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Protein

Profilin-1

Gene

PRO1

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.1 Publication

Miscellaneous

The variability of the residues taking part of IgE-binding epitopes might be responsible of the difference in cross-reactivity among olive pollen cultivars, and between distantly related pollen species, leading to a variable range of allergy reactions among atopic patients.1 Publication

GO - Molecular functioni

  • actin monomer binding Source: AgBase
  • phosphatidylinositol-4,5-bisphosphate binding Source: AgBase
  • proline-rich region binding Source: AgBase

GO - Biological processi

  • nuclear migration Source: AgBase
  • phospholipase C-inhibiting G-protein coupled receptor signaling pathway Source: AgBase
  • regulation of actin cytoskeleton organization Source: AgBase
  • sequestering of actin monomers Source: AgBase

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin-1
Alternative name(s):
Pollen allergen Zea m 12
ZmPRO1
Allergen: Zea m 12
Gene namesi
Name:PRO1
Synonyms:PRF1
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Unplaced

Organism-specific databases

MaizeGDBi51451.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3530. Zea m 12.0101.
682. Zea m 12.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001996462 – 131Profilin-1Add BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi13 ↔ 1151 Publication
Modified residuei111PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated by MAP kinases.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP35081.
PRIDEiP35081.

Expressioni

Tissue specificityi

Pollen specific.

Interactioni

Subunit structurei

Multimer. Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.1 Publication

GO - Molecular functioni

  • actin monomer binding Source: AgBase
  • proline-rich region binding Source: AgBase

Protein-protein interaction databases

STRINGi4577.GRMZM2G074361_P01.

Structurei

3D structure databases

ProteinModelPortaliP35081.
SMRiP35081.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi81 – 97Involved in PIP2 interactionAdd BLAST17

Sequence similaritiesi

Belongs to the profilin family.Curated

Phylogenomic databases

eggNOGiKOG1755. Eukaryota.
ENOG41126PD. LUCA.
HOGENOMiHOG000171591.
KOiK05759.

Family and domain databases

CDDicd00148. PROF. 1 hit.
InterProiView protein in InterPro
IPR005455. PFN.
IPR027310. Profilin_CS.
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiView protein in Pfam
PF00235. Profilin. 1 hit.
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiView protein in SMART
SM00392. PROF. 1 hit.
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiView protein in PROSITE
PS00414. PROFILIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35081-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWQTYVDEH LMCEIEGHHL TSAAIVGHDG ATWAQSTAFP EFKPEEMAAI
60 70 80 90 100
MKDFDEPGHL APTGLILGGT KYMVIQGEPG AVIRGKKGSG GITVKKTGQS
110 120 130
LIIGIYDEPM TPGQCNLVVE RLGDYLLEQG M
Length:131
Mass (Da):14,147
Last modified:February 1, 1994 - v1
Checksum:i3AA320DD721BEBB8
GO

Polymorphismi

Several isoforms of the allergen exist due to polymorphism.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73279 mRNA. Translation: CAA51718.1.
PIRiS35796.
RefSeqiNP_001105450.1. NM_001111980.1.
UniGeneiZm.67167.

Genome annotation databases

GeneIDi542409.
KEGGizma:542409.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPROF1_MAIZE
AccessioniPrimary (citable) accession number: P35081
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 15, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families