P35198 (MTH1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein MTH1

Gene names

Name:	MTH1
Ordered Locus Names:	YDR277C
ORF Names:	D9954.12

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

To yeast STD1/MSN3.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glucose transport Inferred from mutant phenotype. Source: SGD signal transduction Inferred from genetic interaction. Source: SGD
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
HSP82	P02829	3	EBI-11561,EBI-8659

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 433	433	Protein MTH1		PRO_0000096625

Sequences

	Sequence		Length	Mass (Da)
	P35198 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 3A23EF4742632761	FASTA	433	49,060
	10 20 30 40 50 60 MFVSPPPATS KNQVLQRRPL ESTNSNHGFA SSLQAIPENT MSGSDNASFQ SLPLSMSSSQ 70 80 90 100 110 120 STTSSRRENF VNAPPEYTDR ARDEIKKRLL ASSPSRRSHH SSSMHSASRR SSVAESGSLL 130 140 150 160 170 180 SDNASSYQSS IFSAPSTVHT QLTNDSSFSE FPNHKLITRV SLDEALPKTF YDMYSPDILL 190 200 210 220 230 240 ADPSNILCNG RPKFTKRELL DWDLNDIRSL LIVEKLRPEW GNQLPEVITV GDNMPQFRLQ 250 260 270 280 290 300 LLPLYSSDET IIATLVHSDL YMEANLDYEF KLTSAKYTVA TARKRHEHIT GRNEAVMNLS 310 320 330 340 350 360 KPEWRNIIEN YLLNIAVEAQ CRFDFKQRCS EYKKWKLQQS NLKRPDMPPP SIIPRKNSTE 370 380 390 400 410 420 TKSLLKKALL KNIQLKNPNN NLDELMMRSS AATNQQGKNK VSLSKEEKAT IWSQCQAQVY 430 QRLGLDWQPD SVS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Dosage-dependent modulation of glucose repression by MSN3 (STD1) in Saccharomyces cerevisiae." Hubbard E.J.A., Jiang R., Carlson M. Mol. Cell. Biol. 14:1972-1978(1994) [PubMed: 8114728] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC 204508 / S288c.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P. Nature 387:75-78(1997) [PubMed: 9169867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L21933 Unassigned DNA. Translation: AAA18536.1. U51030 Genomic DNA. Translation: AAB64457.1. BK006938 Genomic DNA. Translation: DAA12118.1.
PIR	S46668.
RefSeq	NP_010563.1. NM_001180585.1.
3D structure databases
ProteinModelPortal	P35198.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-803N.
IntAct	P35198. 2 interactions.
MINT	MINT-425217.
STRING	P35198.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YDR277C; YDR277C; YDR277C.
GeneID	851870.
KEGG	sce:YDR277C.
NMPDR	fig|4932.3.peg.1325.
Organism-specific databases
CYGD	YDR277c.
SGD	S000002685. MTH1.
Phylogenomic databases
eggNOG	fuNOG05433.
GeneTree	EFGT00050000008554.
HOGENOM	HBG756486.
OMA	VEAQCRF.
OrthoDB	EOG4F4WM3.
Gene expression databases
ArrayExpress	P35198.
Genevestigator	P35198.
GermOnline	YDR277C. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	969821.

Entry information

Entry name

MTH1_YEAST

Accession

Primary (citable) accession number: P35198
Secondary accession number(s): D6VSQ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	December 14, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program