimary (citable) accession number: P35208
Secondary accession number(s): D6VW59
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families