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Protein

Transforming growth factor beta receptor type 3

Gene

TGFBR3

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.

GO - Molecular functioni

  • coreceptor activity Source: BHF-UCL
  • glycosaminoglycan binding Source: BHF-UCL
  • heparin binding Source: BHF-UCL
  • transforming growth factor beta-activated receptor activity Source: BHF-UCL
  • transforming growth factor beta binding Source: BHF-UCL
  • transforming growth factor beta receptor activity, type III Source: BHF-UCL
  • transforming growth factor beta receptor binding Source: BHF-UCL

GO - Biological processi

  • BMP signaling pathway Source: BHF-UCL
  • cell growth Source: BHF-UCL
  • epithelial to mesenchymal transition Source: BHF-UCL
  • immune response Source: BHF-UCL
  • intracellular signal transduction Source: BHF-UCL
  • negative regulation of cellular component movement Source: BHF-UCL
  • response to follicle-stimulating hormone Source: BHF-UCL
  • signal transduction Source: BHF-UCL
  • transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming growth factor beta receptor type 3
Short name:
TGF-beta receptor type 3
Short name:
TGFR-3
Alternative name(s):
Betaglycan
Transforming growth factor beta receptor III
Short name:
TGF-beta receptor type III
Gene namesi
Name:TGFBR3
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 784764ExtracellularSequence analysisAdd
BLAST
Transmembranei785 – 80622HelicalSequence analysisAdd
BLAST
Topological domaini807 – 84842CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • external side of plasma membrane Source: BHF-UCL
  • extracellular matrix Source: BHF-UCL
  • integral component of membrane Source: BHF-UCL
  • intracellular Source: GOC
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 848828Transforming growth factor beta receptor type 3PRO_0000041665Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence analysis
Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence analysis
Glycosylationi491 – 4911N-linked (GlcNAc...)Sequence analysis
Glycosylationi529 – 5291O-linked (Xyl...) (glycosaminoglycan)Sequence analysis
Glycosylationi533 – 5331O-linked (Xyl...) (glycosaminoglycan)By similarity
Glycosylationi544 – 5441O-linked (Xyl...) (glycosaminoglycan)By similarity
Glycosylationi570 – 5701N-linked (GlcNAc...)Sequence analysis
Glycosylationi589 – 5891N-linked (GlcNAc...)Sequence analysis
Disulfide bondi638 ↔ 704By similarity
Disulfide bondi659 ↔ 729By similarity
Glycosylationi696 – 6961N-linked (GlcNAc...)Sequence analysis
Disulfide bondi709 ↔ 722By similarity

Post-translational modificationi

Extensively modified by glycosaminoglycan groups (GAG).

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Interactioni

Subunit structurei

Interacts with TCTEX1D4.By similarity

GO - Molecular functioni

  • transforming growth factor beta binding Source: BHF-UCL
  • transforming growth factor beta receptor binding Source: BHF-UCL

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini454 – 729276ZPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni736 – 75015Interaction with TGF-beta ligandBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 ZP domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000090193.
HOVERGENiHBG057515.
InParanoidiP35054.
KOiK05843.

Family and domain databases

InterProiIPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35054-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLHCVVALF ALISSCLATA GPEPGVQCAL SPVNASHPVQ ALMESFTVLS
60 70 80 90 100
GCASRGTMGR PQEVHVLNLR AADQGPGQRQ SEVTLHLNPI SSVHIHHKPV
110 120 130 140 150
VFLLNSPQPL VWHLKTERLA VGVSRLFLVS EGSVVHFSSG NFSLSAETEE
160 170 180 190 200
RNFPHGNEHL LNWARKEYGA VTSFTELKIA RNIYIKVGED QVFPPTCSIG
210 220 230 240 250
KNFLSLNYLA EYLQPKPAEG CVVSGRPQEK EVHIIELIAP NSNPYSAFQV
260 270 280 290 300
DIIIDIRPSR KDPELVKNLI LILKCKKSVN WVIKSFDVKG NLKVLAPNSI
310 320 330 340 350
GFGRESERSM IMTKSVRDDI PSTQEKLLRW ALDNGYSPVT SYTVAPVANR
360 370 380 390 400
FHLRLENNEE MRDEEVHTIP PELQILLDPG ALPVLDHPPS GEGAARHGGL
410 420 430 440 450
PFPFPYIPRR GRQDGGKDRL PRPKDPVVPS IQLLPGPREP QEAQGSRDVA
460 470 480 490 500
LSVRCDSEKM LVAVEKDSFQ ASGYPGLELT LLDPTCKAKT NGTHFILESP
510 520 530 540 550
LDGCGTRHRR SAPDGVVYYN SIVIQAPPSG DSSGWPDGYE DLESGDNGFP
560 570 580 590 600
GDVDEGDVAL SSRPELVVFN CSLRPARHPS RAQDPPTRNV TFSMDLYTTD
610 620 630 640 650
LFLAPAQGVF SVAENGHVYV EVSVTKADQE LGFAIQTCFI SPYSNPDRMS
660 670 680 690 700
DYTIIENICP KDESVKFYDP KRVHFPIPQA ETDKKRFSFV FKPVFNTSLL
710 720 730 740 750
FLQCELTLCT KREKEPQKLP KCVLPDEACT SLDASMIWAM MQNKKTFTKP
760 770 780 790 800
LAVIHHEVQF KGPSTKESNP ISPPIFHGLD TLTVMGIAFA AFVIGALLTG
810 820 830 840
ALWYIYSHTG DSAGRQPVPT SPPASENSSA AHSLGSTQST PCSSSSAA
Length:848
Mass (Da):93,005
Last modified:February 1, 1994 - v1
Checksum:i0DD18A78299FE5DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07595 mRNA. Translation: AAA31126.1.
PIRiJC1351.
RefSeqiNP_999437.1. NM_214272.1.
UniGeneiSsc.4253.

Genome annotation databases

GeneIDi397512.
KEGGissc:397512.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07595 mRNA. Translation: AAA31126.1.
PIRiJC1351.
RefSeqiNP_999437.1. NM_214272.1.
UniGeneiSsc.4253.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397512.
KEGGissc:397512.

Organism-specific databases

CTDi7049.

Phylogenomic databases

HOGENOMiHOG000090193.
HOVERGENiHBG057515.
InParanoidiP35054.
KOiK05843.

Family and domain databases

InterProiIPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and characterization of the human and porcine transforming growth factor-beta type III receptors."
    Moren A., Ichijo H., Miyazono K.
    Biochem. Biophys. Res. Commun. 189:356-362(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Uterus.

Entry informationi

Entry nameiTGBR3_PIG
AccessioniPrimary (citable) accession number: P35054
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 6, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.