SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P35044

- TRYA4_LUCCU

UniProt

P35044 - TRYA4_LUCCU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Trypsin alpha-4
Gene
N/A
Organism
Lucilia cuprina (Green bottle fly) (Australian sheep blowfly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei71 – 711Charge relay system By similarity
Active sitei116 – 1161Charge relay system By similarity
Sitei203 – 2031Required for specificity By similarity
Active sitei209 – 2091Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.110.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin alpha-4 (EC:3.4.21.4)
OrganismiLucilia cuprina (Green bottle fly) (Australian sheep blowfly)
Taxonomic identifieri7375 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaOestroideaCalliphoridaeLuciliinaeLucilia

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed prediction
Add
BLAST
Propeptidei17 – 3014Activation peptide
PRO_0000028289Add
BLAST
Chaini31 – 255225Trypsin alpha-4
PRO_0000028290Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 72 By similarity
Disulfide bondi179 ↔ 196 By similarity
Disulfide bondi205 ↔ 229 By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

ProteinModelPortaliP35044.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 253223Peptidase S1
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35044-1 [UniParc]FASTAAdd to Basket

« Hide

MLKFVVLLCA ISCALGAAVP EGMVPQLDGR IVGGVATTIS SFPWQISLQR    50
SGSHSCGGSV YNSRIIVTAA HCLQSVSTSV LKVRRGSSYW NSGGVVVSVA 100
AFKNHEGYNP KTMVNDIAVI RLSSSLTMSS TIKAIALTTA APANGAAATV 150
SGWGTTSSGG SIPAQLRYVD LKIVGRTQCA SSTYGYGSQI KPSMICAYTV 200
GKDSCQGDSG GPLVSGGRLV GVVSWGYGCA FANYPGVYAD VAALRTWVVS 250
AASSV 255
Length:255
Mass (Da):26,119
Last modified:February 1, 1994 - v1
Checksum:i5756AEDA78A3ED46
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L15632 Genomic DNA. Translation: AAA65932.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L15632 Genomic DNA. Translation: AAA65932.1 .

3D structure databases

ProteinModelPortali P35044.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.110.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of a trypsin-like serine protease gene family from the sheep blowfly Lucilia cuprina."
    Casu R.E., Jarmey J.M., Elvin C.M., Eisemann C.H.
    Insect Mol. Biol. 3:159-170(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiTRYA4_LUCCU
AccessioniPrimary (citable) accession number: P35044
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi