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P35000 (VIPR2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vasoactive intestinal polypeptide receptor 2

Short name=VIP-R-2
Alternative name(s):
Pituitary adenylate cyclase-activating polypeptide type III receptor
Short name=PACAP type III receptor
Short name=PACAP-R-3
Short name=PACAP-R3
Gene names
Name:Vipr2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length437 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 437415Vasoactive intestinal polypeptide receptor 2
PRO_0000012862

Regions

Topological domain23 – 125103Extracellular Potential
Transmembrane126 – 15025Helical; Name=1; Potential
Topological domain151 – 1577Cytoplasmic Potential
Transmembrane158 – 17720Helical; Name=2; Potential
Topological domain178 – 20225Extracellular Potential
Transmembrane203 – 22624Helical; Name=3; Potential
Topological domain227 – 23913Cytoplasmic Potential
Transmembrane240 – 26122Helical; Name=4; Potential
Topological domain262 – 27817Extracellular Potential
Transmembrane279 – 30224Helical; Name=5; Potential
Topological domain303 – 32725Cytoplasmic Potential
Transmembrane328 – 34720Helical; Name=6; Potential
Topological domain348 – 35912Extracellular Potential
Transmembrane360 – 37920Helical; Name=7; Potential
Topological domain380 – 43758Cytoplasmic Potential

Amino acid modifications

Glycosylation571N-linked (GlcNAc...) Potential
Glycosylation871N-linked (GlcNAc...) Potential
Glycosylation911N-linked (GlcNAc...) Potential
Disulfide bond37 ↔ 60 By similarity
Disulfide bond51 ↔ 92 By similarity
Disulfide bond74 ↔ 108 By similarity
Disulfide bond201 ↔ 270 By similarity

Experimental info

Sequence conflict3831C → R in AAB60459. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P35000 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 7E10218A9EE31360

FASTA43749,553
        10         20         30         40         50         60 
MRASVVLTCY CWLLVRVSSI HPECRFHLEI QEEETKCAEL LSSQMENHRA CSGVWDNITC 

        70         80         90        100        110        120 
WRPADIGETV TVPCPKVFSN FYSRPGNISK NCTSDGWSET FPDFIDACGY NDPEDESKIT 

       130        140        150        160        170        180 
FYILVKAIYT LGYSVSLMSL TTGSIIICLF RKLHCTRNYI HLNLFLSFML RAISVLVKDS 

       190        200        210        220        230        240 
VLYSSSGTLR CHDQPGSWVG CKLSLVFFQY CIMANFYWLL VEGLYLHTLL VAILPPSRCF 

       250        260        270        280        290        300 
LAYLLIGWGI PSVCIGAWIA TRLSLEDTGC WDTNDHSIPW WVIRMPILIS IVVNFALFIS 

       310        320        330        340        350        360 
IVRILLQKLT SPDVGGNDQS QYKRLAKSTL LLIPLFGVHY MVFAAFPIGI SSTYQILFEL 

       370        380        390        400        410        420 
CVGSFQGLVV AVLYCFLNSE VQCELKRRWR GLCLTQPGSR DYRLHSWSMS RNGSESALQI 

       430 
HRGSRTQSFL QSETSVI 

« Hide

References

[1]"The VIP2 receptor: molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide."
Lutz E.-M., Sheward W.J., West K.M., Morrow J.A., Fink G., Harmar A.J.
FEBS Lett. 334:3-8(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Olfactory bulb.
[2]"Two receptors for vasoactive intestinal polypeptide with similar specificity and complementary distributions."
Usdin T.B., Bonner T.I., Mezey E.
Endocrinology 135:2662-2680(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain cortex.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z25885 mRNA. Translation: CAA81104.1.
U09631 mRNA. Translation: AAB60459.1.
PIRS39069.
RefSeqNP_058934.1. NM_017238.1.
UniGeneRn.10011.

3D structure databases

ProteinModelPortalP35000.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid248189. 1 interaction.
STRING10116.ENSRNOP00000005876.

Chemistry

BindingDBP35000.
GuidetoPHARMACOLOGY372.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP35000.

Proteomic databases

PaxDbP35000.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID29555.
KEGGrno:29555.
UCSCRGD:3962. rat.

Organism-specific databases

CTD7434.
RGD3962. Vipr2.

Phylogenomic databases

eggNOGNOG265142.
HOGENOMHOG000008249.
HOVERGENHBG008318.
InParanoidP35000.
KOK04590.
OrthoDBEOG7TF78W.
PhylomeDBP35000.
TreeFamTF315710.

Gene expression databases

GenevestigatorP35000.

Family and domain databases

InterProIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR001571. GPCR_2_VIP_rcpt.
IPR002284. GPCR_2_VIP_rcpt_2.
[Graphical view]
PANTHERPTHR12011:SF27. PTHR12011:SF27. 1 hit.
PfamPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSPR00249. GPCRSECRETIN.
PR00491. VASOACTVEIPR.
PR01155. VIP2RECEPTOR.
SMARTSM00008. HormR. 1 hit.
[Graphical view]
PROSITEPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio609590.
PROP35000.

Entry information

Entry nameVIPR2_RAT
AccessionPrimary (citable) accession number: P35000
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries