Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P35000

- VIPR2_RAT

UniProt

P35000 - VIPR2_RAT

Protein

Vasoactive intestinal polypeptide receptor 2

Gene

Vipr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.

    GO - Molecular functioni

    1. vasoactive intestinal polypeptide receptor activity Source: RGD

    GO - Biological processi

    1. activation of adenylate cyclase activity Source: RGD
    2. negative regulation of smooth muscle cell proliferation Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vasoactive intestinal polypeptide receptor 2
    Short name:
    VIP-R-2
    Alternative name(s):
    Pituitary adenylate cyclase-activating polypeptide type III receptor
    Short name:
    PACAP type III receptor
    Short name:
    PACAP-R-3
    Short name:
    PACAP-R3
    Gene namesi
    Name:Vipr2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3962. Vipr2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 437415Vasoactive intestinal polypeptide receptor 2PRO_0000012862Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi37 ↔ 60By similarity
    Disulfide bondi51 ↔ 92By similarity
    Glycosylationi57 – 571N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi74 ↔ 108By similarity
    Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi201 ↔ 270By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP35000.

    PTM databases

    PhosphoSiteiP35000.

    Expressioni

    Gene expression databases

    GenevestigatoriP35000.

    Interactioni

    Protein-protein interaction databases

    BioGridi248189. 1 interaction.
    STRINGi10116.ENSRNOP00000005876.

    Structurei

    3D structure databases

    ProteinModelPortaliP35000.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 125103ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini151 – 1577CytoplasmicSequence Analysis
    Topological domaini178 – 20225ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini227 – 23913CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini262 – 27817ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini303 – 32725CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini348 – 35912ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini380 – 43758CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei126 – 15025Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei158 – 17720Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei203 – 22624Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei240 – 26122Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei279 – 30224Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei328 – 34720Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei360 – 37920Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG265142.
    HOGENOMiHOG000008249.
    HOVERGENiHBG008318.
    InParanoidiP35000.
    KOiK04590.
    OrthoDBiEOG7TF78W.
    PhylomeDBiP35000.
    TreeFamiTF315710.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR001571. GPCR_2_VIP_rcpt.
    IPR002284. GPCR_2_VIP_rcpt_2.
    [Graphical view]
    PANTHERiPTHR12011:SF27. PTHR12011:SF27. 1 hit.
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    PR00491. VASOACTVEIPR.
    PR01155. VIP2RECEPTOR.
    SMARTiSM00008. HormR. 1 hit.
    [Graphical view]
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P35000-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRASVVLTCY CWLLVRVSSI HPECRFHLEI QEEETKCAEL LSSQMENHRA    50
    CSGVWDNITC WRPADIGETV TVPCPKVFSN FYSRPGNISK NCTSDGWSET 100
    FPDFIDACGY NDPEDESKIT FYILVKAIYT LGYSVSLMSL TTGSIIICLF 150
    RKLHCTRNYI HLNLFLSFML RAISVLVKDS VLYSSSGTLR CHDQPGSWVG 200
    CKLSLVFFQY CIMANFYWLL VEGLYLHTLL VAILPPSRCF LAYLLIGWGI 250
    PSVCIGAWIA TRLSLEDTGC WDTNDHSIPW WVIRMPILIS IVVNFALFIS 300
    IVRILLQKLT SPDVGGNDQS QYKRLAKSTL LLIPLFGVHY MVFAAFPIGI 350
    SSTYQILFEL CVGSFQGLVV AVLYCFLNSE VQCELKRRWR GLCLTQPGSR 400
    DYRLHSWSMS RNGSESALQI HRGSRTQSFL QSETSVI 437
    Length:437
    Mass (Da):49,553
    Last modified:February 1, 1994 - v1
    Checksum:i7E10218A9EE31360
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti383 – 3831C → R in AAB60459. (PubMed:7988457)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z25885 mRNA. Translation: CAA81104.1.
    U09631 mRNA. Translation: AAB60459.1.
    PIRiS39069.
    RefSeqiNP_058934.1. NM_017238.1.
    UniGeneiRn.10011.

    Genome annotation databases

    GeneIDi29555.
    KEGGirno:29555.
    UCSCiRGD:3962. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z25885 mRNA. Translation: CAA81104.1 .
    U09631 mRNA. Translation: AAB60459.1 .
    PIRi S39069.
    RefSeqi NP_058934.1. NM_017238.1.
    UniGenei Rn.10011.

    3D structure databases

    ProteinModelPortali P35000.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 248189. 1 interaction.
    STRINGi 10116.ENSRNOP00000005876.

    Chemistry

    BindingDBi P35000.
    GuidetoPHARMACOLOGYi 372.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P35000.

    Proteomic databases

    PaxDbi P35000.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 29555.
    KEGGi rno:29555.
    UCSCi RGD:3962. rat.

    Organism-specific databases

    CTDi 7434.
    RGDi 3962. Vipr2.

    Phylogenomic databases

    eggNOGi NOG265142.
    HOGENOMi HOG000008249.
    HOVERGENi HBG008318.
    InParanoidi P35000.
    KOi K04590.
    OrthoDBi EOG7TF78W.
    PhylomeDBi P35000.
    TreeFami TF315710.

    Miscellaneous databases

    NextBioi 609590.
    PROi P35000.

    Gene expression databases

    Genevestigatori P35000.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR001571. GPCR_2_VIP_rcpt.
    IPR002284. GPCR_2_VIP_rcpt_2.
    [Graphical view ]
    PANTHERi PTHR12011:SF27. PTHR12011:SF27. 1 hit.
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    PR00491. VASOACTVEIPR.
    PR01155. VIP2RECEPTOR.
    SMARTi SM00008. HormR. 1 hit.
    [Graphical view ]
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The VIP2 receptor: molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide."
      Lutz E.-M., Sheward W.J., West K.M., Morrow J.A., Fink G., Harmar A.J.
      FEBS Lett. 334:3-8(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Olfactory bulb.
    2. "Two receptors for vasoactive intestinal polypeptide with similar specificity and complementary distributions."
      Usdin T.B., Bonner T.I., Mezey E.
      Endocrinology 135:2662-2680(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiVIPR2_RAT
    AccessioniPrimary (citable) accession number: P35000
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3