Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P34995 (PE2R1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prostaglandin E2 receptor EP1 subtype

Short name=PGE receptor EP1 subtype
Short name=PGE2 receptor EP1 subtype
Alternative name(s):
Prostanoid EP1 receptor
Gene names
Name:PTGER1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length402 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.

Post-translational modification

Phosphorylated Potential.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence BAC05723.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 402402Prostaglandin E2 receptor EP1 subtype
PRO_0000070050

Regions

Topological domain1 – 3535Extracellular Potential
Transmembrane36 – 6227Helical; Name=1; Potential
Topological domain63 – 7210Cytoplasmic Potential
Transmembrane73 – 9624Helical; Name=2; Potential
Topological domain97 – 11115Extracellular Potential
Transmembrane112 – 13322Helical; Name=3; Potential
Topological domain134 – 15522Cytoplasmic Potential
Transmembrane156 – 17722Helical; Name=4; Potential
Topological domain178 – 20124Extracellular Potential
Transmembrane202 – 22726Helical; Name=5; Potential
Topological domain228 – 29467Cytoplasmic Potential
Transmembrane295 – 32127Helical; Name=6; Potential
Topological domain322 – 33211Extracellular Potential
Transmembrane333 – 35422Helical; Name=7; Potential
Topological domain355 – 40248Cytoplasmic Potential

Amino acid modifications

Glycosylation81N-linked (GlcNAc...) Potential
Glycosylation251N-linked (GlcNAc...) Potential
Disulfide bond110 ↔ 188 By similarity

Natural variations

Natural variant711A → T. Ref.1 Ref.3
Corresponds to variant rs1057362 [ dbSNP | Ensembl ].
VAR_017190
Natural variant2231T → M.
Corresponds to variant rs28364042 [ dbSNP | Ensembl ].
VAR_029216
Natural variant2561H → R.
Corresponds to variant rs7249305 [ dbSNP | Ensembl ].
VAR_029217

Experimental info

Sequence conflict2301L → H in AAC37539. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P34995 [UniParc].

Last modified May 10, 2005. Version 3.
Checksum: B925359ABD86880C

FASTA40241,801
        10         20         30         40         50         60 
MSPCGPLNLS LAGEATTCAA PWVPNTSAVP PSGASPALPI FSMTLGAVSN LLALALLAQA 

        70         80         90        100        110        120 
AGRLRRRRSA ATFLLFVASL LATDLAGHVI PGALVLRLYT AGRAPAGGAC HFLGGCMVFF 

       130        140        150        160        170        180 
GLCPLLLGCG MAVERCVGVT RPLLHAARVS VARARLALAA VAAVALAVAL LPLARVGRYE 

       190        200        210        220        230        240 
LQYPGTWCFI GLGPPGGWRQ ALLAGLFASL GLVALLAALV CNTLSGLALL RARWRRRSRR 

       250        260        270        280        290        300 
PPPASGPDSR RRWGAHGPRS ASASSASSIA SASTFFGGSR SSGSARRARA HDVEMVGQLV 

       310        320        330        340        350        360 
GIMVVSCICW SPMLVLVALA VGGWSSTSLQ RPLFLAVRLA SWNQILDPWV YILLRQAVLR 

       370        380        390        400 
QLLRLLPPRA GAKGGPAGLG LTPSAWEASS LRSSRHSGLS HF 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype."
Funk C.D., Furci L., Fitzgerald G.A., Grygorczyk R., Rochette C., Bayne M.A., Abramovitz M., Adam M., Metters K.M.
J. Biol. Chem. 268:26767-26772(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-71.
[2]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Warren C.N., Aronstam R.S., Sharma S.V.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-71.
Tissue: Kidney.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary and Pancreas.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L22647 mRNA. Translation: AAC37539.1.
AB065464 Genomic DNA. Translation: BAC05723.1. Sequence problems.
AY275470 mRNA. Translation: AAP32302.1.
BC039034 mRNA. Translation: AAH39034.1.
BC051286 mRNA. Translation: AAH51286.1.
CCDSCCDS12309.1.
PIRA49690.
RefSeqNP_000946.2. NM_000955.2.
UniGeneHs.159360.

3D structure databases

ProteinModelPortalP34995.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111703. 1 interaction.
STRING9606.ENSP00000292513.

Chemistry

BindingDBP34995.
ChEMBLCHEMBL2363068.
DrugBankDB00770. Alprostadil.
DB00905. Bimatoprost.
DB00297. Bupivacaine.
DB00429. Carboprost Tromethamine.
GuidetoPHARMACOLOGY340.

Protein family/group databases

TCDB9.A.14.9.1. the g-protein-coupled receptor (gpcr) family.
GPCRDBSearch...

Polymorphism databases

DMDM83287886.

Proteomic databases

PaxDbP34995.
PRIDEP34995.

Protocols and materials databases

DNASU5731.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000292513; ENSP00000292513; ENSG00000160951.
GeneID5731.
KEGGhsa:5731.
UCSCuc002mys.3. human.

Organism-specific databases

CTD5731.
GeneCardsGC19M014583.
HGNCHGNC:9593. PTGER1.
MIM176802. gene.
neXtProtNX_P34995.
PharmGKBPA286.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG253446.
HOGENOMHOG000015238.
HOVERGENHBG003621.
InParanoidP34995.
KOK04258.
OMAPAGGACH.
OrthoDBEOG7PP575.
PhylomeDBP34995.
TreeFamTF324982.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP34995.
CleanExHS_PTGER1.
GenevestigatorP34995.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001244. Prostglndn_DP_rcpt.
IPR000708. Prostglndn_EP1_rcpt.
[Graphical view]
PANTHERPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF3. PTHR11866:SF3. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00428. PROSTAGLNDNR.
PR01788. PROSTANOIDR.
PR00580. PRSTNOIDEP1R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiEP1_receptor.
GenomeRNAi5731.
NextBio22294.
PROP34995.
SOURCESearch...

Entry information

Entry namePE2R1_HUMAN
AccessionPrimary (citable) accession number: P34995
Secondary accession number(s): Q5U5U4 expand/collapse secondary AC list , Q86UH3, Q86VB5, Q8NHB2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 10, 2005
Last modified: July 9, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries