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P35016

- ENPL_CATRO

UniProt

P35016 - ENPL_CATRO

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Protein

Endoplasmin homolog

Gene
HSP90
Organism
Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May have a molecular chaperone role in the processing of secreted materials.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei111 – 1111ATP By similarity
Binding sitei155 – 1551ATP By similarity
Binding sitei168 – 1681ATP By similarity
Binding sitei174 – 1741ATP By similarity
Binding sitei200 – 2001ATP; via amide nitrogen By similarity
Binding sitei459 – 4591ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. protein folding Source: InterPro
  2. response to stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmin homolog
Alternative name(s):
Glucose-regulated protein 94 homolog
Short name:
GRP-94 homolog
Gene namesi
Name:HSP90
OrganismiCatharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Taxonomic identifieri4058 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsGentianalesApocynaceaeRauvolfioideaeVinceaeCatharanthinaeCatharanthus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 817797Endoplasmin homologUniRule annotationPRO_0000013602Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi111 – 1111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi306 – 3061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi416 – 4161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi456 – 4561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi624 – 6241N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP35016.
ProMEXiP35016.

Expressioni

Tissue specificityi

Not detected in extracts from young plants unless they are exposed to heat shock for several hours. Found to be constitutively expressed in cell cultures.

Structurei

3D structure databases

ProteinModelPortaliP35016.
SMRiP35016. Positions 77-294.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi814 – 8174Prevents secretion from ERUniRule annotation

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00505. HSP90.
InterProiIPR003594. HATPase_ATP-bd.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00298. HSP90. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35016-1 [UniParc]FASTAAdd to Basket

« Hide

MRKWTVPSVL FLLCPSLSSS CQGRKIHANA EADSDAPVDP PKVEDKIGAV    50
PNGLSTDSDV AKREAESMSM RNLRSDAEKF EFQAEVSRLM DIIINSLYSN 100
KDIFLRELIS NASDALDKIR FLALTDKEIL GEGDTAKLEI QIKLDKEKKI 150
LSIRDRGIGM TKEDLIKNLG TIAKSGTSAF VEKMQTSGDL NLIGQFGVGF 200
YSVYLVPDYV EVISKHNDDK QYIWESKADG AFAISEDVWN EPLGRGTEIR 250
LHLRDEAQEY LDEFKLKELV KRYSEFINFP IYLWASKEVE VEVPAEEDDS 300
SDDEDNKSES SSSEEGEEEE TEKEEDEKKP KTKKVKETTY EWELLNDMKA 350
IWLRNPKDVT DDEYTKFYHS LAKDFSEEKP LAWSHFTAEG DVEFKAFTLL 400
PPKAPQDLYE SYYNSNKSNL KLYVRRVFIS DEFDELLPKY LNFLKGLVDS 450
DTLPLNVSRE MLQQHSSLKT IKKKLIRKAL DMIRKIADED PDEANDKDKK 500
EVEESTDNDE KKGQYAKFWN EFGKSIKLGI IEDAANRNRL AKLLRFESTK 550
SEGKLTSLDQ YISRMKSGQK DIFYITGTSK EQLEKSPFLE RLTKKNYEVI 600
LFTDPVDEYL MQYLMDYEDK KFQNVSKEGL KIGKDSKDKE LKESFKELTK 650
WWKGALASEN VDDVKISNRL ANTPCVVVTS KYGWSSNMER IMQSQTLSDA 700
SKQAYMRGKR VLEINPRHPI IKELRERVVK DAEDESVKQT ARLMYQTALM 750
ESGFMLNDPK EFASSIYDSV KSSLKISPDA TVEEEDDTEE AEAESGTTES 800
SAAEDAGAET LDLKDEL 817
Length:817
Mass (Da):93,492
Last modified:February 1, 1994 - v1
Checksum:i26C06CDC5E0D19FA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L14594 mRNA. Translation: AAA16785.1.
PIRiS39558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L14594 mRNA. Translation: AAA16785.1 .
PIRi S39558.

3D structure databases

ProteinModelPortali P35016.
SMRi P35016. Positions 77-294.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P35016.
ProMEXi P35016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.30.565.10. 1 hit.
HAMAPi MF_00505. HSP90.
InterProi IPR003594. HATPase_ATP-bd.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view ]
PANTHERi PTHR11528. PTHR11528. 1 hit.
Pfami PF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view ]
PIRSFi PIRSF002583. Hsp90. 1 hit.
PRINTSi PR00775. HEATSHOCK90.
SMARTi SM00387. HATPase_c. 1 hit.
[Graphical view ]
SUPFAMi SSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00298. HSP90. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "HSP90 homologue from Madagascar periwinkle (Catharanthus roseus): cDNA sequence, regulation of protein expression and location in the endoplasmic reticulum."
    Schroeder G., Beck M., Eichel J., Vetter H.P., Schroeder J.
    Plant Mol. Biol. 23:583-594(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. CP3A.

Entry informationi

Entry nameiENPL_CATRO
AccessioniPrimary (citable) accession number: P35016
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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