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P34997

- CXCR5_RAT

UniProt

P34997 - CXCR5_RAT

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Protein

C-X-C chemokine receptor type 5

Gene

Cxcr5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes (By similarity).By similarity

GO - Molecular functioni

  1. C-X-C chemokine receptor activity Source: InterPro

GO - Biological processi

  1. B cell activation Source: UniProtKB-KW
  2. chemotaxis Source: InterPro
  3. immune response Source: InterPro
  4. lymph node development Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

B-cell activation

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 5
Short name:
CXC-R5
Short name:
CXCR-5
Alternative name(s):
Burkitt lymphoma receptor 1 homolog
Neurolymphatic receptor
Short name:
NLR
CD_antigen: CD185
Gene namesi
Name:Cxcr5
Synonyms:Blr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi62010. Cxcr5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5757ExtracellularSequence AnalysisAdd
BLAST
Transmembranei58 – 7821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini79 – 9012CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei91 – 11121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini112 – 12615ExtracellularSequence AnalysisAdd
BLAST
Transmembranei127 – 14721Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini148 – 16922CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei170 – 19021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini191 – 22131ExtracellularSequence AnalysisAdd
BLAST
Transmembranei222 – 24221Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini243 – 26119CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei262 – 28221Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini283 – 30624ExtracellularSequence AnalysisAdd
BLAST
Transmembranei307 – 32721Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini328 – 37447CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374C-X-C chemokine receptor type 5PRO_0000069362Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi124 ↔ 204PROSITE-ProRule annotation
Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

PTM databases

PhosphoSiteiP34997.

Expressioni

Tissue specificityi

Expressed in neuronal and lymphatic tissue.

Gene expression databases

GenevestigatoriP34997.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016580.

Structurei

3D structure databases

ProteinModelPortaliP34997.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146951.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP34997.
KOiK04190.
PhylomeDBiP34997.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001053. Chemokine_CXCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF33. PTHR24227:SF33. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00564. CXCCHMKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34997-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSPISLDMG AITYNMDDLY KELAIYSNST EIPLQDSIFC STEEGPLLTS
60 70 80 90 100
FKTIFMPVAY SLIFLLGMMG NILVLVILER HRHTRSSTET FLFHLAVADL
110 120 130 140 150
LLVFILPFAV AEGSVGWVLG TFLCKTVIAL HKINFYCSSL LLACIAVDRY
160 170 180 190 200
LAIVHAVHAY RRRRLLSIHI TCSTIWLAGF LFALPELLFA KVVQPHNNES
210 220 230 240 250
LPQCIFSQEN EAETRAWFAS RFLYHTGGFL LPMLVMAWCY VGVVHRLLQA
260 270 280 290 300
QRRPQRQKAV RVAILVTSIF LLCWSPYHIV IFLDTLERLK AVNSSCELSG
310 320 330 340 350
YLSVAITLCE FLGLAHCCLN PMLYTFAGVK FRSDLSRLLT KLGCAGPASL
360 370
CQLFPGWRKS SLSESENATS LTTF
Length:374
Mass (Da):42,013
Last modified:February 1, 1994 - v1
Checksum:iD87A3AC816207319
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71463 Genomic DNA. Translation: CAA50582.1.
PIRiS32785.
RefSeqiNP_445755.1. NM_053303.1.
UniGeneiRn.127121.

Genome annotation databases

GeneIDi29363.
KEGGirno:29363.
UCSCiRGD:62010. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71463 Genomic DNA. Translation: CAA50582.1 .
PIRi S32785.
RefSeqi NP_445755.1. NM_053303.1.
UniGenei Rn.127121.

3D structure databases

ProteinModelPortali P34997.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000016580.

Chemistry

GuidetoPHARMACOLOGYi 72.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P34997.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 29363.
KEGGi rno:29363.
UCSCi RGD:62010. rat.

Organism-specific databases

CTDi 643.
RGDi 62010. Cxcr5.

Phylogenomic databases

eggNOGi NOG146951.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi P34997.
KOi K04190.
PhylomeDBi P34997.

Miscellaneous databases

NextBioi 608896.
PROi P34997.

Gene expression databases

Genevestigatori P34997.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001053. Chemokine_CXCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
PTHR24227:SF33. PTHR24227:SF33. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00564. CXCCHMKINER5.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of a novel putative G-protein-coupled receptor (NLR) which is expressed in neuronal and lymphatic tissue."
    Kouba M., Vanetti M., Wang X., Schaefer M., Hoellt V.
    FEBS Lett. 321:173-178(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Spleen.

Entry informationi

Entry nameiCXCR5_RAT
AccessioniPrimary (citable) accession number: P34997
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3