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Protein

DnaJ homolog 1, mitochondrial

Gene

MDJ1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in mitochondrial biogenesis and protein folding.2 Publications

Miscellaneous

Present with 7570 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri217 – 297CR-typeAdd BLAST81

GO - Molecular functioni

  • ATPase activator activity Source: SGD
  • ATP binding Source: InterPro
  • heat shock protein binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW
  • unfolded protein binding Source: SGD

GO - Biological processi

  • 'de novo' protein folding Source: SGD
  • mitochondrial genome maintenance Source: SGD
  • protein quality control for misfolded or incompletely synthesized proteins Source: SGD
  • protein refolding Source: SGD
  • response to heat Source: SGD

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-30441-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog 1, mitochondrial
Gene namesi
Name:MDJ1
Ordered Locus Names:YFL016C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFL016C
SGDiS000001878 MDJ1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 55MitochondrionSequence analysisAdd BLAST55
ChainiPRO_000000726856 – 511DnaJ homolog 1, mitochondrialAdd BLAST456

Proteomic databases

MaxQBiP35191
PaxDbiP35191
PRIDEiP35191

Interactioni

GO - Molecular functioni

  • heat shock protein binding Source: InterPro
  • unfolded protein binding Source: SGD

Protein-protein interaction databases

BioGridi31131, 65 interactors
DIPiDIP-764N
IntActiP35191, 60 interactors
MINTiP35191
STRINGi4932.YFL016C

Structurei

3D structure databases

ProteinModelPortaliP35191
SMRiP35191
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 127JAdd BLAST69
Repeati230 – 237CXXCXGXG motif8
Repeati247 – 254CXXCXGXG motif8
Repeati269 – 276CXXCXGXG motif8
Repeati285 – 292CXXCXGXG motif8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi130 – 186Gly-richAdd BLAST57

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri217 – 297CR-typeAdd BLAST81

Keywords - Domaini

Repeat, Transit peptide, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00890000139473
HOGENOMiHOG000226717
InParanoidiP35191
KOiK03686
OMAiDMGGFAD
OrthoDBiEOG092C1UGR

Family and domain databases

CDDicd06257 DnaJ, 1 hit
cd10719 DnaJ_zf, 1 hit
Gene3Di1.10.287.110, 1 hit
HAMAPiMF_01152 DnaJ, 1 hit
InterProiView protein in InterPro
IPR012724 DnaJ
IPR002939 DnaJ_C
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR008971 HSP40/DnaJ_pept-bd
IPR001305 HSP_DnaJ_Cys-rich_dom
IPR036410 HSP_DnaJ_Cys-rich_dom_sf
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF01556 DnaJ_C, 1 hit
PF00684 DnaJ_CXXCXGXG, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF49493 SSF49493, 3 hits
SSF57938 SSF57938, 1 hit
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit
PS51188 ZF_CR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35191-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFQQGVLSR CSGVFRHHVG HSRHINNILY RHAIAFASIA PRIPKSSFHT
60 70 80 90 100
SAIRNNEAFK DPYDTLGLKK SATGAEIKKA YYKLAKKYHP DINKEPDAEK
110 120 130 140 150
KFHDLQNAYE ILSDETKRQQ YDQFGPAAFG GGGAAGGAGG GSGSPFGSQF
160 170 180 190 200
HDFSGFTSAG GSPFGGINFE DLFGAAFGGG GRGSGGASRS SSMFRQYRGD
210 220 230 240 250
PIEIVHKVSF KDAVFGSKNV QLRFSALDPC STCSGTGMKP NTHKVSCSTC
260 270 280 290 300
HGTGTTVHIR GGFQMMSTCP TCNGEGTMKR PQDNCTKCHG EGVQVNRAKT
310 320 330 340 350
ITVDLPHGLQ DGDVVRIPGQ GSYPDIAVEA DLKDSVKLSR GDILVRIRVD
360 370 380 390 400
KDPNFSIKNK YDIWYDKEIP ITTAALGGTV TIPTVEGQKI RIKVAPGTQY
410 420 430 440 450
NQVISIPNMG VPKTSTIRGD MKVQYKIVVK KPQSLAEKCL WEALADVTND
460 470 480 490 500
DMAKKTMQPG TAAGTAINEE ILKKQKQEEE KHAKKDDDNT LKRLENFITN
510
TFRKIKGDKK N
Length:511
Mass (Da):55,561
Last modified:February 1, 1994 - v1
Checksum:i007343427C66D2B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28336 Genomic DNA Translation: CAA82189.1
Z46255 Genomic DNA Translation: CAA86351.1
D50617 Genomic DNA Translation: BAA09222.1
BK006940 Genomic DNA Translation: DAA12424.1
PIRiS38898
RefSeqiNP_116638.1, NM_001179950.1

Genome annotation databases

EnsemblFungiiBAA09222; BAA09222; BAA09222
YFL016C; YFL016C; YFL016C
GeneIDi850530
KEGGisce:YFL016C

Similar proteinsi

Entry informationi

Entry nameiMDJ1_YEAST
AccessioniPrimary (citable) accession number: P35191
Secondary accession number(s): D6VTL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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