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Protein

Ubiquitin-conjugating enzyme E2 11

Gene

UBC11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates the selective degradation of short-lived and abnormal proteins.1 Publication

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei85Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ubiquitin-protein transferase activity Source: TAIR

GO - Biological processi

  • ubiquitin-dependent protein catabolic process Source: TAIR

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-ATH-5689896 Ovarian tumor domain proteases
R-ATH-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-ATH-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-ATH-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 11 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 11
Ubiquitin carrier protein 11
Ubiquitin-conjugating enzyme E2-17 kDa 11
Ubiquitin-protein ligase 11
Gene namesi
Name:UBC11
Ordered Locus Names:At3g08690
ORF Names:F17O14.16
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G08690
TAIRilocus:2077773 AT3G08690

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000825791 – 148Ubiquitin-conjugating enzyme E2 11Add BLAST148

Proteomic databases

PaxDbiP35134
PRIDEiP35134

Expressioni

Tissue specificityi

Ubiquitously expressed. Mainly in petals.

Inductioni

Up-regulated by syringolin, a cell death-inducing chemical.1 Publication

Gene expression databases

ExpressionAtlasiP35134 baseline and differential
GenevisibleiP35134 AT

Interactioni

Subunit structurei

Interacts with the E3 ubiquitin-protein ligases MBR1 and MBR2.1 Publication

Protein-protein interaction databases

BioGridi5351, 7 interactors
IntActiP35134, 3 interactors
STRINGi3702.AT3G08690.1

Structurei

3D structure databases

ProteinModelPortaliP35134
SMRiP35134
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0417 Eukaryota
COG5078 LUCA
HOGENOMiHOG000233455
InParanoidiP35134
KOiK06689
OMAiVANDIFH
OrthoDBiEOG09360PU6
PhylomeDBiP35134

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P35134-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKRILKEL KDLQKDPPSN CSAGPVAEDM FHWQATIMGP PESPYAGGVF
60 70 80 90 100
LVSIHFPPDY PFKPPKVSFK TKVYHPNINS NGSICLDILK EQWSPALTIS
110 120 130 140
KVLLSICSLL TDPNPDDPLV PEIAHMYKTD RSKYESTARS WTQKYAMG
Length:148
Mass (Da):16,551
Last modified:January 24, 2001 - v2
Checksum:i74A0991115BA50EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ027025 mRNA Translation: AAY44851.1
AC012562 Genomic DNA Translation: AAG51362.1
CP002686 Genomic DNA Translation: AEE74664.1
CP002686 Genomic DNA Translation: AEE74665.1
AY063869 mRNA Translation: AAL36225.1
AY091223 mRNA Translation: AAM14162.1
AY086109 mRNA Translation: AAM63316.1
AK228254 mRNA Translation: BAF00202.1
Z14992 mRNA Translation: CAA78716.1
L00641 mRNA Translation: AAA32896.1
PIRiS32673
RefSeqiNP_001189841.1, NM_001202912.1
NP_566331.1, NM_111703.4
UniGeneiAt.202

Genome annotation databases

EnsemblPlantsiAT3G08690.1; AT3G08690.1; AT3G08690
AT3G08690.2; AT3G08690.2; AT3G08690
GeneIDi820016
GrameneiAT3G08690.1; AT3G08690.1; AT3G08690
AT3G08690.2; AT3G08690.2; AT3G08690
KEGGiath:AT3G08690

Similar proteinsi

Entry informationi

Entry nameiUBC11_ARATH
AccessioniPrimary (citable) accession number: P35134
Secondary accession number(s): Q4TYZ9, Q9M9J1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 24, 2001
Last modified: April 25, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health