Reviewed,
UniProtKB/Swiss-Prot P35129 (UBC2_CAEEL)
Last modified
June 16, 2009.
Version 74.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Ubiquitin-conjugating enzyme E2 2 EC=6.3.2.19 Alternative name(s): Ubiquitin-protein ligase 2 Ubiquitin carrier protein 2 Lethal protein 70 | ||||||
| Gene names |
| ||||||
| Organism | Caenorhabditis elegans [Complete proteome] | ||||||
| Taxonomic identifier | 6239 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 147 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. |
| Catalytic activity | ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. |
| Pathway | |
| Sequence similarities | Belongs to the ubiquitin-conjugating enzyme family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 147 | 147 | Ubiquitin-conjugating enzyme E2 2 | PRO_0000082515 | |||||||||||||||||||||||||||
Sites | |||||||||||||||||||||||||||||||
| Active site | 85 | 1 | Glycyl thioester intermediate By similarity | ||||||||||||||||||||||||||||
Natural variations | |||||||||||||||||||||||||||||||
| Natural variant | 75 | 1 | H → Y in let-70(S1132); which shows growth arrest in larval stage. | ||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||
| Helix | 1 – 15 | 15 | |||||||||||||||||||||||||||||
| Beta strand | 19 – 26 | 8 | |||||||||||||||||||||||||||||
| Beta strand | 29 – 38 | 10 | |||||||||||||||||||||||||||||
| Turn | 44 – 47 | 4 | |||||||||||||||||||||||||||||
| Beta strand | 49 – 55 | 7 | |||||||||||||||||||||||||||||
| Turn | 58 – 61 | 4 | |||||||||||||||||||||||||||||
| Beta strand | 66 – 71 | 6 | |||||||||||||||||||||||||||||
| Helix | 87 – 89 | 3 | |||||||||||||||||||||||||||||
| Turn | 90 – 92 | 3 | |||||||||||||||||||||||||||||
| Helix | 99 – 111 | 13 | |||||||||||||||||||||||||||||
| Helix | 121 – 129 | 9 | |||||||||||||||||||||||||||||
| Helix | 131 – 145 | 15 | |||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The ubc-2 gene of Caenorhabditis elegans encodes a ubiquitin-conjugating enzyme involved in selective protein degradation." Zhen M., Heinlein R., Jones D., Jentsch S., Candido E.P.M. Mol. Cell. Biol. 13:1371-1377(1993) [PubMed: 8441382] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "An essential ubiquitin-conjugating enzyme with tissue and developmental specificity in the nematode Caenorhabditis elegans." Zhen M., Scheni J.E., Baillie D.L., Candido E.P.M. EMBO J. 15:3229-3237(1996) [PubMed: 8670823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], IDENTIFICATION AS LET-70. |
| [3] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S56051 Genomic DNA. Translation: AAB25489.2. Z68337 Genomic DNA. Translation: CAA92745.1. | |||||||||||||
| PIR | A48145. T23820. | ||||||||||||
| RefSeq | NP_502065.1. | ||||||||||||
| UniGene | Cel.18192 | ||||||||||||
3D structure databases | |||||||||||||
| |||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| DIP | DIP:24306N. | ||||||||||||
| IntAct | P35129. 3 interactions. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | M7.1. Caenorhabditis elegans. [Contig view] | ||||||||||||
| GeneID | 178006. | ||||||||||||
| KEGG | cel:M7.1. | ||||||||||||
| NMPDR | fig|6239.3.peg.15092. | ||||||||||||
Organism-specific databases | |||||||||||||
| WormBase | WBGene00002344. let-70. | ||||||||||||
| WormPep | M7.1. CE03482. [WorfDB] | ||||||||||||
Phylogenomic databases | |||||||||||||
| OMA | P35129. NFTTRIY. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| BRENDA | 6.3.2.19. 672. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | P35129. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR016135. UBQ-conjugat/RWD-like. IPR000608. UBQ-conjugat_E2. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit. | ||||||||||||
| Pfam | PF00179. UQ_con. 1 hit. [Graphical view] | ||||||||||||
| ProDom | PD000461. UBQ_conjugat. 1 hit. [Graphical view] [Entries sharing at least one domain] | ||||||||||||
| SMART | SM00212. UBCc. 1 hit. [Graphical view] | ||||||||||||
| PROSITE | PS00183. UBIQUITIN_CONJUGAT_1. 1 hit. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 899334. | ||||||||||||
Entry information
| Entry name | UBC2_CAEEL | ||||||||
| Accession | Primary (citable) accession number: P35129 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


