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P35043

- TRYA3_LUCCU

UniProt

P35043 - TRYA3_LUCCU

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Protein

Trypsin alpha-3

Gene
N/A
Organism
Lucilia cuprina (Green bottle fly) (Australian sheep blowfly)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei26 – 261Charge relay systemBy similarity
Sitei113 – 1131Required for specificityBy similarity
Active sitei119 – 1191Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.112.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin alpha-3 (EC:3.4.21.4)
OrganismiLucilia cuprina (Green bottle fly) (Australian sheep blowfly)
Taxonomic identifieri7375 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaOestroideaCalliphoridaeLuciliinaeLucilia

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 165›165Trypsin alpha-3PRO_0000088717Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi89 ↔ 106PROSITE-ProRule annotation
Disulfide bondi115 ↔ 139PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP35043.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini‹1 – 163›163Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P35043-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
NSGGVLVSVA AFKNHEGYNS KTMVNDIAVI RLSSSLTTSS TIKTIGLATA
60 70 80 90 100
APANGAAATV SGWGTTSSGG SIPSQLRYVD VKIVGRTQCA SSTYGYGSEI
110 120 130 140 150
KASMICAYTV GKDSCQGDSG GPLVSGGRLV GVVSWGYGCA AVNYPGVYAD
160
VAALRSWVVS AANSV
Length:165
Mass (Da):16,570
Last modified:February 1, 1994 - v1
Checksum:i26160B1AFF80F1CD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15632 Genomic DNA. Translation: AAA65931.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15632 Genomic DNA. Translation: AAA65931.1 .

3D structure databases

ProteinModelPortali P35043.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.112.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of a trypsin-like serine protease gene family from the sheep blowfly Lucilia cuprina."
    Casu R.E., Jarmey J.M., Elvin C.M., Eisemann C.H.
    Insect Mol. Biol. 3:159-170(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiTRYA3_LUCCU
AccessioniPrimary (citable) accession number: P35043
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3