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Protein

Peptidyl-prolyl cis-trans isomerase D

Gene

CPR5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  • peptidyl-prolyl cis-trans isomerase activity Source: SGD

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase

Enzyme and pathway databases

BioCyciYEAST:YDR304C-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase D (EC:5.2.1.8)
Short name:
PPIase D
Alternative name(s):
Cyclophilin D
Rotamase D
Gene namesi
Name:CPR5
Synonyms:CYP5, CYPD
Ordered Locus Names:YDR304C
ORF Names:D9740.14
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR304C
SGDiS000002712 CPR5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002548823 – 225Peptidyl-prolyl cis-trans isomerase DAdd BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP35176
PaxDbiP35176
PRIDEiP35176

2D gel databases

SWISS-2DPAGEiP35176

PTM databases

iPTMnetiP35176

Interactioni

Protein-protein interaction databases

BioGridi32356, 94 interactors
DIPiDIP-5222N
IntActiP35176, 1 interactor
MINTiP35176
STRINGi4932.YDR304C

Structurei

3D structure databases

ProteinModelPortaliP35176
SMRiP35176
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 195PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST159

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi222 – 225Prevents secretion from ER4

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00760000119072
HOGENOMiHOG000065981
InParanoidiP35176
KOiK03770
OMAiVYFDIKH
OrthoDBiEOG092C5DG5

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit
PS00014 ER_TARGET, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35176-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLQFFSFIT LFACLFTTAI FAKEDTAEDP EITHKVYFDI NHGDKQIGRI
60 70 80 90 100
VMGLYGLTTP QTVENFYQLT ISRDPKMGYL NSIFHRVIPN FMIQGGDFTH
110 120 130 140 150
RSGIGGKSIF GNTFKDENFD VKHDKPGRLS MANRGKNTNG SQFFITTVPC
160 170 180 190 200
PWLDGKHVVF GEVLDGMDVV HYIENVKTDS RNMPVKEVII VESGELETVP
210 220
LDNKDAAKLQ EEIKAEASEA AHDEL
Length:225
Mass (Da):25,327
Last modified:February 1, 1994 - v1
Checksum:iF4861424C8443B58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73142 mRNA Translation: CAA51658.1
U28374 Genomic DNA Translation: AAB64740.1
AY557734 Genomic DNA Translation: AAS56060.1
BK006938 Genomic DNA Translation: DAA12143.1
PIRiS38324
RefSeqiNP_010590.3, NM_001180612.3

Genome annotation databases

EnsemblFungiiYDR304C; YDR304C; YDR304C
GeneIDi851898
KEGGisce:YDR304C

Similar proteinsi

Entry informationi

Entry nameiCYPD_YEAST
AccessioniPrimary (citable) accession number: P35176
Secondary accession number(s): D6VST3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 20, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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