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Protein

Filamentous hemagglutinin transporter protein FhaC

Gene

fhaC

Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Member of a two partner secretion pathway (TPS) in which it mediates the secretion of filamentous hemagglutinin FHA (fhaB).2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Protein transport, Transport

Protein family/group databases

TCDBi1.B.20.1.6. the two-partner secretion (tps) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Filamentous hemagglutinin transporter protein FhaC
Alternative name(s):
TpsB transporter
Gene namesi
Name:fhaC
Ordered Locus Names:BP1884
OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Taxonomic identifieri257313 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000002676 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei242 – 248Beta stranded1 Publication7
Transmembranei261 – 269Beta stranded1 Publication9
Transmembranei277 – 285Beta stranded1 Publication9
Transmembranei294 – 306Beta stranded1 PublicationAdd BLAST13
Transmembranei309 – 321Beta stranded1 PublicationAdd BLAST13
Transmembranei334 – 349Beta stranded1 PublicationAdd BLAST16
Transmembranei354 – 370Beta stranded1 PublicationAdd BLAST17
Transmembranei378 – 395Beta stranded1 PublicationAdd BLAST18
Transmembranei399 – 409Beta stranded1 PublicationAdd BLAST11
Transmembranei431 – 444Beta stranded1 PublicationAdd BLAST14
Transmembranei449 – 460Beta stranded1 PublicationAdd BLAST12
Transmembranei500 – 510Beta stranded1 PublicationAdd BLAST11
Transmembranei516 – 527Beta stranded1 PublicationAdd BLAST12
Transmembranei537 – 547Beta stranded1 PublicationAdd BLAST11
Transmembranei552 – 562Beta stranded1 PublicationAdd BLAST11
Transmembranei575 – 584Beta stranded1 Publication10

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001866631 – 584Filamentous hemagglutinin transporter protein FhaCAdd BLAST554

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

IntActiP35077. 1 interactor.
MINTiMINT-7996278.
STRINGi257313.BP1884.

Structurei

Secondary structure

1584
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi36 – 61Combined sources26
Beta strandi85 – 87Combined sources3
Beta strandi92 – 97Combined sources6
Helixi99 – 101Combined sources3
Helixi108 – 111Combined sources4
Helixi112 – 114Combined sources3
Beta strandi115 – 117Combined sources3
Helixi121 – 137Combined sources17
Beta strandi144 – 153Combined sources10
Beta strandi156 – 162Combined sources7
Beta strandi165 – 171Combined sources7
Helixi179 – 188Combined sources10
Helixi199 – 209Combined sources11
Beta strandi211 – 222Combined sources12
Beta strandi228 – 237Combined sources10
Beta strandi242 – 248Combined sources7
Beta strandi257 – 269Combined sources13
Beta strandi271 – 275Combined sources5
Beta strandi277 – 289Combined sources13
Turni290 – 292Combined sources3
Beta strandi294 – 306Combined sources13
Beta strandi309 – 323Combined sources15
Beta strandi332 – 350Combined sources19
Beta strandi352 – 375Combined sources24
Beta strandi377 – 396Combined sources20
Beta strandi399 – 409Combined sources11
Beta strandi431 – 447Combined sources17
Beta strandi449 – 460Combined sources12
Helixi467 – 469Combined sources3
Beta strandi470 – 473Combined sources4
Beta strandi478 – 481Combined sources4
Turni484 – 486Combined sources3
Beta strandi488 – 501Combined sources14
Beta strandi504 – 506Combined sources3
Beta strandi513 – 527Combined sources15
Beta strandi530 – 532Combined sources3
Beta strandi535 – 549Combined sources15
Beta strandi552 – 561Combined sources10
Beta strandi575 – 584Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NJTX-ray3.50A34-584[»]
4QKYX-ray2.90A31-584[»]
4QL0X-ray2.50A31-584[»]
ProteinModelPortaliP35077.
SMRiP35077.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35077.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 164POTRAPROSITE-ProRule annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni38 – 58Alpha helix H1, not required for FHA secretion1 PublicationAdd BLAST21
Regioni89 – 164POTRA 1; required for FHA secretion but not channel formationSequence analysis1 PublicationAdd BLAST76
Regioni165 – 238POTRA 2; required for FHA secretion but not channel formationSequence analysis1 PublicationAdd BLAST74
Regioni462 – 504Loop L6, required for FHA secretion and possibly for channel stability1 PublicationAdd BLAST43

Domaini

In the crystal structure alpha helix H1 passes through the middle of the pore with its C-terminus in the periplasm and loop L6 also blocks the channel. Both of the POTRA domains are periplasmic; POTRA stands for polypeptide-transport associated.1 Publication

Sequence similaritiesi

Contains 1 POTRA domain.PROSITE-ProRule annotation
Contains 2 POTRA domains.

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4108YH7. Bacteria.
COG2831. LUCA.
HOGENOMiHOG000112585.
KOiK07326.
OMAiQYSRDPL.

Family and domain databases

InterProiIPR005565. Hemolysn_activator_HlyB.
IPR013686. Polypept-transport_assoc_ShlB.
IPR027282. TPS.
[Graphical view]
PfamiPF08479. POTRA_2. 1 hit.
PF03865. ShlB. 1 hit.
[Graphical view]
PIRSFiPIRSF029745. FhaC. 1 hit.
PROSITEiPS51779. POTRA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35077-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDATNRFRP GLVGRALVRA GLLFAVAACA QAQLLPGARD LNRIDDRQRK
60 70 80 90 100
EQLQRDIERA LTRPPVELNP QSEAAAPARK PDATSGHTVT VHAVDLDFGV
110 120 130 140 150
EGRLFDPAPL VQDYLNRPLD NEQLFLLVKA LSAALYDRGY ATSIVTFVPP
160 170 180 190 200
GVVDGVLKLK VEWGRIKGWL IDGKPLEGTR DRMMVFSAMP GWQDKVLNVF
210 220 230 240 250
DIDQAIYNIN NGGKTGNITI VPADEYGYSY LDLQLQRRAL PRVSLGMDNS
260 270 280 290 300
GPGTPENGRY KYNASVTAND LLGLNDTLGL YIGNRYYRDA GHDAERNYDL
310 320 330 340 350
MYSVPLGRTR LDLQTGYSTY RNLLKTRYGQ YQSAGNSRSF GLKATRLLYR
360 370 380 390 400
DTRSQFSVYG GLKLRQNKNY LAGTRLDVSS KHYSDVTVGM QYSTQRGANA
410 420 430 440 450
YFGDLSFTRG VGVNNGKYAA YDERGPQGNV SRFNGSLAWT RYMALAGQPI
460 470 480 490 500
QWASQLGFQY SRQQLLNSYQ ITVGDEYTVR GYNLRTSQSG DSGVYLSNTL
510 520 530 540 550
TVPVQFSLLG KQASVAPFVG ADVGALKSNH PDARTIRMAG LAAGVRFDLP
560 570 580
YARMSFTYSK PVGAQPGGAP RAPVWLYINA GLSF
Length:584
Mass (Da):64,446
Last modified:February 1, 1994 - v1
Checksum:i8E625B2C07702178
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64876 Genomic DNA. Translation: CAA46092.1.
BX640416 Genomic DNA. Translation: CAE42167.1.
PIRiS41526.
RefSeqiNP_880575.1. NC_002929.2.
WP_010930614.1. NC_002929.2.

Genome annotation databases

EnsemblBacteriaiCAE42167; CAE42167; BP1884.
GeneIDi2667436.
KEGGibpe:BP1884.
PATRICi21157054. VBIBorPer7866_2022.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64876 Genomic DNA. Translation: CAA46092.1.
BX640416 Genomic DNA. Translation: CAE42167.1.
PIRiS41526.
RefSeqiNP_880575.1. NC_002929.2.
WP_010930614.1. NC_002929.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NJTX-ray3.50A34-584[»]
4QKYX-ray2.90A31-584[»]
4QL0X-ray2.50A31-584[»]
ProteinModelPortaliP35077.
SMRiP35077.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP35077. 1 interactor.
MINTiMINT-7996278.
STRINGi257313.BP1884.

Protein family/group databases

TCDBi1.B.20.1.6. the two-partner secretion (tps) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE42167; CAE42167; BP1884.
GeneIDi2667436.
KEGGibpe:BP1884.
PATRICi21157054. VBIBorPer7866_2022.

Phylogenomic databases

eggNOGiENOG4108YH7. Bacteria.
COG2831. LUCA.
HOGENOMiHOG000112585.
KOiK07326.
OMAiQYSRDPL.

Miscellaneous databases

EvolutionaryTraceiP35077.

Family and domain databases

InterProiIPR005565. Hemolysn_activator_HlyB.
IPR013686. Polypept-transport_assoc_ShlB.
IPR027282. TPS.
[Graphical view]
PfamiPF08479. POTRA_2. 1 hit.
PF03865. ShlB. 1 hit.
[Graphical view]
PIRSFiPIRSF029745. FhaC. 1 hit.
PROSITEiPS51779. POTRA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFHAC_BORPE
AccessioniPrimary (citable) accession number: P35077
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.