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P34997 (CXCR5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-X-C chemokine receptor type 5

Short name=CXC-R5
Short name=CXCR-5
Alternative name(s):
Burkitt lymphoma receptor 1 homolog
Neurolymphatic receptor
Short name=NLR
CD_antigen=CD185
Gene names
Name:Cxcr5
Synonyms:Blr1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length374 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in neuronal and lymphatic tissue.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 374374C-X-C chemokine receptor type 5
PRO_0000069362

Regions

Topological domain1 – 5757Extracellular Potential
Transmembrane58 – 7821Helical; Name=1; Potential
Topological domain79 – 9012Cytoplasmic Potential
Transmembrane91 – 11121Helical; Name=2; Potential
Topological domain112 – 12615Extracellular Potential
Transmembrane127 – 14721Helical; Name=3; Potential
Topological domain148 – 16922Cytoplasmic Potential
Transmembrane170 – 19021Helical; Name=4; Potential
Topological domain191 – 22131Extracellular Potential
Transmembrane222 – 24221Helical; Name=5; Potential
Topological domain243 – 26119Cytoplasmic Potential
Transmembrane262 – 28221Helical; Name=6; Potential
Topological domain283 – 30624Extracellular Potential
Transmembrane307 – 32721Helical; Name=7; Potential
Topological domain328 – 37447Cytoplasmic Potential

Amino acid modifications

Glycosylation281N-linked (GlcNAc...) Potential
Glycosylation1981N-linked (GlcNAc...) Potential
Disulfide bond124 ↔ 204 Potential

Sequences

Sequence LengthMass (Da)Tools
P34997 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: D87A3AC816207319

FASTA37442,013
        10         20         30         40         50         60 
MNSPISLDMG AITYNMDDLY KELAIYSNST EIPLQDSIFC STEEGPLLTS FKTIFMPVAY 

        70         80         90        100        110        120 
SLIFLLGMMG NILVLVILER HRHTRSSTET FLFHLAVADL LLVFILPFAV AEGSVGWVLG 

       130        140        150        160        170        180 
TFLCKTVIAL HKINFYCSSL LLACIAVDRY LAIVHAVHAY RRRRLLSIHI TCSTIWLAGF 

       190        200        210        220        230        240 
LFALPELLFA KVVQPHNNES LPQCIFSQEN EAETRAWFAS RFLYHTGGFL LPMLVMAWCY 

       250        260        270        280        290        300 
VGVVHRLLQA QRRPQRQKAV RVAILVTSIF LLCWSPYHIV IFLDTLERLK AVNSSCELSG 

       310        320        330        340        350        360 
YLSVAITLCE FLGLAHCCLN PMLYTFAGVK FRSDLSRLLT KLGCAGPASL CQLFPGWRKS 

       370 
SLSESENATS LTTF 

« Hide

References

[1]"Cloning of a novel putative G-protein-coupled receptor (NLR) which is expressed in neuronal and lymphatic tissue."
Kouba M., Vanetti M., Wang X., Schaefer M., Hoellt V.
FEBS Lett. 321:173-178(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Spleen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X71463 Genomic DNA. Translation: CAA50582.1.
PIRS32785.
RefSeqNP_445755.1. NM_053303.1.
UniGeneRn.127121.

3D structure databases

ProteinModelPortalP34997.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000016580.

Chemistry

GuidetoPHARMACOLOGY72.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP34997.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID29363.
KEGGrno:29363.
UCSCRGD:62010. rat.

Organism-specific databases

CTD643.
RGD62010. Cxcr5.

Phylogenomic databases

eggNOGNOG146951.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidP34997.
KOK04190.
PhylomeDBP34997.

Gene expression databases

GenevestigatorP34997.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001053. Chemokine_CXCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF33. PTHR24227:SF33. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00564. CXCCHMKINER5.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio608896.
PROP34997.

Entry information

Entry nameCXCR5_RAT
AccessionPrimary (citable) accession number: P34997
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries