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Protein

Endoplasmin homolog

Gene

HSP90

Organism
Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May have a molecular chaperone role in the processing of secreted materials.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei111ATPBy similarity1
Binding sitei155ATPBy similarity1
Binding sitei168ATPBy similarity1
Binding sitei174ATPBy similarity1
Binding sitei200ATP; via amide nitrogenBy similarity1
Binding sitei459ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmin homolog
Alternative name(s):
Glucose-regulated protein 94 homolog
Short name:
GRP-94 homolog
Gene namesi
Name:HSP90
OrganismiCatharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Taxonomic identifieri4058 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsGentianalesApocynaceaeRauvolfioideaeVinceaeCatharanthinaeCatharanthus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001360221 – 817Endoplasmin homologAdd BLAST797

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi416N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi456N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi624N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP35016

Expressioni

Tissue specificityi

Not detected in extracts from young plants unless they are exposed to heat shock for several hours. Found to be constitutively expressed in cell cultures.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP35016
SMRiP35016
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi814 – 817Prevents secretion from ER4

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Keywords - Domaini

Signal

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505 HSP90, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR019805 Heat_shock_protein_90_CS
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528 PTHR11528, 1 hit
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00183 HSP90, 1 hit
PIRSFiPIRSF002583 Hsp90, 1 hit
PRINTSiPR00775 HEATSHOCK90
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS00298 HSP90, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35016-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKWTVPSVL FLLCPSLSSS CQGRKIHANA EADSDAPVDP PKVEDKIGAV
60 70 80 90 100
PNGLSTDSDV AKREAESMSM RNLRSDAEKF EFQAEVSRLM DIIINSLYSN
110 120 130 140 150
KDIFLRELIS NASDALDKIR FLALTDKEIL GEGDTAKLEI QIKLDKEKKI
160 170 180 190 200
LSIRDRGIGM TKEDLIKNLG TIAKSGTSAF VEKMQTSGDL NLIGQFGVGF
210 220 230 240 250
YSVYLVPDYV EVISKHNDDK QYIWESKADG AFAISEDVWN EPLGRGTEIR
260 270 280 290 300
LHLRDEAQEY LDEFKLKELV KRYSEFINFP IYLWASKEVE VEVPAEEDDS
310 320 330 340 350
SDDEDNKSES SSSEEGEEEE TEKEEDEKKP KTKKVKETTY EWELLNDMKA
360 370 380 390 400
IWLRNPKDVT DDEYTKFYHS LAKDFSEEKP LAWSHFTAEG DVEFKAFTLL
410 420 430 440 450
PPKAPQDLYE SYYNSNKSNL KLYVRRVFIS DEFDELLPKY LNFLKGLVDS
460 470 480 490 500
DTLPLNVSRE MLQQHSSLKT IKKKLIRKAL DMIRKIADED PDEANDKDKK
510 520 530 540 550
EVEESTDNDE KKGQYAKFWN EFGKSIKLGI IEDAANRNRL AKLLRFESTK
560 570 580 590 600
SEGKLTSLDQ YISRMKSGQK DIFYITGTSK EQLEKSPFLE RLTKKNYEVI
610 620 630 640 650
LFTDPVDEYL MQYLMDYEDK KFQNVSKEGL KIGKDSKDKE LKESFKELTK
660 670 680 690 700
WWKGALASEN VDDVKISNRL ANTPCVVVTS KYGWSSNMER IMQSQTLSDA
710 720 730 740 750
SKQAYMRGKR VLEINPRHPI IKELRERVVK DAEDESVKQT ARLMYQTALM
760 770 780 790 800
ESGFMLNDPK EFASSIYDSV KSSLKISPDA TVEEEDDTEE AEAESGTTES
810
SAAEDAGAET LDLKDEL
Length:817
Mass (Da):93,492
Last modified:February 1, 1994 - v1
Checksum:i26C06CDC5E0D19FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14594 mRNA Translation: AAA16785.1
PIRiS39558

Similar proteinsi

Entry informationi

Entry nameiENPL_CATRO
AccessioniPrimary (citable) accession number: P35016
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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