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P34995

- PE2R1_HUMAN

UniProt

P34995 - PE2R1_HUMAN

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Protein

Prostaglandin E2 receptor EP1 subtype

Gene

PTGER1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.

GO - Molecular functioni

  1. prostaglandin E receptor activity Source: ProtInc

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
  2. response to lipopolysaccharide Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18425. Prostanoid ligand receptors.

Protein family/group databases

TCDBi9.A.14.9.1. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E2 receptor EP1 subtype
Short name:
PGE receptor EP1 subtype
Short name:
PGE2 receptor EP1 subtype
Alternative name(s):
Prostanoid EP1 receptor
Gene namesi
Name:PTGER1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:9593. PTGER1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA286.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Prostaglandin E2 receptor EP1 subtypePRO_0000070050Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi110 ↔ 188PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated.Curated

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP34995.
PRIDEiP34995.

Expressioni

Tissue specificityi

Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.

Gene expression databases

BgeeiP34995.
CleanExiHS_PTGER1.
GenevestigatoriP34995.

Interactioni

Protein-protein interaction databases

BioGridi111703. 1 interaction.
STRINGi9606.ENSP00000292513.

Structurei

3D structure databases

ProteinModelPortaliP34995.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
BLAST
Topological domaini63 – 7210CytoplasmicSequence Analysis
Topological domaini97 – 11115ExtracellularSequence AnalysisAdd
BLAST
Topological domaini134 – 15522CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini178 – 20124ExtracellularSequence AnalysisAdd
BLAST
Topological domaini228 – 29467CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini322 – 33211ExtracellularSequence AnalysisAdd
BLAST
Topological domaini355 – 40248CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 6227Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei73 – 9624Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei112 – 13322Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei156 – 17722Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei202 – 22726Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei295 – 32127Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei333 – 35422Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253446.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000015238.
HOVERGENiHBG003621.
InParanoidiP34995.
KOiK04258.
OMAiPAGGACH.
OrthoDBiEOG7PP575.
PhylomeDBiP34995.
TreeFamiTF324982.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001244. Prostglndn_DP_rcpt.
IPR000708. Prostglndn_EP1_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF3. PTHR11866:SF3. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00428. PROSTAGLNDNR.
PR01788. PROSTANOIDR.
PR00580. PRSTNOIDEP1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34995-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPCGPLNLS LAGEATTCAA PWVPNTSAVP PSGASPALPI FSMTLGAVSN
60 70 80 90 100
LLALALLAQA AGRLRRRRSA ATFLLFVASL LATDLAGHVI PGALVLRLYT
110 120 130 140 150
AGRAPAGGAC HFLGGCMVFF GLCPLLLGCG MAVERCVGVT RPLLHAARVS
160 170 180 190 200
VARARLALAA VAAVALAVAL LPLARVGRYE LQYPGTWCFI GLGPPGGWRQ
210 220 230 240 250
ALLAGLFASL GLVALLAALV CNTLSGLALL RARWRRRSRR PPPASGPDSR
260 270 280 290 300
RRWGAHGPRS ASASSASSIA SASTFFGGSR SSGSARRARA HDVEMVGQLV
310 320 330 340 350
GIMVVSCICW SPMLVLVALA VGGWSSTSLQ RPLFLAVRLA SWNQILDPWV
360 370 380 390 400
YILLRQAVLR QLLRLLPPRA GAKGGPAGLG LTPSAWEASS LRSSRHSGLS

HF
Length:402
Mass (Da):41,801
Last modified:May 10, 2005 - v3
Checksum:iB925359ABD86880C
GO

Sequence cautioni

The sequence BAC05723.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti230 – 2301L → H in AAC37539. (PubMed:8253813)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti71 – 711A → T.2 Publications
Corresponds to variant rs1057362 [ dbSNP | Ensembl ].
VAR_017190
Natural varianti223 – 2231T → M.
Corresponds to variant rs28364042 [ dbSNP | Ensembl ].
VAR_029216
Natural varianti256 – 2561H → R.
Corresponds to variant rs7249305 [ dbSNP | Ensembl ].
VAR_029217

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L22647 mRNA. Translation: AAC37539.1.
AB065464 Genomic DNA. Translation: BAC05723.1. Sequence problems.
AY275470 mRNA. Translation: AAP32302.1.
BC039034 mRNA. Translation: AAH39034.1.
BC051286 mRNA. Translation: AAH51286.1.
CCDSiCCDS12309.1.
PIRiA49690.
RefSeqiNP_000946.2. NM_000955.2.
UniGeneiHs.159360.

Genome annotation databases

EnsembliENST00000292513; ENSP00000292513; ENSG00000160951.
GeneIDi5731.
KEGGihsa:5731.
UCSCiuc002mys.3. human.

Polymorphism databases

DMDMi83287886.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L22647 mRNA. Translation: AAC37539.1 .
AB065464 Genomic DNA. Translation: BAC05723.1 . Sequence problems.
AY275470 mRNA. Translation: AAP32302.1 .
BC039034 mRNA. Translation: AAH39034.1 .
BC051286 mRNA. Translation: AAH51286.1 .
CCDSi CCDS12309.1.
PIRi A49690.
RefSeqi NP_000946.2. NM_000955.2.
UniGenei Hs.159360.

3D structure databases

ProteinModelPortali P34995.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111703. 1 interaction.
STRINGi 9606.ENSP00000292513.

Chemistry

BindingDBi P34995.
ChEMBLi CHEMBL1811.
DrugBanki DB00770. Alprostadil.
DB00905. Bimatoprost.
DB00297. Bupivacaine.
DB00429. Carboprost Tromethamine.
DB00917. Dinoprostone.
DB01088. Iloprost.
GuidetoPHARMACOLOGYi 340.

Protein family/group databases

TCDBi 9.A.14.9.1. the g-protein-coupled receptor (gpcr) family.
GPCRDBi Search...

Polymorphism databases

DMDMi 83287886.

Proteomic databases

PaxDbi P34995.
PRIDEi P34995.

Protocols and materials databases

DNASUi 5731.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000292513 ; ENSP00000292513 ; ENSG00000160951 .
GeneIDi 5731.
KEGGi hsa:5731.
UCSCi uc002mys.3. human.

Organism-specific databases

CTDi 5731.
GeneCardsi GC19M014583.
HGNCi HGNC:9593. PTGER1.
MIMi 176802. gene.
neXtProti NX_P34995.
PharmGKBi PA286.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG253446.
GeneTreei ENSGT00760000119188.
HOGENOMi HOG000015238.
HOVERGENi HBG003621.
InParanoidi P34995.
KOi K04258.
OMAi PAGGACH.
OrthoDBi EOG7PP575.
PhylomeDBi P34995.
TreeFami TF324982.

Enzyme and pathway databases

Reactomei REACT_18283. G alpha (q) signalling events.
REACT_18425. Prostanoid ligand receptors.

Miscellaneous databases

GeneWikii EP1_receptor.
GenomeRNAii 5731.
NextBioi 22294.
PROi P34995.
SOURCEi Search...

Gene expression databases

Bgeei P34995.
CleanExi HS_PTGER1.
Genevestigatori P34995.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001244. Prostglndn_DP_rcpt.
IPR000708. Prostglndn_EP1_rcpt.
[Graphical view ]
PANTHERi PTHR11866. PTHR11866. 1 hit.
PTHR11866:SF3. PTHR11866:SF3. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00428. PROSTAGLNDNR.
PR01788. PROSTANOIDR.
PR00580. PRSTNOIDEP1R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype."
    Funk C.D., Furci L., Fitzgerald G.A., Grygorczyk R., Rochette C., Bayne M.A., Abramovitz M., Adam M., Metters K.M.
    J. Biol. Chem. 268:26767-26772(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-71.
  2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Warren C.N., Aronstam R.S., Sharma S.V.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-71.
    Tissue: Kidney.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary and Pancreas.

Entry informationi

Entry nameiPE2R1_HUMAN
AccessioniPrimary (citable) accession number: P34995
Secondary accession number(s): Q5U5U4
, Q86UH3, Q86VB5, Q8NHB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 10, 2005
Last modified: October 29, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3