Reviewed, UniProtKB/Swiss-Prot P35050 (TRYP_PENMO)

Names and origin

Protein names	Recommended name:     Trypsin     EC=3.4.21.4
Organism	Penaeus monodon (Giant tiger prawn)
Taxonomic identifier	6687 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Crustacea › Malacostraca › Eumalacostraca › Eucarida › Decapoda › Dendrobranchiata › Penaeoidea › Penaeidae › Penaeus

Protein attributes

Sequence length	32 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	High efficiency toward native protein substrates including collagens.
Catalytic activity	Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
Subcellular location	Secreted › extracellular space.
Sequence similarities	Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Hydrolase Protease Serine protease
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›32	›32	Trypsin		PRO_0000088719
Regions
	Domain	1 – ›32	›32	Peptidase S1
Experimental info
	Non-terminal residue	32	1

Sequences

	Sequence		Length	Mass (Da)
	P35050-1 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 96A3A5D1F4B19182	FASTA	32	3,330
	10 20 30 IVGGTAVTPG EFPYQLSFQD SIEGVESHFC GG

References

[1]	"The midgut trypsins of shrimp (Penaeus monodon). High efficiency toward native protein substrates including collagens." Lu P.J., Liu H.C., Tsai I.H. Biol. Chem. Hoppe-Seyler 371:851-859(1990) [PubMed: 1963309] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Midgut.

Cross-references

Sequence databases
PIR	S11537.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	S01.111.
Enzyme and pathway databases
BRENDA	3.4.21.4. 1151.
Family and domain databases
InterPro	IPR018114. Peptidase_S1/S6_AS. IPR001254. Peptidase_S1_S6. [Graphical view]
Pfam	PF00089. Trypsin. 1 hit. [Graphical view]
PROSITE	PS50240. TRYPSIN_DOM. Partial match. PS00134. TRYPSIN_HIS. Partial match. PS00135. TRYPSIN_SER. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRYP_PENMO

Accession

Primary (citable) accession number: P35050

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	July 7, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)