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Protein

Olfactory receptor 1D2

Gene

OR1D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for sperm in vitro and is shown to be a strong agonist for OR1D2 in vitro. May also function in olfactory reception.3 Publications

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

  • chemotaxis Source: UniProtKB-KW
  • detection of chemical stimulus involved in sensory perception of smell Source: GOC
  • G-protein coupled receptor signaling pathway Source: UniProtKB
  • movement of cell or subcellular component Source: ProtInc
  • protein import into nucleus, translocation Source: UniProtKB
  • sensory perception of smell Source: ProtInc
  • single fertilization Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis, Fertilization, Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1D2
Alternative name(s):
Olfactory receptor 17-4
Short name:
OR17-4
Olfactory receptor OR17-6
Olfactory receptor-like protein HGMP07E
Gene namesi
Name:OR1D2
Synonyms:OLFR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:8183. OR1D2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 19638ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21923Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini260 – 27112ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29120Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini292 – 31221CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • intracellular Source: GOC
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi230 – 2301S → A: Abolishes nuclear translocation of ARRB2; when associated with A-232 and A-239. 1 Publication
Mutagenesisi232 – 2321S → A: Abolishes nuclear translocation of ARRB2; when associated with A-230 and A-239. 1 Publication
Mutagenesisi239 – 2391S → A: Abolishes nuclear translocation of ARRB2; when associated with A-230 and A-232. 1 Publication
Mutagenesisi312 – 3121T → A: Abolishes nuclear translocation of ARRB2. 1 Publication

Organism-specific databases

PharmGKBiPA32057.

Polymorphism and mutation databases

BioMutaiOR1D2.
DMDMi67477446.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 1D2PRO_0000150418Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP34982.

PTM databases

PhosphoSiteiP34982.

Expressioni

Tissue specificityi

Expressed in testis. Expressed in spermatozoa (at protein level). Expressed in olfactory epithelium.3 Publications

Gene expression databases

BgeeiP34982.
CleanExiHS_OR1D2.
GenevisibleiP34982. HS.

Interactioni

Protein-protein interaction databases

DIPiDIP-46308N.
IntActiP34982. 1 interaction.
MINTiMINT-7295783.
STRINGi9606.ENSP00000327585.

Structurei

3D structure databases

ProteinModelPortaliP34982.
SMRiP34982. Positions 32-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41734.
GeneTreeiENSGT00800000124028.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiP34982.
KOiK04257.
OMAiYLKPLHT.
OrthoDBiEOG7JQBNT.
PhylomeDBiP34982.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34982-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGGNQSEGS EFLLLGMSES PEQQRILFWM FLSMYLVTVV GNVLIILAIS
60 70 80 90 100
SDSRLHTPVY FFLANLSFTD LFFVTNTIPK MLVNLQSHNK AISYAGCLTQ
110 120 130 140 150
LYFLVSLVAL DNLILAVMAY DRYVAICCPL HYTTAMSPKL CILLLSLCWV
160 170 180 190 200
LSVLYGLIHT LLMTRVTFCG SRKIHYIFCE MYVLLRMACS NIQINHTVLI
210 220 230 240 250
ATGCFIFLIP FGFVIISYVL IIRAILRIPS VSKKYKAFST CASHLGAVSL
260 270 280 290 300
FYGTLCMVYL KPLHTYSVKD SVATVMYAVV TPMMNPFIYS LRNKDMHGAL
310
GRLLDKHFKR LT
Length:312
Mass (Da):35,240
Last modified:June 7, 2005 - v2
Checksum:i71B05367C0AA135B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti25 – 251R → Q.2 Publications
Corresponds to variant rs769423 [ dbSNP | Ensembl ].
VAR_019630
Natural varianti31 – 311F → Y.
Corresponds to variant rs9916628 [ dbSNP | Ensembl ].
VAR_057534
Natural varianti214 – 2141V → M.
Corresponds to variant rs55803944 [ dbSNP | Ensembl ].
VAR_062008
Natural varianti240 – 2401T → I.
Corresponds to variant rs4300683 [ dbSNP | Ensembl ].
VAR_057535

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65857 Genomic DNA. Translation: CAA46687.1.
AF087917 Genomic DNA. Translation: AAF37310.1.
BC069552 mRNA. Translation: AAH69552.1.
BC106735 mRNA. Translation: AAI06736.1.
BC106736 mRNA. Translation: AAI06737.1.
U53583 Genomic DNA. Translation: AAC99554.1.
AF399535 Genomic DNA. Translation: AAK95020.1.
U04678 Genomic DNA. Translation: AAA18343.1.
BK004244 Genomic DNA. Translation: DAA04642.1.
CCDSiCCDS11019.1.
PIRiA48413.
I38471.
RefSeqiNP_002539.2. NM_002548.2.
UniGeneiHs.532771.

Genome annotation databases

EnsembliENST00000331459; ENSP00000327585; ENSG00000184166.
GeneIDi4991.
KEGGihsa:4991.
UCSCiuc010vrb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

Love at first smell - Issue 115 of March 2010

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65857 Genomic DNA. Translation: CAA46687.1.
AF087917 Genomic DNA. Translation: AAF37310.1.
BC069552 mRNA. Translation: AAH69552.1.
BC106735 mRNA. Translation: AAI06736.1.
BC106736 mRNA. Translation: AAI06737.1.
U53583 Genomic DNA. Translation: AAC99554.1.
AF399535 Genomic DNA. Translation: AAK95020.1.
U04678 Genomic DNA. Translation: AAA18343.1.
BK004244 Genomic DNA. Translation: DAA04642.1.
CCDSiCCDS11019.1.
PIRiA48413.
I38471.
RefSeqiNP_002539.2. NM_002548.2.
UniGeneiHs.532771.

3D structure databases

ProteinModelPortaliP34982.
SMRiP34982. Positions 32-304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46308N.
IntActiP34982. 1 interaction.
MINTiMINT-7295783.
STRINGi9606.ENSP00000327585.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP34982.

Polymorphism and mutation databases

BioMutaiOR1D2.
DMDMi67477446.

Proteomic databases

PRIDEiP34982.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331459; ENSP00000327585; ENSG00000184166.
GeneIDi4991.
KEGGihsa:4991.
UCSCiuc010vrb.2. human.

Organism-specific databases

CTDi4991.
GeneCardsiGC17M002995.
HGNCiHGNC:8183. OR1D2.
MIMi164342. gene.
neXtProtiNX_P34982.
PharmGKBiPA32057.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG41734.
GeneTreeiENSGT00800000124028.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiP34982.
KOiK04257.
OMAiYLKPLHT.
OrthoDBiEOG7JQBNT.
PhylomeDBiP34982.
TreeFamiTF337210.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR1D2.
GenomeRNAii4991.
NextBioi19220.
PROiP34982.
SOURCEiSearch...

Gene expression databases

BgeeiP34982.
CleanExiHS_OR1D2.
GenevisibleiP34982. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to the 17p13-->p12 region of the human genome and reveals an MspI restriction fragment length polymorphism."
    Schurmans S., Muscatelli F., Miot F., Mattei M.-G., Vassart G., Parmentier M.
    Cytogenet. Cell Genet. 63:200-204(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-25.
  2. "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster."
    Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.
    Genomics 63:227-245(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-25.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Sequence of cosmid ICRF105cF06137 of the human chromosome 17p13.3 olfactory receptor gene cluster."
    Ferraz C., Demaille J.G.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-214.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
  6. "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire."
    Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H., Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.
    Hum. Mol. Genet. 3:229-235(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 118-282.
  7. "Identification of a testicular odorant receptor mediating human sperm chemotaxis."
    Spehr M., Gisselmann G., Poplawski A., Riffell J.A., Wetzel C.H., Zimmer R.K., Hatt H.
    Science 299:2054-2058(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN SPERM CHEMOTAXIS, TISSUE SPECIFICITY.
  8. Cited for: FUNCTION IN OLFACTORY RECEPTION, TISSUE SPECIFICITY.
  9. Cited for: IDENTIFICATION.
  10. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
  11. "Novel function of beta-arrestin2 in the nucleus of mature spermatozoa."
    Neuhaus E.M., Mashukova A., Barbour J., Wolters D., Hatt H.
    J. Cell Sci. 119:3047-3056(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF SER-230; SER-232; SER-239 AND THR-312.

Entry informationi

Entry nameiOR1D2_HUMAN
AccessioniPrimary (citable) accession number: P34982
Secondary accession number(s): Q6IFL8, Q96RA4, Q9UM78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 7, 2005
Last modified: July 22, 2015
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.