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P34982

- OR1D2_HUMAN

UniProt

P34982 - OR1D2_HUMAN

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Protein

Olfactory receptor 1D2

Gene

OR1D2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for sperm in vitro and is shown to be a strong agonist for OR1D2 in vitro. May also function in olfactory reception.3 Publications

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc
  2. olfactory receptor activity Source: UniProtKB

GO - Biological processi

  1. cellular component movement Source: ProtInc
  2. chemotaxis Source: UniProtKB-KW
  3. detection of chemical stimulus involved in sensory perception of smell Source: GOC
  4. G-protein coupled receptor signaling pathway Source: UniProtKB
  5. protein import into nucleus, translocation Source: UniProtKB
  6. sensory perception of smell Source: ProtInc
  7. single fertilization Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis, Fertilization, Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1D2
Alternative name(s):
Olfactory receptor 17-4
Short name:
OR17-4
Olfactory receptor OR17-6
Olfactory receptor-like protein HGMP07E
Gene namesi
Name:OR1D2
Synonyms:OLFR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:8183. OR1D2.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: In spermatazoa is localized in the midpiece and is translocated to the head region upon receptor stimulation with bourgeonal.

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi230 – 2301S → A: Abolishes nuclear translocation of ARRB2; when associated with A-232 and A-239. 1 Publication
Mutagenesisi232 – 2321S → A: Abolishes nuclear translocation of ARRB2; when associated with A-230 and A-239. 1 Publication
Mutagenesisi239 – 2391S → A: Abolishes nuclear translocation of ARRB2; when associated with A-230 and A-232. 1 Publication
Mutagenesisi312 – 3121T → A: Abolishes nuclear translocation of ARRB2. 1 Publication

Organism-specific databases

PharmGKBiPA32057.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 1D2PRO_0000150418Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP34982.

PTM databases

PhosphoSiteiP34982.

Expressioni

Tissue specificityi

Expressed in testis. Expressed in spermatozoa (at protein level). Expressed in olfactory epithelium.3 Publications

Gene expression databases

BgeeiP34982.
CleanExiHS_OR1D2.
GenevestigatoriP34982.

Interactioni

Protein-protein interaction databases

DIPiDIP-46308N.
IntActiP34982. 1 interaction.
MINTiMINT-7295783.
STRINGi9606.ENSP00000327585.

Structurei

3D structure databases

ProteinModelPortaliP34982.
SMRiP34982. Positions 32-304.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini159 – 19638ExtracellularSequence AnalysisAdd
BLAST
Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini260 – 27112ExtracellularSequence AnalysisAdd
BLAST
Topological domaini292 – 31221CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei197 – 21923Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei272 – 29120Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41734.
GeneTreeiENSGT00760000119207.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiP34982.
KOiK04257.
OMAiYLKPLHT.
OrthoDBiEOG7JQBNT.
PhylomeDBiP34982.
TreeFamiTF337210.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34982-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDGGNQSEGS EFLLLGMSES PEQQRILFWM FLSMYLVTVV GNVLIILAIS
60 70 80 90 100
SDSRLHTPVY FFLANLSFTD LFFVTNTIPK MLVNLQSHNK AISYAGCLTQ
110 120 130 140 150
LYFLVSLVAL DNLILAVMAY DRYVAICCPL HYTTAMSPKL CILLLSLCWV
160 170 180 190 200
LSVLYGLIHT LLMTRVTFCG SRKIHYIFCE MYVLLRMACS NIQINHTVLI
210 220 230 240 250
ATGCFIFLIP FGFVIISYVL IIRAILRIPS VSKKYKAFST CASHLGAVSL
260 270 280 290 300
FYGTLCMVYL KPLHTYSVKD SVATVMYAVV TPMMNPFIYS LRNKDMHGAL
310
GRLLDKHFKR LT
Length:312
Mass (Da):35,240
Last modified:June 7, 2005 - v2
Checksum:i71B05367C0AA135B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti25 – 251R → Q.2 Publications
Corresponds to variant rs769423 [ dbSNP | Ensembl ].
VAR_019630
Natural varianti31 – 311F → Y.
Corresponds to variant rs9916628 [ dbSNP | Ensembl ].
VAR_057534
Natural varianti214 – 2141V → M.
Corresponds to variant rs55803944 [ dbSNP | Ensembl ].
VAR_062008
Natural varianti240 – 2401T → I.
Corresponds to variant rs4300683 [ dbSNP | Ensembl ].
VAR_057535

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X65857 Genomic DNA. Translation: CAA46687.1.
AF087917 Genomic DNA. Translation: AAF37310.1.
BC069552 mRNA. Translation: AAH69552.1.
BC106735 mRNA. Translation: AAI06736.1.
BC106736 mRNA. Translation: AAI06737.1.
U53583 Genomic DNA. Translation: AAC99554.1.
AF399535 Genomic DNA. Translation: AAK95020.1.
U04678 Genomic DNA. Translation: AAA18343.1.
BK004244 Genomic DNA. Translation: DAA04642.1.
CCDSiCCDS11019.1.
PIRiA48413.
I38471.
RefSeqiNP_002539.2. NM_002548.2.
UniGeneiHs.532771.

Genome annotation databases

EnsembliENST00000331459; ENSP00000327585; ENSG00000184166.
GeneIDi4991.
KEGGihsa:4991.
UCSCiuc010vrb.2. human.

Polymorphism databases

DMDMi67477446.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

Love at first smell - Issue 115 of March 2010

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X65857 Genomic DNA. Translation: CAA46687.1 .
AF087917 Genomic DNA. Translation: AAF37310.1 .
BC069552 mRNA. Translation: AAH69552.1 .
BC106735 mRNA. Translation: AAI06736.1 .
BC106736 mRNA. Translation: AAI06737.1 .
U53583 Genomic DNA. Translation: AAC99554.1 .
AF399535 Genomic DNA. Translation: AAK95020.1 .
U04678 Genomic DNA. Translation: AAA18343.1 .
BK004244 Genomic DNA. Translation: DAA04642.1 .
CCDSi CCDS11019.1.
PIRi A48413.
I38471.
RefSeqi NP_002539.2. NM_002548.2.
UniGenei Hs.532771.

3D structure databases

ProteinModelPortali P34982.
SMRi P34982. Positions 32-304.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-46308N.
IntActi P34982. 1 interaction.
MINTi MINT-7295783.
STRINGi 9606.ENSP00000327585.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P34982.

Polymorphism databases

DMDMi 67477446.

Proteomic databases

PRIDEi P34982.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000331459 ; ENSP00000327585 ; ENSG00000184166 .
GeneIDi 4991.
KEGGi hsa:4991.
UCSCi uc010vrb.2. human.

Organism-specific databases

CTDi 4991.
GeneCardsi GC17M002995.
HGNCi HGNC:8183. OR1D2.
MIMi 164342. gene.
neXtProti NX_P34982.
PharmGKBi PA32057.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41734.
GeneTreei ENSGT00760000119207.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi P34982.
KOi K04257.
OMAi YLKPLHT.
OrthoDBi EOG7JQBNT.
PhylomeDBi P34982.
TreeFami TF337210.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR1D2.
GenomeRNAii 4991.
NextBioi 19220.
PROi P34982.
SOURCEi Search...

Gene expression databases

Bgeei P34982.
CleanExi HS_OR1D2.
Genevestigatori P34982.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to the 17p13-->p12 region of the human genome and reveals an MspI restriction fragment length polymorphism."
    Schurmans S., Muscatelli F., Miot F., Mattei M.-G., Vassart G., Parmentier M.
    Cytogenet. Cell Genet. 63:200-204(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-25.
  2. "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster."
    Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.
    Genomics 63:227-245(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-25.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Sequence of cosmid ICRF105cF06137 of the human chromosome 17p13.3 olfactory receptor gene cluster."
    Ferraz C., Demaille J.G.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-214.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
  6. "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire."
    Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H., Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.
    Hum. Mol. Genet. 3:229-235(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 118-282.
  7. "Identification of a testicular odorant receptor mediating human sperm chemotaxis."
    Spehr M., Gisselmann G., Poplawski A., Riffell J.A., Wetzel C.H., Zimmer R.K., Hatt H.
    Science 299:2054-2058(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN SPERM CHEMOTAXIS, TISSUE SPECIFICITY.
  8. Cited for: FUNCTION IN OLFACTORY RECEPTION, TISSUE SPECIFICITY.
  9. Cited for: IDENTIFICATION.
  10. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
  11. "Novel function of beta-arrestin2 in the nucleus of mature spermatozoa."
    Neuhaus E.M., Mashukova A., Barbour J., Wolters D., Hatt H.
    J. Cell Sci. 119:3047-3056(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF SER-230; SER-232; SER-239 AND THR-312.

Entry informationi

Entry nameiOR1D2_HUMAN
AccessioniPrimary (citable) accession number: P34982
Secondary accession number(s): Q6IFL8, Q96RA4, Q9UM78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 7, 2005
Last modified: October 29, 2014
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3