P34995 (PE2R1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Prostaglandin E2 receptor EP1 subtype
Short name=PGE receptor EP1 subtype
Short name=PGE2 receptor EP1 subtype

Alternative name(s):
Prostanoid EP1 receptor

Gene names

Name:

PTGER1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	402 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.
Post-translational modification	Phosphorylated Potential.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Sequence caution	The sequence BAC05723.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	prostaglandin E receptor activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 402	402	Prostaglandin E2 receptor EP1 subtype		PRO_0000070050
Regions
	Topological domain	1 – 35	35	Extracellular Potential
	Transmembrane	36 – 62	27	Helical; Name=1; Potential
	Topological domain	63 – 72	10	Cytoplasmic Potential
	Transmembrane	73 – 96	24	Helical; Name=2; Potential
	Topological domain	97 – 111	15	Extracellular Potential
	Transmembrane	112 – 133	22	Helical; Name=3; Potential
	Topological domain	134 – 155	22	Cytoplasmic Potential
	Transmembrane	156 – 177	22	Helical; Name=4; Potential
	Topological domain	178 – 201	24	Extracellular Potential
	Transmembrane	202 – 227	26	Helical; Name=5; Potential
	Topological domain	228 – 294	67	Cytoplasmic Potential
	Transmembrane	295 – 321	27	Helical; Name=6; Potential
	Topological domain	322 – 332	11	Extracellular Potential
	Transmembrane	333 – 354	22	Helical; Name=7; Potential
	Topological domain	355 – 402	48	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	8	1	N-linked (GlcNAc...) Potential
	Glycosylation	25	1	N-linked (GlcNAc...) Potential
	Disulfide bond	110 ↔ 188		By similarity
Natural variations
	Natural variant	71	1	A → T. Ref.1 Ref.3 Corresponds to variant rs1057362 [ dbSNP | Ensembl ].		VAR_017190
	Natural variant	223	1	T → M. Corresponds to variant rs28364042 [ dbSNP | Ensembl ].		VAR_029216
	Natural variant	256	1	H → R. Corresponds to variant rs7249305 [ dbSNP | Ensembl ].		VAR_029217
Experimental info
	Sequence conflict	230	1	L → H in AAC37539. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P34995 [UniParc]. Last modified May 10, 2005. Version 3. Checksum: B925359ABD86880C	FASTA	402	41,801
	10 20 30 40 50 60 MSPCGPLNLS LAGEATTCAA PWVPNTSAVP PSGASPALPI FSMTLGAVSN LLALALLAQA 70 80 90 100 110 120 AGRLRRRRSA ATFLLFVASL LATDLAGHVI PGALVLRLYT AGRAPAGGAC HFLGGCMVFF 130 140 150 160 170 180 GLCPLLLGCG MAVERCVGVT RPLLHAARVS VARARLALAA VAAVALAVAL LPLARVGRYE 190 200 210 220 230 240 LQYPGTWCFI GLGPPGGWRQ ALLAGLFASL GLVALLAALV CNTLSGLALL RARWRRRSRR 250 260 270 280 290 300 PPPASGPDSR RRWGAHGPRS ASASSASSIA SASTFFGGSR SSGSARRARA HDVEMVGQLV 310 320 330 340 350 360 GIMVVSCICW SPMLVLVALA VGGWSSTSLQ RPLFLAVRLA SWNQILDPWV YILLRQAVLR 370 380 390 400 QLLRLLPPRA GAKGGPAGLG LTPSAWEASS LRSSRHSGLS HF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype." Funk C.D., Furci L., Fitzgerald G.A., Grygorczyk R., Rochette C., Bayne M.A., Abramovitz M., Adam M., Metters K.M. J. Biol. Chem. 268:26767-26772(1993) [PubMed: 8253813] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-71.
[2]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Warren C.N., Aronstam R.S., Sharma S.V. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-71. Tissue: Kidney.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary and Pancreas.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L22647 mRNA. Translation: AAC37539.1. AB065464 Genomic DNA. Translation: BAC05723.1. Sequence problems. AY275470 mRNA. Translation: AAP32302.1. BC039034 mRNA. Translation: AAH39034.1. BC051286 mRNA. Translation: AAH51286.1.
IPI	IPI00003081.
PIR	A49690.
RefSeq	NP_000946.2. NM_000955.2.
UniGene	Hs.159360.
3D structure databases
ProteinModelPortal	P34995.
ModBase	Search...
Protein-protein interaction databases
STRING	P34995.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	83287886.
Proteomic databases
PRIDE	P34995.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000292513; ENSP00000292513; ENSG00000160951.
GeneID	5731.
KEGG	hsa:5731.
UCSC	uc002mys.1. human.
Organism-specific databases
CTD	5731.
GeneCards	GC19M014583.
H-InvDB	HIX0027503.
HGNC	HGNC:9593. PTGER1.
MIM	176802. gene.
neXtProt	NX_P34995.
PharmGKB	PA286.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06020.
HOGENOM	HBG446637.
HOVERGEN	HBG003621.
InParanoid	P34995.
OMA	SRRRWGA.
OrthoDB	EOG469QVW.
PhylomeDB	P34995.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P34995.
Bgee	P34995.
CleanEx	HS_PTGER1.
Genevestigator	P34995.
GermOnline	ENSG00000160951. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR008365. Prostanoid_rcpt. IPR001244. Prostglndn_DP_rcpt. IPR000708. Prostglndn_EP1_rcpt. [Graphical view]
KO	K04258.
PANTHER	PTHR11866. Prostanoid_rcpt. 1 hit. PTHR11866:SF3. Prostglndn_EP1_rcpt. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00428. PROSTAGLNDNR. PR01788. PROSTANOIDR. PR00580. PRSTNOIDEP1R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00770. Alprostadil. DB00905. Bimatoprost. DB00297. Bupivacaine. DB00429. Carboprost Tromethamine.
NextBio	22294.
SOURCE	Search...

Entry information

Entry name

PE2R1_HUMAN

Accession

Primary (citable) accession number: P34995
Secondary accession number(s): Q5U5U4 , Q86UH3, Q86VB5, Q8NHB2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	May 10, 2005
Last modified:	January 25, 2012
This is version 102 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.