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P35194

- UTP20_YEAST

UniProt

P35194 - UTP20_YEAST

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Protein

U3 small nucleolar RNA-associated protein 20

Gene

UTP20

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.1 Publication

GO - Biological processi

  1. endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  2. endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  3. endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-28910-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 20
Short name:
U3 snoRNA-associated protein 20
Alternative name(s):
U three protein 20
Gene namesi
Name:UTP20
Ordered Locus Names:YBL004W
ORF Names:YBL0101
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

SGDiS000000100. UTP20.

Subcellular locationi

GO - Cellular componenti

  1. 90S preribosome Source: SGD
  2. cytoplasm Source: SGD
  3. nucleolus Source: SGD
  4. nucleoplasm Source: SGD
  5. preribosome, small subunit precursor Source: SGD
  6. small-subunit processome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 24932493U3 small nucleolar RNA-associated protein 20PRO_0000202465Add
BLAST

Proteomic databases

MaxQBiP35194.
PaxDbiP35194.
PeptideAtlasiP35194.
PRIDEiP35194.

Expressioni

Gene expression databases

GenevestigatoriP35194.

Interactioni

Subunit structurei

Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.1 Publication

Protein-protein interaction databases

BioGridi32698. 87 interactions.
DIPiDIP-2826N.
IntActiP35194. 36 interactions.
MINTiMINT-669095.
STRINGi4932.YBL004W.

Structurei

3D structure databases

ProteinModelPortaliP35194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati227 – 26438HEAT 1Add
BLAST
Repeati495 – 53238HEAT 2Add
BLAST
Repeati576 – 61338HEAT 3Add
BLAST
Repeati845 – 88238HEAT 4Add
BLAST
Repeati1176 – 121439HEAT 5Add
BLAST
Repeati1216 – 125237HEAT 6Add
BLAST
Repeati1342 – 138039HEAT 7Add
BLAST
Repeati1393 – 143038HEAT 8Add
BLAST
Repeati1480 – 152041HEAT 9Add
BLAST
Repeati1522 – 155837HEAT 10Add
BLAST
Repeati1588 – 162538HEAT 11Add
BLAST
Repeati1630 – 166738HEAT 12Add
BLAST
Repeati1890 – 192738HEAT 13Add
BLAST
Repeati1953 – 199240HEAT 14Add
BLAST
Repeati2120 – 215738HEAT 15Add
BLAST
Repeati2358 – 239740HEAT 16Add
BLAST

Sequence similaritiesi

Belongs to the UTP20 family.Curated
Contains 16 HEAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG296791.
GeneTreeiENSGT00390000016813.
HOGENOMiHOG000248819.
InParanoidiP35194.
KOiK14772.
OMAiRDNAMTA.
OrthoDBiEOG7NSB9K.

Family and domain databases

Gene3Di1.25.10.10. 12 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011430. DRIM.
[Graphical view]
PfamiPF07539. DRIM. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 11 hits.

Sequencei

Sequence statusi: Complete.

P35194-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKQRQTTKS SKRYRYSSFK ARIDDLKIEP ARNLEKRVHD YVESSHFLAS
60 70 80 90 100
FDQWKEINLS AKFTEFAAEI EHDVQTLPQI LYHDKKIFNS LVSFINFHDE
110 120 130 140 150
FSLQPLLDLL AQFCHDLGPD FLKFYEEAIK TLINLLDAAI EFESSNVFEW
160 170 180 190 200
GFNCLAYIFK YLSKFLVKKL VLTCDLLIPL LSHSKEYLSR FSAEALSFLV
210 220 230 240 250
RKCPVSNLRE FVRSVFEKLE GDDEQTNLYE GLLILFTESM TSTQETLHSK
260 270 280 290 300
AKAIMSVLLH EALTKSSPER SVSLLSDIWM NISKYASIES LLPVYEVMYQ
310 320 330 340 350
DFNDSLDATN IDRILKVLTT IVFSESGRKI PDWNKITILI ERIMSQSENC
360 370 380 390 400
ASLSQDKVAF LFALFIRNSD VKTLTLFHQK LFNYALTNIS DCFLEFFQFA
410 420 430 440 450
LRLSYERVFS FNGLKFLQLF LKKNWQSQGK KIALFFLEVD DKPELQKVRE
460 470 480 490 500
VNFPEEFILS IRDFFVTAEI NDSNDLFEIY WRAIIFKYSK LQNTEIIIPL
510 520 530 540 550
LERIFSTFAS PDNFTKDMVG TLLKIYRKED DASGNNLLKT ILDNYENYKE
560 570 580 590 600
SLNFLRGWNK LVSNLHPSES LKGLMSHYPS LLLSLTDNFM LPDGKIRYET
610 620 630 640 650
LELMKTLMIL QGMQVPDLLS SCMVIEEIPL TLQNARDLTI RIKNVGAEFG
660 670 680 690 700
KTKTDKLVSS FFLKYLFGLL TVRFSPVWTG VFDTLPNVYT KDEALVWKLV
710 720 730 740 750
LSFIKLPDEN QNLDYYQPLL EDGANKVLWD SSVVRLRDTI DTFSHIWSKY
760 770 780 790 800
STQNTSIIST TIERRGNTTY PILIRNQALK VMLSIPQVAE NHFVDIAPFV
810 820 830 840 850
YNDFKTYKDE EDMENERVIT GSWTEVDRNV FLKTLSKFKN IKNVYSATEL
860 870 880 890 900
HDHLMVLLGS RNTDVQKLAL DALLAYKNPT LNKYRDNLKN LLDDTLFKDE
910 920 930 940 950
ITTFLTENGS QSIKAEDEKV VMPYVLRIFF GRAQVPPTSG QKRSRKIAVI
960 970 980 990 1000
SVLPNFKKPY INDFLSLASE RLDYNYFFGN SHQINSSKAT LKTIRRMTGF
1010 1020 1030 1040 1050
VNIVNSTLSV LRTNFPLHTN SVLQPLIYSI AMAYYVLDTE STEEVHLRKM
1060 1070 1080 1090 1100
ASNLRQQGLK CLSSVFEFVG NTFDWSTSME DIYAVVVKPR ISHFSDENLQ
1110 1120 1130 1140 1150
QPSSLLRLFL YWAHNPSLYQ FLYYDEFATA TALMDTISNQ HVKEAVIGPI
1160 1170 1180 1190 1200
IEAADSIIRN PVNDDHYVDL VTLICTSCLK ILPSLYVKLS DSNSISTFLN
1210 1220 1230 1240 1250
LLVSITEMGF IQDDHVRSRL ISSLISILKG KLKKLQENDT QKILKILKLI
1260 1270 1280 1290 1300
VFNYNCSWSD IEELYTTISS LFKTFDERNL RVSLTELFIE LGRKVPELES
1310 1320 1330 1340 1350
ISKLVADLNS YSSSRMHEYD FPRILSTFKG LIEDGYKSYS ELEWLPLLFT
1360 1370 1380 1390 1400
FLHFINNKEE LALRTNASHA IMKFIDFINE KPNLNEASKS ISMLKDILLP
1410 1420 1430 1440 1450
NIRIGLRDSL EEVQSEYVSV LSYMVKNTKY FTDFEDMAIL LYNGDEEADF
1460 1470 1480 1490 1500
FTNVNHIQLH RRQRAIKRLG EHAHQLKDNS ISHYLIPMIE HYVFSDDERY
1510 1520 1530 1540 1550
RNIGNETQIA IGGLAQHMSW NQYKALLRRY ISMLKTKPNQ MKQAVQLIVQ
1560 1570 1580 1590 1600
LSVPLRETLR IVRDGAESKL TLSKFPSNLD EPSNFIKQEL YPTLSKILGT
1610 1620 1630 1640 1650
RDDETIIERM PIAEALVNIV LGLTNDDITN FLPSILTNIC QVLRSKSEEL
1660 1670 1680 1690 1700
RDAVRVTLGK ISIILGAEYL VFVIKELMAT LKRGSQIHVL SYTVHYILKS
1710 1720 1730 1740 1750
MHGVLKHSDL DTSSSMIVKI IMENIFGFAG EEKDSENYHT KVKEIKSNKS
1760 1770 1780 1790 1800
YDAGEILASN ISLTEFGTLL SPVKALLMVR INLRNQNKLS ELLRRYLLGL
1810 1820 1830 1840 1850
NHNSDSESES ILKFCHQLFQ ESEMSNSPQI PKKKVKDQVD EKEDFFLVNL
1860 1870 1880 1890 1900
ESKSYTINSN SLLLNSTLQK FALDLLRNVI TRHRSFLTVS HLEGFIPFLR
1910 1920 1930 1940 1950
DSLLSENEGV VISTLRILIT LIRLDFSDES SEIFKNCARK VLNIIKVSPS
1960 1970 1980 1990 2000
TSSELCQMGL KFLSAFIRHT DSTLKDTALS YVLGRVLPDL NEPSRQGLAF
2010 2020 2030 2040 2050
NFLKALVSKH IMLPELYDIA DTTREIMVTN HSKEIRDVSR SVYYQFLMEY
2060 2070 2080 2090 2100
DQSKGRLEKQ FKFMVDNLQY PTESGRQSVM ELINLIITKA NPALLSKLSS
2110 2120 2130 2140 2150
SFFLALVNVS FNDDAPRCRE MASVLISTML PKLENKDLEI VEKYIAAWLK
2160 2170 2180 2190 2200
QVDNASFLNL GLRTYKVYLK SIGFEHTIEL DELAIKRIRY ILSDTSVGSE
2210 2220 2230 2240 2250
HQWDLVYSAL NTFSSYMEAT ESVYKHGFKD IWDGIITCLL YPHSWVRQSA
2260 2270 2280 2290 2300
ANLVHQLIAN KDKLEISLTN LEIQTIATRI LHQLGAPSIP ENLANVSIKT
2310 2320 2330 2340 2350
LVNISILWKE QRTPFIMDVS KQTGEDLKYT TAIDYMVTRI GGIIRSDEHR
2360 2370 2380 2390 2400
MDSFMSKKAC IQLLALLVQV LDEDEVIAEG EKILLPLYGY LETYYSRAVD
2410 2420 2430 2440 2450
EEQEELRTLS NECLKILEDK LQVSDFTKIY TAVKQTVLER RKERRSKRAI
2460 2470 2480 2490
LAVNAPQISA DKKLRKHARS REKRKHEKDE NGYYQRRNKR KRA
Length:2,493
Mass (Da):287,560
Last modified:May 15, 2007 - v3
Checksum:iF6ED4E3E9AE0F468
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2440 – 24401R → S in CAA81266. (PubMed:8091860)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z35765 Genomic DNA. Translation: CAA84821.1.
Z26494 Genomic DNA. Translation: CAA81266.1.
BK006936 Genomic DNA. Translation: DAA07118.1.
PIRiS45734.
RefSeqiNP_009551.2. NM_001178244.1.

Genome annotation databases

EnsemblFungiiYBL004W; YBL004W; YBL004W.
GeneIDi852282.
KEGGisce:YBL004W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z35765 Genomic DNA. Translation: CAA84821.1 .
Z26494 Genomic DNA. Translation: CAA81266.1 .
BK006936 Genomic DNA. Translation: DAA07118.1 .
PIRi S45734.
RefSeqi NP_009551.2. NM_001178244.1.

3D structure databases

ProteinModelPortali P35194.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32698. 87 interactions.
DIPi DIP-2826N.
IntActi P35194. 36 interactions.
MINTi MINT-669095.
STRINGi 4932.YBL004W.

Proteomic databases

MaxQBi P35194.
PaxDbi P35194.
PeptideAtlasi P35194.
PRIDEi P35194.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBL004W ; YBL004W ; YBL004W .
GeneIDi 852282.
KEGGi sce:YBL004W.

Organism-specific databases

SGDi S000000100. UTP20.

Phylogenomic databases

eggNOGi NOG296791.
GeneTreei ENSGT00390000016813.
HOGENOMi HOG000248819.
InParanoidi P35194.
KOi K14772.
OMAi RDNAMTA.
OrthoDBi EOG7NSB9K.

Enzyme and pathway databases

BioCyci YEAST:G3O-28910-MONOMER.

Miscellaneous databases

NextBioi 970910.
PROi P35194.

Gene expression databases

Genevestigatori P35194.

Family and domain databases

Gene3Di 1.25.10.10. 12 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011430. DRIM.
[Graphical view ]
Pfami PF07539. DRIM. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 11 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Sequence around the centromere of Saccharomyces cerevisiae chromosome II: similarity of CEN2 to CEN4."
    Wolfe K.H., Lohan A.J.E.
    Yeast 10:S41-S46(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1214-2493.
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. "The small-subunit processome is a ribosome assembly intermediate."
    Bernstein K.A., Gallagher J.E.G., Mitchell B.M., Granneman S., Baserga S.J.
    Eukaryot. Cell 3:1619-1626(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiUTP20_YEAST
AccessioniPrimary (citable) accession number: P35194
Secondary accession number(s): D6VPZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 15, 2007
Last modified: October 29, 2014
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3