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Protein

Adenylate kinase

Gene

adkA

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + AMP = 2 ADP.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 169ATP

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSACI330779:GH9J-565-MONOMER.
BRENDAi2.7.4.3. 6160.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate kinase (EC:2.7.4.3)
Short name:
AK
Alternative name(s):
ATP-AMP transphosphorylase
Gene namesi
Name:adkA
Synonyms:adk
Ordered Locus Names:Saci_0573
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001018 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194Adenylate kinasePRO_0000131825Add
BLAST

Interactioni

Subunit structurei

Homotrimer.

Protein-protein interaction databases

STRINGi330779.Saci_0573.

Structurei

Secondary structure

1
194
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 87Combined sources
Helixi14 – 2613Combined sources
Turni27 – 293Combined sources
Beta strandi32 – 365Combined sources
Helixi37 – 4610Combined sources
Turni47 – 493Combined sources
Helixi54 – 574Combined sources
Helixi62 – 8221Combined sources
Beta strandi85 – 928Combined sources
Beta strandi94 – 985Combined sources
Beta strandi101 – 1066Combined sources
Helixi108 – 1147Combined sources
Beta strandi117 – 1237Combined sources
Helixi126 – 13510Combined sources
Turni137 – 1393Combined sources
Helixi147 – 16822Combined sources
Beta strandi171 – 1766Combined sources
Helixi183 – 19311Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NKSX-ray2.57A/B/C/D/E/F1-194[»]
ProteinModelPortaliP35028.
SMRiP35028. Positions 1-194.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35028.

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal adenylate kinase family.Curated

Phylogenomic databases

eggNOGiarCOG01039. Archaea.
COG2019. LUCA.
HOGENOMiHOG000105936.
KOiK00939.
OMAiHRDEMRK.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00234. Adenylate_kinase_AdkA. 1 hit.
InterProiIPR023477. Adenylate_kinase_AdkA.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P35028-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIGIVTGIP GVGKSTVLAK VKEILDNQGI NNKIINYGDF MLATALKLGY
60 70 80 90 100
AKDRDEMRKL SVEKQKKLQI DAAKGIAEEA RAGGEGYLFI DTHAVIRTPS
110 120 130 140 150
GYLPGLPSYV ITEINPSVIF LLEADPKIIL SRQKRDTTRN RNDYSDESVI
160 170 180 190
LETINFARYA ATASAVLAGS TVKVIVNVEG DPSIAANEII RSMK
Length:194
Mass (Da):21,110
Last modified:February 1, 1995 - v2
Checksum:iC0AA552D8E541900
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73564 Genomic DNA. Translation: CAA51967.1.
CP000077 Genomic DNA. Translation: AAY79965.1.
Y07778 Genomic DNA. Translation: CAA69101.1.
RefSeqiWP_011277467.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY79965; AAY79965; Saci_0573.
GeneIDi3473211.
KEGGisai:Saci_0573.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73564 Genomic DNA. Translation: CAA51967.1.
CP000077 Genomic DNA. Translation: AAY79965.1.
Y07778 Genomic DNA. Translation: CAA69101.1.
RefSeqiWP_011277467.1. NC_007181.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NKSX-ray2.57A/B/C/D/E/F1-194[»]
ProteinModelPortaliP35028.
SMRiP35028. Positions 1-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi330779.Saci_0573.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY79965; AAY79965; Saci_0573.
GeneIDi3473211.
KEGGisai:Saci_0573.

Phylogenomic databases

eggNOGiarCOG01039. Archaea.
COG2019. LUCA.
HOGENOMiHOG000105936.
KOiK00939.
OMAiHRDEMRK.

Enzyme and pathway databases

BioCyciSACI330779:GH9J-565-MONOMER.
BRENDAi2.7.4.3. 6160.

Miscellaneous databases

EvolutionaryTraceiP35028.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00234. Adenylate_kinase_AdkA. 1 hit.
InterProiIPR023477. Adenylate_kinase_AdkA.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKADA_SULAC
AccessioniPrimary (citable) accession number: P35028
Secondary accession number(s): Q4JB64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1995
Last modified: December 9, 2015
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.