UniProtKB - P35172 (TREB_YEAST)
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Protein
Probable trehalase
Gene
NTH2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Miscellaneous
Present with 2500 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
Alpha,alpha-trehalose + H2O = beta-D-glucose + alpha-D-glucose.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 331 | SubstrateBy similarity | 1 | |
Binding sitei | 375 | SubstrateBy similarity | 1 | |
Binding sitei | 384 | SubstrateBy similarity | 1 | |
Binding sitei | 505 | Substrate; via carbonyl oxygenBy similarity | 1 | |
Active sitei | 507 | Proton donor/acceptorBy similarity | 1 | |
Active sitei | 703 | Proton donor/acceptorBy similarity | 1 |
GO - Molecular functioni
- alpha,alpha-trehalase activity Source: SGD
- calcium ion binding Source: InterPro
GO - Biological processi
- trehalose catabolic process Source: SGD
Keywordsi
Molecular function | Glycosidase, Hydrolase |
Enzyme and pathway databases
BioCyci | MetaCyc:YBR001C-MONOMER. YEAST:YBR001C-MONOMER. |
Protein family/group databases
CAZyi | GH37. Glycoside Hydrolase Family 37. |
Names & Taxonomyi
Protein namesi | Recommended name: Probable trehalase (EC:3.2.1.28)Alternative name(s): Alpha,alpha-trehalase Alpha,alpha-trehalose glucohydrolase |
Gene namesi | Name:NTH2 Ordered Locus Names:YBR001C ORF Names:YBR0106 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YBR001C. |
SGDi | S000000205. NTH2. |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173800 | 1 – 780 | Probable trehalaseAdd BLAST | 780 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 52 | PhosphoserineCombined sources | 1 | |
Modified residuei | 53 | PhosphoserineCombined sources | 1 | |
Modified residuei | 88 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 112 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P35172. |
PaxDbi | P35172. |
PRIDEi | P35172. |
PTM databases
iPTMneti | P35172. |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGridi | 32702. 72 interactors. |
DIPi | DIP-6841N. |
IntActi | P35172. 14 interactors. |
MINTi | P35172. |
STRINGi | 4932.YBR001C. |
Structurei
3D structure databases
ProteinModelPortali | P35172. |
SMRi | P35172. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 338 – 339 | Substrate bindingBy similarity | 2 | |
Regioni | 384 – 386 | Substrate bindingBy similarity | 3 |
Sequence similaritiesi
Belongs to the glycosyl hydrolase 37 family.Curated
Phylogenomic databases
GeneTreei | ENSGT00390000006949. |
HOGENOMi | HOG000192885. |
InParanoidi | P35172. |
KOi | K01194. |
OMAi | HDYGRKH. |
OrthoDBi | EOG092C0UDQ. |
Family and domain databases
Gene3Di | 1.50.10.10. 1 hit. |
InterProi | View protein in InterPro IPR008928. 6-hairpin_glycosidase_sf. IPR012341. 6hp_glycosidase-like_sf. IPR001661. Glyco_hydro_37. IPR018232. Glyco_hydro_37_CS. IPR011120. Trehalase_Ca-bd. |
PANTHERi | PTHR23403. PTHR23403. 1 hit. |
Pfami | View protein in Pfam PF01204. Trehalase. 1 hit. PF07492. Trehalase_Ca-bi. 1 hit. |
PRINTSi | PR00744. GLHYDRLASE37. |
SUPFAMi | SSF48208. SSF48208. 1 hit. |
PROSITEi | View protein in PROSITE PS00927. TREHALASE_1. 1 hit. PS00928. TREHALASE_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
P35172-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVDFLPKVTE INPPSEGNDG EDNIKPLSSG SEQRPLKEEG QQGGRRHHRR
60 70 80 90 100
LSSMHEYFDP FSNAEVYYGP ITDPRKQSKI HRLNRTRTMS VFNKVSDFKN
110 120 130 140 150
GMKDYTLKRR GSEDDSFLSS QGNRRFYIDN VDLALDELLA SEDTDKNHQI
160 170 180 190 200
TIEDTGPKVI KVGTANSNGF KHVNVRGTYM LSNLLQELTI AKSFGRHQIF
210 220 230 240 250
LDEARINENP VDRLSRLITT QFWTSLTRRV DLYNIAEIAR DSKIDTPGAK
260 270 280 290 300
NPRIYVPYNC PEQYEFYIQA SQMNPSLKLE VEYLPKDITA EYVKSLNDTP
310 320 330 340 350
GLLALAMEEH VNPSTGERSL VGYPYAVPGG RFNELYGWDS YLMALGLIES
360 370 380 390 400
NKVDVARGMV EHFIFEIDHY SKILNANRSY YLCRSQPPFL TDMALLVFEK
410 420 430 440 450
IGGKNNPNAI QLLKRAFRAA IKEYKEVWMS SPRLDSLTGL SCYHSDGIGI
460 470 480 490 500
PPETEPDHFD TILLPYAEKY NVTLEKLRYL YNEGMIKEPK LDAFFLHDRA
510 520 530 540 550
VRESGHDTTY RFEGVCAYLA TIDLNSLLYK YEKDIAFVIK EYFGNEYKDE
560 570 580 590 600
NDGTVTDSEH WEELAELRKT RINKYMWDED SGFFFYYNTK LKCRTSYESA
610 620 630 640 650
TTFWSLWAGL ATEEQAKITV EKALPQLEML GGLVACTEKS RGPISIDRPI
660 670 680 690 700
RQWDYPFGWA PHQILAWKGL SAYGYQQVAT RLAYRWLYMI TKSFVDYNGM
710 720 730 740 750
VVEKYDVTRG TDPHRVDAEY GNQGADFKGV ATEGFGWVNT SYLLGLKYMN
760 770 780
NHARRALAAC SPPLPFFNSL KPSEKKLYYL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z26494 Genomic DNA. Translation: CAA81270.1. Z35870 Genomic DNA. Translation: CAA84937.1. BK006936 Genomic DNA. Translation: DAA07122.1. |
PIRi | S44560. |
RefSeqi | NP_009555.1. NM_001178349.1. |
Genome annotation databases
EnsemblFungii | YBR001C; YBR001C; YBR001C. |
GeneIDi | 852286. |
KEGGi | sce:YBR001C. |
Similar proteinsi
Entry informationi
Entry namei | TREB_YEAST | |
Accessioni | P35172Primary (citable) accession number: P35172 Secondary accession number(s): D6VQ02 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | February 1, 1994 | |
Last modified: | March 28, 2018 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |