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P34981 (TRFR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thyrotropin-releasing hormone receptor

Short name=TRH-R
Alternative name(s):
Thyroliberin receptor
Gene names
Name:TRHR
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 398398Thyrotropin-releasing hormone receptor
PRO_0000070187

Regions

Topological domain1 – 2828Extracellular Potential
Transmembrane29 – 5123Helical; Name=1; Potential
Topological domain52 – 6110Cytoplasmic Potential
Transmembrane62 – 8322Helical; Name=2; Potential
Topological domain84 – 9916Extracellular Potential
Transmembrane100 – 12122Helical; Name=3; Potential
Topological domain122 – 14423Cytoplasmic Potential
Transmembrane145 – 16824Helical; Name=4; Potential
Topological domain169 – 19325Extracellular Potential
Transmembrane194 – 21522Helical; Name=5; Potential
Topological domain216 – 26651Cytoplasmic Potential
Transmembrane267 – 28822Helical; Name=6; Potential
Topological domain289 – 2968Extracellular Potential
Transmembrane297 – 31923Helical; Name=7; Potential
Topological domain320 – 39879Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Glycosylation101N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 179 Ref.9

Natural variations

Natural variant101N → K.
Corresponds to variant rs5774 [ dbSNP | Ensembl ].
VAR_011857
Natural variant1681I → M.
Corresponds to variant rs13306060 [ dbSNP | Ensembl ].
VAR_049450

Sequences

Sequence LengthMass (Da)Tools
P34981 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: FE920B5F2E933D3E

FASTA39845,085
        10         20         30         40         50         60 
MENETVSELN QTQLQPRAVV ALEYQVVTIL LVLIICGLGI VGNIMVVLVV MRTKHMRTPT 

        70         80         90        100        110        120 
NCYLVSLAVA DLMVLVAAGL PNITDSIYGS WVYGYVGCLC ITYLQYLGIN ASSCSITAFT 

       130        140        150        160        170        180 
IERYIAICHP IKAQFLCTFS RAKKIIIFVW AFTSLYCMLW FFLLDLNIST YKDAIVISCG 

       190        200        210        220        230        240 
YKISRNYYSP IYLMDFGVFY VVPMILATVL YGFIARILFL NPIPSDPKEN SKTWKNDSTH 

       250        260        270        280        290        300 
QNTNLNVNTS NRCFNSTVSS RKQVTKMLAV VVILFALLWM PYRTLVVVNS FLSSPFQENW 

       310        320        330        340        350        360 
FLLFCRICIY LNSAINPVIY NLMSQKFRAA FRKLCNCKQK PTEKPANYSV ALNYSVIKES 

       370        380        390 
DHFSTELDDI TVTDTYLSAT KVSFDDTCLA SEVSFSQS 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a functional human thyrotropin-releasing hormone receptor."
Matre V., Karlsen H.E., Wright M.S., Lundell I., Fjeldheim K., Gabrielsen O.S., Larhammar D., Gautvik K.M.
Biochem. Biophys. Res. Commun. 195:179-185(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene."
Yamada M., Monden T., Satoh T., Satoh N., Murakami M., Iriuchijima T., Kakegawa T., Mori M.
Biochem. Biophys. Res. Commun. 195:737-745(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pituitary.
[3]"Cloning and functional characterisation of the human TRH receptor."
Duthie S.M., Taylor P.L., Anderson L., Cook J., Eidne K.A.
Mol. Cell. Endocrinol. 95:R11-R15(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene."
Hinuma S., Hosoya M., Ogi K., Tanaka H., Nagai Y., Onda H.
Biochim. Biophys. Acta 1219:251-259(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene."
Iwasaki T., Yamada M., Satoh T., Konaka S., Ren Y., Hashimoto K., Kohga H., Kato Y., Mori M.
J. Biol. Chem. 271:22183-22188(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pituitary.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[8]"Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor."
Matre V., Hovring P.I., Orstavik S., Frengen E., Rian E., Velickovic Z., Murray-Mcintosh R.P., Gautvik K.M.
J. Neurochem. 72:40-50(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-263.
Tissue: Placenta.
[9]"A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor."
Cook J.V., McGregor A., Lee T., Milligan G., Eidne K.A.
Endocrinology 137:2851-2858(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: DISULFIDE BOND.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D16845 mRNA. Translation: BAA04120.1.
X75071 mRNA. Translation: CAA52965.1.
X72089 mRNA. Translation: CAA50979.1.
S75283, S75281 Genomic DNA. Translation: AAB32222.1.
D85376 Genomic DNA. Translation: BAA12796.1.
AY493373 mRNA. Translation: AAR84356.1.
BC105045 mRNA. Translation: AAI05046.1.
BC113360 mRNA. Translation: AAI13361.1.
AJ011701 Genomic DNA. Translation: CAA09746.1.
PIRJN0708. S40682.
RefSeqNP_003292.1. NM_003301.5.
UniGeneHs.3022.

3D structure databases

ProteinModelPortalP34981.
SMRP34981. Positions 27-353.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113052. 1 interaction.
STRING9606.ENSP00000309818.

Chemistry

BindingDBP34981.
ChEMBLCHEMBL1810.
GuidetoPHARMACOLOGY363.

Protein family/group databases

TCDB9.A.14.1.4. the g-protein-coupled receptor (gpcr) family.
GPCRDBSearch...

PTM databases

PhosphoSiteP34981.

Polymorphism databases

DMDM464921.

Proteomic databases

PaxDbP34981.
PRIDEP34981.

Protocols and materials databases

DNASU7201.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000311762; ENSP00000309818; ENSG00000174417.
ENST00000518632; ENSP00000430711; ENSG00000174417.
GeneID7201.
KEGGhsa:7201.
UCSCuc003ymz.4. human.

Organism-specific databases

CTD7201.
GeneCardsGC08P110168.
HGNCHGNC:12299. TRHR.
MIM188545. gene+phenotype.
neXtProtNX_P34981.
Orphanet99832. Resistance to thyrotropin-releasing hormone syndrome.
PharmGKBPA36979.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG303917.
HOGENOMHOG000017249.
HOVERGENHBG007549.
InParanoidP34981.
KOK04282.
OMAKPANYSV.
OrthoDBEOG789CCX.
PhylomeDBP34981.
TreeFamTF326170.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP34981.
CleanExHS_TRHR.
GenevestigatorP34981.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002120. TRH_rcpt_1.
[Graphical view]
PANTHERPTHR24243:SF51. PTHR24243:SF51. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00751. THYROLIBRINR.
PR01846. TRHRFAMILY.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiThyrotropin-releasing_hormone_receptor.
GenomeRNAi7201.
NextBio28220.
PROP34981.
SOURCESearch...

Entry information

Entry nameTRFR_HUMAN
AccessionPrimary (citable) accession number: P34981
Secondary accession number(s): Q2M339
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries