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Protein

Trypsin

Gene
N/A
Organism
Fusarium oxysporum (Fusarium vascular wilt)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Charge relay system1
Active sitei108Charge relay system1
Sitei198Required for specificity1
Active sitei204Charge relay system1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.4. 2351.

Protein family/group databases

MEROPSiS01.103.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin (EC:3.4.21.4)
OrganismiFusarium oxysporum (Fusarium vascular wilt)
Taxonomic identifieri5507 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium oxysporum species complex

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000002830118 – 24Activation peptide7
ChainiPRO_000002830225 – 248TrypsinAdd BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 66
Disulfide bondi174 ↔ 189
Disulfide bondi200 ↔ 225

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

Secondary structure

1248
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi39 – 44Combined sources6
Beta strandi47 – 56Combined sources10
Beta strandi59 – 62Combined sources4
Helixi64 – 67Combined sources4
Helixi72 – 74Combined sources3
Beta strandi75 – 80Combined sources6
Beta strandi82 – 91Combined sources10
Beta strandi93 – 98Combined sources6
Beta strandi110 – 116Combined sources7
Beta strandi141 – 147Combined sources7
Beta strandi162 – 169Combined sources8
Helixi171 – 178Combined sources8
Turni180 – 182Combined sources3
Beta strandi187 – 190Combined sources4
Beta strandi207 – 209Combined sources3
Beta strandi215 – 221Combined sources7
Beta strandi223 – 226Combined sources4
Beta strandi232 – 236Combined sources5
Turni237 – 239Combined sources3
Helixi241 – 247Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FN8X-ray0.81A25-248[»]
1FY4X-ray0.81A25-248[»]
1FY5X-ray0.81A25-248[»]
1GDNX-ray0.81A25-248[»]
1GDQX-ray0.93A25-248[»]
1GDUX-ray1.07A25-248[»]
1PPZX-ray1.23A25-248[»]
1PQ5X-ray0.85A25-248[»]
1PQ7X-ray0.80A25-248[»]
1PQ8X-ray1.00A25-248[»]
1PQAX-ray1.23A25-248[»]
1TRYX-ray1.55A25-248[»]
1XVMX-ray1.10A25-248[»]
1XVOX-ray0.84A25-248[»]
2G51X-ray1.84A25-248[»]
2G52X-ray1.84A25-248[»]
2VU8X-ray1.80E25-248[»]
ProteinModelPortaliP35049.
SMRiP35049.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35049.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 248Peptidase S1PROSITE-ProRule annotationAdd BLAST224

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35049-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKFASVVAL VAPLAAAAPQ EIPNIVGGTS ASAGDFPFIV SISRNGGPWC
60 70 80 90 100
GGSLLNANTV LTAAHCVSGY AQSGFQIRAG SLSRTSGGIT SSLSSVRVHP
110 120 130 140 150
SYSGNNNDLA ILKLSTSIPS GGNIGYARLA ASGSDPVAGS SATVAGWGAT
160 170 180 190 200
SEGGSSTPVN LLKVTVPIVS RATCRAQYGT SAITNQMFCA GVSSGGKDSC
210 220 230 240
QGDSGGPIVD SSNTLIGAVS WGNGCARPNY SGVYASVGAL RSFIDTYA
Length:248
Mass (Da):24,576
Last modified:February 1, 1994 - v1
Checksum:i1A0EBA88C3E70294
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S63827 mRNA. Translation: AAB27568.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S63827 mRNA. Translation: AAB27568.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FN8X-ray0.81A25-248[»]
1FY4X-ray0.81A25-248[»]
1FY5X-ray0.81A25-248[»]
1GDNX-ray0.81A25-248[»]
1GDQX-ray0.93A25-248[»]
1GDUX-ray1.07A25-248[»]
1PPZX-ray1.23A25-248[»]
1PQ5X-ray0.85A25-248[»]
1PQ7X-ray0.80A25-248[»]
1PQ8X-ray1.00A25-248[»]
1PQAX-ray1.23A25-248[»]
1TRYX-ray1.55A25-248[»]
1XVMX-ray1.10A25-248[»]
1XVOX-ray0.84A25-248[»]
2G51X-ray1.84A25-248[»]
2G52X-ray1.84A25-248[»]
2VU8X-ray1.80E25-248[»]
ProteinModelPortaliP35049.
SMRiP35049.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS01.103.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.

Enzyme and pathway databases

BRENDAi3.4.21.4. 2351.

Miscellaneous databases

EvolutionaryTraceiP35049.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRYP_FUSOX
AccessioniPrimary (citable) accession number: P35049
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.