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P35208

- SPT10_YEAST

UniProt

P35208 - SPT10_YEAST

Protein

Protein SPT10

Gene

SPT10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Required for normal transcription at a number of loci in yeast. Affects transcription at Ty1 elements, at PHO5, STE6 and ADH2.

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: SGD
    2. sequence-specific DNA binding Source: SGD

    GO - Biological processi

    1. chromatin silencing at rDNA Source: SGD
    2. chromatin silencing at silent mating-type cassette Source: SGD
    3. chromatin silencing at telomere Source: SGD
    4. DNA repair Source: SGD
    5. histone acetylation Source: SGD
    6. negative regulation of transcription from RNA polymerase II promoter Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31577-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein SPT10
    Gene namesi
    Name:SPT10
    Synonyms:CRE1, SUD1
    Ordered Locus Names:YJL127C
    ORF Names:J0702
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJL127c.
    SGDiS000003663. SPT10.

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi388 – 3881C → S: Loss of complementation of the suppression phenotype. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 640640Protein SPT10PRO_0000072160Add
    BLAST

    Proteomic databases

    MaxQBiP35208.
    PaxDbiP35208.

    Expressioni

    Gene expression databases

    GenevestigatoriP35208.

    Interactioni

    Protein-protein interaction databases

    BioGridi33629. 102 interactions.
    IntActiP35208. 32 interactions.
    MINTiMINT-4491021.
    STRINGi4932.YJL127C.

    Structurei

    3D structure databases

    ProteinModelPortaliP35208.
    SMRiP35208. Positions 168-250.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini121 – 259139N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0454.
    HOGENOMiHOG000141837.
    OMAiTIMNDAM.
    OrthoDBiEOG7NPG51.

    Family and domain databases

    Gene3Di3.40.630.30. 2 hits.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    IPR015416. Znf_H2C2_histone_UAS-bd.
    [Graphical view]
    PfamiPF00583. Acetyltransf_1. 1 hit.
    PF09337. zf-H2C2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    PROSITEiPS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35208-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLNQHTSSVP DDEHLQMAHQ NSSSEVRNEA AVPDQLLTPL QPYTILLKDG    50
    ETIATMYPIP AYPDLLPLGL LNFLLDEFNM EVEKGDSFPY YETLSLEEFK 100
    NVWFHNDGHV CIMVLGEIPE LDYSMDTEAD TNDNFGTEIE TTKHTTQYKK 150
    RKERRNLNLS MQWEKQCLGI FDLKPAYPGR SAHVVTGTFL VNAGIRGKGI 200
    GKTLMETFIE WSKKLGFTSS FFPLIYGTNV GIRRILEGLN FRRIGKLPEA 250
    GILKGFDVPV DSFMYGKEFT HITKSIDLLR DPQKSIEIGK YERLKHFLET 300
    GKYPLHCDRN EKARLRVLSK THSVLNGKLM TKGKEIIYDT DQQIQIALEI 350
    HLMEHLGINK VTSKIGEKYH WRGIKSTVSE VISRCQKCKM RYKDGTGVII 400
    EQKRAVKQAH MLPTQHIETI NNPRKSKKHD NALLGQAINF PQNIISSTLN 450
    DVEGEPTPPD TNIVQPTFQN ATNSPATTAE ANEANKRSEF LSSIQSTPLL 500
    DDEQSMNSFN RFVEEENSRK RRKYLDVASN GIVPHLTNNE SQDHANPVNR 550
    DERDMNHSVP DLDRNDHTIM NDAMLSLEDN VMAALEMVQK EQQQKINHRG 600
    EDVTGQQIDL NNSEGNENSV TKIVNNESNT FTEHNSNIYY 640
    Length:640
    Mass (Da):72,922
    Last modified:February 1, 1994 - v1
    Checksum:i9E81C87E2A66D6C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L24435 Genomic DNA. Translation: AAA35077.1.
    Z49402 Genomic DNA. Translation: CAA89422.1.
    X65186 Genomic DNA. Translation: CAA46300.1.
    BK006943 Genomic DNA. Translation: DAA08675.1.
    PIRiS47865.
    RefSeqiNP_012408.1. NM_001181560.1.

    Genome annotation databases

    EnsemblFungiiYJL127C; YJL127C; YJL127C.
    GeneIDi853315.
    KEGGisce:YJL127C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L24435 Genomic DNA. Translation: AAA35077.1 .
    Z49402 Genomic DNA. Translation: CAA89422.1 .
    X65186 Genomic DNA. Translation: CAA46300.1 .
    BK006943 Genomic DNA. Translation: DAA08675.1 .
    PIRi S47865.
    RefSeqi NP_012408.1. NM_001181560.1.

    3D structure databases

    ProteinModelPortali P35208.
    SMRi P35208. Positions 168-250.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33629. 102 interactions.
    IntActi P35208. 32 interactions.
    MINTi MINT-4491021.
    STRINGi 4932.YJL127C.

    Proteomic databases

    MaxQBi P35208.
    PaxDbi P35208.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJL127C ; YJL127C ; YJL127C .
    GeneIDi 853315.
    KEGGi sce:YJL127C.

    Organism-specific databases

    CYGDi YJL127c.
    SGDi S000003663. SPT10.

    Phylogenomic databases

    eggNOGi COG0454.
    HOGENOMi HOG000141837.
    OMAi TIMNDAM.
    OrthoDBi EOG7NPG51.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31577-MONOMER.

    Miscellaneous databases

    NextBioi 973657.

    Gene expression databases

    Genevestigatori P35208.

    Family and domain databases

    Gene3Di 3.40.630.30. 2 hits.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    IPR015416. Znf_H2C2_histone_UAS-bd.
    [Graphical view ]
    Pfami PF00583. Acetyltransf_1. 1 hit.
    PF09337. zf-H2C2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    PROSITEi PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The SPT10 and SPT21 genes of Saccharomyces cerevisiae."
      Natsoulis G., Winston F., Boeke J.D.
      Genetics 136:93-105(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], MUTAGENESIS.
    2. "Sequencing analysis of a 40.2 kb fragment of yeast chromosome X reveals 19 open reading frames including URA2 (5' end), TRK1, PBS2, SPT10, GCD14, RPE1, PHO86, NCA3, ASF1, CCT7, GZF3, two tRNA genes, three remnant delta elements and a Ty4 transposon."
      Cziepluch C., Kordes E., Pujol A., Jauniaux J.-C.
      Yeast 12:1471-1474(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    3. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. "Isolation and characterization of the SUD1 gene, which encodes a global repressor of core promoter activity in Saccharomyces cerevisiae."
      Yamashita I.
      Mol. Gen. Genet. 241:616-626(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 80-640.
      Strain: S288c / GRF88.
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSPT10_YEAST
    AccessioniPrimary (citable) accession number: P35208
    Secondary accession number(s): D6VW59
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1500 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3