Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P34981

- TRFR_HUMAN

UniProt

P34981 - TRFR_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Thyrotropin-releasing hormone receptor

Gene

TRHR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. thyrotropin-releasing hormone receptor activity Source: ProtInc

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Protein family/group databases

TCDBi9.A.14.1.4. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Thyrotropin-releasing hormone receptor
Short name:
TRH-R
Alternative name(s):
Thyroliberin receptor
Gene namesi
Name:TRHR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:12299. TRHR.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828ExtracellularSequence AnalysisAdd
BLAST
Transmembranei29 – 5123Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini52 – 6110CytoplasmicSequence Analysis
Transmembranei62 – 8322Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini84 – 9916ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12122Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini122 – 14423CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei145 – 16824Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini169 – 19325ExtracellularSequence AnalysisAdd
BLAST
Transmembranei194 – 21522Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini216 – 26651CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei267 – 28822Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini289 – 2968ExtracellularSequence Analysis
Transmembranei297 – 31923Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini320 – 39879CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

MIMi188545. gene+phenotype.
Orphaneti99832. Resistance to thyrotropin-releasing hormone syndrome.
PharmGKBiPA36979.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Thyrotropin-releasing hormone receptorPRO_0000070187Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 1791 PublicationPROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP34981.
PRIDEiP34981.

PTM databases

PhosphoSiteiP34981.

Expressioni

Gene expression databases

BgeeiP34981.
CleanExiHS_TRHR.
GenevestigatoriP34981.

Interactioni

Protein-protein interaction databases

BioGridi113052. 2 interactions.
STRINGi9606.ENSP00000309818.

Structurei

3D structure databases

ProteinModelPortaliP34981.
SMRiP34981. Positions 22-353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG303917.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000017249.
HOVERGENiHBG007549.
InParanoidiP34981.
KOiK04282.
OMAiTVVSCGY.
OrthoDBiEOG789CCX.
PhylomeDBiP34981.
TreeFamiTF326170.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002120. TRH_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00751. THYROLIBRINR.
PR01846. TRHRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34981-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENETVSELN QTQLQPRAVV ALEYQVVTIL LVLIICGLGI VGNIMVVLVV
60 70 80 90 100
MRTKHMRTPT NCYLVSLAVA DLMVLVAAGL PNITDSIYGS WVYGYVGCLC
110 120 130 140 150
ITYLQYLGIN ASSCSITAFT IERYIAICHP IKAQFLCTFS RAKKIIIFVW
160 170 180 190 200
AFTSLYCMLW FFLLDLNIST YKDAIVISCG YKISRNYYSP IYLMDFGVFY
210 220 230 240 250
VVPMILATVL YGFIARILFL NPIPSDPKEN SKTWKNDSTH QNTNLNVNTS
260 270 280 290 300
NRCFNSTVSS RKQVTKMLAV VVILFALLWM PYRTLVVVNS FLSSPFQENW
310 320 330 340 350
FLLFCRICIY LNSAINPVIY NLMSQKFRAA FRKLCNCKQK PTEKPANYSV
360 370 380 390
ALNYSVIKES DHFSTELDDI TVTDTYLSAT KVSFDDTCLA SEVSFSQS
Length:398
Mass (Da):45,085
Last modified:February 1, 1994 - v1
Checksum:iFE920B5F2E933D3E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101N → K.
Corresponds to variant rs5774 [ dbSNP | Ensembl ].
VAR_011857
Natural varianti168 – 1681I → M.
Corresponds to variant rs13306060 [ dbSNP | Ensembl ].
VAR_049450

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16845 mRNA. Translation: BAA04120.1.
X75071 mRNA. Translation: CAA52965.1.
X72089 mRNA. Translation: CAA50979.1.
S75283, S75281 Genomic DNA. Translation: AAB32222.1.
D85376 Genomic DNA. Translation: BAA12796.1.
AY493373 mRNA. Translation: AAR84356.1.
BC105045 mRNA. Translation: AAI05046.1.
BC113360 mRNA. Translation: AAI13361.1.
AJ011701 Genomic DNA. Translation: CAA09746.1.
CCDSiCCDS6311.1.
PIRiS40682. JN0708.
RefSeqiNP_003292.1. NM_003301.5.
UniGeneiHs.3022.

Genome annotation databases

EnsembliENST00000311762; ENSP00000309818; ENSG00000174417.
ENST00000518632; ENSP00000430711; ENSG00000174417.
GeneIDi7201.
KEGGihsa:7201.
UCSCiuc003ymz.4. human.

Polymorphism databases

DMDMi464921.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16845 mRNA. Translation: BAA04120.1 .
X75071 mRNA. Translation: CAA52965.1 .
X72089 mRNA. Translation: CAA50979.1 .
S75283 , S75281 Genomic DNA. Translation: AAB32222.1 .
D85376 Genomic DNA. Translation: BAA12796.1 .
AY493373 mRNA. Translation: AAR84356.1 .
BC105045 mRNA. Translation: AAI05046.1 .
BC113360 mRNA. Translation: AAI13361.1 .
AJ011701 Genomic DNA. Translation: CAA09746.1 .
CCDSi CCDS6311.1.
PIRi S40682. JN0708.
RefSeqi NP_003292.1. NM_003301.5.
UniGenei Hs.3022.

3D structure databases

ProteinModelPortali P34981.
SMRi P34981. Positions 22-353.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113052. 2 interactions.
STRINGi 9606.ENSP00000309818.

Chemistry

BindingDBi P34981.
ChEMBLi CHEMBL1810.
GuidetoPHARMACOLOGYi 363.

Protein family/group databases

TCDBi 9.A.14.1.4. the g-protein-coupled receptor (gpcr) family.
GPCRDBi Search...

PTM databases

PhosphoSitei P34981.

Polymorphism databases

DMDMi 464921.

Proteomic databases

PaxDbi P34981.
PRIDEi P34981.

Protocols and materials databases

DNASUi 7201.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000311762 ; ENSP00000309818 ; ENSG00000174417 .
ENST00000518632 ; ENSP00000430711 ; ENSG00000174417 .
GeneIDi 7201.
KEGGi hsa:7201.
UCSCi uc003ymz.4. human.

Organism-specific databases

CTDi 7201.
GeneCardsi GC08P110168.
HGNCi HGNC:12299. TRHR.
MIMi 188545. gene+phenotype.
neXtProti NX_P34981.
Orphaneti 99832. Resistance to thyrotropin-releasing hormone syndrome.
PharmGKBi PA36979.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG303917.
GeneTreei ENSGT00700000104070.
HOGENOMi HOG000017249.
HOVERGENi HBG007549.
InParanoidi P34981.
KOi K04282.
OMAi TVVSCGY.
OrthoDBi EOG789CCX.
PhylomeDBi P34981.
TreeFami TF326170.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

GeneWikii Thyrotropin-releasing_hormone_receptor.
GenomeRNAii 7201.
NextBioi 28220.
PROi P34981.
SOURCEi Search...

Gene expression databases

Bgeei P34981.
CleanExi HS_TRHR.
Genevestigatori P34981.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002120. TRH_rcpt_1.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00751. THYROLIBRINR.
PR01846. TRHRFAMILY.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene."
    Yamada M., Monden T., Satoh T., Satoh N., Murakami M., Iriuchijima T., Kakegawa T., Mori M.
    Biochem. Biophys. Res. Commun. 195:737-745(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pituitary.
  3. "Cloning and functional characterisation of the human TRH receptor."
    Duthie S.M., Taylor P.L., Anderson L., Cook J., Eidne K.A.
    Mol. Cell. Endocrinol. 95:R11-R15(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene."
    Hinuma S., Hosoya M., Ogi K., Tanaka H., Nagai Y., Onda H.
    Biochim. Biophys. Acta 1219:251-259(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene."
    Iwasaki T., Yamada M., Satoh T., Konaka S., Ren Y., Hashimoto K., Kohga H., Kato Y., Mori M.
    J. Biol. Chem. 271:22183-22188(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  8. "Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor."
    Matre V., Hovring P.I., Orstavik S., Frengen E., Rian E., Velickovic Z., Murray-Mcintosh R.P., Gautvik K.M.
    J. Neurochem. 72:40-50(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-263.
    Tissue: Placenta.
  9. "A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor."
    Cook J.V., McGregor A., Lee T., Milligan G., Eidne K.A.
    Endocrinology 137:2851-2858(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BOND.

Entry informationi

Entry nameiTRFR_HUMAN
AccessioniPrimary (citable) accession number: P34981
Secondary accession number(s): Q2M339
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 26, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3