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P34982 (OR1D2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 136. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 1D2
Alternative name(s):
Olfactory receptor 17-4
Short name=OR17-4
Olfactory receptor OR17-6
Olfactory receptor-like protein HGMP07E
Gene names
Name:OR1D2
Synonyms:OLFR1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for sperm in vitro and is shown to be a strong agonist for OR1D2 in vitro. May also function in olfactory reception. Ref.7 Ref.8 Ref.11

Subcellular location

Cell membrane; Multi-pass membrane protein. Note: In spermatazoa is localized in the midpiece and is translocated to the head region upon receptor stimulation with bourgeonal. Ref.11

Tissue specificity

Expressed in testis. Expressed in spermatozoa (at protein level). Expressed in olfactory epithelium. Ref.7 Ref.8 Ref.11

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Olfactory receptor 1D2
PRO_0000150418

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4924Helical; Name=1; Potential
Topological domain50 – 578Cytoplasmic Potential
Transmembrane58 – 7922Helical; Name=2; Potential
Topological domain80 – 10021Extracellular Potential
Transmembrane101 – 12020Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 15819Helical; Name=4; Potential
Topological domain159 – 19638Extracellular Potential
Transmembrane197 – 21923Helical; Name=5; Potential
Topological domain220 – 23617Cytoplasmic Potential
Transmembrane237 – 25923Helical; Name=6; Potential
Topological domain260 – 27112Extracellular Potential
Transmembrane272 – 29120Helical; Name=7; Potential
Topological domain292 – 31221Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation1951N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant251R → Q. Ref.1 Ref.2
Corresponds to variant rs769423 [ dbSNP | Ensembl ].
VAR_019630
Natural variant311F → Y.
Corresponds to variant rs9916628 [ dbSNP | Ensembl ].
VAR_057534
Natural variant2141V → M.
Corresponds to variant rs55803944 [ dbSNP | Ensembl ].
VAR_062008
Natural variant2401T → I.
Corresponds to variant rs4300683 [ dbSNP | Ensembl ].
VAR_057535

Experimental info

Mutagenesis2301S → A: Abolishes nuclear translocation of ARRB2; when associated with A-232 and A-239. Ref.11
Mutagenesis2321S → A: Abolishes nuclear translocation of ARRB2; when associated with A-230 and A-239. Ref.11
Mutagenesis2391S → A: Abolishes nuclear translocation of ARRB2; when associated with A-230 and A-232. Ref.11
Mutagenesis3121T → A: Abolishes nuclear translocation of ARRB2. Ref.11

Sequences

Sequence LengthMass (Da)Tools
P34982 [UniParc].

Last modified June 7, 2005. Version 2.
Checksum: 71B05367C0AA135B

FASTA31235,240
        10         20         30         40         50         60 
MDGGNQSEGS EFLLLGMSES PEQQRILFWM FLSMYLVTVV GNVLIILAIS SDSRLHTPVY 

        70         80         90        100        110        120 
FFLANLSFTD LFFVTNTIPK MLVNLQSHNK AISYAGCLTQ LYFLVSLVAL DNLILAVMAY 

       130        140        150        160        170        180 
DRYVAICCPL HYTTAMSPKL CILLLSLCWV LSVLYGLIHT LLMTRVTFCG SRKIHYIFCE 

       190        200        210        220        230        240 
MYVLLRMACS NIQINHTVLI ATGCFIFLIP FGFVIISYVL IIRAILRIPS VSKKYKAFST 

       250        260        270        280        290        300 
CASHLGAVSL FYGTLCMVYL KPLHTYSVKD SVATVMYAVV TPMMNPFIYS LRNKDMHGAL 

       310 
GRLLDKHFKR LT 

« Hide

References

« Hide 'large scale' references
[1]"The OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to the 17p13-->p12 region of the human genome and reveals an MspI restriction fragment length polymorphism."
Schurmans S., Muscatelli F., Miot F., Mattei M.-G., Vassart G., Parmentier M.
Cytogenet. Cell Genet. 63:200-204(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-25.
[2]"Sequence, structure, and evolution of a complete human olfactory receptor gene cluster."
Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.
Genomics 63:227-245(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-25.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Sequence of cosmid ICRF105cF06137 of the human chromosome 17p13.3 olfactory receptor gene cluster."
Ferraz C., Demaille J.G.
Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-214.
[5]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
[6]"Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire."
Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H., Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.
Hum. Mol. Genet. 3:229-235(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 118-282.
[7]"Identification of a testicular odorant receptor mediating human sperm chemotaxis."
Spehr M., Gisselmann G., Poplawski A., Riffell J.A., Wetzel C.H., Zimmer R.K., Hatt H.
Science 299:2054-2058(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN SPERM CHEMOTAXIS, TISSUE SPECIFICITY.
[8]"Dual capacity of a human olfactory receptor."
Spehr M., Schwane K., Heilmann S., Gisselmann G., Hummel T., Hatt H.
Curr. Biol. 14:R832-R833(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN OLFACTORY RECEPTION, TISSUE SPECIFICITY.
[9]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[10]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
[11]"Novel function of beta-arrestin2 in the nucleus of mature spermatozoa."
Neuhaus E.M., Mashukova A., Barbour J., Wolters D., Hatt H.
J. Cell Sci. 119:3047-3056(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF SER-230; SER-232; SER-239 AND THR-312.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X65857 Genomic DNA. Translation: CAA46687.1.
AF087917 Genomic DNA. Translation: AAF37310.1.
BC069552 mRNA. Translation: AAH69552.1.
BC106735 mRNA. Translation: AAI06736.1.
BC106736 mRNA. Translation: AAI06737.1.
U53583 Genomic DNA. Translation: AAC99554.1.
AF399535 Genomic DNA. Translation: AAK95020.1.
U04678 Genomic DNA. Translation: AAA18343.1.
BK004244 Genomic DNA. Translation: DAA04642.1.
PIRA48413.
I38471.
RefSeqNP_002539.2. NM_002548.2.
UniGeneHs.532771.

3D structure databases

ProteinModelPortalP34982.
SMRP34982. Positions 32-306.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-46308N.
IntActP34982. 1 interaction.
MINTMINT-7295783.
STRING9606.ENSP00000327585.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP34982.

Polymorphism databases

DMDM67477446.

Proteomic databases

PRIDEP34982.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000331459; ENSP00000327585; ENSG00000184166.
GeneID4991.
KEGGhsa:4991.
UCSCuc010vrb.2. human.

Organism-specific databases

CTD4991.
GeneCardsGC17M002995.
HGNCHGNC:8183. OR1D2.
MIM164342. gene.
neXtProtNX_P34982.
PharmGKBPA32057.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41734.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidP34982.
KOK04257.
OMAYLKPLHT.
OrthoDBEOG7JQBNT.
PhylomeDBP34982.
TreeFamTF337210.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP34982.
CleanExHS_OR1D2.
GenevestigatorP34982.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR1D2.
GenomeRNAi4991.
NextBio19220.
PROP34982.
SOURCESearch...

Entry information

Entry nameOR1D2_HUMAN
AccessionPrimary (citable) accession number: P34982
Secondary accession number(s): Q6IFL8, Q96RA4, Q9UM78
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 7, 2005
Last modified: April 16, 2014
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries