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P34982

- OR1D2_HUMAN

UniProt

P34982 - OR1D2_HUMAN

Protein

Olfactory receptor 1D2

Gene

OR1D2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 2 (07 Jun 2005)
      Previous versions | rss
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    Functioni

    Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for sperm in vitro and is shown to be a strong agonist for OR1D2 in vitro. May also function in olfactory reception.3 Publications

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc
    2. olfactory receptor activity Source: UniProtKB

    GO - Biological processi

    1. cellular component movement Source: ProtInc
    2. chemotaxis Source: UniProtKB-KW
    3. detection of chemical stimulus involved in sensory perception of smell Source: GOC
    4. G-protein coupled receptor signaling pathway Source: UniProtKB
    5. protein import into nucleus, translocation Source: UniProtKB
    6. sensory perception of smell Source: ProtInc
    7. single fertilization Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Chemotaxis, Fertilization, Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 1D2
    Alternative name(s):
    Olfactory receptor 17-4
    Short name:
    OR17-4
    Olfactory receptor OR17-6
    Olfactory receptor-like protein HGMP07E
    Gene namesi
    Name:OR1D2
    Synonyms:OLFR1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:8183. OR1D2.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: In spermatazoa is localized in the midpiece and is translocated to the head region upon receptor stimulation with bourgeonal.

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi230 – 2301S → A: Abolishes nuclear translocation of ARRB2; when associated with A-232 and A-239. 1 Publication
    Mutagenesisi232 – 2321S → A: Abolishes nuclear translocation of ARRB2; when associated with A-230 and A-239. 1 Publication
    Mutagenesisi239 – 2391S → A: Abolishes nuclear translocation of ARRB2; when associated with A-230 and A-232. 1 Publication
    Mutagenesisi312 – 3121T → A: Abolishes nuclear translocation of ARRB2. 1 Publication

    Organism-specific databases

    PharmGKBiPA32057.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Olfactory receptor 1D2PRO_0000150418Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation
    Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP34982.

    PTM databases

    PhosphoSiteiP34982.

    Expressioni

    Tissue specificityi

    Expressed in testis. Expressed in spermatozoa (at protein level). Expressed in olfactory epithelium.3 Publications

    Gene expression databases

    BgeeiP34982.
    CleanExiHS_OR1D2.
    GenevestigatoriP34982.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-46308N.
    IntActiP34982. 1 interaction.
    MINTiMINT-7295783.
    STRINGi9606.ENSP00000327585.

    Structurei

    3D structure databases

    ProteinModelPortaliP34982.
    SMRiP34982. Positions 32-304.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 578CytoplasmicSequence Analysis
    Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19638ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27112ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 31221CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 21923Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29120Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41734.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiP34982.
    KOiK04257.
    OMAiYLKPLHT.
    OrthoDBiEOG7JQBNT.
    PhylomeDBiP34982.
    TreeFamiTF337210.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34982-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGGNQSEGS EFLLLGMSES PEQQRILFWM FLSMYLVTVV GNVLIILAIS    50
    SDSRLHTPVY FFLANLSFTD LFFVTNTIPK MLVNLQSHNK AISYAGCLTQ 100
    LYFLVSLVAL DNLILAVMAY DRYVAICCPL HYTTAMSPKL CILLLSLCWV 150
    LSVLYGLIHT LLMTRVTFCG SRKIHYIFCE MYVLLRMACS NIQINHTVLI 200
    ATGCFIFLIP FGFVIISYVL IIRAILRIPS VSKKYKAFST CASHLGAVSL 250
    FYGTLCMVYL KPLHTYSVKD SVATVMYAVV TPMMNPFIYS LRNKDMHGAL 300
    GRLLDKHFKR LT 312
    Length:312
    Mass (Da):35,240
    Last modified:June 7, 2005 - v2
    Checksum:i71B05367C0AA135B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti25 – 251R → Q.2 Publications
    Corresponds to variant rs769423 [ dbSNP | Ensembl ].
    VAR_019630
    Natural varianti31 – 311F → Y.
    Corresponds to variant rs9916628 [ dbSNP | Ensembl ].
    VAR_057534
    Natural varianti214 – 2141V → M.
    Corresponds to variant rs55803944 [ dbSNP | Ensembl ].
    VAR_062008
    Natural varianti240 – 2401T → I.
    Corresponds to variant rs4300683 [ dbSNP | Ensembl ].
    VAR_057535

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65857 Genomic DNA. Translation: CAA46687.1.
    AF087917 Genomic DNA. Translation: AAF37310.1.
    BC069552 mRNA. Translation: AAH69552.1.
    BC106735 mRNA. Translation: AAI06736.1.
    BC106736 mRNA. Translation: AAI06737.1.
    U53583 Genomic DNA. Translation: AAC99554.1.
    AF399535 Genomic DNA. Translation: AAK95020.1.
    U04678 Genomic DNA. Translation: AAA18343.1.
    BK004244 Genomic DNA. Translation: DAA04642.1.
    CCDSiCCDS11019.1.
    PIRiA48413.
    I38471.
    RefSeqiNP_002539.2. NM_002548.2.
    UniGeneiHs.532771.

    Genome annotation databases

    EnsembliENST00000331459; ENSP00000327585; ENSG00000184166.
    GeneIDi4991.
    KEGGihsa:4991.
    UCSCiuc010vrb.2. human.

    Polymorphism databases

    DMDMi67477446.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Love at first smell - Issue 115 of March 2010

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65857 Genomic DNA. Translation: CAA46687.1 .
    AF087917 Genomic DNA. Translation: AAF37310.1 .
    BC069552 mRNA. Translation: AAH69552.1 .
    BC106735 mRNA. Translation: AAI06736.1 .
    BC106736 mRNA. Translation: AAI06737.1 .
    U53583 Genomic DNA. Translation: AAC99554.1 .
    AF399535 Genomic DNA. Translation: AAK95020.1 .
    U04678 Genomic DNA. Translation: AAA18343.1 .
    BK004244 Genomic DNA. Translation: DAA04642.1 .
    CCDSi CCDS11019.1.
    PIRi A48413.
    I38471.
    RefSeqi NP_002539.2. NM_002548.2.
    UniGenei Hs.532771.

    3D structure databases

    ProteinModelPortali P34982.
    SMRi P34982. Positions 32-304.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-46308N.
    IntActi P34982. 1 interaction.
    MINTi MINT-7295783.
    STRINGi 9606.ENSP00000327585.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P34982.

    Polymorphism databases

    DMDMi 67477446.

    Proteomic databases

    PRIDEi P34982.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000331459 ; ENSP00000327585 ; ENSG00000184166 .
    GeneIDi 4991.
    KEGGi hsa:4991.
    UCSCi uc010vrb.2. human.

    Organism-specific databases

    CTDi 4991.
    GeneCardsi GC17M002995.
    HGNCi HGNC:8183. OR1D2.
    MIMi 164342. gene.
    neXtProti NX_P34982.
    PharmGKBi PA32057.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41734.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi P34982.
    KOi K04257.
    OMAi YLKPLHT.
    OrthoDBi EOG7JQBNT.
    PhylomeDBi P34982.
    TreeFami TF337210.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR1D2.
    GenomeRNAii 4991.
    NextBioi 19220.
    PROi P34982.
    SOURCEi Search...

    Gene expression databases

    Bgeei P34982.
    CleanExi HS_OR1D2.
    Genevestigatori P34982.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to the 17p13-->p12 region of the human genome and reveals an MspI restriction fragment length polymorphism."
      Schurmans S., Muscatelli F., Miot F., Mattei M.-G., Vassart G., Parmentier M.
      Cytogenet. Cell Genet. 63:200-204(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-25.
    2. "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster."
      Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.
      Genomics 63:227-245(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-25.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Sequence of cosmid ICRF105cF06137 of the human chromosome 17p13.3 olfactory receptor gene cluster."
      Ferraz C., Demaille J.G.
      Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-214.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
    6. "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire."
      Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H., Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.
      Hum. Mol. Genet. 3:229-235(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 118-282.
    7. "Identification of a testicular odorant receptor mediating human sperm chemotaxis."
      Spehr M., Gisselmann G., Poplawski A., Riffell J.A., Wetzel C.H., Zimmer R.K., Hatt H.
      Science 299:2054-2058(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN SPERM CHEMOTAXIS, TISSUE SPECIFICITY.
    8. Cited for: FUNCTION IN OLFACTORY RECEPTION, TISSUE SPECIFICITY.
    9. Cited for: IDENTIFICATION.
    10. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
    11. "Novel function of beta-arrestin2 in the nucleus of mature spermatozoa."
      Neuhaus E.M., Mashukova A., Barbour J., Wolters D., Hatt H.
      J. Cell Sci. 119:3047-3056(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF SER-230; SER-232; SER-239 AND THR-312.

    Entry informationi

    Entry nameiOR1D2_HUMAN
    AccessioniPrimary (citable) accession number: P34982
    Secondary accession number(s): Q6IFL8, Q96RA4, Q9UM78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 140 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3