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P35000

- VIPR2_RAT

UniProt

P35000 - VIPR2_RAT

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Protein

Vasoactive intestinal polypeptide receptor 2

Gene

Vipr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.

GO - Molecular functioni

  1. vasoactive intestinal polypeptide receptor activity Source: RGD

GO - Biological processi

  1. activation of adenylate cyclase activity Source: RGD
  2. negative regulation of smooth muscle cell proliferation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_246814. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasoactive intestinal polypeptide receptor 2
Short name:
VIP-R-2
Alternative name(s):
Pituitary adenylate cyclase-activating polypeptide type III receptor
Short name:
PACAP type III receptor
Short name:
PACAP-R-3
Short name:
PACAP-R3
Gene namesi
Name:Vipr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3962. Vipr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 125103ExtracellularSequence AnalysisAdd
BLAST
Transmembranei126 – 15025Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini151 – 1577CytoplasmicSequence Analysis
Transmembranei158 – 17720Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini178 – 20225ExtracellularSequence AnalysisAdd
BLAST
Transmembranei203 – 22624Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini227 – 23913CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei240 – 26122Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini262 – 27817ExtracellularSequence AnalysisAdd
BLAST
Transmembranei279 – 30224Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini303 – 32725CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei328 – 34720Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini348 – 35912ExtracellularSequence AnalysisAdd
BLAST
Transmembranei360 – 37920Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini380 – 43758CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 437415Vasoactive intestinal polypeptide receptor 2PRO_0000012862Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 60By similarity
Disulfide bondi51 ↔ 92By similarity
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi74 ↔ 108By similarity
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi201 ↔ 270By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35000.

PTM databases

PhosphoSiteiP35000.

Expressioni

Gene expression databases

ExpressionAtlasiP35000. baseline.
GenevestigatoriP35000.

Interactioni

Protein-protein interaction databases

BioGridi248189. 1 interaction.
STRINGi10116.ENSRNOP00000005876.

Structurei

3D structure databases

ProteinModelPortaliP35000.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG265142.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiP35000.
KOiK04590.
OrthoDBiEOG7TF78W.
PhylomeDBiP35000.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR001571. GPCR_2_VIP_rcpt.
IPR002284. GPCR_2_VIP_rcpt_2.
[Graphical view]
PANTHERiPTHR12011:SF27. PTHR12011:SF27. 1 hit.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00491. VASOACTVEIPR.
PR01155. VIP2RECEPTOR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35000-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRASVVLTCY CWLLVRVSSI HPECRFHLEI QEEETKCAEL LSSQMENHRA
60 70 80 90 100
CSGVWDNITC WRPADIGETV TVPCPKVFSN FYSRPGNISK NCTSDGWSET
110 120 130 140 150
FPDFIDACGY NDPEDESKIT FYILVKAIYT LGYSVSLMSL TTGSIIICLF
160 170 180 190 200
RKLHCTRNYI HLNLFLSFML RAISVLVKDS VLYSSSGTLR CHDQPGSWVG
210 220 230 240 250
CKLSLVFFQY CIMANFYWLL VEGLYLHTLL VAILPPSRCF LAYLLIGWGI
260 270 280 290 300
PSVCIGAWIA TRLSLEDTGC WDTNDHSIPW WVIRMPILIS IVVNFALFIS
310 320 330 340 350
IVRILLQKLT SPDVGGNDQS QYKRLAKSTL LLIPLFGVHY MVFAAFPIGI
360 370 380 390 400
SSTYQILFEL CVGSFQGLVV AVLYCFLNSE VQCELKRRWR GLCLTQPGSR
410 420 430
DYRLHSWSMS RNGSESALQI HRGSRTQSFL QSETSVI
Length:437
Mass (Da):49,553
Last modified:February 1, 1994 - v1
Checksum:i7E10218A9EE31360
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti383 – 3831C → R in AAB60459. (PubMed:7988457)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z25885 mRNA. Translation: CAA81104.1.
U09631 mRNA. Translation: AAB60459.1.
PIRiS39069.
RefSeqiNP_058934.1. NM_017238.1.
UniGeneiRn.10011.

Genome annotation databases

GeneIDi29555.
KEGGirno:29555.
UCSCiRGD:3962. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z25885 mRNA. Translation: CAA81104.1 .
U09631 mRNA. Translation: AAB60459.1 .
PIRi S39069.
RefSeqi NP_058934.1. NM_017238.1.
UniGenei Rn.10011.

3D structure databases

ProteinModelPortali P35000.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 248189. 1 interaction.
STRINGi 10116.ENSRNOP00000005876.

Chemistry

BindingDBi P35000.
GuidetoPHARMACOLOGYi 372.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P35000.

Proteomic databases

PaxDbi P35000.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 29555.
KEGGi rno:29555.
UCSCi RGD:3962. rat.

Organism-specific databases

CTDi 7434.
RGDi 3962. Vipr2.

Phylogenomic databases

eggNOGi NOG265142.
HOGENOMi HOG000008249.
HOVERGENi HBG008318.
InParanoidi P35000.
KOi K04590.
OrthoDBi EOG7TF78W.
PhylomeDBi P35000.
TreeFami TF315710.

Enzyme and pathway databases

Reactomei REACT_246814. G alpha (s) signalling events.

Miscellaneous databases

NextBioi 609590.
PROi P35000.

Gene expression databases

ExpressionAtlasi P35000. baseline.
Genevestigatori P35000.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR001571. GPCR_2_VIP_rcpt.
IPR002284. GPCR_2_VIP_rcpt_2.
[Graphical view ]
PANTHERi PTHR12011:SF27. PTHR12011:SF27. 1 hit.
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
PR00491. VASOACTVEIPR.
PR01155. VIP2RECEPTOR.
SMARTi SM00008. HormR. 1 hit.
[Graphical view ]
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The VIP2 receptor: molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide."
    Lutz E.-M., Sheward W.J., West K.M., Morrow J.A., Fink G., Harmar A.J.
    FEBS Lett. 334:3-8(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Olfactory bulb.
  2. "Two receptors for vasoactive intestinal polypeptide with similar specificity and complementary distributions."
    Usdin T.B., Bonner T.I., Mezey E.
    Endocrinology 135:2662-2680(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain cortex.

Entry informationi

Entry nameiVIPR2_RAT
AccessioniPrimary (citable) accession number: P35000
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 26, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3