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Protein

Mitochondrial import receptor subunit TOM20

Gene

TOM20

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Central component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore.

Miscellaneous

Present with 5680 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • mitochondrial outer membrane translocase complex assembly Source: SGD
  • protein import into mitochondrial matrix Source: SGD
  • tRNA import into mitochondrion Source: SGD

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30794-MONOMER

Protein family/group databases

TCDBi3.A.8.1.1 the mitochondrial protein translocase (mpt) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM20
Alternative name(s):
Mitochondrial 20 kDa outer membrane protein
Protein MAS20
Translocase of outer membrane 20 kDa subunit
Gene namesi
Name:TOM20
Synonyms:MAS20, MOM19
Ordered Locus Names:YGR082W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR082W
SGDiS000003314 TOM20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8Mitochondrial intermembraneSequence analysis8
Transmembranei9 – 28HelicalSequence analysisAdd BLAST20
Topological domaini29 – 183CytoplasmicSequence analysisAdd BLAST155

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000515501 – 183Mitochondrial import receptor subunit TOM20Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei172PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP35180
PaxDbiP35180
PRIDEiP35180

PTM databases

iPTMnetiP35180

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOM5, TOM6, TOM7, TOM20, TOM22, TOM40 and TOM70). In the complex, interacts with TOM22.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33324, 89 interactors
DIPiDIP-2539N
IntActiP35180, 20 interactors
MINTiP35180
STRINGi4932.YGR082W

Structurei

3D structure databases

ProteinModelPortaliP35180
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tom20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000216577
InParanoidiP35180
KOiK17770
OMAiFVGYCFY
OrthoDBiEOG092C52RN

Family and domain databases

Gene3Di1.20.960.10, 1 hit
InterProiView protein in InterPro
IPR002056 MAS20
IPR023392 Tom20_dom_sf
PANTHERiPTHR12430 PTHR12430, 1 hit
PfamiView protein in Pfam
PF02064 MAS20, 1 hit
PIRSFiPIRSF037707 MAS20_rcpt, 1 hit
PRINTSiPR00351 OM20RECEPTOR
SUPFAMiSSF47157 SSF47157, 1 hit
TIGRFAMsiTIGR00985 3a0801s04tom, 1 hit

Sequencei

Sequence statusi: Complete.

P35180-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQSNPILRG LAITTAIAAL SATGYAIYFD YQRRNSPQFR KVLRQRAKEQ
60 70 80 90 100
AKMEEQAKTH AKEVKLQKVT EFLSMELAKD PIPSDPSERE ATFTTNVENG
110 120 130 140 150
ERLSMQQGKE LEAASKFYKA LTVYPQPADL LGIYQRSIPE AIYEYIILMI
160 170 180
AILPPANVAS FVKGVVGSKA ESDAVAEAND IDD
Length:183
Mass (Da):20,317
Last modified:February 1, 1994 - v1
Checksum:i9F76FE6010278410
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76139 Genomic DNA Translation: CAA53742.1
X75319 mRNA Translation: CAA53068.1
Z72867 Genomic DNA Translation: CAA97084.1
AY557775 Genomic DNA Translation: AAS56101.1
BK006941 Genomic DNA Translation: DAA08175.1
PIRiS39568
RefSeqiNP_011596.1, NM_001181211.1

Genome annotation databases

EnsemblFungiiYGR082W; YGR082W; YGR082W
GeneIDi852973
KEGGisce:YGR082W

Similar proteinsi

Entry informationi

Entry nameiTOM20_YEAST
AccessioniPrimary (citable) accession number: P35180
Secondary accession number(s): D6VUL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health