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P35016

- ENPL_CATRO

UniProt

P35016 - ENPL_CATRO

Protein

Endoplasmin homolog

Gene

HSP90

Organism
Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    May have a molecular chaperone role in the processing of secreted materials.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei111 – 1111ATPBy similarity
    Binding sitei155 – 1551ATPBy similarity
    Binding sitei168 – 1681ATPBy similarity
    Binding sitei174 – 1741ATPBy similarity
    Binding sitei200 – 2001ATP; via amide nitrogenBy similarity
    Binding sitei459 – 4591ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein folding Source: InterPro
    2. response to stress Source: InterPro

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    ATP-binding, Calcium, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endoplasmin homolog
    Alternative name(s):
    Glucose-regulated protein 94 homolog
    Short name:
    GRP-94 homolog
    Gene namesi
    Name:HSP90
    OrganismiCatharanthus roseus (Madagascar periwinkle) (Vinca rosea)
    Taxonomic identifieri4058 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsGentianalesApocynaceaeRauvolfioideaeVinceaeCatharanthinaeCatharanthus

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 817797Endoplasmin homologPRO_0000013602Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi416 – 4161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi456 – 4561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi624 – 6241N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP35016.
    ProMEXiP35016.

    Expressioni

    Tissue specificityi

    Not detected in extracts from young plants unless they are exposed to heat shock for several hours. Found to be constitutively expressed in cell cultures.

    Structurei

    3D structure databases

    ProteinModelPortaliP35016.
    SMRiP35016. Positions 77-294.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi814 – 8174Prevents secretion from ER

    Sequence similaritiesi

    Belongs to the heat shock protein 90 family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.30.565.10. 1 hit.
    HAMAPiMF_00505. HSP90.
    InterProiIPR003594. HATPase_ATP-bd.
    IPR019805. Heat_shock_protein_90_CS.
    IPR001404. Hsp90_fam.
    IPR020575. Hsp90_N.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    [Graphical view]
    PANTHERiPTHR11528. PTHR11528. 1 hit.
    PfamiPF02518. HATPase_c. 1 hit.
    PF00183. HSP90. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002583. Hsp90. 1 hit.
    PRINTSiPR00775. HEATSHOCK90.
    SMARTiSM00387. HATPase_c. 1 hit.
    [Graphical view]
    SUPFAMiSSF54211. SSF54211. 1 hit.
    SSF55874. SSF55874. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00298. HSP90. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P35016-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKWTVPSVL FLLCPSLSSS CQGRKIHANA EADSDAPVDP PKVEDKIGAV    50
    PNGLSTDSDV AKREAESMSM RNLRSDAEKF EFQAEVSRLM DIIINSLYSN 100
    KDIFLRELIS NASDALDKIR FLALTDKEIL GEGDTAKLEI QIKLDKEKKI 150
    LSIRDRGIGM TKEDLIKNLG TIAKSGTSAF VEKMQTSGDL NLIGQFGVGF 200
    YSVYLVPDYV EVISKHNDDK QYIWESKADG AFAISEDVWN EPLGRGTEIR 250
    LHLRDEAQEY LDEFKLKELV KRYSEFINFP IYLWASKEVE VEVPAEEDDS 300
    SDDEDNKSES SSSEEGEEEE TEKEEDEKKP KTKKVKETTY EWELLNDMKA 350
    IWLRNPKDVT DDEYTKFYHS LAKDFSEEKP LAWSHFTAEG DVEFKAFTLL 400
    PPKAPQDLYE SYYNSNKSNL KLYVRRVFIS DEFDELLPKY LNFLKGLVDS 450
    DTLPLNVSRE MLQQHSSLKT IKKKLIRKAL DMIRKIADED PDEANDKDKK 500
    EVEESTDNDE KKGQYAKFWN EFGKSIKLGI IEDAANRNRL AKLLRFESTK 550
    SEGKLTSLDQ YISRMKSGQK DIFYITGTSK EQLEKSPFLE RLTKKNYEVI 600
    LFTDPVDEYL MQYLMDYEDK KFQNVSKEGL KIGKDSKDKE LKESFKELTK 650
    WWKGALASEN VDDVKISNRL ANTPCVVVTS KYGWSSNMER IMQSQTLSDA 700
    SKQAYMRGKR VLEINPRHPI IKELRERVVK DAEDESVKQT ARLMYQTALM 750
    ESGFMLNDPK EFASSIYDSV KSSLKISPDA TVEEEDDTEE AEAESGTTES 800
    SAAEDAGAET LDLKDEL 817
    Length:817
    Mass (Da):93,492
    Last modified:February 1, 1994 - v1
    Checksum:i26C06CDC5E0D19FA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14594 mRNA. Translation: AAA16785.1.
    PIRiS39558.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14594 mRNA. Translation: AAA16785.1 .
    PIRi S39558.

    3D structure databases

    ProteinModelPortali P35016.
    SMRi P35016. Positions 77-294.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P35016.
    ProMEXi P35016.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.30.565.10. 1 hit.
    HAMAPi MF_00505. HSP90.
    InterProi IPR003594. HATPase_ATP-bd.
    IPR019805. Heat_shock_protein_90_CS.
    IPR001404. Hsp90_fam.
    IPR020575. Hsp90_N.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    [Graphical view ]
    PANTHERi PTHR11528. PTHR11528. 1 hit.
    Pfami PF02518. HATPase_c. 1 hit.
    PF00183. HSP90. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002583. Hsp90. 1 hit.
    PRINTSi PR00775. HEATSHOCK90.
    SMARTi SM00387. HATPase_c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54211. SSF54211. 1 hit.
    SSF55874. SSF55874. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00298. HSP90. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "HSP90 homologue from Madagascar periwinkle (Catharanthus roseus): cDNA sequence, regulation of protein expression and location in the endoplasmic reticulum."
      Schroeder G., Beck M., Eichel J., Vetter H.P., Schroeder J.
      Plant Mol. Biol. 23:583-594(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. CP3A.

    Entry informationi

    Entry nameiENPL_CATRO
    AccessioniPrimary (citable) accession number: P35016
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3