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P35044 (TRYA4_LUCCU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length255 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Subcellular location

Secretedextracellular space.

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Zymogen
Gene Ontology (GO)
   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Propeptide17 – 3014Activation peptide
PRO_0000028289
Chain31 – 255225Trypsin alpha-4
PRO_0000028290

Regions

Domain31 – 253223Peptidase S1

Sites

Active site711Charge relay system By similarity
Active site1161Charge relay system By similarity
Active site2091Charge relay system By similarity
Site2031Required for specificity By similarity

Amino acid modifications

Disulfide bond56 ↔ 72 By similarity
Disulfide bond179 ↔ 196 By similarity
Disulfide bond205 ↔ 229 By similarity

Sequences

Sequence LengthMass (Da)Tools
P35044 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 5756AEDA78A3ED46

FASTA25526,119
        10         20         30         40         50         60 
MLKFVVLLCA ISCALGAAVP EGMVPQLDGR IVGGVATTIS SFPWQISLQR SGSHSCGGSV 

        70         80         90        100        110        120 
YNSRIIVTAA HCLQSVSTSV LKVRRGSSYW NSGGVVVSVA AFKNHEGYNP KTMVNDIAVI 

       130        140        150        160        170        180 
RLSSSLTMSS TIKAIALTTA APANGAAATV SGWGTTSSGG SIPAQLRYVD LKIVGRTQCA 

       190        200        210        220        230        240 
SSTYGYGSQI KPSMICAYTV GKDSCQGDSG GPLVSGGRLV GVVSWGYGCA FANYPGVYAD 

       250 
VAALRTWVVS AASSV 

« Hide

References

[1]"Isolation of a trypsin-like serine protease gene family from the sheep blowfly Lucilia cuprina."
Casu R.E., Jarmey J.M., Elvin C.M., Eisemann C.H.
Insect Mol. Biol. 3:159-170(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L15632 Genomic DNA. Translation: AAA65932.1.

3D structure databases

ProteinModelPortalP35044.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS01.110.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRYA4_LUCCU
AccessionPrimary (citable) accession number: P35044
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries