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P34997

- CXCR5_RAT

UniProt

P34997 - CXCR5_RAT

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Protein

C-X-C chemokine receptor type 5

Gene
Cxcr5, Blr1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes By similarity.

GO - Molecular functioni

  1. C-X-C chemokine receptor activity Source: InterPro

GO - Biological processi

  1. B cell activation Source: UniProtKB-KW
  2. chemotaxis Source: InterPro
  3. immune response Source: InterPro
  4. lymph node development Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

B-cell activation

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 5
Short name:
CXC-R5
Short name:
CXCR-5
Alternative name(s):
Burkitt lymphoma receptor 1 homolog
Neurolymphatic receptor
Short name:
NLR
CD_antigen: CD185
Gene namesi
Name:Cxcr5
Synonyms:Blr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi62010. Cxcr5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5757Extracellular Reviewed predictionAdd
BLAST
Transmembranei58 – 7821Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini79 – 9012Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei91 – 11121Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini112 – 12615Extracellular Reviewed predictionAdd
BLAST
Transmembranei127 – 14721Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini148 – 16922Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei170 – 19021Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini191 – 22131Extracellular Reviewed predictionAdd
BLAST
Transmembranei222 – 24221Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini243 – 26119Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei262 – 28221Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini283 – 30624Extracellular Reviewed predictionAdd
BLAST
Transmembranei307 – 32721Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini328 – 37447Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374C-X-C chemokine receptor type 5PRO_0000069362Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi124 ↔ 204 Reviewed prediction
Glycosylationi198 – 1981N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

PTM databases

PhosphoSiteiP34997.

Expressioni

Tissue specificityi

Expressed in neuronal and lymphatic tissue.

Gene expression databases

GenevestigatoriP34997.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016580.

Structurei

3D structure databases

ProteinModelPortaliP34997.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146951.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP34997.
KOiK04190.
PhylomeDBiP34997.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001053. Chemokine_CXCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF33. PTHR24227:SF33. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00564. CXCCHMKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34997-1 [UniParc]FASTAAdd to Basket

« Hide

MNSPISLDMG AITYNMDDLY KELAIYSNST EIPLQDSIFC STEEGPLLTS    50
FKTIFMPVAY SLIFLLGMMG NILVLVILER HRHTRSSTET FLFHLAVADL 100
LLVFILPFAV AEGSVGWVLG TFLCKTVIAL HKINFYCSSL LLACIAVDRY 150
LAIVHAVHAY RRRRLLSIHI TCSTIWLAGF LFALPELLFA KVVQPHNNES 200
LPQCIFSQEN EAETRAWFAS RFLYHTGGFL LPMLVMAWCY VGVVHRLLQA 250
QRRPQRQKAV RVAILVTSIF LLCWSPYHIV IFLDTLERLK AVNSSCELSG 300
YLSVAITLCE FLGLAHCCLN PMLYTFAGVK FRSDLSRLLT KLGCAGPASL 350
CQLFPGWRKS SLSESENATS LTTF 374
Length:374
Mass (Da):42,013
Last modified:February 1, 1994 - v1
Checksum:iD87A3AC816207319
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X71463 Genomic DNA. Translation: CAA50582.1.
PIRiS32785.
RefSeqiNP_445755.1. NM_053303.1.
UniGeneiRn.127121.

Genome annotation databases

GeneIDi29363.
KEGGirno:29363.
UCSCiRGD:62010. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X71463 Genomic DNA. Translation: CAA50582.1 .
PIRi S32785.
RefSeqi NP_445755.1. NM_053303.1.
UniGenei Rn.127121.

3D structure databases

ProteinModelPortali P34997.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000016580.

Chemistry

GuidetoPHARMACOLOGYi 72.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P34997.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 29363.
KEGGi rno:29363.
UCSCi RGD:62010. rat.

Organism-specific databases

CTDi 643.
RGDi 62010. Cxcr5.

Phylogenomic databases

eggNOGi NOG146951.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi P34997.
KOi K04190.
PhylomeDBi P34997.

Miscellaneous databases

NextBioi 608896.
PROi P34997.

Gene expression databases

Genevestigatori P34997.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001053. Chemokine_CXCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
PTHR24227:SF33. PTHR24227:SF33. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00564. CXCCHMKINER5.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of a novel putative G-protein-coupled receptor (NLR) which is expressed in neuronal and lymphatic tissue."
    Kouba M., Vanetti M., Wang X., Schaefer M., Hoellt V.
    FEBS Lett. 321:173-178(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Spleen.

Entry informationi

Entry nameiCXCR5_RAT
AccessioniPrimary (citable) accession number: P34997
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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