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P35194

- UTP20_YEAST

UniProt

P35194 - UTP20_YEAST

Protein

U3 small nucleolar RNA-associated protein 20

Gene

UTP20

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 3 (15 May 2007)
      Previous versions | rss
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    Functioni

    Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.1 Publication

    GO - Molecular functioni

    1. protein binding Source: HGNC

    GO - Biological processi

    1. endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    2. endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    3. endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    Ribosome biogenesis, rRNA processing

    Enzyme and pathway databases

    BioCyciYEAST:G3O-28910-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    U3 small nucleolar RNA-associated protein 20
    Short name:
    U3 snoRNA-associated protein 20
    Alternative name(s):
    U three protein 20
    Gene namesi
    Name:UTP20
    Ordered Locus Names:YBL004W
    ORF Names:YBL0101
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    SGDiS000000100. UTP20.

    Subcellular locationi

    GO - Cellular componenti

    1. 90S preribosome Source: SGD
    2. cytoplasm Source: SGD
    3. nucleolus Source: SGD
    4. nucleoplasm Source: SGD
    5. preribosome, small subunit precursor Source: SGD
    6. small-subunit processome Source: SGD

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 24932493U3 small nucleolar RNA-associated protein 20PRO_0000202465Add
    BLAST

    Proteomic databases

    MaxQBiP35194.
    PaxDbiP35194.
    PeptideAtlasiP35194.
    PRIDEiP35194.

    Expressioni

    Gene expression databases

    GenevestigatoriP35194.

    Interactioni

    Subunit structurei

    Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.1 Publication

    Protein-protein interaction databases

    BioGridi32698. 87 interactions.
    DIPiDIP-2826N.
    IntActiP35194. 36 interactions.
    MINTiMINT-669095.
    STRINGi4932.YBL004W.

    Structurei

    3D structure databases

    ProteinModelPortaliP35194.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati227 – 26438HEAT 1Add
    BLAST
    Repeati495 – 53238HEAT 2Add
    BLAST
    Repeati576 – 61338HEAT 3Add
    BLAST
    Repeati845 – 88238HEAT 4Add
    BLAST
    Repeati1176 – 121439HEAT 5Add
    BLAST
    Repeati1216 – 125237HEAT 6Add
    BLAST
    Repeati1342 – 138039HEAT 7Add
    BLAST
    Repeati1393 – 143038HEAT 8Add
    BLAST
    Repeati1480 – 152041HEAT 9Add
    BLAST
    Repeati1522 – 155837HEAT 10Add
    BLAST
    Repeati1588 – 162538HEAT 11Add
    BLAST
    Repeati1630 – 166738HEAT 12Add
    BLAST
    Repeati1890 – 192738HEAT 13Add
    BLAST
    Repeati1953 – 199240HEAT 14Add
    BLAST
    Repeati2120 – 215738HEAT 15Add
    BLAST
    Repeati2358 – 239740HEAT 16Add
    BLAST

    Sequence similaritiesi

    Belongs to the UTP20 family.Curated
    Contains 16 HEAT repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG296791.
    GeneTreeiENSGT00390000016813.
    HOGENOMiHOG000248819.
    KOiK14772.
    OMAiRDNAMTA.
    OrthoDBiEOG7NSB9K.

    Family and domain databases

    Gene3Di1.25.10.10. 12 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR011430. DRIM.
    [Graphical view]
    PfamiPF07539. DRIM. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 11 hits.

    Sequencei

    Sequence statusi: Complete.

    P35194-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKQRQTTKS SKRYRYSSFK ARIDDLKIEP ARNLEKRVHD YVESSHFLAS     50
    FDQWKEINLS AKFTEFAAEI EHDVQTLPQI LYHDKKIFNS LVSFINFHDE 100
    FSLQPLLDLL AQFCHDLGPD FLKFYEEAIK TLINLLDAAI EFESSNVFEW 150
    GFNCLAYIFK YLSKFLVKKL VLTCDLLIPL LSHSKEYLSR FSAEALSFLV 200
    RKCPVSNLRE FVRSVFEKLE GDDEQTNLYE GLLILFTESM TSTQETLHSK 250
    AKAIMSVLLH EALTKSSPER SVSLLSDIWM NISKYASIES LLPVYEVMYQ 300
    DFNDSLDATN IDRILKVLTT IVFSESGRKI PDWNKITILI ERIMSQSENC 350
    ASLSQDKVAF LFALFIRNSD VKTLTLFHQK LFNYALTNIS DCFLEFFQFA 400
    LRLSYERVFS FNGLKFLQLF LKKNWQSQGK KIALFFLEVD DKPELQKVRE 450
    VNFPEEFILS IRDFFVTAEI NDSNDLFEIY WRAIIFKYSK LQNTEIIIPL 500
    LERIFSTFAS PDNFTKDMVG TLLKIYRKED DASGNNLLKT ILDNYENYKE 550
    SLNFLRGWNK LVSNLHPSES LKGLMSHYPS LLLSLTDNFM LPDGKIRYET 600
    LELMKTLMIL QGMQVPDLLS SCMVIEEIPL TLQNARDLTI RIKNVGAEFG 650
    KTKTDKLVSS FFLKYLFGLL TVRFSPVWTG VFDTLPNVYT KDEALVWKLV 700
    LSFIKLPDEN QNLDYYQPLL EDGANKVLWD SSVVRLRDTI DTFSHIWSKY 750
    STQNTSIIST TIERRGNTTY PILIRNQALK VMLSIPQVAE NHFVDIAPFV 800
    YNDFKTYKDE EDMENERVIT GSWTEVDRNV FLKTLSKFKN IKNVYSATEL 850
    HDHLMVLLGS RNTDVQKLAL DALLAYKNPT LNKYRDNLKN LLDDTLFKDE 900
    ITTFLTENGS QSIKAEDEKV VMPYVLRIFF GRAQVPPTSG QKRSRKIAVI 950
    SVLPNFKKPY INDFLSLASE RLDYNYFFGN SHQINSSKAT LKTIRRMTGF 1000
    VNIVNSTLSV LRTNFPLHTN SVLQPLIYSI AMAYYVLDTE STEEVHLRKM 1050
    ASNLRQQGLK CLSSVFEFVG NTFDWSTSME DIYAVVVKPR ISHFSDENLQ 1100
    QPSSLLRLFL YWAHNPSLYQ FLYYDEFATA TALMDTISNQ HVKEAVIGPI 1150
    IEAADSIIRN PVNDDHYVDL VTLICTSCLK ILPSLYVKLS DSNSISTFLN 1200
    LLVSITEMGF IQDDHVRSRL ISSLISILKG KLKKLQENDT QKILKILKLI 1250
    VFNYNCSWSD IEELYTTISS LFKTFDERNL RVSLTELFIE LGRKVPELES 1300
    ISKLVADLNS YSSSRMHEYD FPRILSTFKG LIEDGYKSYS ELEWLPLLFT 1350
    FLHFINNKEE LALRTNASHA IMKFIDFINE KPNLNEASKS ISMLKDILLP 1400
    NIRIGLRDSL EEVQSEYVSV LSYMVKNTKY FTDFEDMAIL LYNGDEEADF 1450
    FTNVNHIQLH RRQRAIKRLG EHAHQLKDNS ISHYLIPMIE HYVFSDDERY 1500
    RNIGNETQIA IGGLAQHMSW NQYKALLRRY ISMLKTKPNQ MKQAVQLIVQ 1550
    LSVPLRETLR IVRDGAESKL TLSKFPSNLD EPSNFIKQEL YPTLSKILGT 1600
    RDDETIIERM PIAEALVNIV LGLTNDDITN FLPSILTNIC QVLRSKSEEL 1650
    RDAVRVTLGK ISIILGAEYL VFVIKELMAT LKRGSQIHVL SYTVHYILKS 1700
    MHGVLKHSDL DTSSSMIVKI IMENIFGFAG EEKDSENYHT KVKEIKSNKS 1750
    YDAGEILASN ISLTEFGTLL SPVKALLMVR INLRNQNKLS ELLRRYLLGL 1800
    NHNSDSESES ILKFCHQLFQ ESEMSNSPQI PKKKVKDQVD EKEDFFLVNL 1850
    ESKSYTINSN SLLLNSTLQK FALDLLRNVI TRHRSFLTVS HLEGFIPFLR 1900
    DSLLSENEGV VISTLRILIT LIRLDFSDES SEIFKNCARK VLNIIKVSPS 1950
    TSSELCQMGL KFLSAFIRHT DSTLKDTALS YVLGRVLPDL NEPSRQGLAF 2000
    NFLKALVSKH IMLPELYDIA DTTREIMVTN HSKEIRDVSR SVYYQFLMEY 2050
    DQSKGRLEKQ FKFMVDNLQY PTESGRQSVM ELINLIITKA NPALLSKLSS 2100
    SFFLALVNVS FNDDAPRCRE MASVLISTML PKLENKDLEI VEKYIAAWLK 2150
    QVDNASFLNL GLRTYKVYLK SIGFEHTIEL DELAIKRIRY ILSDTSVGSE 2200
    HQWDLVYSAL NTFSSYMEAT ESVYKHGFKD IWDGIITCLL YPHSWVRQSA 2250
    ANLVHQLIAN KDKLEISLTN LEIQTIATRI LHQLGAPSIP ENLANVSIKT 2300
    LVNISILWKE QRTPFIMDVS KQTGEDLKYT TAIDYMVTRI GGIIRSDEHR 2350
    MDSFMSKKAC IQLLALLVQV LDEDEVIAEG EKILLPLYGY LETYYSRAVD 2400
    EEQEELRTLS NECLKILEDK LQVSDFTKIY TAVKQTVLER RKERRSKRAI 2450
    LAVNAPQISA DKKLRKHARS REKRKHEKDE NGYYQRRNKR KRA 2493
    Length:2,493
    Mass (Da):287,560
    Last modified:May 15, 2007 - v3
    Checksum:iF6ED4E3E9AE0F468
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2440 – 24401R → S in CAA81266. (PubMed:8091860)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z35765 Genomic DNA. Translation: CAA84821.1.
    Z26494 Genomic DNA. Translation: CAA81266.1.
    BK006936 Genomic DNA. Translation: DAA07118.1.
    PIRiS45734.
    RefSeqiNP_009551.2. NM_001178244.1.

    Genome annotation databases

    EnsemblFungiiYBL004W; YBL004W; YBL004W.
    GeneIDi852282.
    KEGGisce:YBL004W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z35765 Genomic DNA. Translation: CAA84821.1 .
    Z26494 Genomic DNA. Translation: CAA81266.1 .
    BK006936 Genomic DNA. Translation: DAA07118.1 .
    PIRi S45734.
    RefSeqi NP_009551.2. NM_001178244.1.

    3D structure databases

    ProteinModelPortali P35194.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32698. 87 interactions.
    DIPi DIP-2826N.
    IntActi P35194. 36 interactions.
    MINTi MINT-669095.
    STRINGi 4932.YBL004W.

    Proteomic databases

    MaxQBi P35194.
    PaxDbi P35194.
    PeptideAtlasi P35194.
    PRIDEi P35194.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBL004W ; YBL004W ; YBL004W .
    GeneIDi 852282.
    KEGGi sce:YBL004W.

    Organism-specific databases

    SGDi S000000100. UTP20.

    Phylogenomic databases

    eggNOGi NOG296791.
    GeneTreei ENSGT00390000016813.
    HOGENOMi HOG000248819.
    KOi K14772.
    OMAi RDNAMTA.
    OrthoDBi EOG7NSB9K.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-28910-MONOMER.

    Miscellaneous databases

    NextBioi 970910.
    PROi P35194.

    Gene expression databases

    Genevestigatori P35194.

    Family and domain databases

    Gene3Di 1.25.10.10. 12 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR011430. DRIM.
    [Graphical view ]
    Pfami PF07539. DRIM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 11 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Sequence around the centromere of Saccharomyces cerevisiae chromosome II: similarity of CEN2 to CEN4."
      Wolfe K.H., Lohan A.J.E.
      Yeast 10:S41-S46(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1214-2493.
      Strain: ATCC 204508 / S288c.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. "The small-subunit processome is a ribosome assembly intermediate."
      Bernstein K.A., Gallagher J.E.G., Mitchell B.M., Granneman S., Baserga S.J.
      Eukaryot. Cell 3:1619-1626(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiUTP20_YEAST
    AccessioniPrimary (citable) accession number: P35194
    Secondary accession number(s): D6VPZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 122 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3