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Protein

Phospho-2-dehydro-3-deoxyheptonate aldolase

Gene

aroG

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

Catalytic activityi

Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.

Pathwayi: chorismate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase (Cgl2178), Phospho-2-dehydro-3-deoxyheptonate aldolase (aroG)
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroQ)
  4. Quinate/shikimate dehydrogenase (NAD(+)) (aroE)
  5. Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00053; UER00084.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolase (EC:2.5.1.54)
Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
DAHP synthase
Phospho-2-keto-3-deoxyheptonate aldolase
Gene namesi
Name:aroG
Synonyms:aroF
Ordered Locus Names:Cgl0990, cg1129
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000582 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Phospho-2-dehydro-3-deoxyheptonate aldolasePRO_0000140829Add
BLAST

Proteomic databases

PRIDEiP35170.

Interactioni

Protein-protein interaction databases

STRINGi196627.cg1129.

Structurei

3D structure databases

ProteinModelPortaliP35170.
SMRiP35170. Positions 15-362.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-I DAHP synthase family.Curated

Phylogenomic databases

eggNOGiENOG4105E99. Bacteria.
COG0722. LUCA.
HOGENOMiHOG000220501.
KOiK01626.
OMAiDGCIDWA.
OrthoDBiEOG63JR9W.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006219. DHAP_synth_1.
[Graphical view]
PANTHERiPTHR21225. PTHR21225. 1 hit.
PfamiPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMsiTIGR00034. aroFGH. 1 hit.

Sequencei

Sequence statusi: Complete.

P35170-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPVSLENA ASTSNKRVVA FHELPSPTDL IAANPLTPKQ ASKVEQDRQD
60 70 80 90 100
IADIFAGDDD RLVVVVGPCS VHDPEAAIDY ANRLAPLAKR LDQDLKIVMR
110 120 130 140 150
VYFEKPRTIV GWKGLINDPH LNETYDIPEG LRIARKVLID VVNLDLPVGC
160 170 180 190 200
EFLEPNSPQY YADTVAWGAI GARTTESQVH RQLASGMSMP IGFKNGTDGN
210 220 230 240 250
IQVAVDAVQA AQNPHFFFGT SDDGALSVVE TAGNSNSHII LRGGTSGPNH
260 270 280 290 300
DAASVEAVVE KLGENARLMI DASHANSGKD HIRQVEVVRE IAEQISGGSE
310 320 330 340 350
AVAGIMIESF LVGGAQNLDP AKLRINGGEG LVYGQSVTDK CIDIDTTIDL
360
LAELAAAVRE RRAAAK
Length:366
Mass (Da):39,131
Last modified:July 11, 2002 - v2
Checksum:i1EDA38DD26E29D58
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti109 – 1091I → T in AAA23292 (PubMed:8097175).Curated
Sequence conflicti181 – 1811R → RR in AAA23292 (PubMed:8097175).Curated
Sequence conflicti356 – 3561A → T in AAA23292 (PubMed:8097175).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07603 Genomic DNA. Translation: AAA23292.1.
BA000036 Genomic DNA. Translation: BAB98383.1.
BX927151 Genomic DNA. Translation: CAF19696.1.
PIRiI40837.
RefSeqiNP_600217.1. NC_003450.3.
WP_011014031.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB98383; BAB98383; BAB98383.
CAF19696; CAF19696; cg1129.
GeneIDi1018979.
KEGGicgb:cg1129.
cgl:NCgl0950.
PATRICi21494034. VBICorGlu203724_0974.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07603 Genomic DNA. Translation: AAA23292.1.
BA000036 Genomic DNA. Translation: BAB98383.1.
BX927151 Genomic DNA. Translation: CAF19696.1.
PIRiI40837.
RefSeqiNP_600217.1. NC_003450.3.
WP_011014031.1. NC_006958.1.

3D structure databases

ProteinModelPortaliP35170.
SMRiP35170. Positions 15-362.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196627.cg1129.

Proteomic databases

PRIDEiP35170.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB98383; BAB98383; BAB98383.
CAF19696; CAF19696; cg1129.
GeneIDi1018979.
KEGGicgb:cg1129.
cgl:NCgl0950.
PATRICi21494034. VBICorGlu203724_0974.

Phylogenomic databases

eggNOGiENOG4105E99. Bacteria.
COG0722. LUCA.
HOGENOMiHOG000220501.
KOiK01626.
OMAiDGCIDWA.
OrthoDBiEOG63JR9W.

Enzyme and pathway databases

UniPathwayiUPA00053; UER00084.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006219. DHAP_synth_1.
[Graphical view]
PANTHERiPTHR21225. PTHR21225. 1 hit.
PfamiPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMsiTIGR00034. aroFGH. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The cloning and nucleotide sequence of a Corynebacterium glutamicum 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase gene."
    Chen C.-C., Liao C.-C., Hsu W.-H.
    FEMS Microbiol. Lett. 107:223-230(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CCRC 18310.
  2. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiAROG_CORGL
AccessioniPrimary (citable) accession number: P35170
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: July 11, 2002
Last modified: November 11, 2015
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.