Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P35203

- CBF3C_YEAST

UniProt

P35203 - CBF3C_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Centromere DNA-binding protein complex CBF3 subunit C

Gene

CTF13

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts as central component of the centromere DNA-binding protein complex CBF3, which is essential for chromosome segregation and movement of centromeres along microtubules. CBF3 is required for the recruitment of other kinetochore complexes to CEN DNA. It plays a role in the attachment of chromosomes to the spindle and binds selectively to a highly conserved DNA sequence called CDEIII, found in centromers and in several promoters. The association of CBF3C with CBF3D and SGT1 is required for CBF3C activation and CBF3 assembly.

GO - Molecular functioni

  1. centromeric DNA binding Source: SGD
  2. DNA binding, bending Source: SGD

GO - Biological processi

  1. kinetochore assembly Source: SGD
  2. septin ring assembly Source: SGD
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32794-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere DNA-binding protein complex CBF3 subunit C
Alternative name(s):
Chromosome transmission fidelity protein 13
Kinetochore protein CTF13
Gene namesi
Name:CTF13
Synonyms:CBF3C
Ordered Locus Names:YMR094W
ORF Names:YM6543.01, YM9582.19
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

SGDiS000004700. CTF13.

Subcellular locationi

GO - Cellular componenti

  1. CBF3 complex Source: SGD
  2. condensed nuclear chromosome kinetochore Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 478477Centromere DNA-binding protein complex CBF3 subunit CPRO_0000089370Add
BLAST

Proteomic databases

MaxQBiP35203.
PaxDbiP35203.
PeptideAtlasiP35203.

Expressioni

Gene expression databases

GenevestigatoriP35203.

Interactioni

Subunit structurei

Component of the CBF3 copmplex, which is formed of CBF3A/CBF2, CBF3B/CEP3, CBF3C/CTF13 and CBF3D. CBF3C interacts with CBF3D and SGT1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CBF2P325043EBI-4085,EBI-4069
CEP3P409692EBI-4085,EBI-4077
DAM1P532672EBI-4085,EBI-23268
SGT1Q084463EBI-4085,EBI-17070
SKP1P522865EBI-4085,EBI-4090

Protein-protein interaction databases

BioGridi35269. 41 interactions.
DIPiDIP-1277N.
IntActiP35203. 7 interactions.
MINTiMINT-392923.
STRINGi4932.YMR094W.

Structurei

3D structure databases

ProteinModelPortaliP35203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi198 – 22225Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi216 – 22914Ser-richAdd
BLAST

Phylogenomic databases

eggNOGiNOG42730.
HOGENOMiHOG000111346.
InParanoidiP35203.
KOiK11576.
OMAiGARDNPG.
OrthoDBiEOG73BVQJ.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35203-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSFNPVRFL ELPIDIRKEV YFHLDGNFCG AHPYPIDILY KSNDVELPGK
60 70 80 90 100
PSYKRSKRSK KLLRYMYPVF ATYLNIFEYS PQLIEKWLEY AFWLRYDCLV
110 120 130 140 150
LDCFKVNHLY DGTLIDALEW TYLDNELRLA YFNKASMLEV WYTFKEYKKW
160 170 180 190 200
VIDSVAFDEL DLLNVSNIQF NIDNLTPQLV DKCLSILEQK DLFATIGEVQ
210 220 230 240 250
FGQDEEVGEE KDVDVSGANS DENSSPSSTI KNKKRSASKR SHSDNGNVGA
260 270 280 290 300
THNQLTSISV IRTIRSMESM KSLRKITVRG EKLYELLINF HGFRDNPGKT
310 320 330 340 350
ISYIVKRRIN EIRLSRMNQI SRTGLADFTR WDNLQKLVLS RVAYIDLNSI
360 370 380 390 400
VFPKNFKSLT MKRVSKIKWW NIEENILKEL KVDKRTFKSL YIKEDDSKFT
410 420 430 440 450
KFFNLRHTRI KELDKSEINQ ITYLRCQAIV WLSFRTLNHI KLQNVSEVFN
460 470
NIIVPRALFD SKRVEIYRCE KISQVLVI
Length:478
Mass (Da):56,336
Last modified:January 23, 2007 - v3
Checksum:i77B1C012FD74E56F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10063 Genomic DNA. Translation: AAA34536.1.
Z49259 Genomic DNA. Translation: CAA89241.1.
Z49807 Genomic DNA. Translation: CAA89895.1.
BK006946 Genomic DNA. Translation: DAA09991.1.
PIRiA40747.
RefSeqiNP_013812.1. NM_001182594.1.

Genome annotation databases

EnsemblFungiiYMR094W; YMR094W; YMR094W.
GeneIDi855119.
KEGGisce:YMR094W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10063 Genomic DNA. Translation: AAA34536.1 .
Z49259 Genomic DNA. Translation: CAA89241.1 .
Z49807 Genomic DNA. Translation: CAA89895.1 .
BK006946 Genomic DNA. Translation: DAA09991.1 .
PIRi A40747.
RefSeqi NP_013812.1. NM_001182594.1.

3D structure databases

ProteinModelPortali P35203.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35269. 41 interactions.
DIPi DIP-1277N.
IntActi P35203. 7 interactions.
MINTi MINT-392923.
STRINGi 4932.YMR094W.

Proteomic databases

MaxQBi P35203.
PaxDbi P35203.
PeptideAtlasi P35203.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR094W ; YMR094W ; YMR094W .
GeneIDi 855119.
KEGGi sce:YMR094W.

Organism-specific databases

SGDi S000004700. CTF13.

Phylogenomic databases

eggNOGi NOG42730.
HOGENOMi HOG000111346.
InParanoidi P35203.
KOi K11576.
OMAi GARDNPG.
OrthoDBi EOG73BVQJ.

Enzyme and pathway databases

BioCyci YEAST:G3O-32794-MONOMER.

Miscellaneous databases

NextBioi 978470.

Gene expression databases

Genevestigatori P35203.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of essential components of the S. cerevisiae kinetochore."
    Doheny K.F., Sorger P.K., Hyman A.A., Tugendreich S., Spencer F., Hieter P.
    Cell 73:761-774(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "A zinc finger protein, essential for chromosome segregation, constitutes a putative DNA binding subunit of the Saccharomyces cerevisiae kinetochore complex, Cbf3."
    Lechner J.
    EMBO J. 13:5203-5211(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-8; 10-17 AND 342-349.
  5. "Sgt1p and Skp1p modulate the assembly and turnover of CBF3 complexes required for proper kinetochore function."
    Rodrigo-Brenni M.C., Thomas S., Bouck D.C., Kaplan K.B.
    Mol. Biol. Cell 15:3366-3378(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: ASSEMBLY OF THE CBF3 COMPLEX, INTERACTION WITH CBF3D AND SGT1.

Entry informationi

Entry nameiCBF3C_YEAST
AccessioniPrimary (citable) accession number: P35203
Secondary accession number(s): D6VZR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3