P34982 (OR1D2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 1D2

Alternative name(s):
Olfactory receptor 17-4
Short name=OR17-4
Olfactory receptor OR17-6
Olfactory receptor-like protein HGMP07E

Gene names

Name:	OR1D2
Synonyms:	OLFR1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for sperm in vitro and is shown to be a strong agonist for OR1D2 in vitro. May also function in olfactory reception. Ref.7 Ref.8 Ref.11
Subcellular location	Cell membrane; Multi-pass membrane protein. Note: In spermatazoa is localized in the midpiece and is translocated to the head region upon receptor stimulation with bourgeonal. Ref.11
Tissue specificity	Expressed in testis. Expressed in spermatozoa (at protein level). Expressed in olfactory epithelium. Ref.7 Ref.8 Ref.11
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Chemotaxis Fertilization Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular component movement Traceable author statement PubMed 1370859. Source: ProtInc chemotaxis Inferred from electronic annotation. Source: UniProtKB-KW protein import into nucleus, translocation Inferred from mutant phenotype Ref.11. Source: UniProtKB single fertilization Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	G-protein coupled receptor activity Traceable author statement PubMed 1315913. Source: ProtInc olfactory receptor activity Inferred from direct assay Ref.7. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Olfactory receptor 1D2		PRO_0000150418
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 49	24	Helical; Name=1; Potential
	Topological domain	50 – 57	8	Cytoplasmic Potential
	Transmembrane	58 – 79	22	Helical; Name=2; Potential
	Topological domain	80 – 100	21	Extracellular Potential
	Transmembrane	101 – 120	20	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 158	19	Helical; Name=4; Potential
	Topological domain	159 – 196	38	Extracellular Potential
	Transmembrane	197 – 219	23	Helical; Name=5; Potential
	Topological domain	220 – 236	17	Cytoplasmic Potential
	Transmembrane	237 – 259	23	Helical; Name=6; Potential
	Topological domain	260 – 271	12	Extracellular Potential
	Transmembrane	272 – 291	20	Helical; Name=7; Potential
	Topological domain	292 – 312	21	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Glycosylation	195	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity
Natural variations
	Natural variant	25	1	R → Q. Ref.1 Ref.2 Corresponds to variant rs769423 [ dbSNP | Ensembl ].		VAR_019630
	Natural variant	31	1	F → Y. Corresponds to variant rs9916628 [ dbSNP | Ensembl ].		VAR_057534
	Natural variant	214	1	V → M. Corresponds to variant rs55803944 [ dbSNP | Ensembl ].		VAR_062008
	Natural variant	240	1	T → I. Corresponds to variant rs4300683 [ dbSNP | Ensembl ].		VAR_057535
Experimental info
	Mutagenesis	230	1	S → A: Abolishes nuclear translocation of ARRB2; when associated with A-232 and A-239. Ref.11
	Mutagenesis	232	1	S → A: Abolishes nuclear translocation of ARRB2; when associated with A-230 and A-239. Ref.11
	Mutagenesis	239	1	S → A: Abolishes nuclear translocation of ARRB2; when associated with A-230 and A-232. Ref.11
	Mutagenesis	312	1	T → A: Abolishes nuclear translocation of ARRB2. Ref.11

Sequences

	Sequence		Length	Mass (Da)
	P34982 [UniParc]. Last modified June 7, 2005. Version 2. Checksum: 71B05367C0AA135B	FASTA	312	35,240
	10 20 30 40 50 60 MDGGNQSEGS EFLLLGMSES PEQQRILFWM FLSMYLVTVV GNVLIILAIS SDSRLHTPVY 70 80 90 100 110 120 FFLANLSFTD LFFVTNTIPK MLVNLQSHNK AISYAGCLTQ LYFLVSLVAL DNLILAVMAY 130 140 150 160 170 180 DRYVAICCPL HYTTAMSPKL CILLLSLCWV LSVLYGLIHT LLMTRVTFCG SRKIHYIFCE 190 200 210 220 230 240 MYVLLRMACS NIQINHTVLI ATGCFIFLIP FGFVIISYVL IIRAILRIPS VSKKYKAFST 250 260 270 280 290 300 CASHLGAVSL FYGTLCMVYL KPLHTYSVKD SVATVMYAVV TPMMNPFIYS LRNKDMHGAL 310 GRLLDKHFKR LT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to the 17p13-->p12 region of the human genome and reveals an MspI restriction fragment length polymorphism." Schurmans S., Muscatelli F., Miot F., Mattei M.-G., Vassart G., Parmentier M. Cytogenet. Cell Genet. 63:200-204(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-25.
[2]	"Sequence, structure, and evolution of a complete human olfactory receptor gene cluster." Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D. Genomics 63:227-245(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-25.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Sequence of cosmid ICRF105cF06137 of the human chromosome 17p13.3 olfactory receptor gene cluster." Ferraz C., Demaille J.G. Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-214.
[5]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
[6]	"Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire." Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H., Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A. Hum. Mol. Genet. 3:229-235(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 118-282.
[7]	"Identification of a testicular odorant receptor mediating human sperm chemotaxis." Spehr M., Gisselmann G., Poplawski A., Riffell J.A., Wetzel C.H., Zimmer R.K., Hatt H. Science 299:2054-2058(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN SPERM CHEMOTAXIS, TISSUE SPECIFICITY.
[8]	"Dual capacity of a human olfactory receptor." Spehr M., Schwane K., Heilmann S., Gisselmann G., Hummel T., Hatt H. Curr. Biol. 14:R832-R833(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN OLFACTORY RECEPTION, TISSUE SPECIFICITY.
[9]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[10]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
[11]	"Novel function of beta-arrestin2 in the nucleus of mature spermatozoa." Neuhaus E.M., Mashukova A., Barbour J., Wolters D., Hatt H. J. Cell Sci. 119:3047-3056(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF SER-230; SER-232; SER-239 AND THR-312.
+	Additional computationally mapped references.

Web resources

Protein Spotlight

Love at first smell - Issue 115 of March 2010

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	X65857 Genomic DNA. Translation: CAA46687.1. AF087917 Genomic DNA. Translation: AAF37310.1. BC069552 mRNA. Translation: AAH69552.1. BC106735 mRNA. Translation: AAI06736.1. BC106736 mRNA. Translation: AAI06737.1. U53583 Genomic DNA. Translation: AAC99554.1. AF399535 Genomic DNA. Translation: AAK95020.1. U04678 Genomic DNA. Translation: AAA18343.1. BK004244 Genomic DNA. Translation: DAA04642.1.
IPI	IPI00003067.
PIR	A48413. I38471.
RefSeq	NP_002539.2. NM_002548.2.
UniGene	Hs.532771.
3D structure databases
ProteinModelPortal	P34982.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-46308N.
MINT	MINT-7295783.
STRING	9606.ENSP00000327585.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P34982.
Polymorphism databases
DMDM	67477446.
Proteomic databases
PRIDE	P34982.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000331459; ENSP00000327585; ENSG00000184166.
GeneID	4991.
KEGG	hsa:4991.
UCSC	uc010vrb.2. human.
Organism-specific databases
CTD	4991.
GeneCards	GC17M002995.
HGNC	HGNC:8183. OR1D2.
MIM	164342. gene.
neXtProt	NX_P34982.
PharmGKB	PA32057.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG41734.
HOGENOM	HOG000041364.
HOVERGEN	HBG017625.
InParanoid	P34982.
KO	K04257.
OMA	INHTVLI.
OrthoDB	EOG45QHDN.
PhylomeDB	P34982.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	P34982.
CleanEx	HS_OR1D2.
Genevestigator	P34982.
GermOnline	ENSG00000184166. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	4991.
NextBio	19220.
SOURCE	Search...

Entry information

Entry name

OR1D2_HUMAN

Accession

Primary (citable) accession number: P34982
Secondary accession number(s): Q6IFL8, Q96RA4, Q9UM78

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	June 7, 2005
Last modified:	May 1, 2013
This is version 128 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.