Endoplasmin homolog precursor - Catharanthus roseus (Madagascar periwinkle)

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P35016 (ENPL_CATRO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 84. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Endoplasmin homolog

Alternative name(s):
Glucose-regulated protein 94 homolog
Short name=GRP-94 homolog

Gene names

Name:

HSP90

Organism

Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)

Taxonomic identifier

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Gentianales › Apocynaceae › Rauvolfioideae › Vinceae › Catharanthus

Protein attributes

Sequence length	817 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May have a molecular chaperone role in the processing of secreted materials.
Subcellular location	Endoplasmic reticulum lumen.
Tissue specificity	Not detected in extracts from young plants unless they are exposed to heat shock for several hours. Found to be constitutively expressed in cell cultures.
Sequence similarities	Belongs to the heat shock protein 90 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Domain	Signal
Ligand	ATP-binding Calcium Nucleotide-binding
Molecular function	Chaperone
PTM	Glycoprotein
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: InterPro response to stress Inferred from electronic annotation. Source: InterPro
Cellular_component	endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

20

Potential

Chain

797

Endoplasmin homolog

PRO_0000013602

Regions

Motif

4

Prevents secretion from ER

Sites

Binding site

1

ATP By similarity

Binding site

1

ATP By similarity

Binding site

1

ATP By similarity

Binding site

1

ATP By similarity

Binding site

1

ATP; via amide nitrogen By similarity

Binding site

1

ATP By similarity

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

P35016 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 26C06CDC5E0D19FA
Show »

817

93,492

        10         20         30         40         50         60 
MRKWTVPSVL FLLCPSLSSS CQGRKIHANA EADSDAPVDP PKVEDKIGAV PNGLSTDSDV 

        70         80         90        100        110        120 
AKREAESMSM RNLRSDAEKF EFQAEVSRLM DIIINSLYSN KDIFLRELIS NASDALDKIR 

       130        140        150        160        170        180 
FLALTDKEIL GEGDTAKLEI QIKLDKEKKI LSIRDRGIGM TKEDLIKNLG TIAKSGTSAF 

       190        200        210        220        230        240 
VEKMQTSGDL NLIGQFGVGF YSVYLVPDYV EVISKHNDDK QYIWESKADG AFAISEDVWN 

       250        260        270        280        290        300 
EPLGRGTEIR LHLRDEAQEY LDEFKLKELV KRYSEFINFP IYLWASKEVE VEVPAEEDDS 

       310        320        330        340        350        360 
SDDEDNKSES SSSEEGEEEE TEKEEDEKKP KTKKVKETTY EWELLNDMKA IWLRNPKDVT 

       370        380        390        400        410        420 
DDEYTKFYHS LAKDFSEEKP LAWSHFTAEG DVEFKAFTLL PPKAPQDLYE SYYNSNKSNL 

       430        440        450        460        470        480 
KLYVRRVFIS DEFDELLPKY LNFLKGLVDS DTLPLNVSRE MLQQHSSLKT IKKKLIRKAL 

       490        500        510        520        530        540 
DMIRKIADED PDEANDKDKK EVEESTDNDE KKGQYAKFWN EFGKSIKLGI IEDAANRNRL 

       550        560        570        580        590        600 
AKLLRFESTK SEGKLTSLDQ YISRMKSGQK DIFYITGTSK EQLEKSPFLE RLTKKNYEVI 

       610        620        630        640        650        660 
LFTDPVDEYL MQYLMDYEDK KFQNVSKEGL KIGKDSKDKE LKESFKELTK WWKGALASEN 

       670        680        690        700        710        720 
VDDVKISNRL ANTPCVVVTS KYGWSSNMER IMQSQTLSDA SKQAYMRGKR VLEINPRHPI 

       730        740        750        760        770        780 
IKELRERVVK DAEDESVKQT ARLMYQTALM ESGFMLNDPK EFASSIYDSV KSSLKISPDA 

       790        800        810 
TVEEEDDTEE AEAESGTTES SAAEDAGAET LDLKDEL

References

[1]

"HSP90 homologue from Madagascar periwinkle (Catharanthus roseus): cDNA sequence, regulation of protein expression and location in the endoplasmic reticulum."
Schroeder G., Beck M., Eichel J., Vetter H.P., Schroeder J.
Plant Mol. Biol. 23:583-594(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. CP3A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L14594 mRNA. Translation: AAA16785.1.
PIR	S39558.
3D structure databases
ProteinModelPortal	P35016.
SMR	P35016. Positions 77-294.
ModBase	Search...
Proteomic databases
PRIDE	P35016.
ProMEX	P35016.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.30.565.10. 1 hit.
InterPro	IPR015566. Endoplasmin. IPR003594. HATPase_ATP-bd. IPR019805. Heat_shock_protein_90_CS. IPR001404. Hsp90. IPR020575. Hsp90_N. IPR020568. Ribosomal_S5_D2-typ_fold. [Graphical view]
PANTHER	PTHR11528. PTHR11528. 1 hit. PTHR11528:SF21. PTHR11528:SF21. 1 hit.
Pfam	PF02518. HATPase_c. 1 hit. PF00183. HSP90. 1 hit. [Graphical view]
PIRSF	PIRSF002583. Hsp90. 1 hit.
PRINTS	PR00775. HEATSHOCK90.
SMART	SM00387. HATPase_c. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
PROSITE	PS00014. ER_TARGET. 1 hit. PS00298. HSP90. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ENPL_CATRO

Accession

Primary (citable) accession number: P35016

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents