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Protein

Cytochrome c oxidase subunit 7A2, mitochondrial

Gene

Cox7a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7A2, mitochondrial
Alternative name(s):
Cytochrome c oxidase subunit VIIa-liver/heart
Short name:
Cytochrome c oxidase subunit VIIa-L
Gene namesi
Name:Cox7a2
Synonyms:Cox7a3, Cox7al
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi68365. Cox7a2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 23Mitochondrion2 PublicationsAdd BLAST23
ChainiPRO_000000614724 – 83Cytochrome c oxidase subunit 7A2, mitochondrialAdd BLAST60

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP35171.
PRIDEiP35171.

PTM databases

iPTMnetiP35171.
PhosphoSitePlusiP35171.

Expressioni

Gene expression databases

BgeeiENSRNOG00000042903.
ExpressionAtlasiP35171. baseline.
GenevisibleiP35171. RN.

Interactioni

Subunit structurei

Interacts with PET100.By similarity

Protein-protein interaction databases

CORUMiP35171.
STRINGi10116.ENSRNOP00000060398.

Structurei

3D structure databases

ProteinModelPortaliP35171.
SMRiP35171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIa family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IZJ9. Eukaryota.
ENOG41124EQ. LUCA.
GeneTreeiENSGT00400000022054.
HOGENOMiHOG000264231.
HOVERGENiHBG051095.
InParanoidiP35171.
KOiK02270.
OMAiHFENKVP.
OrthoDBiEOG091G12UD.
PhylomeDBiP35171.
TreeFamiTF105067.

Family and domain databases

CDDicd00928. Cyt_c_Oxidase_VIIa. 1 hit.
Gene3Di4.10.91.10. 1 hit.
InterProiView protein in InterPro
IPR003177. Cyt_c_oxidase_su7a.
IPR036539. Cyt_c_oxidase_su7a_sf.
PANTHERiPTHR10510. PTHR10510. 1 hit.
SUPFAMiSSF81419. SSF81419. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35171-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRNVLALRQ IAQRTISTTS RRHFENKVPE KQKLFQEDNG MPVHLKGGTS
60 70 80
DALLYRATML LTVGGTAYAI YMLAMAAFPK KQN
Length:83
Mass (Da):9,353
Last modified:February 1, 1994 - v1
Checksum:iCC0EA163CD47150B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54080 mRNA. Translation: CAA38017.1.
PIRiS13099.
S65385.
RefSeqiNP_071948.1. NM_022503.2.
XP_003751415.1. XM_003751367.3.
XP_003752782.1. XM_003752734.3.
UniGeneiRn.1745.

Genome annotation databases

EnsembliENSRNOT00000066084; ENSRNOP00000060398; ENSRNOG00000042903.
GeneIDi29507.
688386.
KEGGirno:29507.
rno:688386.
UCSCiRGD:68365. rat.

Similar proteinsi

Entry informationi

Entry nameiCX7A2_RAT
AccessioniPrimary (citable) accession number: P35171
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 22, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families