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Protein

Ubiquitin-conjugating enzyme E2-17 kDa

Gene
N/A
Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins.PROSITE-ProRule annotation

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei85Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2-17 kDa (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme
Ubiquitin carrier protein
Ubiquitin-protein ligase
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
Proteomesi
  • UP000004994 Componenti: Chromosome 6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000825801 – 148Ubiquitin-conjugating enzyme E2-17 kDaAdd BLAST148

Proteomic databases

PaxDbiP35135

Expressioni

Gene expression databases

ExpressionAtlasiP35135 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi4081.Solyc06g082600.2.1

Structurei

3D structure databases

ProteinModelPortaliP35135
SMRiP35135
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0417 Eukaryota
COG5078 LUCA
InParanoidiP35135
OMAiKNKYETT
OrthoDBiEOG09360PU6

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.101 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P35135-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKRILKEL KDLQKDPPTS CSAGPVAEDM FHWQATIMGP TDSPYAGGVF
60 70 80 90 100
LVSIHFPPDY PFKPPKVAFR TKVFHPNINS NGSICLDILK EQWSPALTIS
110 120 130 140
KVLLSICSLL TDPNPDDPLV PEIAHMYKTD RAKYETTARS WTQKYAMG
Length:148
Mass (Da):16,522
Last modified:February 1, 1994 - v1
Checksum:i4247FF721B98059F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23762 mRNA Translation: AAA34125.1
RefSeqiNP_001234247.1, NM_001247318.2
NP_001294911.1, NM_001307982.1
NP_001294913.1, NM_001307984.1
XP_019069675.1, XM_019214130.1
UniGeneiLes.19083

Genome annotation databases

EnsemblPlantsiSolyc06g007510.2.1; Solyc06g007510.2.1; Solyc06g007510.2
Solyc06g082600.2.1; Solyc06g082600.2.1; Solyc06g082600.2
GeneIDi100301932
101249087
GrameneiSolyc06g007510.2.1; Solyc06g007510.2.1; Solyc06g007510.2
Solyc06g082600.2.1; Solyc06g082600.2.1; Solyc06g082600.2
KEGGisly:100301932
sly:101249087

Similar proteinsi

Entry informationi

Entry nameiUBC4_SOLLC
AccessioniPrimary (citable) accession number: P35135
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome