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Protein

C-X-C chemokine receptor type 5

Gene

Cxcr5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

B-cell activation

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 5
Short name:
CXC-R5
Short name:
CXCR-5
Alternative name(s):
Burkitt lymphoma receptor 1 homolog
Neurolymphatic receptor
Short name:
NLR
CD_antigen: CD185
Gene namesi
Name:Cxcr5
Synonyms:Blr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi62010. Cxcr5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57ExtracellularSequence analysisAdd BLAST57
Transmembranei58 – 78Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini79 – 90CytoplasmicSequence analysisAdd BLAST12
Transmembranei91 – 111Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini112 – 126ExtracellularSequence analysisAdd BLAST15
Transmembranei127 – 147Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini148 – 169CytoplasmicSequence analysisAdd BLAST22
Transmembranei170 – 190Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini191 – 221ExtracellularSequence analysisAdd BLAST31
Transmembranei222 – 242Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini243 – 261CytoplasmicSequence analysisAdd BLAST19
Transmembranei262 – 282Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini283 – 306ExtracellularSequence analysisAdd BLAST24
Transmembranei307 – 327Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini328 – 374CytoplasmicSequence analysisAdd BLAST47

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693621 – 374C-X-C chemokine receptor type 5Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi124 ↔ 204PROSITE-ProRule annotation
Glycosylationi198N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP34997.

PTM databases

PhosphoSitePlusiP34997.

Expressioni

Tissue specificityi

Expressed in neuronal and lymphatic tissue.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016580.

Structurei

3D structure databases

ProteinModelPortaliP34997.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE41. Eukaryota.
ENOG410YWPA. LUCA.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP34997.
KOiK04190.
PhylomeDBiP34997.

Family and domain databases

InterProiIPR001053. Chemokine_CXCR5.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00564. CXCCHMKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34997-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSPISLDMG AITYNMDDLY KELAIYSNST EIPLQDSIFC STEEGPLLTS
60 70 80 90 100
FKTIFMPVAY SLIFLLGMMG NILVLVILER HRHTRSSTET FLFHLAVADL
110 120 130 140 150
LLVFILPFAV AEGSVGWVLG TFLCKTVIAL HKINFYCSSL LLACIAVDRY
160 170 180 190 200
LAIVHAVHAY RRRRLLSIHI TCSTIWLAGF LFALPELLFA KVVQPHNNES
210 220 230 240 250
LPQCIFSQEN EAETRAWFAS RFLYHTGGFL LPMLVMAWCY VGVVHRLLQA
260 270 280 290 300
QRRPQRQKAV RVAILVTSIF LLCWSPYHIV IFLDTLERLK AVNSSCELSG
310 320 330 340 350
YLSVAITLCE FLGLAHCCLN PMLYTFAGVK FRSDLSRLLT KLGCAGPASL
360 370
CQLFPGWRKS SLSESENATS LTTF
Length:374
Mass (Da):42,013
Last modified:February 1, 1994 - v1
Checksum:iD87A3AC816207319
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71463 Genomic DNA. Translation: CAA50582.1.
PIRiS32785.
RefSeqiNP_445755.1. NM_053303.1.
UniGeneiRn.127121.

Genome annotation databases

GeneIDi29363.
KEGGirno:29363.
UCSCiRGD:62010. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71463 Genomic DNA. Translation: CAA50582.1.
PIRiS32785.
RefSeqiNP_445755.1. NM_053303.1.
UniGeneiRn.127121.

3D structure databases

ProteinModelPortaliP34997.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016580.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP34997.

Proteomic databases

PaxDbiP34997.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29363.
KEGGirno:29363.
UCSCiRGD:62010. rat.

Organism-specific databases

CTDi643.
RGDi62010. Cxcr5.

Phylogenomic databases

eggNOGiENOG410IE41. Eukaryota.
ENOG410YWPA. LUCA.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP34997.
KOiK04190.
PhylomeDBiP34997.

Miscellaneous databases

PROiP34997.

Family and domain databases

InterProiIPR001053. Chemokine_CXCR5.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00564. CXCCHMKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXCR5_RAT
AccessioniPrimary (citable) accession number: P34997
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.