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P35044

- TRYA4_LUCCU

UniProt

P35044 - TRYA4_LUCCU

Protein

Trypsin alpha-4

Gene
N/A
Organism
Lucilia cuprina (Green bottle fly) (Australian sheep blowfly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    • Comment

    Functioni

    Catalytic activityi

    Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei71 – 711Charge relay systemBy similarity
    Active sitei116 – 1161Charge relay systemBy similarity
    Sitei203 – 2031Required for specificityBy similarity
    Active sitei209 – 2091Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.110.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trypsin alpha-4 (EC:3.4.21.4)
    OrganismiLucilia cuprina (Green bottle fly) (Australian sheep blowfly)
    Taxonomic identifieri7375 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaOestroideaCalliphoridaeLuciliinaeLucilia

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Propeptidei17 – 3014Activation peptidePRO_0000028289Add
    BLAST
    Chaini31 – 255225Trypsin alpha-4PRO_0000028290Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi56 ↔ 72PROSITE-ProRule annotation
    Disulfide bondi179 ↔ 196PROSITE-ProRule annotation
    Disulfide bondi205 ↔ 229PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Zymogen

    Structurei

    3D structure databases

    ProteinModelPortaliP35044.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 253223Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P35044-1 [UniParc]FASTAAdd to Basket

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    MLKFVVLLCA ISCALGAAVP EGMVPQLDGR IVGGVATTIS SFPWQISLQR    50
    SGSHSCGGSV YNSRIIVTAA HCLQSVSTSV LKVRRGSSYW NSGGVVVSVA 100
    AFKNHEGYNP KTMVNDIAVI RLSSSLTMSS TIKAIALTTA APANGAAATV 150
    SGWGTTSSGG SIPAQLRYVD LKIVGRTQCA SSTYGYGSQI KPSMICAYTV 200
    GKDSCQGDSG GPLVSGGRLV GVVSWGYGCA FANYPGVYAD VAALRTWVVS 250
    AASSV 255
    Length:255
    Mass (Da):26,119
    Last modified:February 1, 1994 - v1
    Checksum:i5756AEDA78A3ED46
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L15632 Genomic DNA. Translation: AAA65932.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L15632 Genomic DNA. Translation: AAA65932.1 .

    3D structure databases

    ProteinModelPortali P35044.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S01.110.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a trypsin-like serine protease gene family from the sheep blowfly Lucilia cuprina."
      Casu R.E., Jarmey J.M., Elvin C.M., Eisemann C.H.
      Insect Mol. Biol. 3:159-170(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiTRYA4_LUCCU
    AccessioniPrimary (citable) accession number: P35044
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3