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P35032

- TRY2_SALSA

UniProt

P35032 - TRY2_SALSA

Protein

Trypsin-2

Gene
N/A
Organism
Salmo salar (Atlantic salmon)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei49 – 491Charge relay systemBy similarity
    Metal bindingi61 – 611CalciumBy similarity
    Metal bindingi63 – 631Calcium; via carbonyl oxygenBy similarity
    Metal bindingi66 – 661Calcium; via carbonyl oxygenBy similarity
    Metal bindingi71 – 711CalciumBy similarity
    Active sitei93 – 931Charge relay systemBy similarity
    Sitei179 – 1791Required for specificityBy similarity
    Active sitei185 – 1851Charge relay systemBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. digestion Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Digestion

    Keywords - Ligandi

    Calcium, Metal-binding

    Protein family/group databases

    MEROPSiS01.125.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trypsin-2 (EC:3.4.21.4)
    Alternative name(s):
    Trypsin II
    OrganismiSalmo salar (Atlantic salmon)
    Taxonomic identifieri8030 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei‹1 – 4›4Sequence Analysis
    Propeptidei5 – 95Activation peptidePRO_0000028227
    Chaini10 – 231222Trypsin-2PRO_0000028228Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi16 ↔ 145PROSITE-ProRule annotation
    Disulfide bondi34 ↔ 50PROSITE-ProRule annotation
    Disulfide bondi118 ↔ 218PROSITE-ProRule annotation
    Disulfide bondi125 ↔ 191PROSITE-ProRule annotation
    Disulfide bondi156 ↔ 170PROSITE-ProRule annotation
    Disulfide bondi181 ↔ 205PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Zymogen

    Structurei

    3D structure databases

    ProteinModelPortaliP35032.
    SMRiP35032. Positions 10-231.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 229220Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG013304.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P35032-1 [UniParc]FASTAAdd to Basket

    « Hide

    AAFATEDDKI VGGYECKAYS QPHQVSLNSG YHFCGGSLVN ENWVVSAAHC    50
    YQSRVEVRLG EHNIQVTEGS EQFISSSRVI RHPNYSSYNI DNDIMLIKLS 100
    KPATLNTYVQ PVALPTSCAP AGTMCTVSGW GNTMSSTADK NKLQCLNIPI 150
    LSYSDCNNSY PGMITNAMFC AGYLEGGKDS CQGDSGGPVV CNGELQGVVS 200
    WGYGCAEPGN PGVYAKVCIF NDWLTSTMAT Y 231
    Length:231
    Mass (Da):24,823
    Last modified:February 1, 1994 - v1
    Checksum:iC54A1CAFE74FAE18
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70073 mRNA. Translation: CAA49678.1.
    PIRiS66658. S31778.
    UniGeneiSsa.19782.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70073 mRNA. Translation: CAA49678.1 .
    PIRi S66658. S31778.
    UniGenei Ssa.19782.

    3D structure databases

    ProteinModelPortali P35032.
    SMRi P35032. Positions 10-231.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S01.125.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG013304.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of anionic and cationic variants of trypsin from Atlantic salmon."
      Male R., Lorens J.B., Smals A.O., Torrissen K.R.
      Eur. J. Biochem. 232:677-685(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pancreas.

    Entry informationi

    Entry nameiTRY2_SALSA
    AccessioniPrimary (citable) accession number: P35032
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3