SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P35032

- TRY2_SALSA

UniProt

P35032 - TRY2_SALSA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Trypsin-2
Gene
N/A
Organism
Salmo salar (Atlantic salmon)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Cofactori

Binds 1 calcium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei49 – 491Charge relay system By similarity
Metal bindingi61 – 611Calcium By similarity
Metal bindingi63 – 631Calcium; via carbonyl oxygen By similarity
Metal bindingi66 – 661Calcium; via carbonyl oxygen By similarity
Metal bindingi71 – 711Calcium By similarity
Active sitei93 – 931Charge relay system By similarity
Sitei179 – 1791Required for specificity By similarity
Active sitei185 – 1851Charge relay system By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. digestion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Digestion

Keywords - Ligandi

Calcium, Metal-binding

Protein family/group databases

MEROPSiS01.125.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin-2 (EC:3.4.21.4)
Alternative name(s):
Trypsin II
OrganismiSalmo salar (Atlantic salmon)
Taxonomic identifieri8030 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei‹1 – 4›4 Reviewed prediction
Propeptidei5 – 95Activation peptide
PRO_0000028227
Chaini10 – 231222Trypsin-2
PRO_0000028228Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi16 ↔ 145 By similarity
Disulfide bondi34 ↔ 50 By similarity
Disulfide bondi118 ↔ 218 By similarity
Disulfide bondi125 ↔ 191 By similarity
Disulfide bondi156 ↔ 170 By similarity
Disulfide bondi181 ↔ 205 By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

ProteinModelPortaliP35032.
SMRiP35032. Positions 10-231.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 229220Peptidase S1
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG013304.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35032-1 [UniParc]FASTAAdd to Basket

« Hide

AAFATEDDKI VGGYECKAYS QPHQVSLNSG YHFCGGSLVN ENWVVSAAHC    50
YQSRVEVRLG EHNIQVTEGS EQFISSSRVI RHPNYSSYNI DNDIMLIKLS 100
KPATLNTYVQ PVALPTSCAP AGTMCTVSGW GNTMSSTADK NKLQCLNIPI 150
LSYSDCNNSY PGMITNAMFC AGYLEGGKDS CQGDSGGPVV CNGELQGVVS 200
WGYGCAEPGN PGVYAKVCIF NDWLTSTMAT Y 231
Length:231
Mass (Da):24,823
Last modified:February 1, 1994 - v1
Checksum:iC54A1CAFE74FAE18
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70073 mRNA. Translation: CAA49678.1.
PIRiS66658. S31778.
UniGeneiSsa.19782.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70073 mRNA. Translation: CAA49678.1 .
PIRi S66658. S31778.
UniGenei Ssa.19782.

3D structure databases

ProteinModelPortali P35032.
SMRi P35032. Positions 10-231.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.125.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG013304.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of anionic and cationic variants of trypsin from Atlantic salmon."
    Male R., Lorens J.B., Smals A.O., Torrissen K.R.
    Eur. J. Biochem. 232:677-685(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreas.

Entry informationi

Entry nameiTRY2_SALSA
AccessioniPrimary (citable) accession number: P35032
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 11, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi