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P35016

- ENPL_CATRO

UniProt

P35016 - ENPL_CATRO

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Protein

Endoplasmin homolog

Gene

HSP90

Organism
Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May have a molecular chaperone role in the processing of secreted materials.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei111 – 1111ATPBy similarity
Binding sitei155 – 1551ATPBy similarity
Binding sitei168 – 1681ATPBy similarity
Binding sitei174 – 1741ATPBy similarity
Binding sitei200 – 2001ATP; via amide nitrogenBy similarity
Binding sitei459 – 4591ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. protein folding Source: InterPro
  2. response to stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmin homolog
Alternative name(s):
Glucose-regulated protein 94 homolog
Short name:
GRP-94 homolog
Gene namesi
Name:HSP90
OrganismiCatharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Taxonomic identifieri4058 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsGentianalesApocynaceaeRauvolfioideaeVinceaeCatharanthinaeCatharanthus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 817797Endoplasmin homologPRO_0000013602Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi416 – 4161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi456 – 4561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi624 – 6241N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP35016.
ProMEXiP35016.

Expressioni

Tissue specificityi

Not detected in extracts from young plants unless they are exposed to heat shock for several hours. Found to be constitutively expressed in cell cultures.

Structurei

3D structure databases

ProteinModelPortaliP35016.
SMRiP35016. Positions 77-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi814 – 8174Prevents secretion from ER

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00505. HSP90.
InterProiIPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00298. HSP90. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35016 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRKWTVPSVL FLLCPSLSSS CQGRKIHANA EADSDAPVDP PKVEDKIGAV
60 70 80 90 100
PNGLSTDSDV AKREAESMSM RNLRSDAEKF EFQAEVSRLM DIIINSLYSN
110 120 130 140 150
KDIFLRELIS NASDALDKIR FLALTDKEIL GEGDTAKLEI QIKLDKEKKI
160 170 180 190 200
LSIRDRGIGM TKEDLIKNLG TIAKSGTSAF VEKMQTSGDL NLIGQFGVGF
210 220 230 240 250
YSVYLVPDYV EVISKHNDDK QYIWESKADG AFAISEDVWN EPLGRGTEIR
260 270 280 290 300
LHLRDEAQEY LDEFKLKELV KRYSEFINFP IYLWASKEVE VEVPAEEDDS
310 320 330 340 350
SDDEDNKSES SSSEEGEEEE TEKEEDEKKP KTKKVKETTY EWELLNDMKA
360 370 380 390 400
IWLRNPKDVT DDEYTKFYHS LAKDFSEEKP LAWSHFTAEG DVEFKAFTLL
410 420 430 440 450
PPKAPQDLYE SYYNSNKSNL KLYVRRVFIS DEFDELLPKY LNFLKGLVDS
460 470 480 490 500
DTLPLNVSRE MLQQHSSLKT IKKKLIRKAL DMIRKIADED PDEANDKDKK
510 520 530 540 550
EVEESTDNDE KKGQYAKFWN EFGKSIKLGI IEDAANRNRL AKLLRFESTK
560 570 580 590 600
SEGKLTSLDQ YISRMKSGQK DIFYITGTSK EQLEKSPFLE RLTKKNYEVI
610 620 630 640 650
LFTDPVDEYL MQYLMDYEDK KFQNVSKEGL KIGKDSKDKE LKESFKELTK
660 670 680 690 700
WWKGALASEN VDDVKISNRL ANTPCVVVTS KYGWSSNMER IMQSQTLSDA
710 720 730 740 750
SKQAYMRGKR VLEINPRHPI IKELRERVVK DAEDESVKQT ARLMYQTALM
760 770 780 790 800
ESGFMLNDPK EFASSIYDSV KSSLKISPDA TVEEEDDTEE AEAESGTTES
810
SAAEDAGAET LDLKDEL
Length:817
Mass (Da):93,492
Last modified:February 1, 1994 - v1
Checksum:i26C06CDC5E0D19FA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L14594 mRNA. Translation: AAA16785.1.
PIRiS39558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L14594 mRNA. Translation: AAA16785.1 .
PIRi S39558.

3D structure databases

ProteinModelPortali P35016.
SMRi P35016. Positions 77-294.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P35016.
ProMEXi P35016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.30.565.10. 1 hit.
HAMAPi MF_00505. HSP90.
InterProi IPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view ]
PANTHERi PTHR11528. PTHR11528. 1 hit.
Pfami PF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view ]
PIRSFi PIRSF002583. Hsp90. 1 hit.
PRINTSi PR00775. HEATSHOCK90.
SMARTi SM00387. HATPase_c. 1 hit.
[Graphical view ]
SUPFAMi SSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00298. HSP90. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "HSP90 homologue from Madagascar periwinkle (Catharanthus roseus): cDNA sequence, regulation of protein expression and location in the endoplasmic reticulum."
    Schroeder G., Beck M., Eichel J., Vetter H.P., Schroeder J.
    Plant Mol. Biol. 23:583-594(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. CP3A.

Entry informationi

Entry nameiENPL_CATRO
AccessioniPrimary (citable) accession number: P35016
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3