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P35034 (TRYP_PLEPL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Subcellular location

Secretedextracellular space.

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Zymogen
Gene Ontology (GO)
   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Propeptide16 – 227Activation peptide
PRO_0000028237
Chain23 – 250228Trypsin
PRO_0000028238

Regions

Domain23 – 247225Peptidase S1

Sites

Active site621Charge relay system By similarity
Active site1061Charge relay system By similarity
Active site2031Charge relay system By similarity
Site1971Required for specificity By similarity

Amino acid modifications

Disulfide bond29 ↔ 163 By similarity
Disulfide bond47 ↔ 63 By similarity
Disulfide bond133 ↔ 236 By similarity
Disulfide bond140 ↔ 209 By similarity
Disulfide bond174 ↔ 188 By similarity
Disulfide bond199 ↔ 223 By similarity

Sequences

Sequence LengthMass (Da)Tools
P35034 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 637DE96185C1ABAA

FASTA25027,528
        10         20         30         40         50         60 
MRLLALLLMV GAAVAVPRED GRIIGGHECA AHSRPFMASL NYGYHFCGGV LINNQWVLSV 

        70         80         90        100        110        120 
AHCWYNPYAM QVMLGEHDLR KFEGTEQLMK TDTIIWHPNY DYQTLDLTSC SSSSTILWKV 

       130        140        150        160        170        180 
THAVAPIPLP TSCPVAGTPC SVSGWGNTAR DGDEVYLPTL LQCMDVPIVD EEQCMKSYPD 

       190        200        210        220        230        240 
MISPRMVCAG FMDGSRDACN GDSGSPLVCR GEVYGLVSWG QGCAQPNYPG VYVKLCEFLG 

       250 
WIERTLEAYP 

« Hide

References

[1]Leaver M.J., George S.G.
Submitted (NOV-1990) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X56744 mRNA. Translation: CAA40068.1.
PIRS31384.

3D structure databases

ProteinModelPortalP35034.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS01.124.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG013304.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRYP_PLEPL
AccessionPrimary (citable) accession number: P35034
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries