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P34995

- PE2R1_HUMAN

UniProt

P34995 - PE2R1_HUMAN

Protein

Prostaglandin E2 receptor EP1 subtype

Gene

PTGER1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 3 (10 May 2005)
      Previous versions | rss
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    Functioni

    Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.

    GO - Molecular functioni

    1. prostaglandin E receptor activity Source: ProtInc

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: ProtInc
    2. response to lipopolysaccharide Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_18283. G alpha (q) signalling events.
    REACT_18425. Prostanoid ligand receptors.

    Protein family/group databases

    TCDBi9.A.14.9.1. the g-protein-coupled receptor (gpcr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prostaglandin E2 receptor EP1 subtype
    Short name:
    PGE receptor EP1 subtype
    Short name:
    PGE2 receptor EP1 subtype
    Alternative name(s):
    Prostanoid EP1 receptor
    Gene namesi
    Name:PTGER1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:9593. PTGER1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA286.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 402402Prostaglandin E2 receptor EP1 subtypePRO_0000070050Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi110 ↔ 188PROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylated.Curated

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP34995.
    PRIDEiP34995.

    Expressioni

    Tissue specificityi

    Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.

    Gene expression databases

    BgeeiP34995.
    CleanExiHS_PTGER1.
    GenevestigatoriP34995.

    Interactioni

    Protein-protein interaction databases

    BioGridi111703. 1 interaction.
    STRINGi9606.ENSP00000292513.

    Structurei

    3D structure databases

    ProteinModelPortaliP34995.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini63 – 7210CytoplasmicSequence Analysis
    Topological domaini97 – 11115ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini134 – 15522CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini178 – 20124ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini228 – 29467CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini322 – 33211ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini355 – 40248CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 6227Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei73 – 9624Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei112 – 13322Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei156 – 17722Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei202 – 22726Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei295 – 32127Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei333 – 35422Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG253446.
    HOGENOMiHOG000015238.
    HOVERGENiHBG003621.
    InParanoidiP34995.
    KOiK04258.
    OMAiPAGGACH.
    OrthoDBiEOG7PP575.
    PhylomeDBiP34995.
    TreeFamiTF324982.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008365. Prostanoid_rcpt.
    IPR001244. Prostglndn_DP_rcpt.
    IPR000708. Prostglndn_EP1_rcpt.
    [Graphical view]
    PANTHERiPTHR11866. PTHR11866. 1 hit.
    PTHR11866:SF3. PTHR11866:SF3. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00428. PROSTAGLNDNR.
    PR01788. PROSTANOIDR.
    PR00580. PRSTNOIDEP1R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34995-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPCGPLNLS LAGEATTCAA PWVPNTSAVP PSGASPALPI FSMTLGAVSN    50
    LLALALLAQA AGRLRRRRSA ATFLLFVASL LATDLAGHVI PGALVLRLYT 100
    AGRAPAGGAC HFLGGCMVFF GLCPLLLGCG MAVERCVGVT RPLLHAARVS 150
    VARARLALAA VAAVALAVAL LPLARVGRYE LQYPGTWCFI GLGPPGGWRQ 200
    ALLAGLFASL GLVALLAALV CNTLSGLALL RARWRRRSRR PPPASGPDSR 250
    RRWGAHGPRS ASASSASSIA SASTFFGGSR SSGSARRARA HDVEMVGQLV 300
    GIMVVSCICW SPMLVLVALA VGGWSSTSLQ RPLFLAVRLA SWNQILDPWV 350
    YILLRQAVLR QLLRLLPPRA GAKGGPAGLG LTPSAWEASS LRSSRHSGLS 400
    HF 402
    Length:402
    Mass (Da):41,801
    Last modified:May 10, 2005 - v3
    Checksum:iB925359ABD86880C
    GO

    Sequence cautioni

    The sequence BAC05723.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti230 – 2301L → H in AAC37539. (PubMed:8253813)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti71 – 711A → T.2 Publications
    Corresponds to variant rs1057362 [ dbSNP | Ensembl ].
    VAR_017190
    Natural varianti223 – 2231T → M.
    Corresponds to variant rs28364042 [ dbSNP | Ensembl ].
    VAR_029216
    Natural varianti256 – 2561H → R.
    Corresponds to variant rs7249305 [ dbSNP | Ensembl ].
    VAR_029217

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L22647 mRNA. Translation: AAC37539.1.
    AB065464 Genomic DNA. Translation: BAC05723.1. Sequence problems.
    AY275470 mRNA. Translation: AAP32302.1.
    BC039034 mRNA. Translation: AAH39034.1.
    BC051286 mRNA. Translation: AAH51286.1.
    CCDSiCCDS12309.1.
    PIRiA49690.
    RefSeqiNP_000946.2. NM_000955.2.
    UniGeneiHs.159360.

    Genome annotation databases

    EnsembliENST00000292513; ENSP00000292513; ENSG00000160951.
    GeneIDi5731.
    KEGGihsa:5731.
    UCSCiuc002mys.3. human.

    Polymorphism databases

    DMDMi83287886.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L22647 mRNA. Translation: AAC37539.1 .
    AB065464 Genomic DNA. Translation: BAC05723.1 . Sequence problems.
    AY275470 mRNA. Translation: AAP32302.1 .
    BC039034 mRNA. Translation: AAH39034.1 .
    BC051286 mRNA. Translation: AAH51286.1 .
    CCDSi CCDS12309.1.
    PIRi A49690.
    RefSeqi NP_000946.2. NM_000955.2.
    UniGenei Hs.159360.

    3D structure databases

    ProteinModelPortali P34995.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111703. 1 interaction.
    STRINGi 9606.ENSP00000292513.

    Chemistry

    BindingDBi P34995.
    ChEMBLi CHEMBL2363068.
    DrugBanki DB00770. Alprostadil.
    DB00905. Bimatoprost.
    DB00297. Bupivacaine.
    DB00429. Carboprost Tromethamine.
    GuidetoPHARMACOLOGYi 340.

    Protein family/group databases

    TCDBi 9.A.14.9.1. the g-protein-coupled receptor (gpcr) family.
    GPCRDBi Search...

    Polymorphism databases

    DMDMi 83287886.

    Proteomic databases

    PaxDbi P34995.
    PRIDEi P34995.

    Protocols and materials databases

    DNASUi 5731.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000292513 ; ENSP00000292513 ; ENSG00000160951 .
    GeneIDi 5731.
    KEGGi hsa:5731.
    UCSCi uc002mys.3. human.

    Organism-specific databases

    CTDi 5731.
    GeneCardsi GC19M014583.
    HGNCi HGNC:9593. PTGER1.
    MIMi 176802. gene.
    neXtProti NX_P34995.
    PharmGKBi PA286.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG253446.
    HOGENOMi HOG000015238.
    HOVERGENi HBG003621.
    InParanoidi P34995.
    KOi K04258.
    OMAi PAGGACH.
    OrthoDBi EOG7PP575.
    PhylomeDBi P34995.
    TreeFami TF324982.

    Enzyme and pathway databases

    Reactomei REACT_18283. G alpha (q) signalling events.
    REACT_18425. Prostanoid ligand receptors.

    Miscellaneous databases

    GeneWikii EP1_receptor.
    GenomeRNAii 5731.
    NextBioi 22294.
    PROi P34995.
    SOURCEi Search...

    Gene expression databases

    Bgeei P34995.
    CleanExi HS_PTGER1.
    Genevestigatori P34995.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008365. Prostanoid_rcpt.
    IPR001244. Prostglndn_DP_rcpt.
    IPR000708. Prostglndn_EP1_rcpt.
    [Graphical view ]
    PANTHERi PTHR11866. PTHR11866. 1 hit.
    PTHR11866:SF3. PTHR11866:SF3. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00428. PROSTAGLNDNR.
    PR01788. PROSTANOIDR.
    PR00580. PRSTNOIDEP1R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype."
      Funk C.D., Furci L., Fitzgerald G.A., Grygorczyk R., Rochette C., Bayne M.A., Abramovitz M., Adam M., Metters K.M.
      J. Biol. Chem. 268:26767-26772(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-71.
    2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Warren C.N., Aronstam R.S., Sharma S.V.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-71.
      Tissue: Kidney.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary and Pancreas.

    Entry informationi

    Entry nameiPE2R1_HUMAN
    AccessioniPrimary (citable) accession number: P34995
    Secondary accession number(s): Q5U5U4
    , Q86UH3, Q86VB5, Q8NHB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 126 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3