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P35033

- TRY3_SALSA

UniProt

P35033 - TRY3_SALSA

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Protein
Trypsin-3
Gene
N/A
Organism
Salmo salar (Atlantic salmon)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Cofactori

Binds 1 calcium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei55 – 551Charge relay system By similarity
Metal bindingi67 – 671Calcium By similarity
Metal bindingi69 – 691Calcium; via carbonyl oxygen By similarity
Metal bindingi72 – 721Calcium; via carbonyl oxygen
Metal bindingi77 – 771Calcium By similarity
Active sitei99 – 991Charge relay system By similarity
Sitei186 – 1861Required for specificity By similarity
Active sitei192 – 1921Charge relay system By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. digestion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Digestion

Keywords - Ligandi

Calcium, Metal-binding

Protein family/group databases

MEROPSiS01.126.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin-3 (EC:3.4.21.4)
Alternative name(s):
Trypsin III
OrganismiSalmo salar (Atlantic salmon)
Taxonomic identifieri8030 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei‹1 – 7›7 Reviewed prediction
Propeptidei8 – 158Activation peptide
PRO_0000028229
Chaini16 – 238223Trypsin-3
PRO_0000028230Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi22 ↔ 152
Disulfide bondi40 ↔ 56
Disulfide bondi124 ↔ 225
Disulfide bondi131 ↔ 198
Disulfide bondi163 ↔ 177
Disulfide bondi188 ↔ 212

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni26 – 294
Beta strandi30 – 356
Beta strandi38 – 5215
Helixi54 – 563
Beta strandi62 – 665
Beta strandi68 – 725
Beta strandi78 – 8710
Turni93 – 964
Beta strandi101 – 1077
Beta strandi130 – 1378
Beta strandi141 – 1433
Beta strandi151 – 1577
Helixi160 – 1667
Turni168 – 1703
Beta strandi175 – 1795
Beta strandi195 – 1984
Beta strandi201 – 2088
Beta strandi210 – 2134
Beta strandi219 – 2235
Helixi224 – 2274
Helixi228 – 23710

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A0JX-ray1.70A/B/C/D16-238[»]
ProteinModelPortaliP35033.
SMRiP35033. Positions 16-238.

Miscellaneous databases

EvolutionaryTraceiP35033.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 236221Peptidase S1
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG013304.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35033-1 [UniParc]FASTAAdd to Basket

« Hide

FAVAFAAPID DEDDKIVGGY ECRKNSASYQ ASLQSGYHFC GGSLISSTWV    50
VSAAHCYKSR IQVRLGEHNI AVNEGTEQFI DSVKVIMHPS YNSRNLDNDI 100
MLIKLSKPAS LNSYVSTVAL PSSCASSGTR CLVSGWGNLS GSSSNYPDTL 150
RCLDLPILSS SSCNSAYPGQ ITSNMFCAGF MEGGKDSCQG DSGGPVVCNG 200
QLQGVVSWGY GCAQRNKPGV YTKVCNYRSW ISSTMSSN 238
Length:238
Mass (Da):25,389
Last modified:February 1, 1994 - v1
Checksum:iAE799B80E8393023
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70074 mRNA. Translation: CAA49679.1.
PIRiS66657. S31779.
UniGeneiSsa.23520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70074 mRNA. Translation: CAA49679.1 .
PIRi S66657. S31779.
UniGenei Ssa.23520.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1A0J X-ray 1.70 A/B/C/D 16-238 [» ]
ProteinModelPortali P35033.
SMRi P35033. Positions 16-238.
ModBasei Search...

Protein family/group databases

MEROPSi S01.126.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG013304.

Miscellaneous databases

EvolutionaryTracei P35033.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of anionic and cationic variants of trypsin from Atlantic salmon."
    Male R., Lorens J.B., Smals A.O., Torrissen K.R.
    Eur. J. Biochem. 232:677-685(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreas.

Entry informationi

Entry nameiTRY3_SALSA
AccessioniPrimary (citable) accession number: P35033
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 11, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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