Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P35194 (UTP20_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
U3 small nucleolar RNA-associated protein 20

Short name=U3 snoRNA-associated protein 20
Alternative name(s):
U three protein 20
Gene names
Name:UTP20
Ordered Locus Names:YBL004W
ORF Names:YBL0101
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length2493 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Ref.5

Subunit structure

Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Ref.5

Subcellular location

Cytoplasm. Nucleusnucleolus Ref.4 Ref.5.

Sequence similarities

Belongs to the UTP20 family.

Contains 16 HEAT repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 24932493U3 small nucleolar RNA-associated protein 20
PRO_0000202465

Regions

Repeat227 – 26438HEAT 1
Repeat495 – 53238HEAT 2
Repeat576 – 61338HEAT 3
Repeat845 – 88238HEAT 4
Repeat1176 – 121439HEAT 5
Repeat1216 – 125237HEAT 6
Repeat1342 – 138039HEAT 7
Repeat1393 – 143038HEAT 8
Repeat1480 – 152041HEAT 9
Repeat1522 – 155837HEAT 10
Repeat1588 – 162538HEAT 11
Repeat1630 – 166738HEAT 12
Repeat1890 – 192738HEAT 13
Repeat1953 – 199240HEAT 14
Repeat2120 – 215738HEAT 15
Repeat2358 – 239740HEAT 16

Experimental info

Sequence conflict24401R → S in CAA81266. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P35194 [UniParc].

Last modified May 15, 2007. Version 3.
Checksum: F6ED4E3E9AE0F468

FASTA2,493287,560
        10         20         30         40         50         60 
MAKQRQTTKS SKRYRYSSFK ARIDDLKIEP ARNLEKRVHD YVESSHFLAS FDQWKEINLS 

        70         80         90        100        110        120 
AKFTEFAAEI EHDVQTLPQI LYHDKKIFNS LVSFINFHDE FSLQPLLDLL AQFCHDLGPD 

       130        140        150        160        170        180 
FLKFYEEAIK TLINLLDAAI EFESSNVFEW GFNCLAYIFK YLSKFLVKKL VLTCDLLIPL 

       190        200        210        220        230        240 
LSHSKEYLSR FSAEALSFLV RKCPVSNLRE FVRSVFEKLE GDDEQTNLYE GLLILFTESM 

       250        260        270        280        290        300 
TSTQETLHSK AKAIMSVLLH EALTKSSPER SVSLLSDIWM NISKYASIES LLPVYEVMYQ 

       310        320        330        340        350        360 
DFNDSLDATN IDRILKVLTT IVFSESGRKI PDWNKITILI ERIMSQSENC ASLSQDKVAF 

       370        380        390        400        410        420 
LFALFIRNSD VKTLTLFHQK LFNYALTNIS DCFLEFFQFA LRLSYERVFS FNGLKFLQLF 

       430        440        450        460        470        480 
LKKNWQSQGK KIALFFLEVD DKPELQKVRE VNFPEEFILS IRDFFVTAEI NDSNDLFEIY 

       490        500        510        520        530        540 
WRAIIFKYSK LQNTEIIIPL LERIFSTFAS PDNFTKDMVG TLLKIYRKED DASGNNLLKT 

       550        560        570        580        590        600 
ILDNYENYKE SLNFLRGWNK LVSNLHPSES LKGLMSHYPS LLLSLTDNFM LPDGKIRYET 

       610        620        630        640        650        660 
LELMKTLMIL QGMQVPDLLS SCMVIEEIPL TLQNARDLTI RIKNVGAEFG KTKTDKLVSS 

       670        680        690        700        710        720 
FFLKYLFGLL TVRFSPVWTG VFDTLPNVYT KDEALVWKLV LSFIKLPDEN QNLDYYQPLL 

       730        740        750        760        770        780 
EDGANKVLWD SSVVRLRDTI DTFSHIWSKY STQNTSIIST TIERRGNTTY PILIRNQALK 

       790        800        810        820        830        840 
VMLSIPQVAE NHFVDIAPFV YNDFKTYKDE EDMENERVIT GSWTEVDRNV FLKTLSKFKN 

       850        860        870        880        890        900 
IKNVYSATEL HDHLMVLLGS RNTDVQKLAL DALLAYKNPT LNKYRDNLKN LLDDTLFKDE 

       910        920        930        940        950        960 
ITTFLTENGS QSIKAEDEKV VMPYVLRIFF GRAQVPPTSG QKRSRKIAVI SVLPNFKKPY 

       970        980        990       1000       1010       1020 
INDFLSLASE RLDYNYFFGN SHQINSSKAT LKTIRRMTGF VNIVNSTLSV LRTNFPLHTN 

      1030       1040       1050       1060       1070       1080 
SVLQPLIYSI AMAYYVLDTE STEEVHLRKM ASNLRQQGLK CLSSVFEFVG NTFDWSTSME 

      1090       1100       1110       1120       1130       1140 
DIYAVVVKPR ISHFSDENLQ QPSSLLRLFL YWAHNPSLYQ FLYYDEFATA TALMDTISNQ 

      1150       1160       1170       1180       1190       1200 
HVKEAVIGPI IEAADSIIRN PVNDDHYVDL VTLICTSCLK ILPSLYVKLS DSNSISTFLN 

      1210       1220       1230       1240       1250       1260 
LLVSITEMGF IQDDHVRSRL ISSLISILKG KLKKLQENDT QKILKILKLI VFNYNCSWSD 

      1270       1280       1290       1300       1310       1320 
IEELYTTISS LFKTFDERNL RVSLTELFIE LGRKVPELES ISKLVADLNS YSSSRMHEYD 

      1330       1340       1350       1360       1370       1380 
FPRILSTFKG LIEDGYKSYS ELEWLPLLFT FLHFINNKEE LALRTNASHA IMKFIDFINE 

      1390       1400       1410       1420       1430       1440 
KPNLNEASKS ISMLKDILLP NIRIGLRDSL EEVQSEYVSV LSYMVKNTKY FTDFEDMAIL 

      1450       1460       1470       1480       1490       1500 
LYNGDEEADF FTNVNHIQLH RRQRAIKRLG EHAHQLKDNS ISHYLIPMIE HYVFSDDERY 

      1510       1520       1530       1540       1550       1560 
RNIGNETQIA IGGLAQHMSW NQYKALLRRY ISMLKTKPNQ MKQAVQLIVQ LSVPLRETLR 

      1570       1580       1590       1600       1610       1620 
IVRDGAESKL TLSKFPSNLD EPSNFIKQEL YPTLSKILGT RDDETIIERM PIAEALVNIV 

      1630       1640       1650       1660       1670       1680 
LGLTNDDITN FLPSILTNIC QVLRSKSEEL RDAVRVTLGK ISIILGAEYL VFVIKELMAT 

      1690       1700       1710       1720       1730       1740 
LKRGSQIHVL SYTVHYILKS MHGVLKHSDL DTSSSMIVKI IMENIFGFAG EEKDSENYHT 

      1750       1760       1770       1780       1790       1800 
KVKEIKSNKS YDAGEILASN ISLTEFGTLL SPVKALLMVR INLRNQNKLS ELLRRYLLGL 

      1810       1820       1830       1840       1850       1860 
NHNSDSESES ILKFCHQLFQ ESEMSNSPQI PKKKVKDQVD EKEDFFLVNL ESKSYTINSN 

      1870       1880       1890       1900       1910       1920 
SLLLNSTLQK FALDLLRNVI TRHRSFLTVS HLEGFIPFLR DSLLSENEGV VISTLRILIT 

      1930       1940       1950       1960       1970       1980 
LIRLDFSDES SEIFKNCARK VLNIIKVSPS TSSELCQMGL KFLSAFIRHT DSTLKDTALS 

      1990       2000       2010       2020       2030       2040 
YVLGRVLPDL NEPSRQGLAF NFLKALVSKH IMLPELYDIA DTTREIMVTN HSKEIRDVSR 

      2050       2060       2070       2080       2090       2100 
SVYYQFLMEY DQSKGRLEKQ FKFMVDNLQY PTESGRQSVM ELINLIITKA NPALLSKLSS 

      2110       2120       2130       2140       2150       2160 
SFFLALVNVS FNDDAPRCRE MASVLISTML PKLENKDLEI VEKYIAAWLK QVDNASFLNL 

      2170       2180       2190       2200       2210       2220 
GLRTYKVYLK SIGFEHTIEL DELAIKRIRY ILSDTSVGSE HQWDLVYSAL NTFSSYMEAT 

      2230       2240       2250       2260       2270       2280 
ESVYKHGFKD IWDGIITCLL YPHSWVRQSA ANLVHQLIAN KDKLEISLTN LEIQTIATRI 

      2290       2300       2310       2320       2330       2340 
LHQLGAPSIP ENLANVSIKT LVNISILWKE QRTPFIMDVS KQTGEDLKYT TAIDYMVTRI 

      2350       2360       2370       2380       2390       2400 
GGIIRSDEHR MDSFMSKKAC IQLLALLVQV LDEDEVIAEG EKILLPLYGY LETYYSRAVD 

      2410       2420       2430       2440       2450       2460 
EEQEELRTLS NECLKILEDK LQVSDFTKIY TAVKQTVLER RKERRSKRAI LAVNAPQISA 

      2470       2480       2490 
DKKLRKHARS REKRKHEKDE NGYYQRRNKR KRA 

« Hide

References

« Hide 'large scale' references
[1]"Complete DNA sequence of yeast chromosome II."
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. expand/collapse author list , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Sequence around the centromere of Saccharomyces cerevisiae chromosome II: similarity of CEN2 to CEN4."
Wolfe K.H., Lohan A.J.E.
Yeast 10:S41-S46(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1214-2493.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"The small-subunit processome is a ribosome assembly intermediate."
Bernstein K.A., Gallagher J.E.G., Mitchell B.M., Granneman S., Baserga S.J.
Eukaryot. Cell 3:1619-1626(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z35765 Genomic DNA. Translation: CAA84821.1.
Z26494 Genomic DNA. Translation: CAA81266.1.
BK006936 Genomic DNA. Translation: DAA07118.1.
PIRS45734.
RefSeqNP_009551.2. NM_001178244.1.

3D structure databases

ProteinModelPortalP35194.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid32698. 87 interactions.
DIPDIP-2826N.
IntActP35194. 36 interactions.
MINTMINT-669095.
STRING4932.YBL004W.

Proteomic databases

MaxQBP35194.
PaxDbP35194.
PeptideAtlasP35194.
PRIDEP35194.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYBL004W; YBL004W; YBL004W.
GeneID852282.
KEGGsce:YBL004W.

Organism-specific databases

SGDS000000100. UTP20.

Phylogenomic databases

eggNOGNOG296791.
GeneTreeENSGT00390000016813.
HOGENOMHOG000248819.
KOK14772.
OMARDNAMTA.
OrthoDBEOG7NSB9K.

Enzyme and pathway databases

BioCycYEAST:G3O-28910-MONOMER.

Gene expression databases

GenevestigatorP35194.

Family and domain databases

Gene3D1.25.10.10. 12 hits.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011430. DRIM.
[Graphical view]
PfamPF07539. DRIM. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 11 hits.
ProtoNetSearch...

Other

NextBio970910.
PROP35194.

Entry information

Entry nameUTP20_YEAST
AccessionPrimary (citable) accession number: P35194
Secondary accession number(s): D6VPZ8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 15, 2007
Last modified: June 11, 2014
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome II

Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families