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P35125

- UBP6_HUMAN

UniProt

P35125 - UBP6_HUMAN

Protein

Ubiquitin carboxyl-terminal hydrolase 6

Gene

USP6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.3 Publications

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei541 – 5411Nucleophile
    Active sitei1328 – 13281Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. calmodulin binding Source: UniProtKB
    2. cysteine-type endopeptidase activity Source: UniProtKB
    3. nucleic acid binding Source: ProtInc
    4. protein binding Source: UniProtKB
    5. Rab GTPase activator activity Source: InterPro
    6. ubiquitin-specific protease activity Source: UniProtKB

    GO - Biological processi

    1. cellular protein modification process Source: UniProtKB
    2. protein deubiquitination Source: UniProtKB
    3. regulation of vesicle-mediated transport Source: UniProtKB
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Calmodulin-binding

    Protein family/group databases

    MEROPSiC19.009.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 6 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 6
    Proto-oncogene TRE-2
    Ubiquitin thioesterase 6
    Ubiquitin-specific-processing protease 6
    Gene namesi
    Name:USP6
    Synonyms:HRP1, TRE2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:12629. USP6.

    Subcellular locationi

    Cell membrane. Cytoplasm. Endosome
    Note: Localizes to the plasma membrane and to filamentous structures within the cell corresponding to ARF6 regulated tubular endosomes. Activation of RAC1 and CDC42 can direct the relocalization of USP6 to the plasma membrane in a manner that depends on the integrity of the actin cytoskeleton.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. lysosome Source: ProtInc
    3. plasma membrane Source: UniProtKB
    4. recycling endosome Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Endosome, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving USP6 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with CDH11. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi150 – 1501T → R: Does not restore GAP activity in yeast complementation assay. 1 Publication
    Mutagenesisi187 – 1871R → Q: Does not restore GAP activity in yeast complementation assay. 1 Publication
    Mutagenesisi541 – 5411C → S: Loss of enzyme activity. 1 Publication

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    PharmGKBiPA37254.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14061406Ubiquitin carboxyl-terminal hydrolase 6PRO_0000080625Add
    BLAST

    Post-translational modificationi

    Monubiquitinated; ubiquitination is calmodulin and calcium dependent.1 Publication

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    MaxQBiP35125.
    PaxDbiP35125.
    PRIDEiP35125.

    PTM databases

    PhosphoSiteiP35125.

    Expressioni

    Tissue specificityi

    Testis specific. Expressed in various cancer cell lines.2 Publications

    Gene expression databases

    ArrayExpressiP35125.
    BgeeiP35125.
    CleanExiHS_USP6.
    GenevestigatoriP35125.

    Organism-specific databases

    HPAiHPA011742.

    Interactioni

    Subunit structurei

    Interacts with RAC1 and CDC42. Interacts (via Rab-GAP TBC domain) with ARF6. Interacts with calmodulin (CALM1, CALM2 and/or CALM3); the interaction is calcium-dependent.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ANKRD44Q8N8A24EBI-954590,EBI-1245329
    MYL2P109165EBI-954590,EBI-725770

    Protein-protein interaction databases

    BioGridi114552. 12 interactions.
    IntActiP35125. 5 interactions.
    MINTiMINT-2865848.
    STRINGi9606.ENSP00000250066.

    Structurei

    3D structure databases

    ProteinModelPortaliP35125.
    SMRiP35125. Positions 72-341, 528-713, 1031-1110, 1311-1367.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini100 – 292193Rab-GAP TBCPROSITE-ProRule annotationAdd
    BLAST
    Domaini532 – 1369838USPAdd
    BLAST

    Domaini

    The Rab-GAP TBC domain lacks GTPase activator activity but is necessary for interaction with ARF6.

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5210.
    HOGENOMiHOG000154762.
    InParanoidiP35125.
    KOiK11837.
    OMAiHDSNIKN.
    OrthoDBiEOG7PP55V.
    PhylomeDBiP35125.
    TreeFamiTF324190.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000195. Rab-GTPase-TBC_dom.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00566. RabGAP-TBC. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view]
    SMARTiSM00164. TBC. 1 hit.
    [Graphical view]
    SUPFAMiSSF47923. SSF47923. 2 hits.
    PROSITEiPS50086. TBC_RABGAP. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P35125-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDMVENADSL QAQERKDILM KYDKGHRAGL PEDKGPEPVG INSSIDRFGI     50
    LHETELPPVT AREAKKIRRE MTRTSKWMEM LGEWETYKHS SKLIDRVYKG 100
    IPMNIRGPVW SVLLNIQEIK LKNPGRYQIM KERGKRSSEH IHHIDLDVRT 150
    TLRNHVFFRD RYGAKQRELF YILLAYSEYN PEVGYCRDLS HITALFLLYL 200
    PEEDAFWALV QLLASERHSL PGFHSPNGGT VQGLQDQQEH VVPKSQPKTM 250
    WHQDKEGLCG QCASLGCLLR NLIDGISLGL TLRLWDVYLV EGEQVLMPIT 300
    SIALKVQQKR LMKTSRCGLW ARLRNQFFDT WAMNDDTVLK HLRASTKKLT 350
    RKQGDLPPPA KREQGSLAPR PVPASRGGKT LCKGYRQAPP GPPAQFQRPI 400
    CSASPPWASR FSTPCPGGAV REDTYPVGTQ GVPSLALAQG GPQGSWRFLE 450
    WKSMPRLPTD LDIGGPWFPH YDFEWSCWVR AISQEDQLAT CWQAEHCGEV 500
    HNKDMSWPEE MSFTANSSKI DRQKVPTEKG ATGLSNLGNT CFMNSSIQCV 550
    SNTQPLTQYF ISGRHLYELN RTNPIGMKGH MAKCYGDLVQ ELWSGTQKSV 600
    APLKLRRTIA KYAPKFDGFQ QQDSQELLAF LLDGLHEDLN RVHEKPYVEL 650
    KDSDGRPDWE VAAEAWDNHL RRNRSIIVDL FHGQLRSQVK CKTCGHISVR 700
    FDPFNFLSLP LPMDSYMDLE ITVIKLDGTT PVRYGLRLNM DEKYTGLKKQ 750
    LRDLCGLNSE QILLAEVHDS NIKNFPQDNQ KVQLSVSGFL CAFEIPVPSS 800
    PISASSPTQI DFSSSPSTNG MFTLTTNGDL PKPIFIPNGM PNTVVPCGTE 850
    KNFTNGMVNG HMPSLPDSPF TGYIIAVHRK MMRTELYFLS PQENRPSLFG 900
    MPLIVPCTVH TRKKDLYDAV WIQVSWLARP LPPQEASIHA QDRDNCMGYQ 950
    YPFTLRVVQK DGNSCAWCPQ YRFCRGCKID CGEDRAFIGN AYIAVDWHPT 1000
    ALHLRYQTSQ ERVVDKHESV EQSRRAQAEP INLDSCLRAF TSEEELGESE 1050
    MYYCSKCKTH CLATKKLDLW RLPPFLIIHL KRFQFVNDQW IKSQKIVRFL 1100
    RESFDPSAFL VPRDPALCQH KPLTPQGDEL SKPRILAREV KKVDAQSSAG 1150
    KEDMLLSKSP SSLSANISSS PKGSPSSSRK SGTSCPSSKN SSPNSSPRTL 1200
    GRSKGRLRLP QIGSKNKPSS SKKNLDASKE NGAGQICELA DALSRGHMRG 1250
    GSQPELVTPQ DHEVALANGF LYEHEACGNG CGDGYSNGQL GNHSEEDSTD 1300
    DQREDTHIKP IYNLYAISCH SGILSGGHYI TYAKNPNCKW YCYNDSSCEE 1350
    LHPDEIDTDS AYILFYEQQG IDYAQFLPKI DGKKMADTSS TDEDSESDYE 1400
    KYSMLQ 1406
    Length:1,406
    Mass (Da):158,658
    Last modified:July 19, 2004 - v2
    Checksum:iD3A6822CEB441DB3
    GO
    Isoform 2 (identifier: P35125-2) [UniParc]FASTAAdd to Basket

    Also known as: 213(ORF2)

    The sequence of this isoform differs from the canonical sequence as follows:
         1-317: Missing.
         318-359: GLWARLRNQF...TRKQGDLPPP → MPQRLPHARQ...HRDPKDSRDA

    Show »
    Length:1,089
    Mass (Da):121,943
    Checksum:iA660606208ABD9EB
    GO
    Isoform 3 (identifier: P35125-3) [UniParc]FASTAAdd to Basket

    Also known as: 210(ORF1), oncTre210p

    The sequence of this isoform differs from the canonical sequence as follows:
         774-786: NFPQDNQKVQLSV → ISPLHHLQMECSP
         787-1406: Missing.

    Note: Was shown to be tumorigenic in transfected mice and seems not to act as GTPase activating protein.

    Show »
    Length:786
    Mass (Da):89,577
    Checksum:i6D5D93D2CE65D879
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti963 – 9631N → I in CAA45111. (PubMed:1565468)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti475 – 4751W → R.1 Publication
    Corresponds to variant rs8073787 [ dbSNP | Ensembl ].
    VAR_051522
    Natural varianti525 – 5251V → I.
    Corresponds to variant rs2304449 [ dbSNP | Ensembl ].
    VAR_059749
    Natural varianti912 – 9121R → Q.1 Publication
    Corresponds to variant rs9899177 [ dbSNP | Ensembl ].
    VAR_051523
    Natural varianti1330 – 13301I → V.
    Corresponds to variant rs1053611 [ dbSNP | Ensembl ].
    VAR_051524

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 317317Missing in isoform 2. 1 PublicationVSP_010878Add
    BLAST
    Alternative sequencei318 – 35942GLWAR…DLPPP → MPQRLPHARQHTPLPLGSAD YRRVVSVRPQGPHRDPKDSR DA in isoform 2. 1 PublicationVSP_010879Add
    BLAST
    Alternative sequencei774 – 78613NFPQD…VQLSV → ISPLHHLQMECSP in isoform 3. 1 PublicationVSP_010880Add
    BLAST
    Alternative sequencei787 – 1406620Missing in isoform 3. 1 PublicationVSP_010881Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63546 mRNA. Translation: CAA45108.1.
    X63547 mRNA. Translation: CAA45111.1.
    AY143550 mRNA. Translation: AAN38838.1.
    AY163314 Genomic DNA. Translation: AAO21348.1.
    CCDSiCCDS11069.2. [P35125-1]
    PIRiS57867.
    S57868. S22158.
    S57874. S22155.
    RefSeqiNP_004496.2. NM_004505.2.
    XP_005256902.1. XM_005256845.2.
    UniGeneiHs.448851.

    Genome annotation databases

    EnsembliENST00000250066; ENSP00000250066; ENSG00000129204. [P35125-1]
    ENST00000572949; ENSP00000461581; ENSG00000129204. [P35125-3]
    ENST00000574788; ENSP00000460380; ENSG00000129204. [P35125-1]
    GeneIDi9098.
    KEGGihsa:9098.
    UCSCiuc002gau.1. human. [P35125-1]
    uc010ckz.1. human. [P35125-2]

    Polymorphism databases

    DMDMi50403738.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63546 mRNA. Translation: CAA45108.1 .
    X63547 mRNA. Translation: CAA45111.1 .
    AY143550 mRNA. Translation: AAN38838.1 .
    AY163314 Genomic DNA. Translation: AAO21348.1 .
    CCDSi CCDS11069.2. [P35125-1 ]
    PIRi S57867.
    S57868. S22158.
    S57874. S22155.
    RefSeqi NP_004496.2. NM_004505.2.
    XP_005256902.1. XM_005256845.2.
    UniGenei Hs.448851.

    3D structure databases

    ProteinModelPortali P35125.
    SMRi P35125. Positions 72-341, 528-713, 1031-1110, 1311-1367.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114552. 12 interactions.
    IntActi P35125. 5 interactions.
    MINTi MINT-2865848.
    STRINGi 9606.ENSP00000250066.

    Protein family/group databases

    MEROPSi C19.009.

    PTM databases

    PhosphoSitei P35125.

    Polymorphism databases

    DMDMi 50403738.

    Proteomic databases

    MaxQBi P35125.
    PaxDbi P35125.
    PRIDEi P35125.

    Protocols and materials databases

    DNASUi 9098.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000250066 ; ENSP00000250066 ; ENSG00000129204 . [P35125-1 ]
    ENST00000572949 ; ENSP00000461581 ; ENSG00000129204 . [P35125-3 ]
    ENST00000574788 ; ENSP00000460380 ; ENSG00000129204 . [P35125-1 ]
    GeneIDi 9098.
    KEGGi hsa:9098.
    UCSCi uc002gau.1. human. [P35125-1 ]
    uc010ckz.1. human. [P35125-2 ]

    Organism-specific databases

    CTDi 9098.
    GeneCardsi GC17P005019.
    H-InvDB HIX0202554.
    HGNCi HGNC:12629. USP6.
    HPAi HPA011742.
    MIMi 604334. gene.
    neXtProti NX_P35125.
    PharmGKBi PA37254.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5210.
    HOGENOMi HOG000154762.
    InParanoidi P35125.
    KOi K11837.
    OMAi HDSNIKN.
    OrthoDBi EOG7PP55V.
    PhylomeDBi P35125.
    TreeFami TF324190.

    Miscellaneous databases

    ChiTaRSi USP6. human.
    GeneWikii USP6.
    GenomeRNAii 9098.
    NextBioi 34099.
    PROi P35125.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P35125.
    Bgeei P35125.
    CleanExi HS_USP6.
    Genevestigatori P35125.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000195. Rab-GTPase-TBC_dom.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00566. RabGAP-TBC. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view ]
    SMARTi SM00164. TBC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47923. SSF47923. 2 hits.
    PROSITEi PS50086. TBC_RABGAP. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel transcriptional unit of the tre oncogene widely expressed in human cancer cells."
      Nakamura T., Hillova J., Mariage-Samson R., Onno M., Huebner K., Cannizzaro L.A., Boghosian-Sell L., Croce C.M., Hill M.
      Oncogene 7:733-741(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), TISSUE SPECIFICITY, VARIANTS ARG-475 AND GLN-912.
      Tissue: Ewing sarcoma.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, TISSUE SPECIFICITY, DISCUSSION OF TRE2 EVOLUTION.
    3. "The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene."
      Papa F.R., Hochstrasser M.
      Nature 366:313-319(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    4. "Expression in a RabGAP yeast mutant of two human homologues, one of which is an oncogene."
      Bizimungu C., De Neve N., Burny A., Bach S., Bontemps F., Portetelle D., Vandenbol M.
      Biochem. Biophys. Res. Commun. 310:498-504(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF THR-150 AND ARG-187.
    5. "The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling."
      Masuda-Robens J.M., Kutney S.N., Qi H., Chou M.M.
      Mol. Cell. Biol. 23:2151-2161(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH RAC1 AND CDC42.
    6. Cited for: CHROMOSOMAL TRANSLOCATION WITH CDH11.
    7. "The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6."
      Martinu L., Masuda-Robens J.M., Robertson S.E., Santy L.C., Casanova J.E., Chou M.M.
      Mol. Cell. Biol. 24:9752-9762(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ARF6.
    8. "Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6."
      Shen C., Ye Y., Robertson S.E., Lau A.W., Mak D.O., Chou M.M.
      J. Biol. Chem. 280:35967-35973(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CALMODULIN, UBIQUITINATION, MUTAGENESIS OF CYS-541.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NF-kappaB."
      Ye Y., Pringle L.M., Lau A.W., Riquelme D.N., Wang H., Jiang T., Lev D., Welman A., Blobel G.A., Oliveira A.M., Chou M.M.
      Oncogene 29:3619-3629(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiUBP6_HUMAN
    AccessioniPrimary (citable) accession number: P35125
    Secondary accession number(s): Q15634, Q86WP6, Q8IWT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The USP6 gene only exists in the primate lineage.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3