Reviewed, UniProtKB/Swiss-Prot P35051 (TRYP_PROAT)

Names and origin

Protein names	Recommended name:     Trypsin     EC=3.4.21.4
Organism	Protopterus aethiopicus (Marbled lungfish)
Taxonomic identifier	7886 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Dipnoi › Lepidosireniformes › Protopteridae › Protopterus

Protein attributes

Sequence length	21 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
Subcellular location	Secreted › extracellular space.
Sequence similarities	Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Hydrolase Protease Serine protease
PTM	Zymogen
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	serine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 7	7	Activation peptide		PRO_0000028313
	Chain	8 – ›21	›14	Trypsin		PRO_0000028314
Regions
	Domain	8 – ›21	›14	Peptidase S1
Experimental info
	Non-terminal residue	21	1

Sequences

	Sequence		Length	Mass (Da)
	P35051-1 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 88E2FB11D130729D	FASTA	21	2,455
	10 20 FPIEEDKIVG GYECPKHXVP W

References

[1]	"Comparison of the amino terminal sequences of bovine, dogfish, and lungfish trypsinogens." Hermodson M.A., Tye R.W., Reeck G.R., Neurath H., Walsh K.A. FEBS Lett. 14:222-224(1971) [PubMed: 11945763] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Pancreas.

Cross-references

Sequence databases
PIR	A27719.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	S01.125.
Phylogenomic databases
HOVERGEN	P35051.
Enzyme and pathway databases
BRENDA	3.4.21.4. 39285.
Family and domain databases
InterPro	IPR018114. Peptidase_S1/S6_AS. [Graphical view]
PROSITE	PS50240. TRYPSIN_DOM. Partial match. PS00134. TRYPSIN_HIS. Partial match. PS00135. TRYPSIN_SER. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRYP_PROAT

Accession

Primary (citable) accession number: P35051

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	June 16, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)