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Protein

Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2

Gene

CSG2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for calcium regulation. May regulate calcium accumulation by a non-vacuole organelle. Also regulates the activity of CSH1 and SUR1 during mannosyl phosphorylinositol ceramide synthesis.1 Publication

GO - Molecular functioni

  • enzyme regulator activity Source: SGD

GO - Biological processi

  • cellular calcium ion homeostasis Source: SGD
  • glycosphingolipid biosynthetic process Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER3O-695.
YEAST:MONOMER3O-695.

Protein family/group databases

TCDBi2.A.7.27.1. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2
Gene namesi
Name:CSG2
Synonyms:CLS2
Ordered Locus Names:YBR036C
ORF Names:YBR0404
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR036C.
SGDiS000000240. CSG2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 50LumenalSequence analysisAdd BLAST33
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Topological domaini72 – 141CytoplasmicSequence analysisAdd BLAST70
Transmembranei142 – 161HelicalSequence analysisAdd BLAST20
Topological domaini162 – 167LumenalSequence analysis6
Transmembranei168 – 187HelicalSequence analysisAdd BLAST20
Topological domaini188 – 197CytoplasmicSequence analysis10
Transmembranei198 – 217HelicalSequence analysisAdd BLAST20
Topological domaini218 – 245LumenalSequence analysisAdd BLAST28
Transmembranei246 – 265HelicalSequence analysisAdd BLAST20
Topological domaini266 – 285CytoplasmicSequence analysisAdd BLAST20
Transmembranei286 – 305HelicalSequence analysisAdd BLAST20
Topological domaini306 – 324LumenalSequence analysisAdd BLAST19
Transmembranei325 – 344HelicalSequence analysisAdd BLAST20
Topological domaini345 – 355CytoplasmicSequence analysisAdd BLAST11
Transmembranei356 – 374HelicalSequence analysisAdd BLAST19
Topological domaini375 – 385LumenalSequence analysisAdd BLAST11
Transmembranei386 – 404HelicalSequence analysisAdd BLAST19
Topological domaini405 – 410CytoplasmicSequence analysis6

GO - Cellular componenti

  • integral component of endoplasmic reticulum membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002101218 – 410Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2Add BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi35N-linked (GlcNAc...)Sequence analysis1
Glycosylationi49N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP35206.

Interactioni

Subunit structurei

Heterodimer of CSH1 and CSG2, and SUR1 and CSG2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CSH1P382872EBI-2051140,EBI-20861
SHR3Q027743EBI-2051140,EBI-17099

Protein-protein interaction databases

BioGridi32737. 453 interactors.
DIPiDIP-8095N.
IntActiP35206. 37 interactors.
MINTiMINT-1354206.

Structurei

3D structure databases

ProteinModelPortaliP35206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000172600.
InParanoidiP35206.
OMAiRWEVIGY.
OrthoDBiEOG092C2HSG.

Family and domain databases

InterProiIPR031581. Csg2.
IPR018247. EF_Hand_1_Ca_BS.
[Graphical view]
PfamiPF16965. CSG2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35206-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTLLWFSS VIGYVIQTKC LSNIQSKKEI SVGPNGTIAT PETNGDNGNS
60 70 80 90 100
SSLTFYLTFM YFASWLLLVP ASRLWEKMRP MFVSDSDSNR NSQFDNNNSG
110 120 130 140 150
SVTNEDVDTF SHVLDDPQPR IPAQQQKQKI ISVATFKYVA KLTVLALIMI
160 170 180 190 200
VADLTYNMAL SLSPAFDVAL MQNTAIFEIV TLLYGVCGIS RKNYVFRNFL
210 220 230 240 250
IMMNAVIGIL IISYTKATCD MLAGKLSVNP NTGELSDPFL FDRLKGALIC
260 270 280 290 300
GLGALIMGPF AVLWNRWFCS NISKNENSAV VLVKQSTHMA LIGIIGMVIL
310 320 330 340 350
LPFIPKFPSR ESVESISLFY NDKSFWFSLL GSIIFGSLPS LISILELNRK
360 370 380 390 400
APAEYLTTCN LGAIIFMGLA EWVCEPTQTT IVRWEVIGYI MLTVSLLVLS
410
VTLGEGKYHH
Length:410
Mass (Da):45,442
Last modified:October 5, 2010 - v2
Checksum:i15780FEBA54E4FD2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68L → W in AAA34533 (PubMed:8125941).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24113 mRNA. Translation: AAA34533.1.
D28120 Genomic DNA. Translation: BAA05666.1.
Z35905 Genomic DNA. Translation: CAA84978.1.
X76078 Genomic DNA. No translation available.
X17441 Genomic DNA. Translation: CAA35491.1.
BK006936 Genomic DNA. Translation: DAA07156.1.
PIRiS45894.
RefSeqiNP_009592.1. NM_001178384.1.

Genome annotation databases

EnsemblFungiiYBR036C; YBR036C; YBR036C.
GeneIDi852324.
KEGGisce:YBR036C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24113 mRNA. Translation: AAA34533.1.
D28120 Genomic DNA. Translation: BAA05666.1.
Z35905 Genomic DNA. Translation: CAA84978.1.
X76078 Genomic DNA. No translation available.
X17441 Genomic DNA. Translation: CAA35491.1.
BK006936 Genomic DNA. Translation: DAA07156.1.
PIRiS45894.
RefSeqiNP_009592.1. NM_001178384.1.

3D structure databases

ProteinModelPortaliP35206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32737. 453 interactors.
DIPiDIP-8095N.
IntActiP35206. 37 interactors.
MINTiMINT-1354206.

Protein family/group databases

TCDBi2.A.7.27.1. the drug/metabolite transporter (dmt) superfamily.

Proteomic databases

PRIDEiP35206.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR036C; YBR036C; YBR036C.
GeneIDi852324.
KEGGisce:YBR036C.

Organism-specific databases

EuPathDBiFungiDB:YBR036C.
SGDiS000000240. CSG2.

Phylogenomic databases

HOGENOMiHOG000172600.
InParanoidiP35206.
OMAiRWEVIGY.
OrthoDBiEOG092C2HSG.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER3O-695.
YEAST:MONOMER3O-695.

Miscellaneous databases

PROiP35206.

Family and domain databases

InterProiIPR031581. Csg2.
IPR018247. EF_Hand_1_Ca_BS.
[Graphical view]
PfamiPF16965. CSG2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSG2_YEAST
AccessioniPrimary (citable) accession number: P35206
Secondary accession number(s): D6VQ36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 5, 2010
Last modified: November 2, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.