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P35034

- TRYP_PLEPL

UniProt

P35034 - TRYP_PLEPL

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Protein

Trypsin

Gene
N/A
Organism
Pleuronectes platessa (European plaice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei62 – 621Charge relay systemBy similarity
Active sitei106 – 1061Charge relay systemBy similarity
Sitei197 – 1971Required for specificityBy similarity
Active sitei203 – 2031Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.124.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin (EC:3.4.21.4)
OrganismiPleuronectes platessa (European plaice)
Taxonomic identifieri8262 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataCarangariaPleuronectiformesPleuronectoideiPleuronectidaePleuronectes

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence AnalysisAdd
BLAST
Propeptidei16 – 227Activation peptidePRO_0000028237
Chaini23 – 250228TrypsinPRO_0000028238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 163PROSITE-ProRule annotation
Disulfide bondi47 ↔ 63PROSITE-ProRule annotation
Disulfide bondi133 ↔ 236PROSITE-ProRule annotation
Disulfide bondi140 ↔ 209PROSITE-ProRule annotation
Disulfide bondi174 ↔ 188PROSITE-ProRule annotation
Disulfide bondi199 ↔ 223PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

ProteinModelPortaliP35034.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 247225Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG013304.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35034-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLLALLLMV GAAVAVPRED GRIIGGHECA AHSRPFMASL NYGYHFCGGV
60 70 80 90 100
LINNQWVLSV AHCWYNPYAM QVMLGEHDLR KFEGTEQLMK TDTIIWHPNY
110 120 130 140 150
DYQTLDLTSC SSSSTILWKV THAVAPIPLP TSCPVAGTPC SVSGWGNTAR
160 170 180 190 200
DGDEVYLPTL LQCMDVPIVD EEQCMKSYPD MISPRMVCAG FMDGSRDACN
210 220 230 240 250
GDSGSPLVCR GEVYGLVSWG QGCAQPNYPG VYVKLCEFLG WIERTLEAYP
Length:250
Mass (Da):27,528
Last modified:February 1, 1994 - v1
Checksum:i637DE96185C1ABAA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56744 mRNA. Translation: CAA40068.1.
PIRiS31384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56744 mRNA. Translation: CAA40068.1 .
PIRi S31384.

3D structure databases

ProteinModelPortali P35034.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.124.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG013304.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Leaver M.J., George S.G.
    Submitted (NOV-1990) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiTRYP_PLEPL
AccessioniPrimary (citable) accession number: P35034
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3