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Protein

Ribosomal large subunit pseudouridine synthase B

Gene

rluB

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for synthesis of pseudouridine from uracil-2633 in 23S ribosomal RNA.

Catalytic activityi

23S rRNA uridine(2605) = 23S rRNA pseudouridine(2605).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei102NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, RNA-binding
Biological processrRNA processing

Enzyme and pathway databases

BioCyciBSUB:BSU23160-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal large subunit pseudouridine synthase B (EC:5.4.99.22)
Alternative name(s):
23S rRNA pseudouridine(2605) synthase
rRNA pseudouridylate synthase B
rRNA-uridine isomerase B
Gene namesi
Name:rluB
Synonyms:ypuL
Ordered Locus Names:BSU23160
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000999791 – 244Ribosomal large subunit pseudouridine synthase BAdd BLAST244

Proteomic databases

PaxDbiP35159
PRIDEiP35159

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100012716

Structurei

3D structure databases

ProteinModelPortaliP35159
SMRiP35159
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 68S4 RNA-bindingPROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Belongs to the pseudouridine synthase RsuA family.Curated

Phylogenomic databases

eggNOGiENOG4105FE9 Bacteria
COG1187 LUCA
HOGENOMiHOG000044954
InParanoidiP35159
KOiK06178
OMAiSMEFAPF
PhylomeDBiP35159

Family and domain databases

CDDicd00165 S4, 1 hit
Gene3Di3.10.290.10, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR000748 PsdUridine_synth_RsuA/RluB/E/F
IPR018496 PsdUridine_synth_RsuA/RluB_CS
IPR006145 PsdUridine_synth_RsuA/RluD
IPR002942 S4_RNA-bd
IPR036986 S4_RNA-bd_sf
PANTHERiPTHR21600 PTHR21600, 1 hit
PfamiView protein in Pfam
PF00849 PseudoU_synth_2, 1 hit
PF01479 S4, 1 hit
SMARTiView protein in SMART
SM00363 S4, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00093 TIGR00093, 1 hit
PROSITEiView protein in PROSITE
PS01149 PSI_RSU, 1 hit
PS50889 S4, 1 hit

Sequencei

Sequence statusi: Complete.

P35159-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERLQKVIAH AGVASRRKAE ELIKEGKVKV NGKVVTELGV KVTGSDQIEV
60 70 80 90 100
NGLKVEREEP VYFLLYKPRG VISAAQDDKG RKVVTDFFKN IPQRIYPIGR
110 120 130 140 150
LDYDTSGLLL LTNDGEFANK LMHPKYEIDK TYVAKVKGIP PKELLRKLER
160 170 180 190 200
GIRLEEGKTA PAKAKLLSLD KKKQTSIIQL TIHEGRNRQV RRMFEAIGHE
210 220 230 240
VIKLKREEYA FLNLRGLHTG DARELTPHEV KRLRALADHG KNAF
Length:244
Mass (Da):27,738
Last modified:July 7, 2009 - v2
Checksum:iBD18C7E3A8A7C3D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17R → S in AAA67493 (PubMed:7934829).Curated1
Sequence conflicti226 – 244TPHEV…GKNAF → RLTK in AAA67493 (PubMed:7934829).CuratedAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09228 Genomic DNA Translation: AAA67493.1
AL009126 Genomic DNA Translation: CAB14248.2
PIRiS45555
RefSeqiNP_390197.2, NC_000964.3
WP_004398815.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB14248; CAB14248; BSU23160
GeneIDi938955
KEGGibsu:BSU23160
PATRICifig|224308.179.peg.2523

Similar proteinsi

Entry informationi

Entry nameiRLUB_BACSU
AccessioniPrimary (citable) accession number: P35159
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: July 7, 2009
Last modified: May 23, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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