P34997 (CXCR5_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-X-C chemokine receptor type 5
Short name=CXC-R5
Short name=CXCR-5

Alternative name(s):
Burkitt lymphoma receptor 1 homolog
Neurolymphatic receptor
Short name=NLR
CD_antigen=CD185

Gene names

Name:	Cxcr5
Synonyms:	Blr1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	374 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in neuronal and lymphatic tissue.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	B-cell activation
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	B cell activation Inferred from electronic annotation. Source: UniProtKB-KW chemotaxis Inferred from electronic annotation. Source: InterPro elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	C-X-C chemokine receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 374	374	C-X-C chemokine receptor type 5		PRO_0000069362
Regions
	Topological domain	1 – 57	57	Extracellular Potential
	Transmembrane	58 – 78	21	Helical; Name=1; Potential
	Topological domain	79 – 90	12	Cytoplasmic Potential
	Transmembrane	91 – 111	21	Helical; Name=2; Potential
	Topological domain	112 – 126	15	Extracellular Potential
	Transmembrane	127 – 147	21	Helical; Name=3; Potential
	Topological domain	148 – 169	22	Cytoplasmic Potential
	Transmembrane	170 – 190	21	Helical; Name=4; Potential
	Topological domain	191 – 221	31	Extracellular Potential
	Transmembrane	222 – 242	21	Helical; Name=5; Potential
	Topological domain	243 – 261	19	Cytoplasmic Potential
	Transmembrane	262 – 282	21	Helical; Name=6; Potential
	Topological domain	283 – 306	24	Extracellular Potential
	Transmembrane	307 – 327	21	Helical; Name=7; Potential
	Topological domain	328 – 374	47	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	28	1	N-linked (GlcNAc...) Potential
	Glycosylation	198	1	N-linked (GlcNAc...) Potential
	Disulfide bond	124 ↔ 204		Potential

Sequences

	Sequence		Length	Mass (Da)
	P34997 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: D87A3AC816207319	FASTA	374	42,013
	10 20 30 40 50 60 MNSPISLDMG AITYNMDDLY KELAIYSNST EIPLQDSIFC STEEGPLLTS FKTIFMPVAY 70 80 90 100 110 120 SLIFLLGMMG NILVLVILER HRHTRSSTET FLFHLAVADL LLVFILPFAV AEGSVGWVLG 130 140 150 160 170 180 TFLCKTVIAL HKINFYCSSL LLACIAVDRY LAIVHAVHAY RRRRLLSIHI TCSTIWLAGF 190 200 210 220 230 240 LFALPELLFA KVVQPHNNES LPQCIFSQEN EAETRAWFAS RFLYHTGGFL LPMLVMAWCY 250 260 270 280 290 300 VGVVHRLLQA QRRPQRQKAV RVAILVTSIF LLCWSPYHIV IFLDTLERLK AVNSSCELSG 310 320 330 340 350 360 YLSVAITLCE FLGLAHCCLN PMLYTFAGVK FRSDLSRLLT KLGCAGPASL CQLFPGWRKS 370 SLSESENATS LTTF

References

[1]	"Cloning of a novel putative G-protein-coupled receptor (NLR) which is expressed in neuronal and lymphatic tissue." Kouba M., Vanetti M., Wang X., Schaefer M., Hoellt V. FEBS Lett. 321:173-178(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Spleen.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X71463 Genomic DNA. Translation: CAA50582.1.
IPI	IPI00199947.
PIR	S32785.
RefSeq	NP_445755.1. NM_053303.1.
UniGene	Rn.127121.
3D structure databases
ProteinModelPortal	P34997.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000016580.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P34997.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	29363.
KEGG	rno:29363.
UCSC	RGD:62010. rat.
Organism-specific databases
CTD	643.
RGD	62010. Cxcr5.
Phylogenomic databases
eggNOG	NOG146951.
HOGENOM	HOG000234122.
HOVERGEN	HBG106917.
InParanoid	P34997.
KO	K04190.
OrthoDB	EOG4PZJ6X.
Gene expression databases
Genevestigator	P34997.
GermOnline	ENSRNOG00000012430. Rattus norvegicus.
Family and domain databases
InterPro	IPR001053. Chemokine_CXCR5. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00564. CXCCHMKINER5. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	608896.

Entry information

Entry name

CXCR5_RAT

Accession

Primary (citable) accession number: P34997

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program