P35081 (PROF1_MAIZE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Profilin-1

Alternative name(s):
ZmPRO1

Gene names

Name:	PRO1
Synonyms:	PRF1

Organism

Zea mays (Maize)

Taxonomic identifier

4577 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Liliopsida › commelinids › Poales › Poaceae › PACMAD clade › Panicoideae › Andropogoneae › Zea

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Subunit structure	Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.
Subcellular location	Cytoplasm › cytoskeleton.
Tissue specificity	Pollen specific.
Sequence similarities	Belongs to the profilin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Ligand	Actin-binding
Gene Ontology (GO)
Biological_process	actin cytoskeleton organization Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: EnsemblPlants/Gramene phragmoplast Inferred from electronic annotation. Source: EnsemblPlants/Gramene
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 131	130	Profilin-1		PRO_0000199646

Sequences

	Sequence		Length	Mass (Da)
	P35081 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 3AA320DD721BEBB8	FASTA	131	14,147
	10 20 30 40 50 60 MSWQTYVDEH LMCEIEGHHL TSAAIVGHDG ATWAQSTAFP EFKPEEMAAI MKDFDEPGHL 70 80 90 100 110 120 APTGLILGGT KYMVIQGEPG AVIRGKKGSG GITVKKTGQS LIIGIYDEPM TPGQCNLVVE 130 RLGDYLLEQG M

References

[1]	"The profilin multigene family of maize: differential expression of three isoforms." Staiger C.J., Goodbody K.C., Hussey P.J., Valenta R., Droebak B.K., Lloyd C.W. Plant J. 4:631-641(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. A188. Tissue: Pollen.
[2]	"Maize profilin isoforms are functionally distinct." Kovar D.R., Droebak B.K., Staiger C.J. Plant Cell 12:583-598(2000) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION. Strain: cv. B73.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X73279 mRNA. Translation: CAA51718.1.
PIR	S35796.
RefSeq	NP_001105450.1. NM_001111980.1.
UniGene	Zm.67167.
3D structure databases
ProteinModelPortal	P35081.
SMR	P35081. Positions 2-131.
ModBase	Search...
Protein family/group databases
Allergome	3530. Zea m 12.0101. 682. Zea m 12.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	542409.
KEGG	zma:542409.
Organism-specific databases
Gramene	P35081.
MaizeGDB	51451.
Phylogenomic databases
HOGENOM	HOG000171591.
KO	K05759.
Family and domain databases
InterPro	IPR027310. Profilin_CS. IPR005455. Profilin_eukaryotes/bac. [Graphical view]
PANTHER	PTHR11604. PTHR11604. 1 hit.
Pfam	PF00235. Profilin. 1 hit. [Graphical view]
PRINTS	PR00392. PROFILIN. PR01640. PROFILINPLNT.
SMART	SM00392. PROF. 1 hit. [Graphical view]
SUPFAM	SSF55770. Profilin. 1 hit.
PROSITE	PS00414. PROFILIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROF1_MAIZE

Accession

Primary (citable) accession number: P35081

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program