Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin-conjugating enzyme E2 11

Gene

UBC11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates the selective degradation of short-lived and abnormal proteins.1 Publication

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei85 – 851Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ubiquitin-protein transferase activity Source: TAIR

GO - Biological processi

  • ubiquitin-dependent protein catabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G08690-MONOMER.
ARA:GQT-2213-MONOMER.
ReactomeiR-ATH-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-ATH-179409. APC-Cdc20 mediated degradation of Nek2A.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 11 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 11
Ubiquitin carrier protein 11
Ubiquitin-conjugating enzyme E2-17 kDa 11
Ubiquitin-protein ligase 11
Gene namesi
Name:UBC11
Ordered Locus Names:At3g08690
ORF Names:F17O14.16
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G08690.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 148148Ubiquitin-conjugating enzyme E2 11PRO_0000082579Add
BLAST

Proteomic databases

PaxDbiP35134.
PRIDEiP35134.

Expressioni

Tissue specificityi

Ubiquitously expressed. Mainly in petals.

Inductioni

Up-regulated by syringolin, a cell death-inducing chemical.1 Publication

Gene expression databases

GenevisibleiP35134. AT.

Interactioni

Subunit structurei

Interacts with the E3 ubiquitin-protein ligases MBR1 and MBR2.1 Publication

Protein-protein interaction databases

BioGridi5351. 6 interactions.
IntActiP35134. 3 interactions.
STRINGi3702.AT3G08690.1.

Structurei

3D structure databases

ProteinModelPortaliP35134.
SMRiP35134. Positions 2-146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0417. Eukaryota.
COG5078. LUCA.
HOGENOMiHOG000233455.
InParanoidiP35134.
KOiK06689.
OMAiTIAREWT.
OrthoDBiEOG09360PU6.
PhylomeDBiP35134.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35134-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKRILKEL KDLQKDPPSN CSAGPVAEDM FHWQATIMGP PESPYAGGVF
60 70 80 90 100
LVSIHFPPDY PFKPPKVSFK TKVYHPNINS NGSICLDILK EQWSPALTIS
110 120 130 140
KVLLSICSLL TDPNPDDPLV PEIAHMYKTD RSKYESTARS WTQKYAMG
Length:148
Mass (Da):16,551
Last modified:January 24, 2001 - v2
Checksum:i74A0991115BA50EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ027025 mRNA. Translation: AAY44851.1.
AC012562 Genomic DNA. Translation: AAG51362.1.
CP002686 Genomic DNA. Translation: AEE74664.1.
CP002686 Genomic DNA. Translation: AEE74665.1.
AY063869 mRNA. Translation: AAL36225.1.
AY091223 mRNA. Translation: AAM14162.1.
AY086109 mRNA. Translation: AAM63316.1.
AK228254 mRNA. Translation: BAF00202.1.
Z14992 mRNA. Translation: CAA78716.1.
L00641 mRNA. Translation: AAA32896.1.
PIRiS32673.
RefSeqiNP_001189841.1. NM_001202912.1.
NP_566331.1. NM_111703.3.
UniGeneiAt.202.

Genome annotation databases

EnsemblPlantsiAT3G08690.1; AT3G08690.1; AT3G08690.
AT3G08690.2; AT3G08690.2; AT3G08690.
GeneIDi820016.
GrameneiAT3G08690.1; AT3G08690.1; AT3G08690.
AT3G08690.2; AT3G08690.2; AT3G08690.
KEGGiath:AT3G08690.

Cross-referencesi

Web resourcesi

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ027025 mRNA. Translation: AAY44851.1.
AC012562 Genomic DNA. Translation: AAG51362.1.
CP002686 Genomic DNA. Translation: AEE74664.1.
CP002686 Genomic DNA. Translation: AEE74665.1.
AY063869 mRNA. Translation: AAL36225.1.
AY091223 mRNA. Translation: AAM14162.1.
AY086109 mRNA. Translation: AAM63316.1.
AK228254 mRNA. Translation: BAF00202.1.
Z14992 mRNA. Translation: CAA78716.1.
L00641 mRNA. Translation: AAA32896.1.
PIRiS32673.
RefSeqiNP_001189841.1. NM_001202912.1.
NP_566331.1. NM_111703.3.
UniGeneiAt.202.

3D structure databases

ProteinModelPortaliP35134.
SMRiP35134. Positions 2-146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi5351. 6 interactions.
IntActiP35134. 3 interactions.
STRINGi3702.AT3G08690.1.

Proteomic databases

PaxDbiP35134.
PRIDEiP35134.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G08690.1; AT3G08690.1; AT3G08690.
AT3G08690.2; AT3G08690.2; AT3G08690.
GeneIDi820016.
GrameneiAT3G08690.1; AT3G08690.1; AT3G08690.
AT3G08690.2; AT3G08690.2; AT3G08690.
KEGGiath:AT3G08690.

Organism-specific databases

TAIRiAT3G08690.

Phylogenomic databases

eggNOGiKOG0417. Eukaryota.
COG5078. LUCA.
HOGENOMiHOG000233455.
InParanoidiP35134.
KOiK06689.
OMAiTIAREWT.
OrthoDBiEOG09360PU6.
PhylomeDBiP35134.

Enzyme and pathway databases

UniPathwayiUPA00143.
BioCyciARA:AT3G08690-MONOMER.
ARA:GQT-2213-MONOMER.
ReactomeiR-ATH-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-ATH-179409. APC-Cdc20 mediated degradation of Nek2A.

Miscellaneous databases

PROiP35134.

Gene expression databases

GenevisibleiP35134. AT.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBC11_ARATH
AccessioniPrimary (citable) accession number: P35134
Secondary accession number(s): Q4TYZ9, Q9M9J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 24, 2001
Last modified: September 7, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.