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P35016 (ENPL_CATRO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endoplasmin homolog
Alternative name(s):
Glucose-regulated protein 94 homolog
Short name=GRP-94 homolog
Gene names
Name:HSP90
OrganismCatharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Taxonomic identifier4058 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsGentianalesApocynaceaeRauvolfioideaeVinceaeCatharanthus

Protein attributes

Sequence length817 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May have a molecular chaperone role in the processing of secreted materials. HAMAP-Rule MF_00505

Subcellular location

Endoplasmic reticulum lumen HAMAP-Rule MF_00505.

Tissue specificity

Not detected in extracts from young plants unless they are exposed to heat shock for several hours. Found to be constitutively expressed in cell cultures.

Sequence similarities

Belongs to the heat shock protein 90 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainSignal
   LigandATP-binding
Calcium
Nucleotide-binding
   Molecular functionChaperone
   PTMGlycoprotein
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: InterPro

response to stress

Inferred from electronic annotation. Source: InterPro

   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 817797Endoplasmin homolog HAMAP-Rule MF_00505
PRO_0000013602

Regions

Motif814 – 8174Prevents secretion from ER HAMAP-Rule MF_00505

Sites

Binding site1111ATP By similarity
Binding site1551ATP By similarity
Binding site1681ATP By similarity
Binding site1741ATP By similarity
Binding site2001ATP; via amide nitrogen By similarity
Binding site4591ATP By similarity

Amino acid modifications

Glycosylation1111N-linked (GlcNAc...) Potential
Glycosylation3061N-linked (GlcNAc...) Potential
Glycosylation4161N-linked (GlcNAc...) Potential
Glycosylation4561N-linked (GlcNAc...) Potential
Glycosylation6241N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P35016 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 26C06CDC5E0D19FA

FASTA81793,492
        10         20         30         40         50         60 
MRKWTVPSVL FLLCPSLSSS CQGRKIHANA EADSDAPVDP PKVEDKIGAV PNGLSTDSDV 

        70         80         90        100        110        120 
AKREAESMSM RNLRSDAEKF EFQAEVSRLM DIIINSLYSN KDIFLRELIS NASDALDKIR 

       130        140        150        160        170        180 
FLALTDKEIL GEGDTAKLEI QIKLDKEKKI LSIRDRGIGM TKEDLIKNLG TIAKSGTSAF 

       190        200        210        220        230        240 
VEKMQTSGDL NLIGQFGVGF YSVYLVPDYV EVISKHNDDK QYIWESKADG AFAISEDVWN 

       250        260        270        280        290        300 
EPLGRGTEIR LHLRDEAQEY LDEFKLKELV KRYSEFINFP IYLWASKEVE VEVPAEEDDS 

       310        320        330        340        350        360 
SDDEDNKSES SSSEEGEEEE TEKEEDEKKP KTKKVKETTY EWELLNDMKA IWLRNPKDVT 

       370        380        390        400        410        420 
DDEYTKFYHS LAKDFSEEKP LAWSHFTAEG DVEFKAFTLL PPKAPQDLYE SYYNSNKSNL 

       430        440        450        460        470        480 
KLYVRRVFIS DEFDELLPKY LNFLKGLVDS DTLPLNVSRE MLQQHSSLKT IKKKLIRKAL 

       490        500        510        520        530        540 
DMIRKIADED PDEANDKDKK EVEESTDNDE KKGQYAKFWN EFGKSIKLGI IEDAANRNRL 

       550        560        570        580        590        600 
AKLLRFESTK SEGKLTSLDQ YISRMKSGQK DIFYITGTSK EQLEKSPFLE RLTKKNYEVI 

       610        620        630        640        650        660 
LFTDPVDEYL MQYLMDYEDK KFQNVSKEGL KIGKDSKDKE LKESFKELTK WWKGALASEN 

       670        680        690        700        710        720 
VDDVKISNRL ANTPCVVVTS KYGWSSNMER IMQSQTLSDA SKQAYMRGKR VLEINPRHPI 

       730        740        750        760        770        780 
IKELRERVVK DAEDESVKQT ARLMYQTALM ESGFMLNDPK EFASSIYDSV KSSLKISPDA 

       790        800        810 
TVEEEDDTEE AEAESGTTES SAAEDAGAET LDLKDEL 

« Hide

References

[1]"HSP90 homologue from Madagascar periwinkle (Catharanthus roseus): cDNA sequence, regulation of protein expression and location in the endoplasmic reticulum."
Schroeder G., Beck M., Eichel J., Vetter H.P., Schroeder J.
Plant Mol. Biol. 23:583-594(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. CP3A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L14594 mRNA. Translation: AAA16785.1.
PIRS39558.

3D structure databases

ProteinModelPortalP35016.
SMRP35016. Positions 77-294.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP35016.
ProMEXP35016.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.565.10. 1 hit.
HAMAPMF_00505. HSP90.
InterProIPR015566. Endoplasmin.
IPR003594. HATPase_ATP-bd.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERPTHR11528. PTHR11528. 1 hit.
PTHR11528:SF21. PTHR11528:SF21. 1 hit.
PfamPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view]
PIRSFPIRSF002583. Hsp90. 1 hit.
PRINTSPR00775. HEATSHOCK90.
SMARTSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00298. HSP90. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameENPL_CATRO
AccessionPrimary (citable) accession number: P35016
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: February 19, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families