P34994 (SSR2_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Somatostatin receptor type 2
Short name=SS-2-R
Short name=SS2-R
Short name=SS2R

Alternative name(s):
SRIF-1

Gene names

Name:

SSTR2

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	369 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels.
Subunit structure	The C-terminus interacts with SHANK1 PDZ domain By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	somatostatin receptor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 369	369	Somatostatin receptor type 2		PRO_0000070122
Regions
	Topological domain	1 – 43	43	Extracellular Potential
	Transmembrane	44 – 67	24	Helical; Name=1; Potential
	Topological domain	68 – 78	11	Cytoplasmic Potential
	Transmembrane	79 – 103	25	Helical; Name=2; Potential
	Topological domain	104 – 118	15	Extracellular Potential
	Transmembrane	119 – 138	20	Helical; Name=3; Potential
	Topological domain	139 – 161	23	Cytoplasmic Potential
	Transmembrane	162 – 181	20	Helical; Name=4; Potential
	Topological domain	182 – 207	26	Extracellular Potential
	Transmembrane	208 – 229	22	Helical; Name=5; Potential
	Topological domain	230 – 253	24	Cytoplasmic Potential
	Transmembrane	254 – 278	25	Helical; Name=6; Potential
	Topological domain	279 – 288	10	Extracellular Potential
	Transmembrane	289 – 303	15	Helical; Name=7; Potential
	Topological domain	304 – 369	66	Cytoplasmic Potential
Amino acid modifications
	Lipidation	328	1	S-palmitoyl cysteine Potential
	Glycosylation	9	1	N-linked (GlcNAc...) Potential
	Glycosylation	22	1	N-linked (GlcNAc...) Potential
	Glycosylation	29	1	N-linked (GlcNAc...) Potential
	Glycosylation	32	1	N-linked (GlcNAc...) Potential
	Disulfide bond	115 ↔ 193		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P34994 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: C4C8347764EA2E70	FASTA	369	41,219
	10 20 30 40 50 60 MDMAYELLNG SQPWLSSPFD LNGSVATANS SNQTEPYYDL TSNAVLTFIY FVVCIIGLCG 70 80 90 100 110 120 NTLVIYVILR YAKMKTITNI YILNLAIADE LFMLGLPFLA MQVALVHWPF GKAICRVVMT 130 140 150 160 170 180 VDGINQFTSI FCLTVMSIDR YLAVVHPIKS AKWRRPRTAK MINVAVWGVS LLVILPIMIY 190 200 210 220 230 240 AGLRSNQWGR SSCTINWPGE SGAWYTGFII YAFILGFLVP LTIICLCYLF IIIKVKSSGI 250 260 270 280 290 300 RVGSSKRKKS EKKVTRMVSI VVAVFIFCWL PFYIFNVSSV SVAISPTPAL KGMFDFVVVL 310 320 330 340 350 360 TYANSCANPI LYAFLSDNFK KSFQNVLCLV KVSGTDDGER SDSKQDKSRL NETTETQRTL LNGDLQTSI

References

[1]	"Molecular cloning and sequencing of porcine somatostatin receptor 2." Matsumoto K., Yokogoshi Y., Fujinaka Y., Zhang C., Saito S. Biochem. Biophys. Res. Commun. 199:298-305(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	D21338 Genomic DNA. Translation: BAA04810.1.
PIR	JC2083.
RefSeq	NP_001011694.1. NM_001011694.1.
UniGene	Ssc.42757.
3D structure databases
ProteinModelPortal	P34994.
ModBase	Search...
Protein-protein interaction databases
STRING	9823.ENSSSCP00000018276.
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSSSCT00000018778; ENSSSCP00000018276; ENSSSCG00000017249.
GeneID	497059.
KEGG	ssc:497059.
Organism-specific databases
CTD	6752.
Phylogenomic databases
eggNOG	NOG274661.
GeneTree	ENSGT00630000089736.
HOGENOM	HOG000230485.
HOVERGEN	HBG106919.
KO	K04218.
OMA	STVVITC.
OrthoDB	EOG4PK283.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000586. Somatstn_rcpt. IPR002074. Somatstn_rcpt_2. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00246. SOMATOSTATNR. PR00588. SOMATOSTTN2R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SSR2_PIG

Accession

Primary (citable) accession number: P34994

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	April 3, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program