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P35000

- VIPR2_RAT

UniProt

P35000 - VIPR2_RAT

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Protein

Vasoactive intestinal polypeptide receptor 2

Gene
Vipr2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.

GO - Molecular functioni

  1. vasoactive intestinal polypeptide receptor activity Source: RGD

GO - Biological processi

  1. activation of adenylate cyclase activity Source: RGD
  2. negative regulation of smooth muscle cell proliferation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Vasoactive intestinal polypeptide receptor 2
Short name:
VIP-R-2
Alternative name(s):
Pituitary adenylate cyclase-activating polypeptide type III receptor
Short name:
PACAP type III receptor
Short name:
PACAP-R-3
Short name:
PACAP-R3
Gene namesi
Name:Vipr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3962. Vipr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 125103Extracellular Reviewed predictionAdd
BLAST
Transmembranei126 – 15025Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini151 – 1577Cytoplasmic Reviewed prediction
Transmembranei158 – 17720Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini178 – 20225Extracellular Reviewed predictionAdd
BLAST
Transmembranei203 – 22624Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini227 – 23913Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei240 – 26122Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini262 – 27817Extracellular Reviewed predictionAdd
BLAST
Transmembranei279 – 30224Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini303 – 32725Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei328 – 34720Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini348 – 35912Extracellular Reviewed predictionAdd
BLAST
Transmembranei360 – 37920Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini380 – 43758Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Chaini23 – 437415Vasoactive intestinal polypeptide receptor 2PRO_0000012862Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 60 By similarity
Disulfide bondi51 ↔ 92 By similarity
Glycosylationi57 – 571N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi74 ↔ 108 By similarity
Glycosylationi87 – 871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi91 – 911N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi201 ↔ 270 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35000.

PTM databases

PhosphoSiteiP35000.

Expressioni

Gene expression databases

GenevestigatoriP35000.

Interactioni

Protein-protein interaction databases

BioGridi248189. 1 interaction.
STRINGi10116.ENSRNOP00000005876.

Structurei

3D structure databases

ProteinModelPortaliP35000.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG265142.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiP35000.
KOiK04590.
OrthoDBiEOG7TF78W.
PhylomeDBiP35000.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR001571. GPCR_2_VIP_rcpt.
IPR002284. GPCR_2_VIP_rcpt_2.
[Graphical view]
PANTHERiPTHR12011:SF27. PTHR12011:SF27. 1 hit.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00491. VASOACTVEIPR.
PR01155. VIP2RECEPTOR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35000-1 [UniParc]FASTAAdd to Basket

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MRASVVLTCY CWLLVRVSSI HPECRFHLEI QEEETKCAEL LSSQMENHRA    50
CSGVWDNITC WRPADIGETV TVPCPKVFSN FYSRPGNISK NCTSDGWSET 100
FPDFIDACGY NDPEDESKIT FYILVKAIYT LGYSVSLMSL TTGSIIICLF 150
RKLHCTRNYI HLNLFLSFML RAISVLVKDS VLYSSSGTLR CHDQPGSWVG 200
CKLSLVFFQY CIMANFYWLL VEGLYLHTLL VAILPPSRCF LAYLLIGWGI 250
PSVCIGAWIA TRLSLEDTGC WDTNDHSIPW WVIRMPILIS IVVNFALFIS 300
IVRILLQKLT SPDVGGNDQS QYKRLAKSTL LLIPLFGVHY MVFAAFPIGI 350
SSTYQILFEL CVGSFQGLVV AVLYCFLNSE VQCELKRRWR GLCLTQPGSR 400
DYRLHSWSMS RNGSESALQI HRGSRTQSFL QSETSVI 437
Length:437
Mass (Da):49,553
Last modified:February 1, 1994 - v1
Checksum:i7E10218A9EE31360
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti383 – 3831C → R in AAB60459. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z25885 mRNA. Translation: CAA81104.1.
U09631 mRNA. Translation: AAB60459.1.
PIRiS39069.
RefSeqiNP_058934.1. NM_017238.1.
UniGeneiRn.10011.

Genome annotation databases

GeneIDi29555.
KEGGirno:29555.
UCSCiRGD:3962. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z25885 mRNA. Translation: CAA81104.1 .
U09631 mRNA. Translation: AAB60459.1 .
PIRi S39069.
RefSeqi NP_058934.1. NM_017238.1.
UniGenei Rn.10011.

3D structure databases

ProteinModelPortali P35000.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 248189. 1 interaction.
STRINGi 10116.ENSRNOP00000005876.

Chemistry

BindingDBi P35000.
GuidetoPHARMACOLOGYi 372.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P35000.

Proteomic databases

PaxDbi P35000.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 29555.
KEGGi rno:29555.
UCSCi RGD:3962. rat.

Organism-specific databases

CTDi 7434.
RGDi 3962. Vipr2.

Phylogenomic databases

eggNOGi NOG265142.
HOGENOMi HOG000008249.
HOVERGENi HBG008318.
InParanoidi P35000.
KOi K04590.
OrthoDBi EOG7TF78W.
PhylomeDBi P35000.
TreeFami TF315710.

Miscellaneous databases

NextBioi 609590.
PROi P35000.

Gene expression databases

Genevestigatori P35000.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR001571. GPCR_2_VIP_rcpt.
IPR002284. GPCR_2_VIP_rcpt_2.
[Graphical view ]
PANTHERi PTHR12011:SF27. PTHR12011:SF27. 1 hit.
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
PR00491. VASOACTVEIPR.
PR01155. VIP2RECEPTOR.
SMARTi SM00008. HormR. 1 hit.
[Graphical view ]
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The VIP2 receptor: molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide."
    Lutz E.-M., Sheward W.J., West K.M., Morrow J.A., Fink G., Harmar A.J.
    FEBS Lett. 334:3-8(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Olfactory bulb.
  2. "Two receptors for vasoactive intestinal polypeptide with similar specificity and complementary distributions."
    Usdin T.B., Bonner T.I., Mezey E.
    Endocrinology 135:2662-2680(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain cortex.

Entry informationi

Entry nameiVIPR2_RAT
AccessioniPrimary (citable) accession number: P35000
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 3, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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