P35024 (RL1_SULAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
50S ribosomal protein L1P

Gene names

Name:	rpl1p
Ordered Locus Names:	Saci_1458

Organism

Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) [Complete proteome] [HAMAP]

Taxonomic identifier

330779 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probably involved in E site tRNA release By similarity. Binds directly to 23S rRNA. HAMAP MF_01318_A Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA By similarity. HAMAP MF_01318_A
Subunit structure	Part of the 50S ribosomal subunit.
Sequence similarities	Belongs to the ribosomal protein L1P family.
Caution	Was originally (Ref.2) thought to originate from S.solfataricus strain P1, but the culture was contaminated with S.acidocaldarius.
Sequence caution	The sequence AAY80779.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Translation regulation
Ligand	RNA-binding rRNA-binding tRNA-binding
Molecular function	Repressor Ribonucleoprotein Ribosomal protein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	regulation of translation Inferred from electronic annotation. Source: UniProtKB-KW translation Inferred from electronic annotation. Source: InterPro
Cellular component	large ribosomal subunit Inferred from electronic annotation. Source: InterPro
Molecular function	rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Inferred from electronic annotation. Source: InterPro tRNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 221

221

50S ribosomal protein L1P HAMAP MF_01318_A

PRO_0000125812

Experimental info

Sequence conflict

73

1

F → S in CAA41763. Ref.1

Sequence conflict

73

1

F → S Ref.2

Sequence conflict

85

1

N → K in CAA41763. Ref.1

Sequence conflict

85

1

N → K Ref.2

Sequence conflict

108

1

R → I in CAA41763. Ref.1

Sequence conflict

108

1

R → I Ref.2

Sequence conflict

159

1

L → I in CAA41763. Ref.1

Sequence conflict

159

1

L → I Ref.2

Secondary structure

1

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221

Helix Strand Turn

Details...

Helix

8 – 19

12

Turn

21 – 23

3

Beta strand

32 – 41

10

Helix

44 – 46

3

Turn

47 – 49

3

Beta strand

52 – 56

5

Beta strand

67 – 70

4

Helix

73 – 81

9

Beta strand

85 – 87

3

Helix

90 – 96

7

Helix

100 – 108

9

Beta strand

111 – 115

5

Helix

117 – 119

3

Helix

120 – 126

7

Helix

128 – 131

4

Helix

132 – 134

3

Beta strand

138 – 140

3

Beta strand

143 – 145

3

Helix

148 – 155

8

Beta strand

157 – 161

5

Beta strand

163 – 174

12

Helix

179 – 196

18

Turn

200 – 202

3

Beta strand

203 – 210

8

Sequences

	Sequence		Length	Mass (Da)
	P35024 [UniParc]. Last modified August 30, 2005. Version 2. Checksum: 47A26B9251F89F2F	FASTA	221	24,935
	10 20 30 40 50 60 MKKVLADKES LIEALKLALS TEYNVKRNFT QSVEIILTFK GIDMKKGDLK LREIVPLPKQ 70 80 90 100 110 120 PSKAKRVLVV PSFEQLEYAK KASPNVVITR EELQKLQGQK RPVKKLARQN EWFLINQESM 130 140 150 160 170 180 ALAGRILGPA LGPRGKFPTP LPNTADISEY INRFKRSVLV KTKDQPQVQV FIGTEDMKPE 190 200 210 220 DLAENAIAVL NAIENKAKVE TNLRNIYVKT TMGKAVKVKR A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and transcription of the L11-L1-L10-L12 ribosomal protein gene operon from the extreme thermophilic archaeon Sulfolobus acidocaldarius." Ramirez C., Shimmin L.C., Leggatt P., Matheson A.T. J. Mol. Biol. 244:242-249(1994) [PubMed: 7966335] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Structure and evolution of the L11, L1, L10, and L12 equivalent ribosomal proteins in eubacteria, archaebacteria, and eucaryotes." Ramirez C., Shimmin L.C., Newton C.H., Matheson A.T., Dennis P.P. Can. J. Microbiol. 35:234-244(1989) [PubMed: 2497941] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	Erratum Ramirez C., Shimmin L.C., Newton C.H., Matheson A.T., Dennis P.P. Can. J. Microbiol. 35:975-975(1989)
[4]	"The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota." Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A. J. Bacteriol. 187:4992-4999(2005) [PubMed: 15995215] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.
[5]	"Structure of the L1 protuberance in the ribosome." Nikulin A., Eliseikina I., Tishchenko S., Nevskaya N., Davydova N., Platonova O., Piendl W., Selmer M., Liljas A., Drygin D., Zimmermann R., Garber M.B., Nikonov S. Nat. Struct. Biol. 10:104-108(2003) [PubMed: 12514741] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 5-220 IN COMPLEX WITH A T.THERMOPHILUS RRNA FRAGMENT.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X59038 Genomic DNA. Translation: CAA41763.1.
CP000077 Genomic DNA. Translation: AAY80779.1. Different initiation.

PIR

S53649.

RefSeq

YP_256072.2. NC_007181.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1MZP	X-ray	2.65	A	5-220	[»]
1PNU	X-ray	8.70	5	5-220	[»]
1PNY	X-ray	9.50	5	5-220	[»]

ProteinModelPortal

P35024.

SMR

P35024. Positions 4-220.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

3473497.

GenomeReviews

Gene locus Saci_1458 in contig CP000077_GR.

KEGG

sai:Saci_1458.

NMPDR

fig|330779.3.peg.2151.

Organism-specific databases

CMR

Search...

Phylogenomic databases

HOGENOM

HBG297400.

PhylomeDB

P35024.

ProtClustDB

PRK04203.

Enzyme and pathway databases

BioCyc

SACI330779:SACI_1458-MONOMER.

Family and domain databases

HAMAP

MF_01318_A. Ribosomal_L1_A.
[Tree]

InterPro

IPR002143. Ribosomal_L1.
IPR016094. Ribosomal_L1_2-a/b-sand.
IPR016095. Ribosomal_L1_3-a/b-sand.
IPR023669. Ribosomal_L1_arc.
IPR023673. Ribosomal_L1_CS.
IPR023674. Ribosomal_L1_SF.
[Graphical view]

Gene3D

G3DSA:3.30.190.20. Ribosomal_L1_2-a/b-sand. 2 hits.
G3DSA:3.40.50.790. Ribosomal_L1_3-a/b-sand. 1 hit.

KO

K02863.

Pfam

PF00687. Ribosomal_L1. 1 hit.
[Graphical view]

PIRSF

PIRSF002155. Ribosomal_L1. 1 hit.

SUPFAM

SSF56808. Ribosomal_L1. 1 hit.

PROSITE

PS01199. RIBOSOMAL_L1. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

RL1_SULAC

Accession

Primary (citable) accession number: P35024
Secondary accession number(s): Q4J8V1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	August 30, 2005
Last modified:	December 14, 2011
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program