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P34981

- TRFR_HUMAN

UniProt

P34981 - TRFR_HUMAN

Protein

Thyrotropin-releasing hormone receptor

Gene

TRHR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

    GO - Molecular functioni

    1. thyrotropin-releasing hormone receptor activity Source: ProtInc

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Protein family/group databases

    TCDBi9.A.14.1.4. the g-protein-coupled receptor (gpcr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thyrotropin-releasing hormone receptor
    Short name:
    TRH-R
    Alternative name(s):
    Thyroliberin receptor
    Gene namesi
    Name:TRHR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:12299. TRHR.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    MIMi188545. gene+phenotype.
    Orphaneti99832. Resistance to thyrotropin-releasing hormone syndrome.
    PharmGKBiPA36979.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 398398Thyrotropin-releasing hormone receptorPRO_0000070187Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 1791 PublicationPROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP34981.
    PRIDEiP34981.

    PTM databases

    PhosphoSiteiP34981.

    Expressioni

    Gene expression databases

    BgeeiP34981.
    CleanExiHS_TRHR.
    GenevestigatoriP34981.

    Interactioni

    Protein-protein interaction databases

    BioGridi113052. 1 interaction.
    STRINGi9606.ENSP00000309818.

    Structurei

    3D structure databases

    ProteinModelPortaliP34981.
    SMRiP34981. Positions 22-334.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2828ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini52 – 6110CytoplasmicSequence Analysis
    Topological domaini84 – 9916ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini122 – 14423CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini169 – 19325ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini216 – 26651CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini289 – 2968ExtracellularSequence Analysis
    Topological domaini320 – 39879CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 5123Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei62 – 8322Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12122Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei145 – 16824Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei194 – 21522Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei267 – 28822Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei297 – 31923Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG303917.
    HOGENOMiHOG000017249.
    HOVERGENiHBG007549.
    InParanoidiP34981.
    KOiK04282.
    OMAiTVVSCGY.
    OrthoDBiEOG789CCX.
    PhylomeDBiP34981.
    TreeFamiTF326170.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002120. TRH_rcpt_1.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00751. THYROLIBRINR.
    PR01846. TRHRFAMILY.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34981-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENETVSELN QTQLQPRAVV ALEYQVVTIL LVLIICGLGI VGNIMVVLVV    50
    MRTKHMRTPT NCYLVSLAVA DLMVLVAAGL PNITDSIYGS WVYGYVGCLC 100
    ITYLQYLGIN ASSCSITAFT IERYIAICHP IKAQFLCTFS RAKKIIIFVW 150
    AFTSLYCMLW FFLLDLNIST YKDAIVISCG YKISRNYYSP IYLMDFGVFY 200
    VVPMILATVL YGFIARILFL NPIPSDPKEN SKTWKNDSTH QNTNLNVNTS 250
    NRCFNSTVSS RKQVTKMLAV VVILFALLWM PYRTLVVVNS FLSSPFQENW 300
    FLLFCRICIY LNSAINPVIY NLMSQKFRAA FRKLCNCKQK PTEKPANYSV 350
    ALNYSVIKES DHFSTELDDI TVTDTYLSAT KVSFDDTCLA SEVSFSQS 398
    Length:398
    Mass (Da):45,085
    Last modified:February 1, 1994 - v1
    Checksum:iFE920B5F2E933D3E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101N → K.
    Corresponds to variant rs5774 [ dbSNP | Ensembl ].
    VAR_011857
    Natural varianti168 – 1681I → M.
    Corresponds to variant rs13306060 [ dbSNP | Ensembl ].
    VAR_049450

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16845 mRNA. Translation: BAA04120.1.
    X75071 mRNA. Translation: CAA52965.1.
    X72089 mRNA. Translation: CAA50979.1.
    S75283, S75281 Genomic DNA. Translation: AAB32222.1.
    D85376 Genomic DNA. Translation: BAA12796.1.
    AY493373 mRNA. Translation: AAR84356.1.
    BC105045 mRNA. Translation: AAI05046.1.
    BC113360 mRNA. Translation: AAI13361.1.
    AJ011701 Genomic DNA. Translation: CAA09746.1.
    CCDSiCCDS6311.1.
    PIRiS40682. JN0708.
    RefSeqiNP_003292.1. NM_003301.5.
    UniGeneiHs.3022.

    Genome annotation databases

    EnsembliENST00000311762; ENSP00000309818; ENSG00000174417.
    ENST00000518632; ENSP00000430711; ENSG00000174417.
    GeneIDi7201.
    KEGGihsa:7201.
    UCSCiuc003ymz.4. human.

    Polymorphism databases

    DMDMi464921.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16845 mRNA. Translation: BAA04120.1 .
    X75071 mRNA. Translation: CAA52965.1 .
    X72089 mRNA. Translation: CAA50979.1 .
    S75283 , S75281 Genomic DNA. Translation: AAB32222.1 .
    D85376 Genomic DNA. Translation: BAA12796.1 .
    AY493373 mRNA. Translation: AAR84356.1 .
    BC105045 mRNA. Translation: AAI05046.1 .
    BC113360 mRNA. Translation: AAI13361.1 .
    AJ011701 Genomic DNA. Translation: CAA09746.1 .
    CCDSi CCDS6311.1.
    PIRi S40682. JN0708.
    RefSeqi NP_003292.1. NM_003301.5.
    UniGenei Hs.3022.

    3D structure databases

    ProteinModelPortali P34981.
    SMRi P34981. Positions 22-334.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113052. 1 interaction.
    STRINGi 9606.ENSP00000309818.

    Chemistry

    BindingDBi P34981.
    ChEMBLi CHEMBL1810.
    GuidetoPHARMACOLOGYi 363.

    Protein family/group databases

    TCDBi 9.A.14.1.4. the g-protein-coupled receptor (gpcr) family.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei P34981.

    Polymorphism databases

    DMDMi 464921.

    Proteomic databases

    PaxDbi P34981.
    PRIDEi P34981.

    Protocols and materials databases

    DNASUi 7201.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311762 ; ENSP00000309818 ; ENSG00000174417 .
    ENST00000518632 ; ENSP00000430711 ; ENSG00000174417 .
    GeneIDi 7201.
    KEGGi hsa:7201.
    UCSCi uc003ymz.4. human.

    Organism-specific databases

    CTDi 7201.
    GeneCardsi GC08P110168.
    HGNCi HGNC:12299. TRHR.
    MIMi 188545. gene+phenotype.
    neXtProti NX_P34981.
    Orphaneti 99832. Resistance to thyrotropin-releasing hormone syndrome.
    PharmGKBi PA36979.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG303917.
    HOGENOMi HOG000017249.
    HOVERGENi HBG007549.
    InParanoidi P34981.
    KOi K04282.
    OMAi TVVSCGY.
    OrthoDBi EOG789CCX.
    PhylomeDBi P34981.
    TreeFami TF326170.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    GeneWikii Thyrotropin-releasing_hormone_receptor.
    GenomeRNAii 7201.
    NextBioi 28220.
    PROi P34981.
    SOURCEi Search...

    Gene expression databases

    Bgeei P34981.
    CleanExi HS_TRHR.
    Genevestigatori P34981.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002120. TRH_rcpt_1.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00751. THYROLIBRINR.
    PR01846. TRHRFAMILY.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene."
      Yamada M., Monden T., Satoh T., Satoh N., Murakami M., Iriuchijima T., Kakegawa T., Mori M.
      Biochem. Biophys. Res. Commun. 195:737-745(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pituitary.
    3. "Cloning and functional characterisation of the human TRH receptor."
      Duthie S.M., Taylor P.L., Anderson L., Cook J., Eidne K.A.
      Mol. Cell. Endocrinol. 95:R11-R15(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene."
      Hinuma S., Hosoya M., Ogi K., Tanaka H., Nagai Y., Onda H.
      Biochim. Biophys. Acta 1219:251-259(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene."
      Iwasaki T., Yamada M., Satoh T., Konaka S., Ren Y., Hashimoto K., Kohga H., Kato Y., Mori M.
      J. Biol. Chem. 271:22183-22188(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    8. "Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor."
      Matre V., Hovring P.I., Orstavik S., Frengen E., Rian E., Velickovic Z., Murray-Mcintosh R.P., Gautvik K.M.
      J. Neurochem. 72:40-50(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-263.
      Tissue: Placenta.
    9. "A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor."
      Cook J.V., McGregor A., Lee T., Milligan G., Eidne K.A.
      Endocrinology 137:2851-2858(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BOND.

    Entry informationi

    Entry nameiTRFR_HUMAN
    AccessioniPrimary (citable) accession number: P34981
    Secondary accession number(s): Q2M339
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3