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Protein

Ubiquitin-conjugating enzyme E2 11

Gene

UBC11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates the selective degradation of short-lived and abnormal proteins.1 Publication

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei85Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ubiquitin-protein transferase activity Source: TAIR

GO - Biological processi

  • ubiquitin-dependent protein catabolic process Source: TAIR

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-ATH-5689896. Ovarian tumor domain proteases.
R-ATH-8866652. Synthesis of active ubiquitin: roles of E1 and E2 enzymes.
R-ATH-8866654. E3 ubiquitin ligases ubiquitinate target proteins.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 11 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 11
Ubiquitin carrier protein 11
Ubiquitin-conjugating enzyme E2-17 kDa 11
Ubiquitin-protein ligase 11
Gene namesi
Name:UBC11
Ordered Locus Names:At3g08690
ORF Names:F17O14.16
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G08690.
TAIRilocus:2077773. AT3G08690.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000825791 – 148Ubiquitin-conjugating enzyme E2 11Add BLAST148

Proteomic databases

PaxDbiP35134.
PRIDEiP35134.

Expressioni

Tissue specificityi

Ubiquitously expressed. Mainly in petals.

Inductioni

Up-regulated by syringolin, a cell death-inducing chemical.1 Publication

Gene expression databases

GenevisibleiP35134. AT.

Interactioni

Subunit structurei

Interacts with the E3 ubiquitin-protein ligases MBR1 and MBR2.1 Publication

Protein-protein interaction databases

BioGridi5351. 7 interactors.
IntActiP35134. 3 interactors.
STRINGi3702.AT3G08690.1.

Structurei

3D structure databases

ProteinModelPortaliP35134.
SMRiP35134.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0417. Eukaryota.
COG5078. LUCA.
HOGENOMiHOG000233455.
InParanoidiP35134.
KOiK06689.
OMAiPEIANMY.
OrthoDBiEOG09360PU6.
PhylomeDBiP35134.

Family and domain databases

CDDicd00195. UBCc. 1 hit.
Gene3Di3.10.110.10. 1 hit.
InterProiView protein in InterPro
IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
PfamiView protein in Pfam
PF00179. UQ_con. 1 hit.
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiView protein in PROSITE
PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P35134-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKRILKEL KDLQKDPPSN CSAGPVAEDM FHWQATIMGP PESPYAGGVF
60 70 80 90 100
LVSIHFPPDY PFKPPKVSFK TKVYHPNINS NGSICLDILK EQWSPALTIS
110 120 130 140
KVLLSICSLL TDPNPDDPLV PEIAHMYKTD RSKYESTARS WTQKYAMG
Length:148
Mass (Da):16,551
Last modified:January 24, 2001 - v2
Checksum:i74A0991115BA50EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ027025 mRNA. Translation: AAY44851.1.
AC012562 Genomic DNA. Translation: AAG51362.1.
CP002686 Genomic DNA. Translation: AEE74664.1.
CP002686 Genomic DNA. Translation: AEE74665.1.
AY063869 mRNA. Translation: AAL36225.1.
AY091223 mRNA. Translation: AAM14162.1.
AY086109 mRNA. Translation: AAM63316.1.
AK228254 mRNA. Translation: BAF00202.1.
Z14992 mRNA. Translation: CAA78716.1.
L00641 mRNA. Translation: AAA32896.1.
PIRiS32673.
RefSeqiNP_001189841.1. NM_001202912.1.
NP_566331.1. NM_111703.4.
UniGeneiAt.202.

Genome annotation databases

EnsemblPlantsiAT3G08690.1; AT3G08690.1; AT3G08690.
AT3G08690.2; AT3G08690.2; AT3G08690.
GeneIDi820016.
GrameneiAT3G08690.1; AT3G08690.1; AT3G08690.
AT3G08690.2; AT3G08690.2; AT3G08690.
KEGGiath:AT3G08690.

Similar proteinsi

Entry informationi

Entry nameiUBC11_ARATH
AccessioniPrimary (citable) accession number: P35134
Secondary accession number(s): Q4TYZ9, Q9M9J1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 24, 2001
Last modified: August 30, 2017
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families