P35190 (CLG1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
PHO85 cyclin CLG1

Alternative name(s):
Cyclin-like G1 protein 1

Gene names

Name:	CLG1
Ordered Locus Names:	YGL215W
ORF Names:	G1105

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	452 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Has a role in cell integrity and polarized cell growth together with the other PCL1/PCL2 cyclin family members.
Subunit structure	Forms a cyclin-CDK complex with PHO85.
Sequence similarities	Belongs to the cyclin family. PCL1,2 subfamily.

Ontologies

Keywords
Molecular function	Cyclin
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	positive regulation of macroautophagy Inferred from mutant phenotype. Source: SGD regulation of cyclin-dependent protein kinase activity Inferred from electronic annotation. Source: InterPro
Cellular component	cyclin-dependent protein kinase holoenzyme complex Inferred from physical interaction Ref.6. Source: SGD
Molecular function	cyclin-dependent protein kinase regulator activity Inferred from physical interaction Ref.6. Source: SGD protein kinase binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PHO85	P17157	3	EBI-4762,EBI-13327

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 452	452	PHO85 cyclin CLG1		PRO_0000080503
Regions
	Compositional bias	395 – 401	7	Poly-Gln

Sequences

	Sequence		Length	Mass (Da)
	P35190 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 579CAE1C45A2BE84	FASTA	452	51,571
	10 20 30 40 50 60 MANTFKYYPE TMGNSSGYPI SLPFPKGSAT SAVNVARQLP KYLGHVPSQS VHTQLPSMAS 70 80 90 100 110 120 LGYFNQPSST YYAPPAPLQQ HQQPPILPPP GLMYTSNNNS NVIPPPVQMI RDGQQQPQQS 130 140 150 160 170 180 NQVNGGVSEN LDYDISIMSK FIMENAFVAF NANYSTDDQT TDLFFKGISS VLNATRLPSA 190 200 210 220 230 240 TIFLAIDYLF KYINKLSNGI HSIGGNSINI IYQNTMIAFI LANKFNDDKT FTNNSWSQAT 250 260 270 280 290 300 GILINVINDF ERQWLRIFNW ELYDSAFLYF EFVKNFEIFK QNQLKPAVAV PTLLSPIVNV 310 320 330 340 350 360 GDTRNVNFNL KPTSTNNLLS PVSNYETPML MPHNMFSSPS YQSNSRSEFS SMNGYYNYYN 370 380 390 400 410 420 YNQPRLNYYQ QFPNIYSSPI SETQFDYDFY NFSSQQQQQQ QKQHSLLPAA PQLPPPHVHN 430 440 450 QSYGHHLGWK SMDDTINHSR FERNYFPYSA VY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"CLG1, a new cyclin-like gene of Saccharomyces cerevisiae." Matsumoto Y., Wickner R.B. Yeast 9:929-931(1993) [PubMed: 8212900] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII." Rieger M., Brueckner M., Schaefer M., Mueller-Auer S. Yeast 13:1077-1090(1997) [PubMed: 9290212] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"Analysis of 21.7 kb DNA sequence from the left arm of chromosome VII reveals 11 open reading frames: two correspond to new genes." Feuermann M., Simeonava L., Souciet J.-L., Potier S. Yeast 13:475-477(1997) [PubMed: 9153757] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed: 9169869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[5]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[6]	"A family of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase." Measday V., Moore L., Retnakaran R., Lee J., Donoviel M., Neiman A.M., Andrews B.J. Mol. Cell. Biol. 17:1212-1223(1997) [PubMed: 9032248] [Abstract] Cited for: INTERACTION WITH PHO85.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L11612 mRNA. Translation: AAA16919.1. Z72737 Genomic DNA. Translation: CAA96931.1. BK006941 Genomic DNA. Translation: DAA07902.1.
PIR	S37607.
RefSeq	NP_011300.1. NM_001181080.1.
3D structure databases
ProteinModelPortal	P35190.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1507N.
IntAct	P35190. 5 interactions.
MINT	MINT-384529.
STRING	P35190.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YGL215W; YGL215W; YGL215W.
GeneID	852657.
KEGG	sce:YGL215W.
NMPDR	fig|4932.3.peg.2403.
Organism-specific databases
CYGD	YGL215w.
SGD	S000003183. CLG1.
Phylogenomic databases
eggNOG	fuNOG10197.
GeneTree	EFGT00050000002146.
HOGENOM	HBG204441.
OMA	YQNTMIA.
OrthoDB	EOG4ZCXCX.
Gene expression databases
ArrayExpress	P35190.
Genevestigator	P35190.
GermOnline	YGL215W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR013922. Cyclin_PHO80-like. [Graphical view]
Pfam	PF08613. Cyclin. 1 hit. [Graphical view]
PROSITE	PS00292. CYCLINS. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	971936.

Entry information

Entry name

CLG1_YEAST

Accession

Primary (citable) accession number: P35190
Secondary accession number(s): D6VTU1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	December 14, 2011
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program