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Protein

Thiol-disulfide oxidoreductase ResA

Gene

resA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c; following this reduction heme can be covalently attached. Does not play a role in sporulation.1 Publication

Pathwayi: cytochrome c assembly

This protein is involved in the pathway cytochrome c assembly, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway cytochrome c assembly and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCytochrome c-type biogenesis

Enzyme and pathway databases

BioCyciBSUB:BSU23150-MONOMER
UniPathwayiUPA00555

Names & Taxonomyi

Protein namesi
Recommended name:
Thiol-disulfide oxidoreductase ResA
Gene namesi
Name:resA
Synonyms:ypxA
Ordered Locus Names:BSU23150
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 30Helical; Signal-anchor for type II membrane proteinCuratedAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001201491 – 179Thiol-disulfide oxidoreductase ResAAdd BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi74 ↔ 77Redox-active

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP35160

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
cccAP244692EBI-15573707,EBI-15573689

Protein-protein interaction databases

DIPiDIP-61132N
IntActiP35160, 1 interactor

Structurei

Secondary structure

1179
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi46 – 48Combined sources3
Beta strandi54 – 56Combined sources3
Helixi57 – 60Combined sources4
Beta strandi63 – 70Combined sources8
Helixi75 – 91Combined sources17
Helixi92 – 94Combined sources3
Beta strandi96 – 104Combined sources9
Helixi107 – 117Combined sources11
Beta strandi123 – 126Combined sources4
Helixi130 – 134Combined sources5
Beta strandi142 – 146Combined sources5
Beta strandi150 – 158Combined sources9
Helixi162 – 172Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ST9X-ray1.50A/B37-179[»]
1SU9X-ray1.95A/B37-179[»]
2F9SX-ray1.40A/B37-179[»]
2H19X-ray2.00A/B37-179[»]
2H1AX-ray2.40A/B37-179[»]
2H1BX-ray1.95A/B/C/D37-179[»]
2H1DX-ray2.60A/B37-179[»]
2H1GX-ray3.10A/B37-179[»]
3C71X-ray1.90A37-179[»]
3C73X-ray2.50A/B40-179[»]
ProteinModelPortaliP35160
SMRiP35160
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35160

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 174ThioredoxinAdd BLAST139

Sequence similaritiesi

Belongs to the thioredoxin family. ResA subfamily.Curated

Keywords - Domaini

Redox-active center, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000097217
InParanoidiP35160
OMAiKWLAEFH
PhylomeDBiP35160

Family and domain databases

HAMAPiMF_01319 ResA, 1 hit
InterProiView protein in InterPro
IPR000866 AhpC/TSA
IPR023555 Thiol-dS_OxRdtase_ResA
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00578 AhpC-TSA, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P35160-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKRRLFIR TGILLVLICA LGYTIYNAVF AGKESISEGS DAPNFVLEDT
60 70 80 90 100
NGKRIELSDL KGKGVFLNFW GTWCEPCKKE FPYMANQYKH FKSQGVEIVA
110 120 130 140 150
VNVGESKIAV HNFMKSYGVN FPVVLDTDRQ VLDAYDVSPL PTTFLINPEG
160 170
KVVKVVTGTM TESMIHDYMN LIKPGETSG
Length:179
Mass (Da):20,008
Last modified:August 29, 2003 - v2
Checksum:iE023A46F4BD702AC
GO

Sequence cautioni

The sequence AAA67494 differs from that shown. Reason: Frameshift at position 39.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09228 Genomic DNA Translation: AAA67494.1 Frameshift.
AL009126 Genomic DNA Translation: CAB14247.2
PIRiS45556
RefSeqiNP_390196.2, NC_000964.3
WP_003230513.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB14247; CAB14247; BSU23150
GeneIDi938958
KEGGibsu:BSU23150
PATRICifig|224308.179.peg.2522

Similar proteinsi

Entry informationi

Entry nameiRESA_BACSU
AccessioniPrimary (citable) accession number: P35160
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: August 29, 2003
Last modified: May 23, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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