P35082 (PROF2_MAIZE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Profilin-2

Alternative name(s):
ZmPRO2

Gene names

Name:	PRO2
Synonyms:	PRF2

Organism

Zea mays (Maize)

Taxonomic identifier

4577 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Liliopsida › commelinids › Poales › Poaceae › PACMAD clade › Panicoideae › Andropogoneae › Zea

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Subunit structure	Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.
Subcellular location	Cytoplasm › cytoskeleton.
Tissue specificity	Pollen specific.
Sequence similarities	Belongs to the profilin family.
Sequence caution	The sequence CAA51719.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Ligand	Actin-binding
Gene Ontology (GO)
Biological_process	actin cytoskeleton organization Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: EnsemblPlants/Gramene phragmoplast Inferred from electronic annotation. Source: EnsemblPlants/Gramene
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 131	130	Profilin-2		PRO_0000199647

Sequences

	Sequence		Length	Mass (Da)
	P35082 [UniParc]. Last modified June 1, 1994. Version 2. Checksum: 0A5F8DDA38B3C666	FASTA	131	14,122
	10 20 30 40 50 60 MSWQAYVDEH LMCEIEGHHL AAAAIVGHDG AAWAQSTAFP EFKTEDMANI MKDFDEPGHL 70 80 90 100 110 120 APTGLFLGPT KYMVIQGEPG AVIRGKKGSG GITVKKTGQA LVVGIYDEPM TPGQCNMVVE 130 RLGDYLLEQG M

References

[1]	"The profilin multigene family of maize: differential expression of three isoforms." Staiger C.J., Goodbody K.C., Hussey P.J., Valenta R., Droebak B.K., Lloyd C.W. Plant J. 4:631-641(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. A188. Tissue: Pollen.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X73280 mRNA. Translation: CAA51719.1. Different initiation.
PIR	S35797.
RefSeq	NP_001105451.1. NM_001111981.2.
UniGene	Zm.94151.
3D structure databases
ProteinModelPortal	P35082.
SMR	P35082. Positions 2-131.
ModBase	Search...
Protein family/group databases
Allergome	3531. Zea m 12.0102. 682. Zea m 12.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	542410.
KEGG	zma:542410.
Organism-specific databases
Gramene	P35082.
MaizeGDB	78603.
Phylogenomic databases
KO	K05759.
Family and domain databases
InterPro	IPR027310. Profilin_CS. IPR005455. Profilin_eukaryotes/bac. [Graphical view]
PANTHER	PTHR11604. PTHR11604. 1 hit.
Pfam	PF00235. Profilin. 1 hit. [Graphical view]
PRINTS	PR00392. PROFILIN. PR01640. PROFILINPLNT.
SMART	SM00392. PROF. 1 hit. [Graphical view]
SUPFAM	SSF55770. Profilin. 1 hit.
PROSITE	PS00414. PROFILIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROF2_MAIZE

Accession

Primary (citable) accession number: P35082

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	June 1, 1994
Last modified:	May 1, 2013
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program