Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

P2Y purinoceptor 1

Gene

P2RY1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for extracellular adenine nucleotides such as ATP and ADP. Seems to mediate its action via a pertussis toxin insensitive G-protein, probably belonging to the G(q) family that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-GGA-416476 G alpha (q) signalling events
R-GGA-417957 P2Y receptors
R-GGA-418592 ADP signalling through P2Y purinoceptor 1

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 1
Short name:
P2Y1
Alternative name(s):
ATP receptor
Purinergic receptor
Gene namesi
Name:P2RY1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 63Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini64 – 76CytoplasmicSequence analysisAdd BLAST13
Transmembranei77 – 98Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini99 – 115ExtracellularSequence analysisAdd BLAST17
Transmembranei116 – 136Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini137 – 155CytoplasmicSequence analysisAdd BLAST19
Transmembranei156 – 177Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini178 – 207ExtracellularSequence analysisAdd BLAST30
Transmembranei208 – 227Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini228 – 254CytoplasmicSequence analysisAdd BLAST27
Transmembranei255 – 274Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini275 – 292ExtracellularSequence analysisAdd BLAST18
Transmembranei293 – 317Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini318 – 362CytoplasmicSequence analysisAdd BLAST45

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700091 – 362P2Y purinoceptor 1Add BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi113 ↔ 191PROSITE-ProRule annotation
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP34996

Expressioni

Tissue specificityi

Brain, spinal cord, gastrointestinal tract, spleen and leg muscle. Is not detected in the heart, liver, stomach, lung and kidney.

Gene expression databases

BgeeiENSGALG00000010357

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000016845

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DDDmodel-140-70[»]
276-103[»]
3114-138[»]
4153-179[»]
5204-232[»]
6249-276[»]
7289-321[»]
ProteinModelPortaliP34996
SMRiP34996
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEMX Eukaryota
ENOG410Z2ZK LUCA
GeneTreeiENSGT00910000144002
HOGENOMiHOG000231307
HOVERGENiHBG101120
InParanoidiP34996
KOiK04270
OMAiHRYTGVV
OrthoDBiEOG091G093Y
PhylomeDBiP34996

Family and domain databases

CDDicd15377 7tmA_P2Y1, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000142 P2Y1_rcpt
PANTHERiPTHR24231:SF2 PTHR24231:SF2, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00595 P2Y1PRNOCPTR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P34996-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEALISAAL NGTQPELLAG GWAAGNATTK CSLTKTGFQF YYLPTVYILV
60 70 80 90 100
FITGFLGNSV AIWMFVFHMR PWSGISVYMF NLALADFLYV LTLPALIFYY
110 120 130 140 150
FNKTDWIFGD VMCKLQRFIF HVNLYGSILF LTCISVHRYT GVVHPLKSLG
160 170 180 190 200
RLKKKNAVYV SSLVWALVVA VIAPILFYSG TGVRRNKTIT CYDTTADEYL
210 220 230 240 250
RSYFVYSMCT TVFMFCIPFI VILGCYGLIV KALIYKDLDN SPLRRKSIYL
260 270 280 290 300
VIIVLTVFAV SYLPFHVMKT LNLRARLDFQ TPQMCAFNDK VYATYQVTRG
310 320 330 340 350
LASLNSCVDP ILYFLAGDTF RRRLSRATRK SSRRSEPNVQ SKSEEMTLNI
360
LTEYKQNGDT SL
Length:362
Mass (Da):41,194
Last modified:February 1, 1994 - v1
Checksum:iA806C88FB9514761
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73268 mRNA Translation: CAA51716.1
PIRiS33733
RefSeqiNP_990664.1, NM_205333.1
UniGeneiGga.5306

Genome annotation databases

EnsembliENSGALT00000016864; ENSGALP00000016845; ENSGALG00000010357
GeneIDi396275
KEGGigga:396275

Similar proteinsi

Entry informationi

Entry nameiP2RY1_CHICK
AccessioniPrimary (citable) accession number: P34996
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: February 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health