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Protein

Cytochrome c oxidase subunit 7A2, mitochondrial

Gene

Cox7a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7A2, mitochondrial
Alternative name(s):
Cytochrome c oxidase subunit VIIa-liver/heart
Short name:
Cytochrome c oxidase subunit VIIa-L
Gene namesi
Name:Cox7a2
Synonyms:Cox7a3, Cox7al
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi68365. Cox7a2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2323Mitochondrion2 PublicationsAdd
BLAST
Chaini24 – 8360Cytochrome c oxidase subunit 7A2, mitochondrialPRO_0000006147Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP35171.
PRIDEiP35171.

PTM databases

iPTMnetiP35171.
PhosphoSiteiP35171.

Expressioni

Gene expression databases

BgeeiENSRNOG00000027791.
ExpressionAtlasiP35171. baseline.
GenevisibleiP35171. RN.

Interactioni

Subunit structurei

Interacts with PET100.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060398.

Structurei

3D structure databases

ProteinModelPortaliP35171.
SMRiP35171. Positions 24-81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIa family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IZJ9. Eukaryota.
ENOG41124EQ. LUCA.
GeneTreeiENSGT00400000022054.
HOGENOMiHOG000264231.
HOVERGENiHBG051095.
InParanoidiP35171.
KOiK02270.
OMAiHFENKVP.
OrthoDBiEOG091G12UD.
PhylomeDBiP35171.
TreeFamiTF105067.

Family and domain databases

Gene3Di4.10.91.10. 1 hit.
InterProiIPR003177. Cyt_c_oxidase_su7a.
[Graphical view]
PANTHERiPTHR10510. PTHR10510. 1 hit.
SUPFAMiSSF81419. SSF81419. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35171-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRNVLALRQ IAQRTISTTS RRHFENKVPE KQKLFQEDNG MPVHLKGGTS
60 70 80
DALLYRATML LTVGGTAYAI YMLAMAAFPK KQN
Length:83
Mass (Da):9,353
Last modified:February 1, 1994 - v1
Checksum:iCC0EA163CD47150B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54080 mRNA. Translation: CAA38017.1.
PIRiS13099.
S65385.
RefSeqiNP_071948.1. NM_022503.2.
XP_003751415.1. XM_003751367.3.
XP_003752782.1. XM_003752734.3.
UniGeneiRn.1745.

Genome annotation databases

EnsembliENSRNOT00000066084; ENSRNOP00000060398; ENSRNOG00000042903.
GeneIDi29507.
688386.
KEGGirno:29507.
rno:688386.
UCSCiRGD:68365. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54080 mRNA. Translation: CAA38017.1.
PIRiS13099.
S65385.
RefSeqiNP_071948.1. NM_022503.2.
XP_003751415.1. XM_003751367.3.
XP_003752782.1. XM_003752734.3.
UniGeneiRn.1745.

3D structure databases

ProteinModelPortaliP35171.
SMRiP35171. Positions 24-81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060398.

PTM databases

iPTMnetiP35171.
PhosphoSiteiP35171.

Proteomic databases

PaxDbiP35171.
PRIDEiP35171.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000066084; ENSRNOP00000060398; ENSRNOG00000042903.
GeneIDi29507.
688386.
KEGGirno:29507.
rno:688386.
UCSCiRGD:68365. rat.

Organism-specific databases

CTDi1347.
688386.
RGDi68365. Cox7a2.

Phylogenomic databases

eggNOGiENOG410IZJ9. Eukaryota.
ENOG41124EQ. LUCA.
GeneTreeiENSGT00400000022054.
HOGENOMiHOG000264231.
HOVERGENiHBG051095.
InParanoidiP35171.
KOiK02270.
OMAiHFENKVP.
OrthoDBiEOG091G12UD.
PhylomeDBiP35171.
TreeFamiTF105067.

Miscellaneous databases

PROiP35171.

Gene expression databases

BgeeiENSRNOG00000027791.
ExpressionAtlasiP35171. baseline.
GenevisibleiP35171. RN.

Family and domain databases

Gene3Di4.10.91.10. 1 hit.
InterProiIPR003177. Cyt_c_oxidase_su7a.
[Graphical view]
PANTHERiPTHR10510. PTHR10510. 1 hit.
SUPFAMiSSF81419. SSF81419. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCX7A2_RAT
AccessioniPrimary (citable) accession number: P35171
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.