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Protein

Vasoactive intestinal polypeptide receptor 2

Gene

Vipr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.

GO - Molecular functioni

  1. vasoactive intestinal polypeptide receptor activity Source: RGD

GO - Biological processi

  1. activation of adenylate cyclase activity Source: RGD
  2. negative regulation of smooth muscle cell proliferation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_287445. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasoactive intestinal polypeptide receptor 2
Short name:
VIP-R-2
Alternative name(s):
Pituitary adenylate cyclase-activating polypeptide type III receptor
Short name:
PACAP type III receptor
Short name:
PACAP-R-3
Short name:
PACAP-R3
Gene namesi
Name:Vipr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3962. Vipr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 125103ExtracellularSequence AnalysisAdd
BLAST
Transmembranei126 – 15025Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini151 – 1577CytoplasmicSequence Analysis
Transmembranei158 – 17720Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini178 – 20225ExtracellularSequence AnalysisAdd
BLAST
Transmembranei203 – 22624Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini227 – 23913CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei240 – 26122Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini262 – 27817ExtracellularSequence AnalysisAdd
BLAST
Transmembranei279 – 30224Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini303 – 32725CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei328 – 34720Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini348 – 35912ExtracellularSequence AnalysisAdd
BLAST
Transmembranei360 – 37920Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini380 – 43758CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 437415Vasoactive intestinal polypeptide receptor 2PRO_0000012862Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 60By similarity
Disulfide bondi51 ↔ 92By similarity
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi74 ↔ 108By similarity
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi201 ↔ 270By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35000.

PTM databases

PhosphoSiteiP35000.

Expressioni

Gene expression databases

ExpressionAtlasiP35000. baseline.
GenevestigatoriP35000.

Interactioni

Protein-protein interaction databases

BioGridi248189. 1 interaction.
STRINGi10116.ENSRNOP00000005876.

Structurei

3D structure databases

ProteinModelPortaliP35000.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG265142.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiP35000.
KOiK04590.
OrthoDBiEOG7TF78W.
PhylomeDBiP35000.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR001571. GPCR_2_VIP_rcpt.
IPR002284. GPCR_2_VIP_rcpt_2.
[Graphical view]
PANTHERiPTHR12011:SF27. PTHR12011:SF27. 1 hit.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00491. VASOACTVEIPR.
PR01155. VIP2RECEPTOR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRASVVLTCY CWLLVRVSSI HPECRFHLEI QEEETKCAEL LSSQMENHRA
60 70 80 90 100
CSGVWDNITC WRPADIGETV TVPCPKVFSN FYSRPGNISK NCTSDGWSET
110 120 130 140 150
FPDFIDACGY NDPEDESKIT FYILVKAIYT LGYSVSLMSL TTGSIIICLF
160 170 180 190 200
RKLHCTRNYI HLNLFLSFML RAISVLVKDS VLYSSSGTLR CHDQPGSWVG
210 220 230 240 250
CKLSLVFFQY CIMANFYWLL VEGLYLHTLL VAILPPSRCF LAYLLIGWGI
260 270 280 290 300
PSVCIGAWIA TRLSLEDTGC WDTNDHSIPW WVIRMPILIS IVVNFALFIS
310 320 330 340 350
IVRILLQKLT SPDVGGNDQS QYKRLAKSTL LLIPLFGVHY MVFAAFPIGI
360 370 380 390 400
SSTYQILFEL CVGSFQGLVV AVLYCFLNSE VQCELKRRWR GLCLTQPGSR
410 420 430
DYRLHSWSMS RNGSESALQI HRGSRTQSFL QSETSVI
Length:437
Mass (Da):49,553
Last modified:February 1, 1994 - v1
Checksum:i7E10218A9EE31360
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti383 – 3831C → R in AAB60459 (PubMed:7988457).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z25885 mRNA. Translation: CAA81104.1.
U09631 mRNA. Translation: AAB60459.1.
PIRiS39069.
RefSeqiNP_058934.1. NM_017238.1.
UniGeneiRn.10011.

Genome annotation databases

GeneIDi29555.
KEGGirno:29555.
UCSCiRGD:3962. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z25885 mRNA. Translation: CAA81104.1.
U09631 mRNA. Translation: AAB60459.1.
PIRiS39069.
RefSeqiNP_058934.1. NM_017238.1.
UniGeneiRn.10011.

3D structure databases

ProteinModelPortaliP35000.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248189. 1 interaction.
STRINGi10116.ENSRNOP00000005876.

Chemistry

BindingDBiP35000.
GuidetoPHARMACOLOGYi372.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP35000.

Proteomic databases

PaxDbiP35000.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29555.
KEGGirno:29555.
UCSCiRGD:3962. rat.

Organism-specific databases

CTDi7434.
RGDi3962. Vipr2.

Phylogenomic databases

eggNOGiNOG265142.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiP35000.
KOiK04590.
OrthoDBiEOG7TF78W.
PhylomeDBiP35000.
TreeFamiTF315710.

Enzyme and pathway databases

ReactomeiREACT_287445. G alpha (s) signalling events.

Miscellaneous databases

NextBioi609590.
PROiP35000.

Gene expression databases

ExpressionAtlasiP35000. baseline.
GenevestigatoriP35000.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR001571. GPCR_2_VIP_rcpt.
IPR002284. GPCR_2_VIP_rcpt_2.
[Graphical view]
PANTHERiPTHR12011:SF27. PTHR12011:SF27. 1 hit.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00491. VASOACTVEIPR.
PR01155. VIP2RECEPTOR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The VIP2 receptor: molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide."
    Lutz E.-M., Sheward W.J., West K.M., Morrow J.A., Fink G., Harmar A.J.
    FEBS Lett. 334:3-8(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Olfactory bulb.
  2. "Two receptors for vasoactive intestinal polypeptide with similar specificity and complementary distributions."
    Usdin T.B., Bonner T.I., Mezey E.
    Endocrinology 135:2662-2680(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain cortex.

Entry informationi

Entry nameiVIPR2_RAT
AccessioniPrimary (citable) accession number: P35000
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 1, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.