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Protein

Profilin-2

Gene

PRO2

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.

Miscellaneous

The variability of the residues taking part of IgE-binding epitopes might be responsible of the difference in cross-reactivity among olive pollen cultivars, and between distantly related pollen species, leading to a variable range of allergy reactions among atopic patients.1 Publication

GO - Molecular functioni

  • actin monomer binding Source: AgBase
  • proline-rich region binding Source: AgBase

GO - Biological processi

  • nuclear migration Source: AgBase
  • regulation of actin cytoskeleton organization Source: AgBase

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin-2
Alternative name(s):
Pollen allergen Zea m 12
ZmPRO2
Allergen: Zea m 12
Gene namesi
Name:PRO2
Synonyms:PRF2
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Unplaced

Organism-specific databases

MaizeGDBi78603

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3531 Zea m 12.0102
682 Zea m 12

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001996472 – 131Profilin-2Add BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi13 ↔ 1151 Publication
Modified residuei111PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated by MAP kinases.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP35082

Expressioni

Tissue specificityi

Pollen specific.

Gene expression databases

ExpressionAtlasiP35082 differential

Interactioni

Subunit structurei

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

GO - Molecular functioni

  • actin monomer binding Source: AgBase
  • proline-rich region binding Source: AgBase

Protein-protein interaction databases

STRINGi4577.GRMZM2G109842_P01

Structurei

3D structure databases

ProteinModelPortaliP35082
SMRiP35082
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi81 – 97Involved in PIP2 interactionAdd BLAST17

Sequence similaritiesi

Belongs to the profilin family.Curated

Phylogenomic databases

eggNOGiKOG1755 Eukaryota
ENOG41126PD LUCA
KOiK05759

Family and domain databases

CDDicd00148 PROF, 1 hit
InterProiView protein in InterPro
IPR005455 PFN
IPR036140 PFN_sf
IPR027310 Profilin_CS
PANTHERiPTHR11604 PTHR11604, 1 hit
PfamiView protein in Pfam
PF00235 Profilin, 1 hit
PRINTSiPR00392 PROFILIN
PR01640 PROFILINPLNT
SMARTiView protein in SMART
SM00392 PROF, 1 hit
SUPFAMiSSF55770 SSF55770, 1 hit
PROSITEiView protein in PROSITE
PS00414 PROFILIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35082-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWQAYVDEH LMCEIEGHHL AAAAIVGHDG AAWAQSTAFP EFKTEDMANI
60 70 80 90 100
MKDFDEPGHL APTGLFLGPT KYMVIQGEPG AVIRGKKGSG GITVKKTGQA
110 120 130
LVVGIYDEPM TPGQCNMVVE RLGDYLLEQG M
Length:131
Mass (Da):14,122
Last modified:June 1, 1994 - v2
Checksum:i0A5F8DDA38B3C666
GO

Sequence cautioni

The sequence CAA51719 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Polymorphismi

Several isoforms of the allergen exist due to polymorphism.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73280 mRNA Translation: CAA51719.1 Different initiation.
PIRiS35797
RefSeqiNP_001105451.1, NM_001111981.2
UniGeneiZm.94151

Genome annotation databases

GeneIDi542410
KEGGizma:542410

Similar proteinsi

Entry informationi

Entry nameiPROF2_MAIZE
AccessioniPrimary (citable) accession number: P35082
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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