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Protein

Adenylate kinase

Gene

adkA

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + AMP = 2 ADP.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 16ATP9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.4.3. 6160.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate kinase (EC:2.7.4.3)
Short name:
AK
Alternative name(s):
ATP-AMP transphosphorylase
Gene namesi
Name:adkA
Synonyms:adk
Ordered Locus Names:Saci_0573
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001018 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001318251 – 194Adenylate kinaseAdd BLAST194

Interactioni

Subunit structurei

Homotrimer.

Protein-protein interaction databases

STRINGi330779.Saci_0573.

Structurei

Secondary structure

1194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 8Combined sources7
Helixi14 – 26Combined sources13
Turni27 – 29Combined sources3
Beta strandi32 – 36Combined sources5
Helixi37 – 46Combined sources10
Turni47 – 49Combined sources3
Helixi54 – 57Combined sources4
Helixi62 – 82Combined sources21
Beta strandi85 – 92Combined sources8
Beta strandi94 – 98Combined sources5
Beta strandi101 – 106Combined sources6
Helixi108 – 114Combined sources7
Beta strandi117 – 123Combined sources7
Helixi126 – 135Combined sources10
Turni137 – 139Combined sources3
Helixi147 – 168Combined sources22
Beta strandi171 – 176Combined sources6
Helixi183 – 193Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NKSX-ray2.57A/B/C/D/E/F1-194[»]
ProteinModelPortaliP35028.
SMRiP35028.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35028.

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal adenylate kinase family.Curated

Phylogenomic databases

eggNOGiarCOG01039. Archaea.
COG2019. LUCA.
HOGENOMiHOG000105936.
KOiK00939.
OMAiHRDEMRK.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00234. Adenylate_kinase_AdkA. 1 hit.
InterProiIPR023477. Adenylate_kinase_AdkA.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P35028-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIGIVTGIP GVGKSTVLAK VKEILDNQGI NNKIINYGDF MLATALKLGY
60 70 80 90 100
AKDRDEMRKL SVEKQKKLQI DAAKGIAEEA RAGGEGYLFI DTHAVIRTPS
110 120 130 140 150
GYLPGLPSYV ITEINPSVIF LLEADPKIIL SRQKRDTTRN RNDYSDESVI
160 170 180 190
LETINFARYA ATASAVLAGS TVKVIVNVEG DPSIAANEII RSMK
Length:194
Mass (Da):21,110
Last modified:February 1, 1995 - v2
Checksum:iC0AA552D8E541900
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73564 Genomic DNA. Translation: CAA51967.1.
CP000077 Genomic DNA. Translation: AAY79965.1.
Y07778 Genomic DNA. Translation: CAA69101.1.
RefSeqiWP_011277467.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY79965; AAY79965; Saci_0573.
GeneIDi3473211.
KEGGisai:Saci_0573.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73564 Genomic DNA. Translation: CAA51967.1.
CP000077 Genomic DNA. Translation: AAY79965.1.
Y07778 Genomic DNA. Translation: CAA69101.1.
RefSeqiWP_011277467.1. NC_007181.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NKSX-ray2.57A/B/C/D/E/F1-194[»]
ProteinModelPortaliP35028.
SMRiP35028.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi330779.Saci_0573.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY79965; AAY79965; Saci_0573.
GeneIDi3473211.
KEGGisai:Saci_0573.

Phylogenomic databases

eggNOGiarCOG01039. Archaea.
COG2019. LUCA.
HOGENOMiHOG000105936.
KOiK00939.
OMAiHRDEMRK.

Enzyme and pathway databases

BRENDAi2.7.4.3. 6160.

Miscellaneous databases

EvolutionaryTraceiP35028.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00234. Adenylate_kinase_AdkA. 1 hit.
InterProiIPR023477. Adenylate_kinase_AdkA.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKADA_SULAC
AccessioniPrimary (citable) accession number: P35028
Secondary accession number(s): Q4JB64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.