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Protein

P2Y purinoceptor 1

Gene

P2RY1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for extracellular adenine nucleotides such as ATP and ADP. Seems to mediate its action via a pertussis toxin insensitive G-protein, probably belonging to the G(q) family that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-GGA-416476. G alpha (q) signalling events.
R-GGA-417957. P2Y receptors.
R-GGA-418592. ADP signalling through P2Y purinoceptor 1.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 1
Short name:
P2Y1
Alternative name(s):
ATP receptor
Purinergic receptor
Gene namesi
Name:P2RY1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 9

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularSequence analysisAdd
BLAST
Transmembranei42 – 6322Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini64 – 7613CytoplasmicSequence analysisAdd
BLAST
Transmembranei77 – 9822Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini99 – 11517ExtracellularSequence analysisAdd
BLAST
Transmembranei116 – 13621Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini137 – 15519CytoplasmicSequence analysisAdd
BLAST
Transmembranei156 – 17722Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini178 – 20730ExtracellularSequence analysisAdd
BLAST
Transmembranei208 – 22720Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini228 – 25427CytoplasmicSequence analysisAdd
BLAST
Transmembranei255 – 27420Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini275 – 29218ExtracellularSequence analysisAdd
BLAST
Transmembranei293 – 31725Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini318 – 36245CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362P2Y purinoceptor 1PRO_0000070009Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence analysis
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence analysis
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence analysis
Disulfide bondi113 ↔ 191PROSITE-ProRule annotation
Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP34996.

Expressioni

Tissue specificityi

Brain, spinal cord, gastrointestinal tract, spleen and leg muscle. Is not detected in the heart, liver, stomach, lung and kidney.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000016845.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DDDmodel-140-70[»]
276-103[»]
3114-138[»]
4153-179[»]
5204-232[»]
6249-276[»]
7289-321[»]
ProteinModelPortaliP34996.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEMX. Eukaryota.
ENOG410Z2ZK. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiP34996.
KOiK04270.
OMAiDYLRSYF.
PhylomeDBiP34996.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000142. P2Y1_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF2. PTHR24231:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00595. P2Y1PRNOCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34996-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEALISAAL NGTQPELLAG GWAAGNATTK CSLTKTGFQF YYLPTVYILV
60 70 80 90 100
FITGFLGNSV AIWMFVFHMR PWSGISVYMF NLALADFLYV LTLPALIFYY
110 120 130 140 150
FNKTDWIFGD VMCKLQRFIF HVNLYGSILF LTCISVHRYT GVVHPLKSLG
160 170 180 190 200
RLKKKNAVYV SSLVWALVVA VIAPILFYSG TGVRRNKTIT CYDTTADEYL
210 220 230 240 250
RSYFVYSMCT TVFMFCIPFI VILGCYGLIV KALIYKDLDN SPLRRKSIYL
260 270 280 290 300
VIIVLTVFAV SYLPFHVMKT LNLRARLDFQ TPQMCAFNDK VYATYQVTRG
310 320 330 340 350
LASLNSCVDP ILYFLAGDTF RRRLSRATRK SSRRSEPNVQ SKSEEMTLNI
360
LTEYKQNGDT SL
Length:362
Mass (Da):41,194
Last modified:February 1, 1994 - v1
Checksum:iA806C88FB9514761
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73268 mRNA. Translation: CAA51716.1.
PIRiS33733.
RefSeqiNP_990664.1. NM_205333.1.
UniGeneiGga.5306.

Genome annotation databases

EnsembliENSGALT00000016864; ENSGALP00000016845; ENSGALG00000010357.
GeneIDi396275.
KEGGigga:396275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73268 mRNA. Translation: CAA51716.1.
PIRiS33733.
RefSeqiNP_990664.1. NM_205333.1.
UniGeneiGga.5306.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DDDmodel-140-70[»]
276-103[»]
3114-138[»]
4153-179[»]
5204-232[»]
6249-276[»]
7289-321[»]
ProteinModelPortaliP34996.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000016845.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP34996.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000016864; ENSGALP00000016845; ENSGALG00000010357.
GeneIDi396275.
KEGGigga:396275.

Organism-specific databases

CTDi5028.

Phylogenomic databases

eggNOGiENOG410IEMX. Eukaryota.
ENOG410Z2ZK. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiP34996.
KOiK04270.
OMAiDYLRSYF.
PhylomeDBiP34996.

Enzyme and pathway databases

ReactomeiR-GGA-416476. G alpha (q) signalling events.
R-GGA-417957. P2Y receptors.
R-GGA-418592. ADP signalling through P2Y purinoceptor 1.

Miscellaneous databases

PROiP34996.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000142. P2Y1_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF2. PTHR24231:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00595. P2Y1PRNOCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and functional expression of a brain G-protein-coupled ATP receptor."
    Webb T.E., Simon J., Krishek B.J., Bateson A.N., Smart T.G., King B.F., Burnstock G., Barnard E.A.
    FEBS Lett. 324:219-225(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Modelling the P2Y purinoceptor using rhodopsin as template."
    van Rhee A.M., Fischer B., van Galen P.J.M., Jacobson K.A.
    Drug Des. Discov. 13:133-154(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING.

Entry informationi

Entry nameiP2RY1_CHICK
AccessioniPrimary (citable) accession number: P34996
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.