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Protein

Protein SPT10

Gene

SPT10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for normal transcription at a number of loci in yeast. Affects transcription at Ty1 elements, at PHO5, STE6 and ADH2.

Miscellaneous

Present with 1500 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • histone acetyltransferase activity Source: SGD
  • histone acetyltransferase activity (H3-K56 specific) Source: SGD
  • promoter-specific chromatin binding Source: SGD
  • sequence-specific DNA binding Source: SGD
  • transferase activity, transferring acyl groups other than amino-acyl groups Source: GO_Central

GO - Biological processi

  • chromatin silencing at rDNA Source: SGD
  • chromatin silencing at silent mating-type cassette Source: SGD
  • chromatin silencing at telomere Source: SGD
  • DNA repair Source: SGD
  • histone acetylation Source: SGD
  • histone H3-K56 acetylation Source: SGD
  • negative regulation of autophagy Source: SGD
  • negative regulation of transcription by RNA polymerase II Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-31577-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SPT10
Gene namesi
Name:SPT10
Synonyms:CRE1, SUD1
Ordered Locus Names:YJL127C
ORF Names:J0702
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:YJL127C
SGDiS000003663 SPT10

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi388C → S: Loss of complementation of the suppression phenotype. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000721601 – 640Protein SPT10Add BLAST640

Proteomic databases

MaxQBiP35208
PaxDbiP35208
PRIDEiP35208

Interactioni

Protein-protein interaction databases

BioGridi33629, 388 interactors
IntActiP35208, 32 interactors
MINTiP35208
STRINGi4932.YJL127C

Structurei

3D structure databases

ProteinModelPortaliP35208
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 259N-acetyltransferasePROSITE-ProRule annotationAdd BLAST139

Phylogenomic databases

HOGENOMiHOG000141837
InParanoidiP35208
OrthoDBiEOG092C3BM1

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom
IPR015416 Znf_H2C2_histone_UAS-bd
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
PF09337 zf-H2C2, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

Sequencei

Sequence statusi: Complete.

P35208-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNQHTSSVP DDEHLQMAHQ NSSSEVRNEA AVPDQLLTPL QPYTILLKDG
60 70 80 90 100
ETIATMYPIP AYPDLLPLGL LNFLLDEFNM EVEKGDSFPY YETLSLEEFK
110 120 130 140 150
NVWFHNDGHV CIMVLGEIPE LDYSMDTEAD TNDNFGTEIE TTKHTTQYKK
160 170 180 190 200
RKERRNLNLS MQWEKQCLGI FDLKPAYPGR SAHVVTGTFL VNAGIRGKGI
210 220 230 240 250
GKTLMETFIE WSKKLGFTSS FFPLIYGTNV GIRRILEGLN FRRIGKLPEA
260 270 280 290 300
GILKGFDVPV DSFMYGKEFT HITKSIDLLR DPQKSIEIGK YERLKHFLET
310 320 330 340 350
GKYPLHCDRN EKARLRVLSK THSVLNGKLM TKGKEIIYDT DQQIQIALEI
360 370 380 390 400
HLMEHLGINK VTSKIGEKYH WRGIKSTVSE VISRCQKCKM RYKDGTGVII
410 420 430 440 450
EQKRAVKQAH MLPTQHIETI NNPRKSKKHD NALLGQAINF PQNIISSTLN
460 470 480 490 500
DVEGEPTPPD TNIVQPTFQN ATNSPATTAE ANEANKRSEF LSSIQSTPLL
510 520 530 540 550
DDEQSMNSFN RFVEEENSRK RRKYLDVASN GIVPHLTNNE SQDHANPVNR
560 570 580 590 600
DERDMNHSVP DLDRNDHTIM NDAMLSLEDN VMAALEMVQK EQQQKINHRG
610 620 630 640
EDVTGQQIDL NNSEGNENSV TKIVNNESNT FTEHNSNIYY
Length:640
Mass (Da):72,922
Last modified:February 1, 1994 - v1
Checksum:i9E81C87E2A66D6C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24435 Genomic DNA Translation: AAA35077.1
Z49402 Genomic DNA Translation: CAA89422.1
X65186 Genomic DNA Translation: CAA46300.1
BK006943 Genomic DNA Translation: DAA08675.1
PIRiS47865
RefSeqiNP_012408.1, NM_001181560.1

Genome annotation databases

EnsemblFungiiYJL127C; YJL127C; YJL127C
GeneIDi853315
KEGGisce:YJL127C

Entry informationi

Entry nameiSPT10_YEAST
AccessioniPrimary (citable) accession number: P35208
Secondary accession number(s): D6VW59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

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