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P34997

- CXCR5_RAT

UniProt

P34997 - CXCR5_RAT

Protein

C-X-C chemokine receptor type 5

Gene

Cxcr5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes By similarity.By similarity

    GO - Molecular functioni

    1. C-X-C chemokine receptor activity Source: InterPro

    GO - Biological processi

    1. B cell activation Source: UniProtKB-KW
    2. chemotaxis Source: InterPro
    3. immune response Source: InterPro
    4. lymph node development Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    B-cell activation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C chemokine receptor type 5
    Short name:
    CXC-R5
    Short name:
    CXCR-5
    Alternative name(s):
    Burkitt lymphoma receptor 1 homolog
    Neurolymphatic receptor
    Short name:
    NLR
    CD_antigen: CD185
    Gene namesi
    Name:Cxcr5
    Synonyms:Blr1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi62010. Cxcr5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 374374C-X-C chemokine receptor type 5PRO_0000069362Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi124 ↔ 204PROSITE-ProRule annotation
    Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    PTM databases

    PhosphoSiteiP34997.

    Expressioni

    Tissue specificityi

    Expressed in neuronal and lymphatic tissue.

    Gene expression databases

    GenevestigatoriP34997.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000016580.

    Structurei

    3D structure databases

    ProteinModelPortaliP34997.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5757ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini79 – 9012CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini112 – 12615ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini148 – 16922CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini191 – 22131ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini243 – 26119CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini283 – 30624ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini328 – 37447CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei58 – 7821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei91 – 11121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei170 – 19021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei222 – 24221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei262 – 28221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei307 – 32721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146951.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiP34997.
    KOiK04190.
    PhylomeDBiP34997.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001053. Chemokine_CXCR5.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF33. PTHR24227:SF33. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00564. CXCCHMKINER5.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34997-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSPISLDMG AITYNMDDLY KELAIYSNST EIPLQDSIFC STEEGPLLTS    50
    FKTIFMPVAY SLIFLLGMMG NILVLVILER HRHTRSSTET FLFHLAVADL 100
    LLVFILPFAV AEGSVGWVLG TFLCKTVIAL HKINFYCSSL LLACIAVDRY 150
    LAIVHAVHAY RRRRLLSIHI TCSTIWLAGF LFALPELLFA KVVQPHNNES 200
    LPQCIFSQEN EAETRAWFAS RFLYHTGGFL LPMLVMAWCY VGVVHRLLQA 250
    QRRPQRQKAV RVAILVTSIF LLCWSPYHIV IFLDTLERLK AVNSSCELSG 300
    YLSVAITLCE FLGLAHCCLN PMLYTFAGVK FRSDLSRLLT KLGCAGPASL 350
    CQLFPGWRKS SLSESENATS LTTF 374
    Length:374
    Mass (Da):42,013
    Last modified:February 1, 1994 - v1
    Checksum:iD87A3AC816207319
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X71463 Genomic DNA. Translation: CAA50582.1.
    PIRiS32785.
    RefSeqiNP_445755.1. NM_053303.1.
    UniGeneiRn.127121.

    Genome annotation databases

    GeneIDi29363.
    KEGGirno:29363.
    UCSCiRGD:62010. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X71463 Genomic DNA. Translation: CAA50582.1 .
    PIRi S32785.
    RefSeqi NP_445755.1. NM_053303.1.
    UniGenei Rn.127121.

    3D structure databases

    ProteinModelPortali P34997.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000016580.

    Chemistry

    GuidetoPHARMACOLOGYi 72.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P34997.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 29363.
    KEGGi rno:29363.
    UCSCi RGD:62010. rat.

    Organism-specific databases

    CTDi 643.
    RGDi 62010. Cxcr5.

    Phylogenomic databases

    eggNOGi NOG146951.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi P34997.
    KOi K04190.
    PhylomeDBi P34997.

    Miscellaneous databases

    NextBioi 608896.
    PROi P34997.

    Gene expression databases

    Genevestigatori P34997.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001053. Chemokine_CXCR5.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF33. PTHR24227:SF33. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00564. CXCCHMKINER5.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a novel putative G-protein-coupled receptor (NLR) which is expressed in neuronal and lymphatic tissue."
      Kouba M., Vanetti M., Wang X., Schaefer M., Hoellt V.
      FEBS Lett. 321:173-178(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Spleen.

    Entry informationi

    Entry nameiCXCR5_RAT
    AccessioniPrimary (citable) accession number: P34997
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3