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Protein

Probetacellulin

Gene

BTC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Mitogen

Enzyme and pathway databases

ReactomeiR-HSA-1227986 Signaling by ERBB2
R-HSA-1236394 Signaling by ERBB4
R-HSA-1250196 SHC1 events in ERBB2 signaling
R-HSA-1250342 PI3K events in ERBB4 signaling
R-HSA-1250347 SHC1 events in ERBB4 signaling
R-HSA-1251985 Nuclear signaling by ERBB4
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1963640 GRB2 events in ERBB2 signaling
R-HSA-1963642 PI3K events in ERBB2 signaling
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6785631 ERBB2 Regulates Cell Motility
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8847993 ERBB2 Activates PTK6 Signaling
R-HSA-8863795 Downregulation of ERBB2 signaling
SignaLinkiP35070
SIGNORiP35070

Names & Taxonomyi

Protein namesi
Recommended name:
Probetacellulin
Cleaved into the following chain:
Betacellulin
Short name:
BTC
Gene namesi
Name:BTC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000174808.11
HGNCiHGNC:1121 BTC
MIMi600345 gene
neXtProtiNX_P35070

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 118ExtracellularSequence analysisAdd BLAST87
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 178CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi685
OpenTargetsiENSG00000174808
PharmGKBiPA25442

Polymorphism and mutation databases

BioMutaiBTC
DMDMi461653

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31By similarityAdd BLAST31
ChainiPRO_000030068532 – 178ProbetacellulinAdd BLAST147
ChainiPRO_000000749032 – 111BetacellulinAdd BLAST80
PropeptideiPRO_0000007491112 – 178Removed in mature formBy similarityAdd BLAST67

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi69 ↔ 82
Disulfide bondi77 ↔ 93
Disulfide bondi95 ↔ 104

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35070
PeptideAtlasiP35070
PRIDEiP35070
ProteomicsDBi54977

PTM databases

PhosphoSitePlusiP35070
SwissPalmiP35070

Expressioni

Tissue specificityi

Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine.1 Publication

Gene expression databases

BgeeiENSG00000174808
CleanExiHS_BTC
ExpressionAtlasiP35070 baseline and differential
GenevisibleiP35070 HS

Interactioni

Subunit structurei

Monomer. Interacts with EGFR and ERBB4.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107150, 20 interactors
DIPiDIP-5768N
IntActiP35070, 8 interactors
MINTiP35070
STRINGi9606.ENSP00000379092

Structurei

Secondary structure

1178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi66 – 68Combined sources3
Helixi71 – 73Combined sources3
Beta strandi82 – 85Combined sources4
Turni86 – 89Combined sources4
Beta strandi90 – 93Combined sources4
Turni101 – 104Combined sources4
Beta strandi106 – 108Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IOXNMR-A62-111[»]
1IP0NMR-A62-111[»]
ProteinModelPortaliP35070
SMRiP35070
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35070

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 105EGF-likePROSITE-ProRule annotationAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi146 – 154Arg/Lys-rich (basic)9

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWUI Eukaryota
ENOG41126JP LUCA
GeneTreeiENSGT00730000110951
HOGENOMiHOG000237352
HOVERGENiHBG004905
InParanoidiP35070
KOiK09783
OMAiILHCVVA
OrthoDBiEOG091G0RK4
PhylomeDBiP35070
TreeFamiTF332938

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR015497 EGF_rcpt_ligand
PANTHERiPTHR10740 PTHR10740, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35070-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRAARCSGA SSLPLLLALA LGLVILHCVV ADGNSTRSPE TNGLLCGDPE
60 70 80 90 100
ENCAATTTQS KRKGHFSRCP KQYKHYCIKG RCRFVVAEQT PSCVCDEGYI
110 120 130 140 150
GARCERVDLF YLRGDRGQIL VICLIAVMVV FIILVIGVCT CCHPLRKRRK
160 170
RKKKEEEMET LGKDITPINE DIEETNIA
Length:178
Mass (Da):19,746
Last modified:February 1, 1994 - v1
Checksum:i27AC77BD92001F0F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0293077C → G. Corresponds to variant dbSNP:rs28549760Ensembl.1
Natural variantiVAR_06115144L → F. Corresponds to variant dbSNP:rs56320257Ensembl.1
Natural variantiVAR_029308124L → M1 PublicationCorresponds to variant dbSNP:rs11938093Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S55606 mRNA Translation: AAB25452.1
BC011618 mRNA Translation: AAH11618.1
CCDSiCCDS3566.1
PIRiJC1467
RefSeqiNP_001303892.1, NM_001316963.1
NP_001720.1, NM_001729.3
XP_011530513.1, XM_011532211.1
UniGeneiHs.591704
Hs.710156

Genome annotation databases

EnsembliENST00000395743; ENSP00000379092; ENSG00000174808
GeneIDi685
KEGGihsa:685
UCSCiuc003hig.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBTC_HUMAN
AccessioniPrimary (citable) accession number: P35070
Secondary accession number(s): Q96F48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 20, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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