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Protein

Probetacellulin

Gene

BTC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Mitogen

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174808-MONOMER.
ReactomeiR-HSA-1227986. Signaling by ERBB2.
R-HSA-1236394. Signaling by ERBB4.
R-HSA-1250196. SHC1 events in ERBB2 signaling.
R-HSA-1250342. PI3K events in ERBB4 signaling.
R-HSA-1250347. SHC1 events in ERBB4 signaling.
R-HSA-1251985. Nuclear signaling by ERBB4.
R-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-1963640. GRB2 events in ERBB2 signaling.
R-HSA-1963642. PI3K events in ERBB2 signaling.
R-HSA-2219530. Constitutive Signaling by Aberrant PI3K in Cancer.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-6785631. ERBB2 Regulates Cell Motility.
R-HSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-HSA-8847993. ERBB2 Activates PTK6 Signaling.
R-HSA-8863795. Downregulation of ERBB2 signaling.
SignaLinkiP35070.
SIGNORiP35070.

Names & Taxonomyi

Protein namesi
Recommended name:
Probetacellulin
Cleaved into the following chain:
Betacellulin
Short name:
BTC
Gene namesi
Name:BTC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:1121. BTC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 118ExtracellularSequence analysisAdd BLAST87
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 178CytoplasmicSequence analysisAdd BLAST39

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi685.
OpenTargetsiENSG00000174808.
PharmGKBiPA25442.

Polymorphism and mutation databases

BioMutaiBTC.
DMDMi461653.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31By similarityAdd BLAST31
ChainiPRO_000030068532 – 178ProbetacellulinAdd BLAST147
ChainiPRO_000000749032 – 111BetacellulinAdd BLAST80
PropeptideiPRO_0000007491112 – 178Removed in mature formBy similarityAdd BLAST67

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi69 ↔ 82
Disulfide bondi77 ↔ 93
Disulfide bondi95 ↔ 104

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35070.
PeptideAtlasiP35070.
PRIDEiP35070.

PTM databases

PhosphoSitePlusiP35070.
SwissPalmiP35070.

Expressioni

Tissue specificityi

Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine.1 Publication

Gene expression databases

BgeeiENSG00000174808.
CleanExiHS_BTC.
ExpressionAtlasiP35070. baseline and differential.
GenevisibleiP35070. HS.

Interactioni

Subunit structurei

Monomer. Interacts with EGFR and ERBB4.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GMPPAQ96IJ63EBI-6590057,EBI-750953
KRT31Q153235EBI-6590057,EBI-948001
S100A4P264472EBI-6590057,EBI-717058

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: ProtInc
  • growth factor activity Source: ProtInc

Protein-protein interaction databases

BioGridi107150. 3 interactors.
DIPiDIP-5768N.
IntActiP35070. 6 interactors.
MINTiMINT-7256522.
STRINGi9606.ENSP00000379092.

Structurei

Secondary structure

1178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi66 – 68Combined sources3
Helixi71 – 73Combined sources3
Beta strandi82 – 85Combined sources4
Turni86 – 89Combined sources4
Beta strandi90 – 93Combined sources4
Turni101 – 104Combined sources4
Beta strandi106 – 108Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IOXNMR-A62-111[»]
1IP0NMR-A62-111[»]
ProteinModelPortaliP35070.
SMRiP35070.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35070.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 105EGF-likePROSITE-ProRule annotationAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi146 – 154Arg/Lys-rich (basic)9

Sequence similaritiesi

Contains 1 EGF-like domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWUI. Eukaryota.
ENOG41126JP. LUCA.
GeneTreeiENSGT00730000110951.
HOGENOMiHOG000237352.
HOVERGENiHBG004905.
InParanoidiP35070.
KOiK09783.
OMAiIGARCER.
OrthoDBiEOG091G0RK4.
PhylomeDBiP35070.
TreeFamiTF332938.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR015497. EGF_rcpt_ligand.
[Graphical view]
PANTHERiPTHR10740. PTHR10740. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35070-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRAARCSGA SSLPLLLALA LGLVILHCVV ADGNSTRSPE TNGLLCGDPE
60 70 80 90 100
ENCAATTTQS KRKGHFSRCP KQYKHYCIKG RCRFVVAEQT PSCVCDEGYI
110 120 130 140 150
GARCERVDLF YLRGDRGQIL VICLIAVMVV FIILVIGVCT CCHPLRKRRK
160 170
RKKKEEEMET LGKDITPINE DIEETNIA
Length:178
Mass (Da):19,746
Last modified:February 1, 1994 - v1
Checksum:i27AC77BD92001F0F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0293077C → G.Corresponds to variant rs28549760dbSNPEnsembl.1
Natural variantiVAR_06115144L → F.Corresponds to variant rs56320257dbSNPEnsembl.1
Natural variantiVAR_029308124L → M.1 PublicationCorresponds to variant rs11938093dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S55606 mRNA. Translation: AAB25452.1.
BC011618 mRNA. Translation: AAH11618.1.
CCDSiCCDS3566.1.
PIRiJC1467.
RefSeqiNP_001303892.1. NM_001316963.1.
NP_001720.1. NM_001729.3.
XP_011530513.1. XM_011532211.1.
UniGeneiHs.591704.
Hs.710156.

Genome annotation databases

EnsembliENST00000395743; ENSP00000379092; ENSG00000174808.
GeneIDi685.
KEGGihsa:685.
UCSCiuc003hig.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S55606 mRNA. Translation: AAB25452.1.
BC011618 mRNA. Translation: AAH11618.1.
CCDSiCCDS3566.1.
PIRiJC1467.
RefSeqiNP_001303892.1. NM_001316963.1.
NP_001720.1. NM_001729.3.
XP_011530513.1. XM_011532211.1.
UniGeneiHs.591704.
Hs.710156.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IOXNMR-A62-111[»]
1IP0NMR-A62-111[»]
ProteinModelPortaliP35070.
SMRiP35070.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107150. 3 interactors.
DIPiDIP-5768N.
IntActiP35070. 6 interactors.
MINTiMINT-7256522.
STRINGi9606.ENSP00000379092.

PTM databases

PhosphoSitePlusiP35070.
SwissPalmiP35070.

Polymorphism and mutation databases

BioMutaiBTC.
DMDMi461653.

Proteomic databases

PaxDbiP35070.
PeptideAtlasiP35070.
PRIDEiP35070.

Protocols and materials databases

DNASUi685.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395743; ENSP00000379092; ENSG00000174808.
GeneIDi685.
KEGGihsa:685.
UCSCiuc003hig.3. human.

Organism-specific databases

CTDi685.
DisGeNETi685.
GeneCardsiBTC.
HGNCiHGNC:1121. BTC.
MIMi600345. gene.
neXtProtiNX_P35070.
OpenTargetsiENSG00000174808.
PharmGKBiPA25442.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWUI. Eukaryota.
ENOG41126JP. LUCA.
GeneTreeiENSGT00730000110951.
HOGENOMiHOG000237352.
HOVERGENiHBG004905.
InParanoidiP35070.
KOiK09783.
OMAiIGARCER.
OrthoDBiEOG091G0RK4.
PhylomeDBiP35070.
TreeFamiTF332938.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174808-MONOMER.
ReactomeiR-HSA-1227986. Signaling by ERBB2.
R-HSA-1236394. Signaling by ERBB4.
R-HSA-1250196. SHC1 events in ERBB2 signaling.
R-HSA-1250342. PI3K events in ERBB4 signaling.
R-HSA-1250347. SHC1 events in ERBB4 signaling.
R-HSA-1251985. Nuclear signaling by ERBB4.
R-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-1963640. GRB2 events in ERBB2 signaling.
R-HSA-1963642. PI3K events in ERBB2 signaling.
R-HSA-2219530. Constitutive Signaling by Aberrant PI3K in Cancer.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-6785631. ERBB2 Regulates Cell Motility.
R-HSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-HSA-8847993. ERBB2 Activates PTK6 Signaling.
R-HSA-8863795. Downregulation of ERBB2 signaling.
SignaLinkiP35070.
SIGNORiP35070.

Miscellaneous databases

ChiTaRSiBTC. human.
EvolutionaryTraceiP35070.
GenomeRNAii685.
PROiP35070.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174808.
CleanExiHS_BTC.
ExpressionAtlasiP35070. baseline and differential.
GenevisibleiP35070. HS.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR015497. EGF_rcpt_ligand.
[Graphical view]
PANTHERiPTHR10740. PTHR10740. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBTC_HUMAN
AccessioniPrimary (citable) accession number: P35070
Secondary accession number(s): Q96F48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 30, 2016
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.